Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 14, 2013, Pages 4085-4090

  Troxler, Thomas ^a   Greenidge, Paulette ^a   Zimmermann, Kaspar ^a   Desrayaud, Sandrine ^a   Drückes, Peter ^a   Schweizer, Tatjana ^a   Stauffer, Daniela ^a   Rovelli, Giorgio ^a   Shimshek, Derya R ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Kinase inhibitors; Leucine rich repeat kinase 2; LRRK2; LRRK2 inhibitors; Parkinson's disease

Indexed keywords

1,4,6,7 TETRAHYDRO PYRROLO[3,2 C ]PYRIDINE; LEUCINE RICH REPEAT KINASE 2; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IC 50; IN VIVO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; CELL LINE; DRUG EVALUATION, PRECLINICAL; HALF-LIFE; INDOLES; MICE; MUTATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 84879419522     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.054     Document Type: Article

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