-
2
-
-
0031013848
-
Prevalence of parkinsonism and Parkinson's disease in Europe: The EURO- PARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease
-
de Rijk MC, Tzourio C, Breteler MM, Dartigues JF, Amaducci L, et al. (1997) Prevalence of parkinsonism and Parkinson's disease in Europe: the EURO- PARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease. J Neurol Neurosurg Psychiatry 62: 10-15.
-
(1997)
J Neurol Neurosurg Psychiatry
, vol.62
, pp. 10-15
-
-
de Rijk, M.C.1
Tzourio, C.2
Breteler, M.M.3
Dartigues, J.F.4
Amaducci, L.5
-
3
-
-
0035687158
-
Societal costs of exposure to toxic substances: Economic and health costs of four case studies that are candidates for environmental causation
-
Muir T, Zegarac M (2001) Societal costs of exposure to toxic substances: economic and health costs of four case studies that are candidates for environmental causation. Environ Health Perspect 109 Suppl 6: 885-903.
-
(2001)
Environ Health Perspect 109 Suppl
, vol.6
, pp. 885-903
-
-
Muir, T.1
Zegarac, M.2
-
4
-
-
34447307390
-
Impact of recent genetic findings in Parkinson's disease
-
Klein C, Lohmann-Hedrich K (2007) Impact of recent genetic findings in Parkinson's disease. Curr Opin Neurol 20: 453-464.
-
(2007)
Curr Opin Neurol
, vol.20
, pp. 453-464
-
-
Klein, C.1
Lohmann-Hedrich, K.2
-
5
-
-
33750594065
-
Genetics of Parkinson's disease and parkinsonism
-
Hardy J, Cai H, Cookson MR, Gwinn-Hardy K, Singleton A (2006) Genetics of Parkinson's disease and parkinsonism. Ann Neurol 60: 389-398.
-
(2006)
Ann Neurol
, vol.60
, pp. 389-398
-
-
Hardy, J.1
Cai, H.2
Cookson, M.R.3
Gwinn-Hardy, K.4
Singleton, A.5
-
6
-
-
0037240325
-
Rare genetic mutations shed light on the pathogenesis of Parkinson disease
-
Dawson TM, Dawson VL (2003) Rare genetic mutations shed light on the pathogenesis of Parkinson disease. J Clin Invest 111: 145-151.
-
(2003)
J Clin Invest
, vol.111
, pp. 145-151
-
-
Dawson, T.M.1
Dawson, V.L.2
-
7
-
-
28544441181
-
Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: Clinical, pathological, olfactory and functional imaging and genetic data
-
Khan NL, Jain S, Lynch JM, Pavese N, Abou-Sleiman P, et al. (2005) Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data. Brain 128: 2786-2796.
-
(2005)
Brain
, vol.128
, pp. 2786-2796
-
-
Khan, N.L.1
Jain, S.2
Lynch, J.M.3
Pavese, N.4
Abou-Sleiman, P.5
-
8
-
-
35848934342
-
Lrrk2 in the limelight!
-
Farrer MJ (2007) Lrrk2 in the limelight! Neurology 69: 1732-1733.
-
(2007)
Neurology
, vol.69
, pp. 1732-1733
-
-
Farrer, M.J.1
-
10
-
-
33748993710
-
Kinase activity of mutant LRRK2 mediates neuronal toxicity
-
Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, et al. (2006) Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat Neurosci 9: 1231-1233.
-
(2006)
Nat Neurosci
, vol.9
, pp. 1231-1233
-
-
Smith, W.W.1
Pei, Z.2
Jiang, H.3
Dawson, V.L.4
Dawson, T.M.5
-
11
-
-
33746267531
-
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
-
Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, et al. (2006) Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. Neurobiol Dis 23: 329-341.
-
(2006)
Neurobiol Dis
, vol.23
, pp. 329-341
-
-
Greggio, E.1
Jain, S.2
Kingsbury, A.3
Bandopadhyay, R.4
Lewis, P.5
-
12
-
-
34247468302
-
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
-
Lewis PA, Greggio E, Beilina A, Jain S, Baker A, et al. (2007) The R1441C mutation of LRRK2 disrupts GTP hydrolysis. Biochem Biophys Res Commun 357: 668-671.
-
(2007)
Biochem Biophys Res Commun
, vol.357
, pp. 668-671
-
-
Lewis, P.A.1
Greggio, E.2
Beilina, A.3
Jain, S.4
Baker, A.5
-
13
-
-
34548621385
-
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
-
Li X, Tan YC, Poulose S, Olanow CW, Huang XY, et al. (2007) Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J Neurochem 103: 238-247.
-
(2007)
J Neurochem
, vol.103
, pp. 238-247
-
-
Li, X.1
Tan, Y.C.2
Poulose, S.3
Olanow, C.W.4
Huang, X.Y.5
-
14
-
-
34548604567
-
The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity
-
Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, et al. (2007) The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Exp Cell Res 313: 3658-3670.
-
(2007)
Exp Cell Res
, vol.313
, pp. 3658-3670
-
-
Guo, L.1
Gandhi, P.N.2
Wang, W.3
Petersen, R.B.4
Wilson-Delfosse, A.L.5
-
15
-
-
51949090816
-
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
-
Imai Y, Gehrke S, Wang HQ, Takahashi R, Hasegawa K, et al. (2008) Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J.
-
(2008)
EMBO J
-
-
Imai, Y.1
Gehrke, S.2
Wang, H.Q.3
Takahashi, R.4
Hasegawa, K.5
-
16
-
-
34447118788
-
LRRK2 phosphorylates moesin at threonine-558: Characterization of how Parkinson's disease mutants affect kinase activity
-
Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, et al. (2007) LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Biochem J 405: 307-317.
-
(2007)
Biochem J
, vol.405
, pp. 307-317
-
-
Jaleel, M.1
Nichols, R.J.2
Deak, M.3
Campbell, D.G.4
Gillardon, F.5
-
17
-
-
28044460070
-
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
-
West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, et al. (2005) Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A 102: 16842-16847.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 16842-16847
-
-
West, A.B.1
Moore, D.J.2
Biskup, S.3
Bugayenko, A.4
Smith, W.W.5
-
18
-
-
47749114984
-
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
-
Greggio E, Zambrano I, Kaganovich A, Beilina A, Taymans JM, et al. (2008) The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. J Biol Chem 283: 16906-16914.
-
(2008)
J Biol Chem
, vol.283
, pp. 16906-16914
-
-
Greggio, E.1
Zambrano, I.2
Kaganovich, A.3
Beilina, A.4
Taymans, J.M.5
-
19
-
-
57649178295
-
Intramolecular activation mechanism of the dictyostelium LRRK2-homolog Roco protein GbpC
-
van Egmond WN, Kortholt A, Plak K, Bosgraaf L, Bosgraaf S, et al. (2008) Intramolecular activation mechanism of the dictyostelium LRRK2-homolog Roco protein GbpC. J Biol Chem.
-
(2008)
J Biol Chem
-
-
van Egmond, W.N.1
Kortholt, A.2
Plak, K.3
Bosgraaf, L.4
Bosgraaf, S.5
-
20
-
-
40349101849
-
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
-
Deng J, Lewis PA, Greggio E, Sluch E, Beilina A, et al. (2008) Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proc Natl Acad Sci U S A 105: 1499-1504.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 1499-1504
-
-
Deng, J.1
Lewis, P.A.2
Greggio, E.3
Sluch, E.4
Beilina, A.5
-
21
-
-
33646151866
-
LRRK2 in Parkinson's disease: Protein domains and functional insights
-
Mata IF, Wedemeyer WJ, Farrer MJ, Taylor JP, Gallo KA (2006) LRRK2 in Parkinson's disease: protein domains and functional insights. Trends Neurosci 29: 286-293.
-
(2006)
Trends Neurosci
, vol.29
, pp. 286-293
-
-
Mata, I.F.1
Wedemeyer, W.J.2
Farrer, M.J.3
Taylor, J.P.4
Gallo, K.A.5
-
22
-
-
34250192244
-
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK 1
-
Greggio E, Lewis PA, van der Brug MP, Ahmad R, Kaganovich A, et al. (2007) Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK 1. J Neurochem 102: 93-102.
-
(2007)
J Neurochem
, vol.102
, pp. 93-102
-
-
Greggio, E.1
Lewis, P.A.2
van der Brug, M.P.3
Ahmad, R.4
Kaganovich, A.5
-
23
-
-
31144443248
-
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
-
Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O'Neill E, et al. (2006) The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum Mol Genet 15: 223-232.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 223-232
-
-
Gloeckner, C.J.1
Kinkl, N.2
Schumacher, A.3
Braun, R.J.4
O'Neill, E.5
-
24
-
-
49949099269
-
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
-
Gotthardt K, Weyand M, Kortholt A, Van Haastert PJ, Wittinghofer A (2008) Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J 27: 2352.
-
(2008)
EMBO J
, vol.27
, pp. 2352
-
-
Gotthardt, K.1
Weyand, M.2
Kortholt, A.3
van Haastert, P.J.4
Wittinghofer, A.5
-
25
-
-
33847267765
-
Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia
-
Farrer MJ, Stone JT, Lin CH, Dachsel JC, Hulihan MM, et al. (2007) Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia. Parkinsonism Relat Disord 13: 89-92.
-
(2007)
Parkinsonism Relat Disord
, vol.13
, pp. 89-92
-
-
Farrer, M.J.1
Stone, J.T.2
Lin, C.H.3
Dachsel, J.C.4
Hulihan, M.M.5
-
26
-
-
33847226901
-
Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population
-
Funayama M, Li Y, Tomiyama H, Yoshino H, Imamichi Y, et al. (2007) Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population. Neuroreport 18: 273-275.
-
(2007)
Neuroreport
, vol.18
, pp. 273-275
-
-
Funayama, M.1
Li, Y.2
Tomiyama, H.3
Yoshino, H.4
Imamichi, Y.5
-
27
-
-
33846358949
-
The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: Genetic and functional evidence
-
Tan EK, Zhao Y, Skipper L, Tan MG, Di Fonzo A, et al. (2007) The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence. Hum Genet 120: 857-863.
-
(2007)
Hum Genet
, vol.120
, pp. 857-863
-
-
Tan, E.K.1
Zhao, Y.2
Skipper, L.3
Tan, M.G.4
Di Fonzo, A.5
-
28
-
-
48449103940
-
Ancient origin of the Parkinson disease gene LRRK 2
-
Marin I (2008) Ancient origin of the Parkinson disease gene LRRK 2. J Mol Evol 67: 41-50.
-
(2008)
J Mol Evol
, vol.67
, pp. 41-50
-
-
Marin, I.1
-
29
-
-
10744220076
-
Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling
-
Petrey D, Xiang Z, Tang CL, Xie L, Gimpelev L, et al. (2003) Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling. Proteins: Structure, Function, and Genetics 53: 430-435.
-
(2003)
Proteins: Structure, Function, and Genetics
, vol.53
, pp. 430-435
-
-
Petrey, D.1
Xiang, Z.2
Tang, C.L.3
Xie, L.4
Gimpelev, L.5
-
30
-
-
59649089328
-
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas- associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
-
Ho CC, Rideout HJ, Ribe E, Troy CM, Dauer WT (2009) The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas- associated protein with death domain and caspase-8 in a cellular model of neurodegeneration. J Neurosci 29: 1011-1016.
-
(2009)
J Neurosci
, vol.29
, pp. 1011-1016
-
-
Ho, C.C.1
Rideout, H.J.2
Ribe, E.3
Troy, C.M.4
Dauer, W.T.5
-
31
-
-
34547093726
-
Identification of potential protein interactors of Lrrk 2
-
Dachsel JC, Taylor JP, Mok SS, Ross OA, Hinkle KM, et al. (2007) Identification of potential protein interactors of Lrrk 2. Parkinsonism Relat Disord 13: 382-385.
-
(2007)
Parkinsonism Relat Disord
, vol.13
, pp. 382-385
-
-
Dachsel, J.C.1
Taylor, J.P.2
Mok, S.S.3
Ross, O.A.4
Hinkle, K.M.5
-
32
-
-
41549144503
-
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine- rich repeat kinase 2
-
Wang L, Xie C, Greggio E, Parisiadou L, Shim H, et al. (2008) The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine- rich repeat kinase 2. J Neurosci 28: 3384-3391.
-
(2008)
J Neurosci
, vol.28
, pp. 3384-3391
-
-
Wang, L.1
Xie, C.2
Greggio, E.3
Parisiadou, L.4
Shim, H.5
-
33
-
-
45549085874
-
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules
-
Gandhi PN, Wang X, Zhu X, Chen SG, Wilson-Delfosse AL (2008) The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules. J Neurosci Res 86: 1711-1720.
-
(2008)
J Neurosci Res
, vol.86
, pp. 1711-1720
-
-
Gandhi, P.N.1
Wang, X.2
Zhu, X.3
Chen, S.G.4
Wilson-Delfosse, A.L.5
-
34
-
-
33746079596
-
A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan
-
Di Fonzo A, Wu-Chou YH, Lu CS, van Doeselaar M, Simons EJ, et al. (2006) A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan. Neurogenetics 7: 133-138.
-
(2006)
Neurogenetics
, vol.7
, pp. 133-138
-
-
Di Fonzo, A.1
Wu-Chou, Y.H.2
Lu, C.S.3
van Doeselaar, M.4
Simons, E.J.5
-
35
-
-
32244443107
-
LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain
-
Korr D, Toschi L, Donner P, Pohlenz HD, Kreft B, et al. (2006) LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain. Cell Signal 18: 910-920.
-
(2006)
Cell Signal
, vol.18
, pp. 910-920
-
-
Korr, D.1
Toschi, L.2
Donner, P.3
Pohlenz, H.D.4
Kreft, B.5
-
36
-
-
33847617975
-
Leucine-rich repeat kinase 1: A paralog of LRRK2 and a candidate gene for Parkinson's disease
-
Taylor JP, Hulihan MM, Kachergus JM, Melrose HL, Lincoln SJ, et al. (2007) Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease. Neurogenetics 8: 95-102.
-
(2007)
Neurogenetics
, vol.8
, pp. 95-102
-
-
Taylor, J.P.1
Hulihan, M.M.2
Kachergus, J.M.3
Melrose, H.L.4
Lincoln, S.J.5
-
37
-
-
34447294546
-
Apoptotic mechanisms in mutant LRRK2-mediated cell death
-
Iaccarino C, Crosio C, Vitale C, Sanna G, Carri MT, et al. (2007) Apoptotic mechanisms in mutant LRRK2-mediated cell death. Hum Mol Genet 16: 1319-1326.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 1319-1326
-
-
Iaccarino, C.1
Crosio, C.2
Vitale, C.3
Sanna, G.4
Carri, M.T.5
-
38
-
-
0034490962
-
Thirty-plus functional families from a single motif
-
Yu L, Gaitatzes C, Neer E, Smith TF (2000) Thirty-plus functional families from a single motif. Protein Sci 9: 2470-2476.
-
(2000)
Protein Sci
, vol.9
, pp. 2470-2476
-
-
Yu, L.1
Gaitatzes, C.2
Neer, E.3
Smith, T.F.4
-
40
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucl Acids Res 25: 3389-3402.
-
(1997)
Nucl Acids Res
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schaffer, A.A.3
Zhang, J.4
Zhang, Z.5
-
41
-
-
0344873345
-
On the role of structural information in remote homology detection and sequence alignment: New methods using hybrid sequence profiles
-
Tang CL, Xie L, Koh IY, Posy S, Alexov E, et al. (2003) On the role of structural information in remote homology detection and sequence alignment: new methods using hybrid sequence profiles. Journal of Molecular Biology 334: 1043-1062.
-
(2003)
Journal of Molecular Biology
, vol.334
, pp. 1043-1062
-
-
Tang, C.L.1
Xie, L.2
Koh, I.Y.3
Posy, S.4
Alexov, E.5
-
42
-
-
0033954256
-
The Protein Data Bank
-
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, et al. (2000) The Protein Data Bank. Nucleic Acids Research 28: 235-242.
-
(2000)
Nucleic Acids Research
, vol.28
, pp. 235-242
-
-
Berman, H.M.1
Westbrook, J.2
Feng, Z.3
Gilliland, G.4
Bhat, T.N.5
-
43
-
-
0036838311
-
Zhou Y (2002) Distance-scaled, finite ideal-gas reference state improves structure-derived potentials of mean force for structure selection and stability prediction.[erratum appears in Protein Sci
-
Zhou H, Zhou Y (2002) Distance-scaled, finite ideal-gas reference state improves structure-derived potentials of mean force for structure selection and stability prediction.[erratum appears in Protein Sci. 2003 Sep;12(9):2121]. Protein Science 11: 2714-2726.
-
(2003)
Sep;12(9):2121]. Protein Science
, vol.11
, pp. 2714-2726
-
-
Zhou, H.1
-
44
-
-
0036432029
-
Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitina- tion
-
Rideout HJ, Stefanis L (2002) Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitina- tion. Mol Cell Neurosci 21: 223-238.
-
(2002)
Mol Cell Neurosci
, vol.21
, pp. 223-238
-
-
Rideout, H.J.1
Stefanis, L.2
-
45
-
-
34548281019
-
Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1
-
Jorgensen ND, Andresen JM, Pitt JE, Swenson MA, Zoghbi HY, et al. (2007) Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1. J Neurochem 102: 2040-2048.
-
(2007)
J Neurochem
, vol.102
, pp. 2040-2048
-
-
Jorgensen, N.D.1
Andresen, J.M.2
Pitt, J.E.3
Swenson, M.A.4
Zoghbi, H.Y.5
|