-
1
-
-
0022617990
-
Type I diabetes mellitus: a chronic autoimmune disease
-
Eisenbarth GS. Type I diabetes mellitus: a chronic autoimmune disease. N Engl J Med 1986: 314: 1360-1368.
-
(1986)
N Engl J Med
, vol.314
, pp. 1360-1368
-
-
Eisenbarth, G.S.1
-
2
-
-
0023252262
-
HLA-DQ-gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
-
Todd JA, Bell JI, McDevitt HO. HLA-DQ-gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 1987: 329: 599-604.
-
(1987)
Nature
, vol.329
, pp. 599-604
-
-
Todd, J.A.1
Bell, J.I.2
McDevitt, H.O.3
-
3
-
-
0001657878
-
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study
-
Morel PA, Dorman JS, Todd JA, McDevitt HO, Trucco M. Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. Proc Natl Acad Sci USA 1988: 85: 8111-8115.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 8111-8115
-
-
Morel, P.A.1
Dorman, J.S.2
Todd, J.A.3
McDevitt, H.O.4
Trucco, M.5
-
4
-
-
0033624114
-
Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: the Finnish Diabetes Prediction and Prevention Study
-
Lonnrot M, Korpela K, Knip M et al. Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: the Finnish Diabetes Prediction and Prevention Study. Diabetes 2000: 8: 1314-1318.
-
(2000)
Diabetes
, vol.8
, pp. 1314-1318
-
-
Lonnrot, M.1
Korpela, K.2
Knip, M.3
-
6
-
-
33846190681
-
TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat
-
Zipris D, Lien E, Nair A et al. TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J Immunol 2007: 2: 693-701.
-
(2007)
J Immunol
, vol.2
, pp. 693-701
-
-
Zipris, D.1
Lien, E.2
Nair, A.3
-
7
-
-
0035992822
-
Enterovirus infections and type 1 diabetes
-
Hyoty H. Enterovirus infections and type 1 diabetes. Ann Med 2002: 3: 138-147.
-
(2002)
Ann Med
, vol.3
, pp. 138-147
-
-
Hyoty, H.1
-
9
-
-
2342458361
-
Autoimmune polyendocrine syndromes
-
Eisenbarth GS, Gottlieb PA. Autoimmune polyendocrine syndromes. N Engl J Med 2004: 20: 2068-2079.
-
(2004)
N Engl J Med
, vol.20
, pp. 2068-2079
-
-
Eisenbarth, G.S.1
Gottlieb, P.A.2
-
10
-
-
0037790522
-
Autoimmune regulator: from loss of function to autoimmunity
-
Pitkänen J, Peterson P. Autoimmune regulator: from loss of function to autoimmunity. Genes Immun 2003: 1: 12-21.
-
(2003)
Genes Immun
, vol.1
, pp. 12-21
-
-
Pitkänen, J.1
Peterson, P.2
-
11
-
-
77951921063
-
Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis
-
Husebye ES, Anderson MS. Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis. Immunity 2010: 4: 479-487.
-
(2010)
Immunity
, vol.4
, pp. 479-487
-
-
Husebye, E.S.1
Anderson, M.S.2
-
12
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003: 5609: 1057-1061.
-
(2003)
Science
, vol.5609
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
13
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K, Onishi Y, Prieto-Martin P et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008: 5899: 271-275.
-
(2008)
Science
, vol.5899
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
-
14
-
-
84905576130
-
Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease
-
Flanagan SE, Haapaniemi E, Russell MA et al. Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. Nat Genet 2014: 8: 812-814.
-
(2014)
Nat Genet
, vol.8
, pp. 812-814
-
-
Flanagan, S.E.1
Haapaniemi, E.2
Russell, M.A.3
-
15
-
-
0016261369
-
Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
-
Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974: 2: 1279-1282.
-
(1974)
Lancet
, vol.2
, pp. 1279-1282
-
-
Bottazzo, G.F.1
Florin-Christensen, A.2
Doniach, D.3
-
16
-
-
0021019885
-
Insulin antibodies in insulin-dependent diabetics before insulin treatment
-
Palmer JP, Asplin CM, Clemons P et al. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 1983: 222: 1337-1339.
-
(1983)
Science
, vol.222
, pp. 1337-1339
-
-
Palmer, J.P.1
Asplin, C.M.2
Clemons, P.3
-
17
-
-
0035928391
-
Type 1 diabetes: new perspectives on disease pathogenesis and treatment
-
Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001: 9277: 221-229.
-
(2001)
Lancet
, vol.9277
, pp. 221-229
-
-
Atkinson, M.A.1
Eisenbarth, G.S.2
-
19
-
-
77954949830
-
Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia
-
Bonifacio E, Yu L, Williams AK et al. Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia. J Clin Endocrinol Metab 2010: 7: 3360-3367.
-
(2010)
J Clin Endocrinol Metab
, vol.7
, pp. 3360-3367
-
-
Bonifacio, E.1
Yu, L.2
Williams, A.K.3
-
20
-
-
77954532446
-
Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes
-
Morran MP, Casu A, Arena VC et al. Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes. Endocrinology 2010: 6: 2528-2537.
-
(2010)
Endocrinology
, vol.6
, pp. 2528-2537
-
-
Morran, M.P.1
Casu, A.2
Arena, V.C.3
-
21
-
-
84879114358
-
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children
-
Ziegler AG, Rewers M, Simell O et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 2013: 23: 2473-2479.
-
(2013)
JAMA
, vol.23
, pp. 2473-2479
-
-
Ziegler, A.G.1
Rewers, M.2
Simell, O.3
-
23
-
-
84873830631
-
Extended family history of type 1 diabetes and phenotype and genotype of newly diagnosed children
-
The Finnish Pediatric Diabetes Register
-
Parkkola A, Härkönen T, Ryhänen S, Ilonen J, Knip M, and the Finnish Pediatric Diabetes Register. Extended family history of type 1 diabetes and phenotype and genotype of newly diagnosed children. Diabetes Care 2013: 36: 348-354.
-
(2013)
Diabetes Care
, vol.36
, pp. 348-354
-
-
Parkkola, A.1
Härkönen, T.2
Ryhänen, S.3
Ilonen, J.4
Knip, M.5
-
24
-
-
0035985090
-
Genetic control of autoimmunity in type I diabetes and associated disorders
-
Redondo MJ, Eisenbarth GS. Genetic control of autoimmunity in type I diabetes and associated disorders. Diabetologia 2002: 45: 605-622.
-
(2002)
Diabetologia
, vol.45
, pp. 605-622
-
-
Redondo, M.J.1
Eisenbarth, G.S.2
-
25
-
-
0026641354
-
Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland
-
Kaprio J, Tuomilehto J, Koskenvuo M et al. Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 1992: 35:1060-1067.
-
(1992)
Diabetologia
, vol.35
, pp. 1060-1067
-
-
Kaprio, J.1
Tuomilehto, J.2
Koskenvuo, M.3
-
26
-
-
58149096363
-
Concordance for islet autoimmunity among monozygotic twins
-
Redondo MJ, Jeffrey J, Fain PR, Eisenbarth GS, Orban T. Concordance for islet autoimmunity among monozygotic twins. N Engl J Med 2008: 26: 2849-2850.
-
(2008)
N Engl J Med
, vol.26
, pp. 2849-2850
-
-
Redondo, M.J.1
Jeffrey, J.2
Fain, P.R.3
Eisenbarth, G.S.4
Orban, T.5
-
27
-
-
0035960269
-
Reanalysis of twin studies suggests that diabetes is mainly genetic
-
Gale EA, Bingley PJ, Eisenbarth GS, Redondo MJ, Kyvik KO, Petersen JS. Reanalysis of twin studies suggests that diabetes is mainly genetic. BMJ 2001: 7319: 997-998.
-
(2001)
BMJ
, vol.7319
, pp. 997-998
-
-
Gale, E.A.1
Bingley, P.J.2
Eisenbarth, G.S.3
Redondo, M.J.4
Kyvik, K.O.5
Petersen, J.S.6
-
28
-
-
14244260204
-
Expression of beta-cell autoimmunity does not differ between potential dizygotic twins and siblings of patients with type 1 diabetes
-
Redondo MJ, Fain PR, Krischer JP et al. Expression of beta-cell autoimmunity does not differ between potential dizygotic twins and siblings of patients with type 1 diabetes. J Autoimmun 2004: 3: 275-279.
-
(2004)
J Autoimmun
, vol.3
, pp. 275-279
-
-
Redondo, M.J.1
Fain, P.R.2
Krischer, J.P.3
-
30
-
-
84942991858
-
Up hill and down dale in the genomic landscape: the odd distribution of matching segments
-
Turner A. Up hill and down dale in the genomic landscape: the odd distribution of matching segments. J Genet Geneal 2010: 1: 4.
-
(2010)
J Genet Geneal
, vol.1
, pp. 4
-
-
Turner, A.1
-
31
-
-
84930092396
-
Baseline heterogeneity in glucose metabolism marks the risk for type 1 diabetes and complicates secondary prevention
-
Elding Larsson H, Larsson C, Lernmark Å. Baseline heterogeneity in glucose metabolism marks the risk for type 1 diabetes and complicates secondary prevention. Acta Diabetol 2014.
-
(2014)
Acta Diabetol
-
-
Elding Larsson, H.1
Larsson, C.2
Lernmark, A.3
-
32
-
-
84874678804
-
Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors
-
Althof N, Whitton JL. Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors. J Virol 2013: 5: 2823-2834.
-
(2013)
J Virol
, vol.5
, pp. 2823-2834
-
-
Althof, N.1
Whitton, J.L.2
-
33
-
-
0031054640
-
Virus-induced transient bone marrow aplasia: major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus
-
Binder D, Fehr J, Hengartner H, Zinkernagel RM. Virus-induced transient bone marrow aplasia: major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus. J Exp Med 1997: 3: 517-530.
-
(1997)
J Exp Med
, vol.3
, pp. 517-530
-
-
Binder, D.1
Fehr, J.2
Hengartner, H.3
Zinkernagel, R.M.4
-
34
-
-
0022592515
-
Norwalk virus outbreak at a college campus
-
40.
-
Alexander WJ, Holmes JR, Shaw JF, Riley WE, Roper WL. Norwalk virus outbreak at a college campus. South Med J 1986: 79: 33-36, 40.
-
(1986)
South Med J
, vol.79
, pp. 33-36
-
-
Alexander, W.J.1
Holmes, J.R.2
Shaw, J.F.3
Riley, W.E.4
Roper, W.L.5
-
35
-
-
0028905334
-
Exposure to superantigens as an immunogenetic explanation of type I diabetes mini-epidemics
-
Trucco M, LaPorte R. Exposure to superantigens as an immunogenetic explanation of type I diabetes mini-epidemics. J Pediatr Endocrinol 1995: 8: 3-10.
-
(1995)
J Pediatr Endocrinol
, vol.8
, pp. 3-10
-
-
Trucco, M.1
LaPorte, R.2
-
36
-
-
0034455489
-
Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells
-
Roivainen M, Rasilainen S, Ylipaasto P et al. Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells. J Clin Endocrinol Metab 2000: 1: 432-440.
-
(2000)
J Clin Endocrinol Metab
, vol.1
, pp. 432-440
-
-
Roivainen, M.1
Rasilainen, S.2
Ylipaasto, P.3
-
37
-
-
84861634115
-
Experimental inoculation of juvenile rhesus macaques with primate enteric caliciviruses
-
Sestak K, Feely S, Fey B et al. Experimental inoculation of juvenile rhesus macaques with primate enteric caliciviruses. PLoS One 2012: 5: e37973.
-
(2012)
PLoS One
, vol.5
, pp. e37973
-
-
Sestak, K.1
Feely, S.2
Fey, B.3
-
38
-
-
84880327999
-
Virus infections among young children - the first year of the INDIS study
-
Simonen-Tikka ML, Klemola P, Suomenrinne S et al. Virus infections among young children - the first year of the INDIS study. J Med Virol 2013: 9: 1678-1684.
-
(2013)
J Med Virol
, vol.9
, pp. 1678-1684
-
-
Simonen-Tikka, M.L.1
Klemola, P.2
Suomenrinne, S.3
-
39
-
-
84879181469
-
Human rhinoviruses in INDIS-study material-evidence for recovery of viable rhinovirus from fecal specimens
-
Savolainen-Kopra C, Simonen-Tikka ML, Klemola P et al. Human rhinoviruses in INDIS-study material-evidence for recovery of viable rhinovirus from fecal specimens. J Med Virol 2013: 8: 1466-1472.
-
(2013)
J Med Virol
, vol.8
, pp. 1466-1472
-
-
Savolainen-Kopra, C.1
Simonen-Tikka, M.L.2
Klemola, P.3
-
40
-
-
84890281518
-
Gnotobiotic mouse model of phage-bacterial host dynamics in the human gut
-
Reyes A, Wu M, McNulty NP, Rohwer FL, Gordon JI. Gnotobiotic mouse model of phage-bacterial host dynamics in the human gut. Proc Natl Acad Sci USA 2013: 50: 20236-20241.
-
(2013)
Proc Natl Acad Sci USA
, vol.50
, pp. 20236-20241
-
-
Reyes, A.1
Wu, M.2
McNulty, N.P.3
Rohwer, F.L.4
Gordon, J.I.5
-
41
-
-
84908328191
-
Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes
-
Nielsen DS, Krych L, Buschard K, Hansen CH, Hansen AK. Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. FEBS Lett 2014: 22: 4234-4243.
-
(2014)
FEBS Lett
, vol.22
, pp. 4234-4243
-
-
Nielsen, D.S.1
Krych, L.2
Buschard, K.3
Hansen, C.H.4
Hansen, A.K.5
-
42
-
-
80054091498
-
Intestinal microbiota promote enteric virus replication and systemic pathogenesis
-
Kuss SK, Best GT, Etheredge CA et al. Intestinal microbiota promote enteric virus replication and systemic pathogenesis. Science 2011: 6053: 249-252.
-
(2011)
Science
, vol.6053
, pp. 249-252
-
-
Kuss, S.K.1
Best, G.T.2
Etheredge, C.A.3
-
43
-
-
54549122338
-
Innate immunity and intestinal microbiota in the development of type 1 diabetes
-
Wen L, Ley RE, Volchkov PY et al. Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature 2008: 7216: 1109-1113.
-
(2008)
Nature
, vol.7216
, pp. 1109-1113
-
-
Wen, L.1
Ley, R.E.2
Volchkov, P.Y.3
-
44
-
-
84867286012
-
Prevention of virus-induced type 1 diabetes with antibiotic therapy
-
Hara N, Alkanani AK, Ir D et al. Prevention of virus-induced type 1 diabetes with antibiotic therapy. J Immunol 2012: 8: 3805-3814.
-
(2012)
J Immunol
, vol.8
, pp. 3805-3814
-
-
Hara, N.1
Alkanani, A.K.2
Ir, D.3
-
45
-
-
80054722148
-
Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes
-
Brown CT, Davis-Richardson AG, Giongo A et al. Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One 2011: 10: e25792.
-
(2011)
PLoS One
, vol.10
, pp. e25792
-
-
Brown, C.T.1
Davis-Richardson, A.G.2
Giongo, A.3
-
46
-
-
84874005935
-
Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study
-
Murri M, Leiva I, Gomez-Zumaquero JM et al. Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study. BMC Med 2013: 11: 46.
-
(2013)
BMC Med
, vol.11
, pp. 46
-
-
Murri, M.1
Leiva, I.2
Gomez-Zumaquero, J.M.3
-
48
-
-
0023912807
-
A molecular basis for MHC class II associated autoimmunity
-
Todd JA, Acha-Orbea H, Bell JI et al. A molecular basis for MHC class II associated autoimmunity. Science 1988: 240: 1003-1009.
-
(1988)
Science
, vol.240
, pp. 1003-1009
-
-
Todd, J.A.1
Acha-Orbea, H.2
Bell, J.I.3
-
49
-
-
0029954214
-
Insulin-dependent diabetes mellitus
-
Tisch R, McDevitt H. Insulin-dependent diabetes mellitus. Cell 1996: 85: 291-297.
-
(1996)
Cell
, vol.85
, pp. 291-297
-
-
Tisch, R.1
McDevitt, H.2
-
50
-
-
0028028985
-
High genetic risk for IDDM in the Pacific Northwest: first report from the Washington State diabetes prediction study
-
Rowe RE, Leech NJ, Nepom GT, McCulloch DK. High genetic risk for IDDM in the Pacific Northwest: first report from the Washington State diabetes prediction study. Diabetes 1994: 43: 87-94.
-
(1994)
Diabetes
, vol.43
, pp. 87-94
-
-
Rowe, R.E.1
Leech, N.J.2
Nepom, G.T.3
McCulloch, D.K.4
-
51
-
-
4043091960
-
Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
-
Barker JM, Barriga KJ, Yu L et al. Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab 2004: 8: 3896-3902.
-
(2004)
J Clin Endocrinol Metab
, vol.8
, pp. 3896-3902
-
-
Barker, J.M.1
Barriga, K.J.2
Yu, L.3
-
52
-
-
0031024575
-
HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection
-
Undlien DE, Friede T, Rammensee HG et al. HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection. Diabetes 1997: 1: 143-149.
-
(1997)
Diabetes
, vol.1
, pp. 143-149
-
-
Undlien, D.E.1
Friede, T.2
Rammensee, H.G.3
-
53
-
-
34548461747
-
HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population
-
Baschal EE, Aly TA, Babu SR et al. HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population. Diabetes 2007: 9: 2405-2409.
-
(2007)
Diabetes
, vol.9
, pp. 2405-2409
-
-
Baschal, E.E.1
Aly, T.A.2
Babu, S.R.3
-
54
-
-
0036165756
-
Progression to insulin-requiring diabetes in seronegative prediabetic subjects: the role of two HLA-DQ high risk haplotypes
-
Pietropaolo M, Becker DJ, LaPorte RE et al. Progression to insulin-requiring diabetes in seronegative prediabetic subjects: the role of two HLA-DQ high risk haplotypes. Diabetologia 2002: 45: 66-76.
-
(2002)
Diabetologia
, vol.45
, pp. 66-76
-
-
Pietropaolo, M.1
Becker, D.J.2
LaPorte, R.E.3
-
55
-
-
0034454503
-
Islet cell antibody-positive relatives with human leukocyte antigen DQA1*0102, DQB1*0602: identification by the Diabetes Prevention Trial-type 1
-
Greenbaum CJ, Schatz DA, Cuthbertson D, Zeidler A, Eisenbarth GS, Krischer JP. Islet cell antibody-positive relatives with human leukocyte antigen DQA1*0102, DQB1*0602: identification by the Diabetes Prevention Trial-type 1. J Clin Endocrinol Metab 2000: 3: 1255-1260.
-
(2000)
J Clin Endocrinol Metab
, vol.3
, pp. 1255-1260
-
-
Greenbaum, C.J.1
Schatz, D.A.2
Cuthbertson, D.3
Zeidler, A.4
Eisenbarth, G.S.5
Krischer, J.P.6
-
56
-
-
0028989040
-
HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody positive first degree relatives of patients with insulin-dependent diabetes
-
Pugliese A, Gianani R, Moromisato R et al. HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody positive first degree relatives of patients with insulin-dependent diabetes. Diabetes 1995: 44: 608-613.
-
(1995)
Diabetes
, vol.44
, pp. 608-613
-
-
Pugliese, A.1
Gianani, R.2
Moromisato, R.3
-
57
-
-
34347341846
-
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
-
Todd JA, Walker NM, Cooper JD et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007: 7: 857-864.
-
(2007)
Nat Genet
, vol.7
, pp. 857-864
-
-
Todd, J.A.1
Walker, N.M.2
Cooper, J.D.3
-
58
-
-
75649098220
-
Current status and the future for the genetics of type I diabetes
-
Rich SS, Akolkar B, Concannon P et al. Current status and the future for the genetics of type I diabetes. Genes Immun 2009: Suppl 1: S128-S131.
-
(2009)
Genes Immun
, pp. S128-S131
-
-
Rich, S.S.1
Akolkar, B.2
Concannon, P.3
-
59
-
-
84868036600
-
Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes
-
Howson JM, Cooper JD, Smyth DJ et al. Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes. Diabetes 2012: 11: 3012-3017.
-
(2012)
Diabetes
, vol.11
, pp. 3012-3017
-
-
Howson, J.M.1
Cooper, J.D.2
Smyth, D.J.3
-
60
-
-
8944259914
-
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry
-
Nistico L, Buzzetti R, Pritchard LE et al. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Hum Mol Genet 1996: 7: 1075-1080.
-
(1996)
Hum Mol Genet
, vol.7
, pp. 1075-1080
-
-
Nistico, L.1
Buzzetti, R.2
Pritchard, L.E.3
-
61
-
-
12144291502
-
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
-
Bottini N, Musumeci L, Alonso A et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 2004: 4: 337-338.
-
(2004)
Nat Genet
, vol.4
, pp. 337-338
-
-
Bottini, N.1
Musumeci, L.2
Alonso, A.3
-
62
-
-
67349199566
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
-
Barrett JC, Clayton DG, Concannon P et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009: 6: 703-707.
-
(2009)
Nat Genet
, vol.6
, pp. 703-707
-
-
Barrett, J.C.1
Clayton, D.G.2
Concannon, P.3
-
63
-
-
0345128844
-
Polymorphic DNA region adjacent to the 5' end of the human insulin gene
-
Bell GI, Karam JH, Rutter WJ. Polymorphic DNA region adjacent to the 5' end of the human insulin gene. Proc Natl Acad Sci USA 1981: 78: 5759-5763.
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 5759-5763
-
-
Bell, G.I.1
Karam, J.H.2
Rutter, W.J.3
-
64
-
-
0020664519
-
Polymorphism in the 5′ flanking region of the human insulin gene: a genetic marker for non-insulin-dependent diabetes
-
Rotwein PS, Chirgwin J, Province M, Knowler WC, Pettitt DJ, Cordell B, Goodman HM, Permutt MA. Polymorphism in the 5′ flanking region of the human insulin gene: a genetic marker for non-insulin-dependent diabetes. N Engl J Med 1983: 308: 65-71.
-
(1983)
N Engl J Med
, vol.308
, pp. 65-71
-
-
Rotwein, P.S.1
Chirgwin, J.2
Province, M.3
Knowler, W.C.4
Pettitt, D.J.5
Cordell, B.6
Goodman, H.M.7
Permutt, M.A.8
-
65
-
-
0020073179
-
Restriction fragment length polymorphism of the insulin gene in diabetes mellitus
-
Owerbach D, Nerup J. Restriction fragment length polymorphism of the insulin gene in diabetes mellitus. Diabetes 1982: 31: 275-277.
-
(1982)
Diabetes
, vol.31
, pp. 275-277
-
-
Owerbach, D.1
Nerup, J.2
-
66
-
-
0025995836
-
Insulin-IGF2 region encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility
-
Julier C, Hyer RN, Davies J et al. Insulin-IGF2 region encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility. Nature 1991: 354: 155-159.
-
(1991)
Nature
, vol.354
, pp. 155-159
-
-
Julier, C.1
Hyer, R.N.2
Davies, J.3
-
67
-
-
17644447822
-
Insulin gene region-encoded susceptibility to type I diabetes is not restricted to HLA-DR4-positive individuals
-
Bain SC, Prins JB, Hearne CM et al. Insulin gene region-encoded susceptibility to type I diabetes is not restricted to HLA-DR4-positive individuals. Nat Genet 1992: 2: 212-215.
-
(1992)
Nat Genet
, vol.2
, pp. 212-215
-
-
Bain, S.C.1
Prins, J.B.2
Hearne, C.M.3
-
68
-
-
0028964371
-
Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype
-
Lucassen AM, Screaton GR, Julier C, Elliot TJ, Lathrop M, Bell JI. Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype. Hum Mol Genet 1994: 4: 501-506.
-
(1994)
Hum Mol Genet
, vol.4
, pp. 501-506
-
-
Lucassen, A.M.1
Screaton, G.R.2
Julier, C.3
Elliot, T.J.4
Lathrop, M.5
Bell, J.I.6
-
69
-
-
0028881617
-
The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription
-
Kennedy GC, German MS, Rutter WJ. The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nat Genet 1995: 9: 293-298.
-
(1995)
Nat Genet
, vol.9
, pp. 293-298
-
-
Kennedy, G.C.1
German, M.S.2
Rutter, W.J.3
-
70
-
-
0028871202
-
Susceptibility to human type I diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
-
Bennett ST, Lucassen AM, Gough SCL et al. Susceptibility to human type I diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet 1995: 9: 284-292.
-
(1995)
Nat Genet
, vol.9
, pp. 284-292
-
-
Bennett, S.T.1
Lucassen, A.M.2
Gough, S.C.L.3
-
71
-
-
18244421874
-
The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
-
Pugliese A, Zeller M, Fernandez JrA et al. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 1997: 15: 293-297.
-
(1997)
Nat Genet
, vol.15
, pp. 293-297
-
-
Pugliese, A.1
Zeller, M.2
Fernandez, J.3
-
72
-
-
18744366947
-
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
-
Nakayama M, Abiru N, Moriyama H et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005: 7039: 220-223.
-
(2005)
Nature
, vol.7039
, pp. 220-223
-
-
Nakayama, M.1
Abiru, N.2
Moriyama, H.3
-
73
-
-
70349194383
-
Thymus-specific deletion of insulin induces autoimmune diabetes
-
Fan Y, Rudert WA, Grupillo M, He J, Sisino G, Trucco M. Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J 2009: 18: 2812-2824.
-
(2009)
EMBO J
, vol.18
, pp. 2812-2824
-
-
Fan, Y.1
Rudert, W.A.2
Grupillo, M.3
He, J.4
Sisino, G.5
Trucco, M.6
-
74
-
-
84901300488
-
Avidity-dependent programming of autoreactive T cells in T1D
-
Durinovic-Bello I, Gersuk VH, Ni C et al. Avidity-dependent programming of autoreactive T cells in T1D. PLoS One 2014: 5: e98074.
-
(2014)
PLoS One
, vol.5
, pp. e98074
-
-
Durinovic-Bello, I.1
Gersuk, V.H.2
Ni, C.3
-
75
-
-
33745169029
-
Role of PTPN22 in type 1 diabetes and other autoimmune diseases
-
Bottini N, Vang T, Cucca F, Mustelin T. Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Semin Immunol 2006: 4: 207-213.
-
(2006)
Semin Immunol
, vol.4
, pp. 207-213
-
-
Bottini, N.1
Vang, T.2
Cucca, F.3
Mustelin, T.4
-
76
-
-
28444469783
-
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
-
Vang T, Congia M, Macis MD et al. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 2005: 12: 1317-1319.
-
(2005)
Nat Genet
, vol.12
, pp. 1317-1319
-
-
Vang, T.1
Congia, M.2
Macis, M.D.3
-
77
-
-
21244490890
-
CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE review and meta-analysis
-
Kavvoura FK, Ioannidis JP. CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE review and meta-analysis. Am J Epidemiol 2005: 1: 3-16.
-
(2005)
Am J Epidemiol
, vol.1
, pp. 3-16
-
-
Kavvoura, F.K.1
Ioannidis, J.P.2
-
78
-
-
8544274482
-
Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
-
Marron MP, Raffel LJ, Garchon HJ et al. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum Mol Genet 1997: 8: 1275-1282.
-
(1997)
Hum Mol Genet
, vol.8
, pp. 1275-1282
-
-
Marron, M.P.1
Raffel, L.J.2
Garchon, H.J.3
-
79
-
-
0029995958
-
Prediction of type I diabetes mellitus in first degree relatives using a combination of insulin, glutamic acid decarboxylase and ICA512bdc/IA-2 autoantibodies
-
Verge CF, Gianani R, Kawasaki E et al. Prediction of type I diabetes mellitus in first degree relatives using a combination of insulin, glutamic acid decarboxylase and ICA512bdc/IA-2 autoantibodies. Diabetes 1996: 45: 926-933.
-
(1996)
Diabetes
, vol.45
, pp. 926-933
-
-
Verge, C.F.1
Gianani, R.2
Kawasaki, E.3
-
80
-
-
36749011882
-
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
-
Wenzlau JM, Juhl K, Yu L et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 2007: 43: 17040-17045.
-
(2007)
Proc Natl Acad Sci USA
, vol.43
, pp. 17040-17045
-
-
Wenzlau, J.M.1
Juhl, K.2
Yu, L.3
-
81
-
-
84884593099
-
Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes
-
pii: a012831
-
Pietropaolo M, Towns R, Eisenbarth GS. Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes. Cold Spring Harb Perspect Med 2012: 2: pii: a012831.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
-
-
Pietropaolo, M.1
Towns, R.2
Eisenbarth, G.S.3
-
82
-
-
0027201783
-
Islet cell autoantigen 69 kDa (ICA69): molecular cloning and characterization of a novel diabetes associated autoantigen
-
Pietropaolo M, Castaño L, Babu S et al. Islet cell autoantigen 69 kDa (ICA69): molecular cloning and characterization of a novel diabetes associated autoantigen. J Clin Invest 1993: 92: 359-371.
-
(1993)
J Clin Invest
, vol.92
, pp. 359-371
-
-
Pietropaolo, M.1
Castaño, L.2
Babu, S.3
-
83
-
-
84926408965
-
Compromised central tolerance of ICA69 induces multiple organ autoimmunity
-
Fan Y, Gualtierotti G, Tajima A et al. Compromised central tolerance of ICA69 induces multiple organ autoimmunity. J Autoimmun 2014: 53: 10-25.
-
(2014)
J Autoimmun
, vol.53
, pp. 10-25
-
-
Fan, Y.1
Gualtierotti, G.2
Tajima, A.3
-
84
-
-
45249117656
-
Identification of novel IGRP epitopes targeted in type 1 diabetes patients
-
Jarchum I, Nichol L, Trucco M, Santamaria P, DiLorenzo TP. Identification of novel IGRP epitopes targeted in type 1 diabetes patients. Clin Immunol 2008: 3: 359-365.
-
(2008)
Clin Immunol
, vol.3
, pp. 359-365
-
-
Jarchum, I.1
Nichol, L.2
Trucco, M.3
Santamaria, P.4
DiLorenzo, T.P.5
-
85
-
-
76949098835
-
Chromogranin A is an autoantigen in type 1 diabetes
-
Stadinski BD, Delong T, Reisdorph N et al. Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol 2010: 3: 225-231.
-
(2010)
Nat Immunol
, vol.3
, pp. 225-231
-
-
Stadinski, B.D.1
Delong, T.2
Reisdorph, N.3
-
86
-
-
0035061536
-
Tolerance to islet autoantigens in type 1 diabetes
-
Bach J-F, Chatenaud L. Tolerance to islet autoantigens in type 1 diabetes. Annu Rev Immunol 2001: 19: 131-161.
-
(2001)
Annu Rev Immunol
, vol.19
, pp. 131-161
-
-
Bach, J.-F.1
Chatenaud, L.2
-
87
-
-
0026502693
-
Peripherin: an islet antigen that is cross-reactive with nonobese diabetic mouse class II gene products
-
Boitard C, Villa MC, Becourt C et al. Peripherin: an islet antigen that is cross-reactive with nonobese diabetic mouse class II gene products. Proc Natl Acad Sci USA 1992: 89: 172-176.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 172-176
-
-
Boitard, C.1
Villa, M.C.2
Becourt, C.3
-
88
-
-
0037327274
-
Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive
-
Winer S, Tsui H, Lau A et al. Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive. Nat Med 2003: 9: 198-205.
-
(2003)
Nat Med
, vol.9
, pp. 198-205
-
-
Winer, S.1
Tsui, H.2
Lau, A.3
-
90
-
-
84857045897
-
Autoantigenesis: the evolution of protein modifications in autoimmune disease
-
Doyle HA, Mamula MJ. Autoantigenesis: the evolution of protein modifications in autoimmune disease. Curr Opin Immunol 2012: 1: 112-118.
-
(2012)
Curr Opin Immunol
, vol.1
, pp. 112-118
-
-
Doyle, H.A.1
Mamula, M.J.2
-
91
-
-
2942612120
-
Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity
-
Soderlin MK, Kastbom A, Kautiainen H, Leirisalo-Repo M, Strandberg G, Skogh T. Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity. Scand J Rheumatol 2004: 3: 185-188.
-
(2004)
Scand J Rheumatol
, vol.3
, pp. 185-188
-
-
Soderlin, M.K.1
Kastbom, A.2
Kautiainen, H.3
Leirisalo-Repo, M.4
Strandberg, G.5
Skogh, T.6
-
92
-
-
33846914679
-
The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis
-
Moscarello MA, Mastronardi FG, Wood DD. The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis. Neurochem Res 2007: 2: 251-256.
-
(2007)
Neurochem Res
, vol.2
, pp. 251-256
-
-
Moscarello, M.A.1
Mastronardi, F.G.2
Wood, D.D.3
-
93
-
-
0035869593
-
The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin
-
Masson-Bessiere C, Sebbag M, Girbal-Neuhauser E et al. The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol 2001: 6: 4177-4184.
-
(2001)
J Immunol
, vol.6
, pp. 4177-4184
-
-
Masson-Bessiere, C.1
Sebbag, M.2
Girbal-Neuhauser, E.3
-
94
-
-
4344679600
-
Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project)
-
Kastbom A, Strandberg G, Lindroos A, Skogh T. Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project). Ann Rheum Dis 2004: 9: 1085-1089.
-
(2004)
Ann Rheum Dis
, vol.9
, pp. 1085-1089
-
-
Kastbom, A.1
Strandberg, G.2
Lindroos, A.3
Skogh, T.4
-
95
-
-
0034652317
-
Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes
-
Yu L, Robles DT, Abiru N, Rewers M, Kelemen K, Eisenbarth GS. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci USA 2000: 4: 1701-1706.
-
(2000)
Proc Natl Acad Sci USA
, vol.4
, pp. 1701-1706
-
-
Yu, L.1
Robles, D.T.2
Abiru, N.3
Rewers, M.4
Kelemen, K.5
Eisenbarth, G.S.6
-
96
-
-
80053628904
-
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
-
Crawford F, Stadinski B, Jin N et al. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci USA 2011: 40: 16729-16734.
-
(2011)
Proc Natl Acad Sci USA
, vol.40
, pp. 16729-16734
-
-
Crawford, F.1
Stadinski, B.2
Jin, N.3
-
97
-
-
0035142467
-
A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin
-
Alleva DG, Crowe PD, Jin L et al. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J Clin Invest 2001: 2: 173-180.
-
(2001)
J Clin Invest
, vol.2
, pp. 173-180
-
-
Alleva, D.G.1
Crowe, P.D.2
Jin, L.3
-
98
-
-
85047690395
-
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
-
Arif S, Tree TI, Astill TP et al. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest 2004: 3: 451-463.
-
(2004)
J Clin Invest
, vol.3
, pp. 451-463
-
-
Arif, S.1
Tree, T.I.2
Astill, T.P.3
-
99
-
-
18744385526
-
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
-
Kent SC, Chen Y, Bregoli L et al. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005: 7039: 224-228.
-
(2005)
Nature
, vol.7039
, pp. 224-228
-
-
Kent, S.C.1
Chen, Y.2
Bregoli, L.3
-
100
-
-
84920024469
-
Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes
-
Pathiraja V, Kuehlich JP, Campbell PD et al. Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes. Diabetes 2015: 1: 172-182.
-
(2015)
Diabetes
, vol.1
, pp. 172-182
-
-
Pathiraja, V.1
Kuehlich, J.P.2
Campbell, P.D.3
-
101
-
-
0024455978
-
Revelation of specificity of 64 K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis: unambiguous identification of 64 K target antigen
-
Baekkeskov S, Warnock G, Christie M, Rajotte RV, Larsen PM, Fey S. Revelation of specificity of 64 K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis: unambiguous identification of 64 K target antigen. Diabetes 1989: 38: 1133-1141.
-
(1989)
Diabetes
, vol.38
, pp. 1133-1141
-
-
Baekkeskov, S.1
Warnock, G.2
Christie, M.3
Rajotte, R.V.4
Larsen, P.M.5
Fey, S.6
-
102
-
-
0023933925
-
Autoantibodies to glutamic acid decarboxylase in a patient with stiffman syndrome, epilepsy, and type I diabetes mellitus
-
Solimena M, Folli F, Denis-Donini S et al. Autoantibodies to glutamic acid decarboxylase in a patient with stiffman syndrome, epilepsy, and type I diabetes mellitus. N Engl J Med 1988: 318: 1012-1020.
-
(1988)
N Engl J Med
, vol.318
, pp. 1012-1020
-
-
Solimena, M.1
Folli, F.2
Denis-Donini, S.3
-
103
-
-
0025039679
-
Identification of the 64 K autoantigen in insulin dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
-
Baekkeskov S, Aanstoot H, Christgau S et al. Identification of the 64 K autoantigen in insulin dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990: 347: 151-156.
-
(1990)
Nature
, vol.347
, pp. 151-156
-
-
Baekkeskov, S.1
Aanstoot, H.2
Christgau, S.3
-
104
-
-
0027529913
-
Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes
-
Atkinson MA, Kaufman DL, Newman D, Tobin AJ, Maclaren NK. Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes. J Clin Invest 1993: 91: 350-356.
-
(1993)
J Clin Invest
, vol.91
, pp. 350-356
-
-
Atkinson, M.A.1
Kaufman, D.L.2
Newman, D.3
Tobin, A.J.4
Maclaren, N.K.5
-
105
-
-
0026046093
-
Cloning and primary structure of a human isoform of glutamic acid decarboxylase from chromosome 10
-
Karlsen AE, Hagopian WA, Grubin CE et al. Cloning and primary structure of a human isoform of glutamic acid decarboxylase from chromosome 10. Proc Natl Acad Sci USA 1991: 88: 8337-8341.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 8337-8341
-
-
Karlsen, A.E.1
Hagopian, W.A.2
Grubin, C.E.3
-
106
-
-
0027450794
-
Autoantibodies in IDDM primarily recognize the 65,000-Mr rather than the 67,000-Mr isoform of glutamic acid decarboxylase
-
Hagopian WA, Michelsen B, Karlsen AE et al. Autoantibodies in IDDM primarily recognize the 65, 000-Mr rather than the 67, 000-Mr isoform of glutamic acid decarboxylase. Diabetes 1993: 42: 631-636.
-
(1993)
Diabetes
, vol.42
, pp. 631-636
-
-
Hagopian, W.A.1
Michelsen, B.2
Karlsen, A.E.3
-
107
-
-
0027930455
-
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
-
Lan MS, Lu J, Goto Y, Notkins AL. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 1994: 13: 505-514.
-
(1994)
DNA Cell Biol
, vol.13
, pp. 505-514
-
-
Lan, M.S.1
Lu, J.2
Goto, Y.3
Notkins, A.L.4
-
108
-
-
0842288452
-
Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics
-
Achenbach P, Warncke K, Reiter J et al. Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 2004: 2: 384-392.
-
(2004)
Diabetes
, vol.2
, pp. 384-392
-
-
Achenbach, P.1
Warncke, K.2
Reiter, J.3
-
109
-
-
0029999246
-
Molecular cloning of phogrin, a protein tyrosyne phosphatase homologue localized to insulin secretory granule membranes
-
Wasmeier C, Hutton JC. Molecular cloning of phogrin, a protein tyrosyne phosphatase homologue localized to insulin secretory granule membranes. J Biol Chem 1996: 30: 18161-18170.
-
(1996)
J Biol Chem
, vol.30
, pp. 18161-18170
-
-
Wasmeier, C.1
Hutton, J.C.2
-
110
-
-
33744975816
-
Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5
-
Mziaut H, Trajkovski M, Kersting S et al. Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5. Nat Cell Biol 2006: 5: 435-445.
-
(2006)
Nat Cell Biol
, vol.5
, pp. 435-445
-
-
Mziaut, H.1
Trajkovski, M.2
Kersting, S.3
-
111
-
-
0031026526
-
Evaluation of islet cell antigen (ICA) 512/IA-2 autoantibody radioassay using overlapping ICA512/IA-2 constructs
-
Kawasaki E, Yu L, Gianani R et al. Evaluation of islet cell antigen (ICA) 512/IA-2 autoantibody radioassay using overlapping ICA512/IA-2 constructs. J Clin Endocrinol Metab 1997: 82: 375-380.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 375-380
-
-
Kawasaki, E.1
Yu, L.2
Gianani, R.3
-
112
-
-
4344665860
-
Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules
-
Chimienti F, Devergnas S, Favier A, Seve M. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004: 9: 2330-2337.
-
(2004)
Diabetes
, vol.9
, pp. 2330-2337
-
-
Chimienti, F.1
Devergnas, S.2
Favier, A.3
Seve, M.4
-
113
-
-
70350331456
-
Zinc, a regulator of islet function and glucose homeostasis
-
Wijesekara N, Chimienti F, Wheeler MB. Zinc, a regulator of islet function and glucose homeostasis. Diabetes Obes Metab 2009: 11 Suppl 4: 202-214.
-
(2009)
Diabetes Obes Metab
, Issue.11
, pp. 202-214
-
-
Wijesekara, N.1
Chimienti, F.2
Wheeler, M.B.3
-
114
-
-
77955514154
-
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
-
Wijesekara N, Dai FF, Hardy AB et al. Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia 2010: 8: 1656-1668.
-
(2010)
Diabetologia
, vol.8
, pp. 1656-1668
-
-
Wijesekara, N.1
Dai, F.F.2
Hardy, A.B.3
-
115
-
-
57749196718
-
Identification of a major humoral epitope in Slc30A8 (ZnT8)
-
Wenzlau JM, Moua O, Liu Y, Eisenbarth GS, Hutton JC, Davidson HW. Identification of a major humoral epitope in Slc30A8 (ZnT8). Ann N Y Acad Sci 2008: 1150: 252-255.
-
(2008)
Ann N Y Acad Sci
, vol.1150
, pp. 252-255
-
-
Wenzlau, J.M.1
Moua, O.2
Liu, Y.3
Eisenbarth, G.S.4
Hutton, J.C.5
Davidson, H.W.6
-
116
-
-
77649272941
-
Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination
-
Yu L, Liu Y, Miao D et al. Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination. J Immunol Methods 2010: 1-2: 20-23.
-
(2010)
J Immunol Methods
, vol.1-2
, pp. 20-23
-
-
Yu, L.1
Liu, Y.2
Miao, D.3
-
117
-
-
84898808958
-
Chromogranin A is a T cell antigen in human type 1 diabetes
-
Gottlieb PA, Delong T, Baker RL et al. Chromogranin A is a T cell antigen in human type 1 diabetes. J Autoimmun 2014: 50: 38-41.
-
(2014)
J Autoimmun
, vol.50
, pp. 38-41
-
-
Gottlieb, P.A.1
Delong, T.2
Baker, R.L.3
-
118
-
-
79951710703
-
Prognostic performance of metabolic indexes in predicting onset of type 1 diabetes
-
Xu P, Wu Y, Zhu Y et al. Prognostic performance of metabolic indexes in predicting onset of type 1 diabetes. Diabetes Care 2010: 12: 2508-2513.
-
(2010)
Diabetes Care
, vol.12
, pp. 2508-2513
-
-
Xu, P.1
Wu, Y.2
Zhu, Y.3
-
119
-
-
80051979794
-
Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young
-
Steck AK, Johnson K, Barriga KJ et al. Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young. Diabetes Care 2011: 6: 1397-1399.
-
(2011)
Diabetes Care
, vol.6
, pp. 1397-1399
-
-
Steck, A.K.1
Johnson, K.2
Barriga, K.J.3
-
120
-
-
0031897241
-
Dual-parameter model for prediction of type I diabetes mellitus
-
Eisenbarth GS, Gianani R, Yu L et al. Dual-parameter model for prediction of type I diabetes mellitus. Proc Assoc Am Physicians 1998: 2: 126-135.
-
(1998)
Proc Assoc Am Physicians
, vol.2
, pp. 126-135
-
-
Eisenbarth, G.S.1
Gianani, R.2
Yu, L.3
-
121
-
-
72249122333
-
Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1
-
Orban T, Sosenko JM, Cuthbertson D et al. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2009: 12: 2269-2274.
-
(2009)
Diabetes Care
, vol.12
, pp. 2269-2274
-
-
Orban, T.1
Sosenko, J.M.2
Cuthbertson, D.3
-
122
-
-
29544444313
-
Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies
-
Pietropaolo M, Yu S, Libman IM et al. Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatr Diabetes 2005: 4: 184-192.
-
(2005)
Pediatr Diabetes
, vol.4
, pp. 184-192
-
-
Pietropaolo, M.1
Yu, S.2
Libman, I.M.3
-
123
-
-
84904537945
-
Islet cell antibodies (ICA) identify autoimmunity in children with new onset diabetes mellitus negative for other islet cell antibodies
-
Andersson C, Kolmodin M, Ivarsson SA et al. Islet cell antibodies (ICA) identify autoimmunity in children with new onset diabetes mellitus negative for other islet cell antibodies. Pediatr Diabetes 2014: 5: 336-344.
-
(2014)
Pediatr Diabetes
, vol.5
, pp. 336-344
-
-
Andersson, C.1
Kolmodin, M.2
Ivarsson, S.A.3
-
124
-
-
84891542721
-
Patterns of beta-cell autoantibody appearance and genetic associations during the first years of life
-
Ilonen J, Hammais A, Laine AP et al. Patterns of beta-cell autoantibody appearance and genetic associations during the first years of life. Diabetes 2013: 10: 3636-3640.
-
(2013)
Diabetes
, vol.10
, pp. 3636-3640
-
-
Ilonen, J.1
Hammais, A.2
Laine, A.P.3
-
125
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold KC, Hagopian W, Auger JA et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 2002: 22: 1692-1698.
-
(2002)
N Engl J Med
, vol.22
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
-
126
-
-
84887055430
-
Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Protege trial
-
Hagopian W, Ferry RJ Jr, Sherry N et al. Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Protege trial. Diabetes 2013: 11: 3901-3908.
-
(2013)
Diabetes
, vol.11
, pp. 3901-3908
-
-
Hagopian, W.1
Ferry, R.J.2
Sherry, N.3
-
127
-
-
84887624109
-
Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial
-
Gitelman SE, Gottlieb PA, Rigby MR et al. Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol 2013: 4: 306-316.
-
(2013)
Lancet Diabetes Endocrinol
, vol.4
, pp. 306-316
-
-
Gitelman, S.E.1
Gottlieb, P.A.2
Rigby, M.R.3
-
128
-
-
84887621720
-
Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial
-
Rigby MR, DiMeglio LA, Rendell MS et al. Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Diabetes Endocrinol 2013: 4: 284-294.
-
(2013)
Lancet Diabetes Endocrinol
, vol.4
, pp. 284-294
-
-
Rigby, M.R.1
DiMeglio, L.A.2
Rendell, M.S.3
-
129
-
-
84920413163
-
Anti-thymocyte globulin/G-CSF treatment preserves beta cell function in patients with established type 1 diabetes
-
Haller MJ, Gitelman SE, Gottlieb PA et al. Anti-thymocyte globulin/G-CSF treatment preserves beta cell function in patients with established type 1 diabetes. J Clin Invest 2015: 1: 448-455.
-
(2015)
J Clin Invest
, vol.1
, pp. 448-455
-
-
Haller, M.J.1
Gitelman, S.E.2
Gottlieb, P.A.3
-
130
-
-
84908066897
-
Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease
-
Simmons K, Michels AW. Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease. Rheum Dis Clin North Am 2014: 4: 797-811.
-
(2014)
Rheum Dis Clin North Am
, vol.4
, pp. 797-811
-
-
Simmons, K.1
Michels, A.W.2
-
131
-
-
33746548378
-
Incidence and trends of childhood type 1 diabetes worldwide 1990-1999
-
The DIAMOND, Group Project. Incidence and trends of childhood type 1 diabetes worldwide 1990-1999. Diabet Med 2006: 23: 857-866.
-
(2006)
Diabet Med
, vol.23
, pp. 857-866
-
-
-
132
-
-
67049159857
-
Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study
-
Patterson CC, Dahlquist GG, Gyurus E, Green A, Soltesz G. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009: 9680: 2027-2033.
-
(2009)
Lancet
, vol.9680
, pp. 2027-2033
-
-
Patterson, C.C.1
Dahlquist, G.G.2
Gyurus, E.3
Green, A.4
Soltesz, G.5
-
133
-
-
43849096855
-
Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study
-
Harjutsalo V, Sjoberg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 2008: 9626: 1777-1782.
-
(2008)
Lancet
, vol.9626
, pp. 1777-1782
-
-
Harjutsalo, V.1
Sjoberg, L.2
Tuomilehto, J.3
-
134
-
-
2542484935
-
Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up
-
Barker JM, Goehrig SH, Barriga K et al. Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up. Diabetes Care 2004: 6: 1399-1404.
-
(2004)
Diabetes Care
, vol.6
, pp. 1399-1404
-
-
Barker, J.M.1
Goehrig, S.H.2
Barriga, K.3
-
135
-
-
84555186979
-
Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay
-
Yu L, Miao D, Scrimgeour L, Johnson K, Rewers M, Eisenbarth GS. Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay. Diabetes 2012: 1: 179-186.
-
(2012)
Diabetes
, vol.1
, pp. 179-186
-
-
Yu, L.1
Miao, D.2
Scrimgeour, L.3
Johnson, K.4
Rewers, M.5
Eisenbarth, G.S.6
-
136
-
-
84891821090
-
GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes
-
Miao D, Guyer KM, Dong F et al. GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes. Diabetes 2013: 12: 4174-4178.
-
(2013)
Diabetes
, vol.12
, pp. 4174-4178
-
-
Miao, D.1
Guyer, K.M.2
Dong, F.3
-
137
-
-
84886055195
-
Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity
-
Yu L, Dong F, Miao D, Fouts AR, Wenzlau JM, Steck AK. Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity. Diabetes Care 2013: 8: 2266-2270.
-
(2013)
Diabetes Care
, vol.8
, pp. 2266-2270
-
-
Yu, L.1
Dong, F.2
Miao, D.3
Fouts, A.R.4
Wenzlau, J.M.5
Steck, A.K.6
-
138
-
-
11144298970
-
Insulin resistance is a risk factor for progression to type 1 diabetes
-
Fourlanos S, Narendran P, Byrnes GB, Colman PG, Harrison LC. Insulin resistance is a risk factor for progression to type 1 diabetes. Diabetologia 2004: 10: 1661-1667.
-
(2004)
Diabetologia
, vol.10
, pp. 1661-1667
-
-
Fourlanos, S.1
Narendran, P.2
Byrnes, G.B.3
Colman, P.G.4
Harrison, L.C.5
-
139
-
-
84916881229
-
Combination therapy for early rheumatoid arthritis: a treatment holiday perspective
-
Hirata S, Tanaka Y. Combination therapy for early rheumatoid arthritis: a treatment holiday perspective. Expert Rev Clin Pharmacol 2015: 1: 115-122.
-
(2015)
Expert Rev Clin Pharmacol
, vol.1
, pp. 115-122
-
-
Hirata, S.1
Tanaka, Y.2
-
140
-
-
78149475225
-
Dietary intervention in infancy and later signs of beta-cell autoimmunity
-
Knip M, Virtanen SM, Seppa K et al. Dietary intervention in infancy and later signs of beta-cell autoimmunity. N Engl J Med 2010: 20: 1900-1908.
-
(2010)
N Engl J Med
, vol.20
, pp. 1900-1908
-
-
Knip, M.1
Virtanen, S.M.2
Seppa, K.3
-
141
-
-
84902209257
-
Hydrolyzed infant formula and early beta-cell autoimmunity: a randomized clinical trial
-
Knip M, Akerblom HK, Becker D et al. Hydrolyzed infant formula and early beta-cell autoimmunity: a randomized clinical trial. JAMA 2014: 22: 2279-2287.
-
(2014)
JAMA
, vol.22
, pp. 2279-2287
-
-
Knip, M.1
Akerblom, H.K.2
Becker, D.3
-
142
-
-
80051982382
-
Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study
-
Hummel S, Pfluger M, Hummel M, Bonifacio E, Ziegler AG. Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study. Diabetes Care 2011: 6: 1301-1305.
-
(2011)
Diabetes Care
, vol.6
, pp. 1301-1305
-
-
Hummel, S.1
Pfluger, M.2
Hummel, M.3
Bonifacio, E.4
Ziegler, A.G.5
-
143
-
-
84555188733
-
Maternal serum levels of 25-hydroxy-vitamin D during pregnancy and risk of type 1 diabetes in the offspring
-
Sorensen IM, Joner G, Jenum PA, Eskild A, Torjesen PA, Stene LC. Maternal serum levels of 25-hydroxy-vitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes 2012: 1: 175-178.
-
(2012)
Diabetes
, vol.1
, pp. 175-178
-
-
Sorensen, I.M.1
Joner, G.2
Jenum, P.A.3
Eskild, A.4
Torjesen, P.A.5
Stene, L.C.6
-
144
-
-
0035802695
-
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
-
Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001: 9292: 1500-1503.
-
(2001)
Lancet
, vol.9292
, pp. 1500-1503
-
-
Hypponen, E.1
Laara, E.2
Reunanen, A.3
Jarvelin, M.R.4
Virtanen, S.M.5
-
145
-
-
84872716878
-
The multiple origins of type 1 diabetes
-
Pugliese A. The multiple origins of type 1 diabetes. Diabet Med 2013: 2: 135-146.
-
(2013)
Diabet Med
, vol.2
, pp. 135-146
-
-
Pugliese, A.1
-
146
-
-
0037198427
-
Effects of insulin in relatives of patients with type 1 diabetes mellitus
-
Diabetes Prevention Trial - Type 1 Diabetes Study Group. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 2002: 22: 1685-1691.
-
(2002)
N Engl J Med
, vol.22
, pp. 1685-1691
-
-
-
147
-
-
18144391496
-
Effects of oral insulin in relatives of patients with type 1 diabetes: the diabetes prevention trial - type 1
-
Skyler JS, Krischer JP, Wolfsdorf J et al. Effects of oral insulin in relatives of patients with type 1 diabetes: the diabetes prevention trial - type 1. Diabetes Care 2005: 5: 1068-1076.
-
(2005)
Diabetes Care
, vol.5
, pp. 1068-1076
-
-
Skyler, J.S.1
Krischer, J.P.2
Wolfsdorf, J.3
-
148
-
-
80054692681
-
Long-term outcome of individuals treated with oral insulin: diabetes prevention trial-type 1 (DPT-1) oral insulin trial
-
Vehik K, Cuthbertson D, Ruhlig H, Schatz DA, Peakman M, Krischer JP. Long-term outcome of individuals treated with oral insulin: diabetes prevention trial-type 1 (DPT-1) oral insulin trial. Diabetes Care 2011: 7: 1585-1590.
-
(2011)
Diabetes Care
, vol.7
, pp. 1585-1590
-
-
Vehik, K.1
Cuthbertson, D.2
Ruhlig, H.3
Schatz, D.A.4
Peakman, M.5
Krischer, J.P.6
-
149
-
-
1642277657
-
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes
-
Gale EA, Bingley PJ, Emmett CL, Collier T. European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 2004: 9413: 925-931.
-
(2004)
Lancet
, vol.9413
, pp. 925-931
-
-
Gale, E.A.1
Bingley, P.J.2
Emmett, C.L.3
Collier, T.4
-
150
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
Keymeulen B, Vandemeulebroucke E, Ziegler AG et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 2005: 25: 2598-2608.
-
(2005)
N Engl J Med
, vol.25
, pp. 2598-2608
-
-
Keymeulen, B.1
Vandemeulebroucke, E.2
Ziegler, A.G.3
-
151
-
-
84872744448
-
The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes
-
Stumpf M, Zhou X, Bluestone JA. The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes. J Immunol 2013: 3: 961-969.
-
(2013)
J Immunol
, vol.3
, pp. 961-969
-
-
Stumpf, M.1
Zhou, X.2
Bluestone, J.A.3
-
152
-
-
84897851090
-
Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment
-
Orban T, Bundy B, Becker DJ et al. Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment. Diabetes Care 2014: 4: 1069-1075.
-
(2014)
Diabetes Care
, vol.4
, pp. 1069-1075
-
-
Orban, T.1
Bundy, B.2
Becker, D.J.3
-
153
-
-
0035076548
-
Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States
-
Redondo MJ, Yu L, Hawa M et al. Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States. Diabetologia 2001: 3: 354-362.
-
(2001)
Diabetologia
, vol.3
, pp. 354-362
-
-
Redondo, M.J.1
Yu, L.2
Hawa, M.3
-
154
-
-
84868197291
-
Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes
-
Redondo MJ, Rodriguez LM, Escalante M, O'Brian SE, Balasubramanyam A, Haymond MW. Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes. Pediatr Diabetes 2012: 7: 564-571.
-
(2012)
Pediatr Diabetes
, vol.7
, pp. 564-571
-
-
Redondo, M.J.1
Rodriguez, L.M.2
Escalante, M.3
O'Brian, S.E.4
Balasubramanyam, A.5
Haymond, M.W.6
-
155
-
-
84881027402
-
Types of pediatric diabetes mellitus defined by anti-islet autoimmunity and random C-peptide at diagnosis
-
Redondo MJ, Rodriguez LM, Escalante M, Smith EO, Balasubramanyam A, Haymond MW. Types of pediatric diabetes mellitus defined by anti-islet autoimmunity and random C-peptide at diagnosis. Pediatr Diabetes 2013: 5: 333-340.
-
(2013)
Pediatr Diabetes
, vol.5
, pp. 333-340
-
-
Redondo, M.J.1
Rodriguez, L.M.2
Escalante, M.3
Smith, E.O.4
Balasubramanyam, A.5
Haymond, M.W.6
-
156
-
-
84942992018
-
Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes
-
Redondo MJ, Muniz J, Rodriguez LM et al. Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes. BMJ Open Diabetes Res Care 2014: 1: e000008.
-
(2014)
BMJ Open Diabetes Res Care
, vol.1
, pp. e000008
-
-
Redondo, M.J.1
Muniz, J.2
Rodriguez, L.M.3
-
157
-
-
33744900639
-
Lessons on autoimmune diabetes from animal models
-
Yang Y, Santamaria P. Lessons on autoimmune diabetes from animal models. Clin Sci (Lond) 2006: 6: 627-639.
-
(2006)
Clin Sci (Lond)
, vol.6
, pp. 627-639
-
-
Yang, Y.1
Santamaria, P.2
-
159
-
-
84887194102
-
Regulatory T-cell therapy in transplantation: moving to the clinic
-
pii: a015552
-
Tang Q, Bluestone JA. Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harb Perspect Med 2013: 3: pii: a015552.
-
(2013)
Cold Spring Harb Perspect Med
, vol.3
-
-
Tang, Q.1
Bluestone, J.A.2
-
160
-
-
77956257716
-
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
-
Grinberg-Bleyer Y, Baeyens A, You S et al. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med 2010: 9: 1871-1878.
-
(2010)
J Exp Med
, vol.9
, pp. 1871-1878
-
-
Grinberg-Bleyer, Y.1
Baeyens, A.2
You, S.3
-
161
-
-
84928589620
-
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
-
Rosenzwajg M, Churlaud G, Mallone R et al. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. J Autoimmun 2015: 58: 48-58.
-
(2015)
J Autoimmun
, vol.58
, pp. 48-58
-
-
Rosenzwajg, M.1
Churlaud, G.2
Mallone, R.3
-
162
-
-
84923510983
-
Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor
-
Lapuerta P, Zambrowicz B, Strumph P, Sands A. Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor. Diab Vasc Dis Res 2015: 2: 101-110.
-
(2015)
Diab Vasc Dis Res
, vol.2
, pp. 101-110
-
-
Lapuerta, P.1
Zambrowicz, B.2
Strumph, P.3
Sands, A.4
-
163
-
-
33750846133
-
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
-
D'Amour KA, Bang AG, Eliazer S et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006: 11: 1392-1401.
-
(2006)
Nat Biotechnol
, vol.11
, pp. 1392-1401
-
-
D'Amour, K.A.1
Bang, A.G.2
Eliazer, S.3
-
164
-
-
84910673362
-
Generation of functional human pancreatic beta cells in vitro
-
Pagliuca FW, Millman JR, Gurtler M et al. Generation of functional human pancreatic beta cells in vitro. Cell 2014: 2: 428-439.
-
(2014)
Cell
, vol.2
, pp. 428-439
-
-
Pagliuca, F.W.1
Millman, J.R.2
Gurtler, M.3
-
165
-
-
84906673582
-
Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease
-
Fox IJ, Daley GQ, Goldman SA, Huard J, Kamp TJ, Trucco M. Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease. Science 2014: 345: 1247391.
-
(2014)
Science
, vol.345
, pp. 1247391
-
-
Fox, I.J.1
Daley, G.Q.2
Goldman, S.A.3
Huard, J.4
Kamp, T.J.5
Trucco, M.6
-
166
-
-
84983134468
-
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
-
Rezania A, Bruin JE, Arora P et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat Biotechnol 2014: 11: 1121-1133.
-
(2014)
Nat Biotechnol
, vol.11
, pp. 1121-1133
-
-
Rezania, A.1
Bruin, J.E.2
Arora, P.3
-
167
-
-
84898466276
-
Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice
-
Di CV, Phillips B, Engman C, Harnaha J, Trucco M, Giannoukakis N. Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice. PLoS One 2014: 1: e83575.
-
(2014)
PLoS One
, vol.1
, pp. e83575
-
-
Di, C.V.1
Phillips, B.2
Engman, C.3
Harnaha, J.4
Trucco, M.5
Giannoukakis, N.6
-
169
-
-
84887025779
-
Targeting the trimolecular complex
-
Michels AW. Targeting the trimolecular complex. Clin Immunol 2013: 3: 339-344.
-
(2013)
Clin Immunol
, vol.3
, pp. 339-344
-
-
Michels, A.W.1
-
170
-
-
84895852712
-
Targeting the trimolecular complex: the pathway towards type 1 diabetes prevention
-
Michels AW. Targeting the trimolecular complex: the pathway towards type 1 diabetes prevention. Diabetes Technol Ther 2013: 15 Suppl 2: S2-8-S2-12.
-
(2013)
Diabetes Technol Ther
, vol.15
, pp. S28-S212
-
-
Michels, A.W.1
-
171
-
-
77951169178
-
Banting Lecture 2009: an unfinished journey: molecular pathogenesis to prevention of type 1A diabetes
-
Eisenbarth GS. Banting Lecture 2009: an unfinished journey: molecular pathogenesis to prevention of type 1A diabetes. Diabetes 2010: 59: 759-774.
-
(2010)
Diabetes
, vol.59
, pp. 759-774
-
-
Eisenbarth, G.S.1
-
172
-
-
42449144715
-
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families
-
Erlich H, Valdes AM, Noble J et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008.
-
(2008)
Diabetes
-
-
Erlich, H.1
Valdes, A.M.2
Noble, J.3
-
173
-
-
82755162147
-
Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation
-
Michels AW, Ostrov DA, Zhang L et al. Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol 2011: 11: 5921-5930.
-
(2011)
J Immunol
, vol.11
, pp. 5921-5930
-
-
Michels, A.W.1
Ostrov, D.A.2
Zhang, L.3
-
174
-
-
84907901062
-
Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes
-
Yang J, Chow IT, Sosinowski T et al. Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes. Proc Natl Acad Sci USA 2014: 41: 14840-14845.
-
(2014)
Proc Natl Acad Sci USA
, vol.41
, pp. 14840-14845
-
-
Yang, J.1
Chow, I.T.2
Sosinowski, T.3
-
175
-
-
84928905602
-
Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects
-
Nakayama M, McDaniel K, Fitzgerald-Miller L et al. Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects. Proc Natl Acad Sci USA 2015: 14: 4429-4434.
-
(2015)
Proc Natl Acad Sci USA
, vol.14
, pp. 4429-4434
-
-
Nakayama, M.1
McDaniel, K.2
Fitzgerald-Miller, L.3
-
176
-
-
79960369940
-
Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope
-
Daniel C, Weigmann B, Bronson R, von BH. Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope. J Exp Med 2011: 7: 1501-1510.
-
(2011)
J Exp Med
, vol.7
, pp. 1501-1510
-
-
Daniel, C.1
Weigmann, B.2
Bronson, R.3
von, B.H.4
-
177
-
-
80855147966
-
Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice
-
Zhang L, Stadinski BD, Michels A, Kappler JW, Eisenbarth GS. Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice. Diabetes Metab Res Rev 2011: 8: 784-789.
-
(2011)
Diabetes Metab Res Rev
, vol.8
, pp. 784-789
-
-
Zhang, L.1
Stadinski, B.D.2
Michels, A.3
Kappler, J.W.4
Eisenbarth, G.S.5
-
178
-
-
77954643719
-
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register
-
Stadinski BD, Zhang L, Crawford F, Marrack P, Eisenbarth GS, Kappler JW. Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci USA 2010: 24: 10978-10983.
-
(2010)
Proc Natl Acad Sci USA
, vol.24
, pp. 10978-10983
-
-
Stadinski, B.D.1
Zhang, L.2
Crawford, F.3
Marrack, P.4
Eisenbarth, G.S.5
Kappler, J.W.6
-
179
-
-
84894354624
-
Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes
-
Zhang L, Crawford F, Yu L et al. Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes. Proc Natl Acad Sci USA 2014: 7: 2656-2661.
-
(2014)
Proc Natl Acad Sci USA
, vol.7
, pp. 2656-2661
-
-
Zhang, L.1
Crawford, F.2
Yu, L.3
-
180
-
-
67349111962
-
Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains
-
Zhang L, Jasinski JM, Kobayashi M et al. Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains. J Autoimmun 2009: 1: 42-49.
-
(2009)
J Autoimmun
, vol.1
, pp. 42-49
-
-
Zhang, L.1
Jasinski, J.M.2
Kobayashi, M.3
-
181
-
-
84859519651
-
Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice
-
Nakayama M, Castoe T, Sosinowski T et al. Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice. Diabetes 2012: 4: 857-865.
-
(2012)
Diabetes
, vol.4
, pp. 857-865
-
-
Nakayama, M.1
Castoe, T.2
Sosinowski, T.3
-
182
-
-
84860579280
-
Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vbeta13 as a therapeutic target and biomarker
-
Liu Z, Cort L, Eberwine R et al. Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vbeta13 as a therapeutic target and biomarker. Diabetes 2012: 5: 1160-1168.
-
(2012)
Diabetes
, vol.5
, pp. 1160-1168
-
-
Liu, Z.1
Cort, L.2
Eberwine, R.3
-
183
-
-
47249124078
-
Human regulatory T cells: role in autoimmune disease and therapeutic opportunities
-
Brusko TM, Putnam AL, Bluestone JA. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol Rev 2008: 223:371-390.
-
(2008)
Immunol Rev
, vol.223
, pp. 371-390
-
-
Brusko, T.M.1
Putnam, A.L.2
Bluestone, J.A.3
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