메뉴 건너뛰기




Volumn 190, Issue 3, 2013, Pages 961-969

The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; ISOPROTEIN; LIGAND; MESSENGER RNA; PROTEIN B7; UNCLASSIFIED DRUG;

EID: 84872744448     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201362     Document Type: Article
Times cited : (36)

References (55)
  • 1
    • 79954459308 scopus 로고    scopus 로고
    • Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/B7 family
    • Bour-Jordan, H., J. H. Esensten, M. Martinez-Llordella, C. Penaranda, M. Stumpf, and J. A. Bluestone. 2011. Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/B7 family. Immunol. Rev. 241: 180-205.
    • (2011) Immunol. Rev. , vol.241 , pp. 180-205
    • Bour-Jordan, H.1    Esensten, J.H.2    Martinez-Llordella, M.3    Penaranda, C.4    Stumpf, M.5    Bluestone, J.A.6
  • 2
    • 49249089425 scopus 로고    scopus 로고
    • Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
    • Fife, B. T., and J. A. Bluestone. 2008. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol. Rev. 224: 166-182.
    • (2008) Immunol. Rev. , vol.224 , pp. 166-182
    • Fife, B.T.1    Bluestone, J.A.2
  • 3
    • 47249153181 scopus 로고    scopus 로고
    • CTLA-4: A key regulatory point in the control of autoimmune disease
    • DOI 10.1111/j.1600-065X.2008.00639.x
    • Scalapino, K. J., and D. I. Daikh. 2008. CTLA-4: A key regulatory point in the control of autoimmune disease. Immunol. Rev. 223: 143-155. (Pubitemid 351986184)
    • (2008) Immunological Reviews , vol.223 , Issue.1 , pp. 143-155
    • Scalapino, K.J.1    Daikh, D.I.2
  • 4
    • 16244369437 scopus 로고    scopus 로고
    • CTLA4 gene polymorphism and autoimmunity
    • DOI 10.1111/j.0105-2896.2005.00249.x
    • Gough, S. C., L. S. Walker, and D. M. Sansom. 2005. CTLA4 gene polymorphism and autoimmunity. Immunol. Rev. 204: 102-115. (Pubitemid 40460496)
    • (2005) Immunological Reviews , vol.204 , pp. 102-115
    • Gough, S.C.L.1    Walker, L.S.K.2    Sansom, D.M.3
  • 5
    • 21844480358 scopus 로고    scopus 로고
    • CTLA-4 (CD152) and its involvement in autoimmune disease
    • DOI 10.1080/08916930500050210
    • Holmberg, D., C. M. Cilio, M. Lundholm, and V. Motta. 2005. CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity 38: 225-233. (Pubitemid 40959896)
    • (2005) Autoimmunity , vol.38 , Issue.3 , pp. 225-233
    • Holmberg, D.1    Cilio, C.M.2    Lundholm, M.3    Motta, V.4
  • 6
    • 80054115387 scopus 로고    scopus 로고
    • CTLA4 gene variants in autoimmunity and cancer: A comparative review
    • Ghaderi, A. 2011. CTLA4 gene variants in autoimmunity and cancer: A comparative review. Iran. J. Immunol. 8: 127-149.
    • (2011) Iran. J. Immunol. , vol.8 , pp. 127-149
    • Ghaderi, A.1
  • 7
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3: 541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 9
    • 0037244012 scopus 로고    scopus 로고
    • Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4
    • DOI 10.1084/jem.20021646
    • Chikuma, S., J. B. Imboden, and J. A. Bluestone. 2003. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 197: 129-135. (Pubitemid 36110264)
    • (2003) Journal of Experimental Medicine , vol.197 , Issue.1 , pp. 129-135
    • Chikuma, S.1    Imboden, J.B.2    Bluestone, J.A.3
  • 10
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • DOI 10.1084/jem.183.6.2541
    • Walunas, T. L., C. Y. Bakker, and J. A. Bluestone. 1996. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183: 2541-2550. (Pubitemid 26192364)
    • (1996) Journal of Experimental Medicine , vol.183 , Issue.6 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 11
    • 0034710983 scopus 로고    scopus 로고
    • Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
    • Luhder, F., C. Chambers, J. P. Allison, C. Benoist, and D. Mathis. 2000. Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells. Proc. Natl. Acad. Sci. USA 97: 12204-12209.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12204-12209
    • Luhder, F.1    Chambers, C.2    Allison, J.P.3    Benoist, C.4    Mathis, D.5
  • 12
    • 0346496097 scopus 로고    scopus 로고
    • CTLA-4 and tolerance: The biochemical point of view
    • DOI 10.1385/IR:28:3:241
    • Chikuma, S., and J. A. Bluestone. 2003. CTLA-4 and tolerance: The biochemical point of view. Immunol. Res. 28: 241-253. (Pubitemid 38091062)
    • (2003) Immunologic Research , vol.28 , Issue.3 , pp. 241-253
    • Chikuma, S.1    Bluestone, J.A.2
  • 14
    • 0025979295 scopus 로고
    • Cd28 and Ctla-4, two related members of the Ig supergene family, are tightly linked on proximal mouse chromosome 1
    • Howard, T. A., J. M. Rochelle, and M. F. Seldin. 1991. Cd28 and Ctla-4, two related members of the Ig supergene family, are tightly linked on proximal mouse chromosome 1. Immunogenetics 33: 74-76.
    • (1991) Immunogenetics , vol.33 , pp. 74-76
    • Howard, T.A.1    Rochelle, J.M.2    Seldin, M.F.3
  • 15
    • 4444369694 scopus 로고    scopus 로고
    • B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse
    • DOI 10.1016/j.immuni.2004.06.017, PII S1074761304002109
    • Pentcheva-Hoang, T., J. G. Egen, K. Wojnoonski, and J. P. Allison. 2004. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity 21: 401-413. (Pubitemid 39208341)
    • (2004) Immunity , vol.21 , Issue.3 , pp. 401-413
    • Pentcheva-Hoang, T.1    Egen, J.G.2    Wojnoonski, K.3    Allison, J.P.4
  • 16
    • 78649851459 scopus 로고    scopus 로고
    • Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters
    • Saito, T., T. Yokosuka, and A. Hashimoto-Tane. 2010. Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters. FEBS Lett. 584: 4865-4871.
    • (2010) FEBS Lett. , vol.584 , pp. 4865-4871
    • Saito, T.1    Yokosuka, T.2    Hashimoto-Tane, A.3
  • 19
    • 65349119978 scopus 로고    scopus 로고
    • CD28 and CTLA-4 coreceptor expression and signal transduction
    • Rudd, C. E., A. Taylor, and H. Schneider. 2009. CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol. Rev. 229: 12-26.
    • (2009) Immunol. Rev. , vol.229 , pp. 12-26
    • Rudd, C.E.1    Taylor, A.2    Schneider, H.3
  • 21
    • 0030001318 scopus 로고    scopus 로고
    • Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
    • Marengere, L. E., P. Waterhouse, G. S. Duncan, H. W. Mittrucker, G. S. Feng, and T. W. Mak. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272: 1170-1173. (Pubitemid 26169471)
    • (1996) Science , vol.272 , Issue.5265 , pp. 1170-1173
    • Marengere, L.E.M.1    Waterhouse, P.2    Duncan, G.S.3    Mittrucker, H.-W.4    Feng, G.-S.5    Mak, T.W.6
  • 23
    • 0036569236 scopus 로고    scopus 로고
    • 319 phosphorylation: A potential role for tyrosine phosphatases
    • Guntermann, C., and D. R. Alexander. 2002. CTLA-4 suppresses proximal TCR signaling in resting human CD4+ T cells by inhibiting ZAP-70 Tyr319 phosphorylation: A potential role for tyrosine phosphatases. J. Immunol. 168: 4420-4429. (Pubitemid 34441343)
    • (2002) Journal of Immunology , vol.168 , Issue.9 , pp. 4420-4429
    • Guntermann, C.1    Alexander, D.R.2
  • 24
    • 0030707866 scopus 로고    scopus 로고
    • 2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor z and ZAP70
    • DOI 10.1084/jem.186.10.1645
    • Calvo, C. R., D. Amsen, and A. M. Kruisbeek. 1997. Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor z and ZAP70. J. Exp. Med. 186: 1645-1653. (Pubitemid 27506278)
    • (1997) Journal of Experimental Medicine , vol.186 , Issue.10 , pp. 1645-1653
    • Calvo, C.R.1    Amsen, D.2    Kruisbeek, A.M.3
  • 26
    • 0036784567 scopus 로고    scopus 로고
    • Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signalregulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ ligand-deficient mice
    • Schneider, H., D. A. Mandelbrot, R. J. Greenwald, F. Ng, R. Lechler, A. H. Sharpe, and C. E. Rudd. 2002. Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signalregulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ ligand-deficient mice. J. Immunol. 169: 3475-3479.
    • (2002) J. Immunol. , vol.169 , pp. 3475-3479
    • Schneider, H.1    Mandelbrot, D.A.2    Greenwald, R.J.3    Ng, F.4    Lechler, R.5    Sharpe, A.H.6    Rudd, C.E.7
  • 30
    • 33847656517 scopus 로고    scopus 로고
    • A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene
    • DOI 10.1007/s00125-007-0603-6
    • Howson, J.M., D. B. Dunger, S. Nutland, H. Stevens, L. S.Wicker, and J. A. Todd. 2007. A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene. Diabetologia 50: 741-746. (Pubitemid 46355837)
    • (2007) Diabetologia , vol.50 , Issue.4 , pp. 741-746
    • Howson, J.M.M.1    Dunger, D.B.2    Nutland, S.3    Stevens, H.4    Wicker, L.S.5    Todd, J.A.6
  • 32
    • 0033820560 scopus 로고    scopus 로고
    • NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans
    • Hill, N. J., P. A. Lyons, N. Armitage, J. A. Todd, L. S. Wicker, and L. B. Peterson. 2000. NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes 49: 1744-1747.
    • (2000) Diabetes , vol.49 , pp. 1744-1747
    • Hill, N.J.1    Lyons, P.A.2    Armitage, N.3    Todd, J.A.4    Wicker, L.S.5    Peterson, L.B.6
  • 34
    • 77954092701 scopus 로고    scopus 로고
    • Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice
    • Araki, M., D. Chung, S. Liu, D. B. Rainbow, G. Chamberlain, V. Garner, K. M. Hunter, L. Vijayakrishnan, L. B. Peterson, M. Oukka, et al. 2009. Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. J. Immunol. 183: 5146-5157.
    • (2009) J. Immunol. , vol.183 , pp. 5146-5157
    • Araki, M.1    Chung, D.2    Liu, S.3    Rainbow, D.B.4    Chamberlain, G.5    Garner, V.6    Hunter, K.M.7    Vijayakrishnan, L.8    Peterson, L.B.9    Oukka, M.10
  • 36
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon, B., D. J. Lenschow, L. Rhee, N. Ashourian, B. Singh, A. Sharpe, and J. A. Bluestone. 2000. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12: 431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3    Ashourian, N.4    Singh, B.5    Sharpe, A.6    Bluestone, J.A.7
  • 38
    • 34548774646 scopus 로고    scopus 로고
    • Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse
    • Bour-Jordan, H., B. L. Salomon, H. L. Thompson, R. Santos, A. K. Abbas, and J. A. Bluestone. 2007. Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse. J. Immunol. 179: 1004-1012.
    • (2007) J. Immunol. , vol.179 , pp. 1004-1012
    • Bour-Jordan, H.1    Salomon, B.L.2    Thompson, H.L.3    Santos, R.4    Abbas, A.K.5    Bluestone, J.A.6
  • 39
    • 80051874888 scopus 로고    scopus 로고
    • The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function
    • Gerold, K. D., P. Zheng, D. B. Rainbow, A. Zernecke, L. S. Wicker, and S. Kissler. 2011. The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function. Diabetes 60: 1955-1963.
    • (2011) Diabetes , vol.60 , pp. 1955-1963
    • Gerold, K.D.1    Zheng, P.2    Rainbow, D.B.3    Zernecke, A.4    Wicker, L.S.5    Kissler, S.6
  • 41
    • 33748460087 scopus 로고    scopus 로고
    • + natural regulatory T cells revealed by DNA microarray analysis
    • DOI 10.1093/intimm/dxl060
    • Sugimoto, N., T. Oida, K. Hirota, K. Nakamura, T. Nomura, T. Uchiyama, and S. Sakaguchi. 2006. Foxp3-dependent and-independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int. Immunol. 18: 1197-1209. (Pubitemid 44349295)
    • (2006) International Immunology , vol.18 , Issue.8 , pp. 1197-1209
    • Sugimoto, N.1    Oida, T.2    Hirota, K.3    Nakamura, K.4    Nomura, T.5    Uchiyama, T.6    Sakaguchi, S.7
  • 42
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton, A. M., P. E. Korty, D. Q. Tran, E. A. Wohlfert, P. E. Murray, Y. Belkaid, and E. M. Shevach. 2010. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J. Immunol. 184: 3433-3441.
    • (2010) J. Immunol. , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6    Shevach, E.M.7
  • 44
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • DOI 10.1016/0092-8674(93)90730-E
    • Katz, J. D., B. Wang, K. Haskins, C. Benoist, and D. Mathis. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74: 1089-1100. (Pubitemid 23289465)
    • (1993) Cell , vol.74 , Issue.6 , pp. 1089-1100
    • Katz, J.D.1    Wang, B.2    Haskins, K.3    Benoist, C.4    Mathis, D.5
  • 48
    • 21244437086 scopus 로고    scopus 로고
    • B7-independent inhibition of T cells by CTLA-4
    • Chikuma, S., A. K. Abbas, and J. A. Bluestone. 2005. B7-independent inhibition of T cells by CTLA-4. J. Immunol. 175: 177-181. (Pubitemid 40884315)
    • (2005) Journal of Immunology , vol.175 , Issue.1 , pp. 177-181
    • Chikuma, S.1    Abbas, A.K.2    Bluestone, J.A.3
  • 50
    • 65349151316 scopus 로고    scopus 로고
    • Regulating the regulators: Costimulatory signals control the homeostasis and function of regulatory T cells
    • Bour-Jordan, H., and J. A. Bluestone. 2009. Regulating the regulators: Costimulatory signals control the homeostasis and function of regulatory T cells. Immunol. Rev. 229: 41-66.
    • (2009) Immunol. Rev. , vol.229 , pp. 41-66
    • Bour-Jordan, H.1    Bluestone, J.A.2
  • 53
    • 55149104594 scopus 로고    scopus 로고
    • Interleukin-35: Odd one out or part of the family?
    • Collison, L. W., and D. A. Vignali. 2008. Interleukin-35: Odd one out or part of the family? Immunol. Rev. 226: 248-262.
    • (2008) Immunol. Rev. , vol.226 , pp. 248-262
    • Collison, L.W.1    Vignali, D.A.2
  • 54
    • 39449126502 scopus 로고    scopus 로고
    • + regulatory T cell: A jack of all trades, master of regulation
    • DOI 10.1038/ni1572, PII NI1572
    • Tang, Q., and J. A. Bluestone. 2008. The Foxp3+ regulatory T cell: A jack of all trades, master of regulation. Nat. Immunol. 9: 239-244. (Pubitemid 351267321)
    • (2008) Nature Immunology , vol.9 , Issue.3 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 55
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs, K. S., S. A. Quezada, C. A. Chambers, A. J. Korman, and J. P. Allison. 2009. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J. Exp. Med. 206: 1717-1725.
    • (2009) J. Exp. Med. , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.