Islet cell antibodies (ICA) identify autoimmunity in children with new onset diabetes mellitus negative for other islet cell antibodies

Pediatric Diabetes

Volumn 15, Issue 5, 2014, Pages 336-344

  Andersson, Cecilia ^a   Kolmodin, Martin ^a   Ivarsson, Sten Anders ^a   Carlsson, Annelie ^b,h   Forsander, Gun ^c,h   Lindblad, Bengt ^d   Ludvigsson, Johnny ^e   Kockum, Ingrid ^f   Marcus, Claude ^f   Samuelsson, Ulf ^g,h   Örtqvist, Eva ^f,h   Lernmark, Åke ^a   Larsson, Helena Elding ^a,h   Törn, Carina ^a   Nilsson, Anita ^h   Samuelsson, Bengt Olof ^h   Snellman, Kalle ^h   Olivecrona, Anna ^h   Stenberg, Ake ^h   Skogsberg, Lars ^h   Nilsson, Nilsösten ^h   Neiderud, Jan ^h   Lagerwall, Ake ^h   Hemmingsson, Kristina ^h   Karin Akesson, ^h   Goran Lundstrom ^h   Ljungcrantz, Magnus ^h   Albinsson, Eva ^h   Larsson, Karin ^h   Gundewall, Christer ^h   Enander, Rebecka ^h   Brännström, Agneta ^h   Nordwall, Maria ^h   Hellenberg, Lennart ^h   Lundberg, Elena ^h   Tollig, Henrik ^h   Bj̈orsell, Britta ^h   Rathsman, Björn ^h   Torbjörnsdotter, Torun ^h   Stjernstedt, Bj örn ^h   Wramner, Nils ^h   Ragnar Hanas, ^h   Swenne, Ingemar ^h   Levin, Anna ^h   Thaström, Anders ^h   Arvidsson, Carl Göran ^h   Edvardsson, Stig ^h   Jönsson, Björn ^h   Gadd, Torsten ^h   Äman, Jan ^h   Florell, Rein ^h   Fureman, Anna Lena ^h   more..

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e LINKÖPING UNIVERSITY   (Sweden)

^f KAROLINSKA INSTITUTE   (Sweden)

^g LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^h NONE

Author keywords

Autoantigens; Diagnostic sensitivity; Type 1 diabetes mellitus

Indexed keywords

PANCREAS ISLET CELL ANTIBODY; AUTOANTIBODY; AUTOANTIGEN; GLUTAMATE DECARBOXYLASE; INSULIN;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNITY; CHILD; CHILDHOOD DISEASE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPLORATORY RESEARCH; FEMALE; HUMAN; IMMUNOFLUORESCENCE TEST; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NEWBORN; POPULATION RESEARCH; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; IMMUNOLOGY; PANCREAS ISLET; PRESCHOOL CHILD; SWEDEN;

ADOLESCENT; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; GLUTAMATE DECARBOXYLASE; HUMANS; INFANT; INSULIN; ISLETS OF LANGERHANS; MALE; SWEDEN;

EID: 84904537945     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/pedi.12093     Document Type: Article

References (49)

1. Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974: 2: 1279-1283.
2. Maccuish AC, Irvine WJ, Barnes EW, Duncan LJ. Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease. Lancet 1974: 2: 1529-1531.
3. Baekkeskov S, Nielsen JH, Marner B, Bilde T, Ludvigsson J, Lernmark A. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 1982: 298: 167-169.
4. Baekkeskov S, Aanstoot HJ, Christgau S et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990: 347: 151-156.
5. Karlsen AE, Hagopian WA, Grubin CE et al. Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc Natl Acad Sci U S A 1991: 88: 8337-8341.
6. Palmer JP, Asplin CM, Clemons P et al. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 1983: 222: 1337-1339.
7. LAN MS, Lu J, Goto Y, Notkins AL. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, ia-2, from human insulinoma. DNA Cell Biol 1994: 13: 505-514.
8. Rabin DU, Pleasic SM, Shapiro JA et al. Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol 1994: 152: 3183-3188.
9. Mansson L, Torn C, Landin-Olsson M. Islet cell antibodies represent autoimmune response against several antigens. Int J Exp Diabetes Res 2001: 2: 85-90.
10. Wenzlau JM, Juhl K, Yu L et al. The cation efflux transporter ZnT8 (Slc30a8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A 2007: 104: 17040-17045.
11. Wenzlau JM, Moua O, Sarkar SA et al. Slc30a8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes. Ann N Y Acad Sci 2008: 1150: 256-259.
12. Wenzlau JM, Liu Y, Yu L et al. A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. Diabetes 2008: 57: 2693-2697.
13. Tuomilehto J, Zimmet P, Mackay IR et al. Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease. Lancet 1994: 343: 1383-1385.
14. Ivarsson SA, Ackefors M, Carlsson A et al. Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring. Autoimmunity 1997: 26: 261-269.
15. Whittingham S, Byron SL, Tuomilehto J et al. Autoantibodies associated with presymptomatic insulin-dependent diabetes mellitus in women. Diabet Med 1997: 14: 678-685.
16. Bingley PJ, Bonifacio E, Williams AJ, Genovese S, Bottazzo GF, Gale EA. Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers. Diabetes 1997: 46: 1701-1710.
17. Samuelsson U, Sundkvist G, Borg H, Fernlund P, LUDVIGSSON J. Islet autoantibodies in the prediction of diabetes in school children. Diabetes Res Clin Pract 2001: 51: 51-57.
18. Achenbach P, Lampasona V, Landherr U et al. Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia 2009: 52: 1881-1888.
19. Knip M, Korhonen S, Kulmala P et al. Prediction of type 1 diabetes in the general population. Diabetes Care 2010: 33: 1206-1212.
20. Bonifacio E, Boitard C, Gleichmann H, Shattock MA, Molenaar JL, Bottazzo GF. Assessment of precision, concordance, specificity, and sensitivity of islet cell antibody measurement in 41 assays. Diabetologia 1990: 33: 731-736.
21. Verge CF, Stenger D, Bonifacio E et al. Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial islet autoantibody workshop. Diabetes 1998: 47: 1857-1866.
22. Bingley PJ, Bonifacio E, Mueller PW. Diabetes antibody standardization program: first assay proficiency evaluation. Diabetes 2003: 52: 1128-1136.
23. Torn C, Mueller PW, Schlosser M, Bonifacio E, Bingley PJ. Diabetes antibody standardization program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 2008: 51: 846-852.
24. Gale EA, Bingley PJ, Emmett CL, Collier T. European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 2004: 363: 925-931.
25. Vehik K, Cuthbertson D, Ruhlig H, Schatz DA, Peakman M, Krischer JP. Long-term outcome of individuals treated with oral insulin: Diabetes prevention trial-type 1 (DPT-1) oral insulin trial. Diabetes Care 2011: 34: 1585-1590.
26. Sosenko JM, Mahon J, Rafkin L et al. A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants. Pediatr Diabetes 2011: 12: 85-90.
27. Andersson C, Larsson K, Vaziri-Sani F et al. The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes. Autoimmunity 2011: 44: 394-405.
28. Vaziri-Sani F, Delli AJ, Elding-Larsson H et al. A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes. J Immunol Methods 2011: 371: 25-37.
29. Vermeulen I, Weets I, Asanghanwa M et al. Contribution of antibodies against IA-2beta and zinc transporter 8 to classification of diabetes diagnosed under 40years of age. Diabetes Care 2011: 34: 1760-1765.
30. Andersson C, Vaziri-Sani F, Delli A et al. Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes. Pediatr Diabetes 2013: 14: 97-105.
31. Elfving M, Lindberg B, Lynch K et al. Number of islet autoantibodies present in newly diagnosed type 1 diabetes children born to non-diabetic mothers is affected by islet autoantibodies present at birth. Pediatr Diabetes 2008: 9: 127-134.
32. Siljander HT, Simell S, Hekkala A et al. Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population. Diabetes 2009: 58: 2835-2842.
33. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2007: 30 (Suppl. 1): S42-S47.
34. Hanberger L, Samuelsson U, Lindblad B, Ludvigsson J, Swedish Childhood Diabetes Registry. A1c in children and adolescents with diabetes in relation to certain clinical parameters: The Swedish Childhood Diabetes Registry SWEDIABKID. Diabetes Care 2008: 31: 927-929.
35. Landin-Olsson M, Sundkvist G, Lernmark A. Prolonged incubation in the two-colour immunofluorescence test increases the prevalence and titres of islet cell antibodies in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1987: 30: 327-332.
36. Landin-Olsson M, Karlsson A, Dahlquist G, Blom L, Lernmark A, Sundkvist G. Islet cell and other organ-specific autoantibodies in all children developing type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children. Diabetologia 1989: 32: 387-395.
37. Lindberg B, Carlsson A, Ericsson UB et al. Prevalence of beta-cell and thyroid autoantibody positivity in schoolchildren during three-year follow-up. Autoimmunity 1999: 31: 175-185.
38. Kiviniemi M, Hermann R, Nurmi J et al. A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (The Environmental Determinants of Diabetes in the Young) study. Diabetes Technol Ther 2007: 9: 460-472.
39. Murphy R, Ellard S, Hattersley AT. Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. Nat Clin Pract Endocrinol Metab 2008: 4: 200-213.
40. Pietropaolo M, Yu S, Libman IM et al. Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatr Diabetes 2005: 6: 184-192.
41. Yu L, Boulware DC, Beam CA et al. Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies. Diabetes Care 2012: 35: 1213-1218.
42. Ludvigsson J, Carlsson A, Forsander G et al. C-peptide in the classification of diabetes in children and adolescents. Pediatr Diabetes 2012: 13: 45-50.
43. Hagopian WA, Sanjeevi CB, Kockum I et al. Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 1995: 95: 1505-1511.
44. Vandewalle CL, Falorni A, Svanholm S, Lernmark A, Pipeleers DG, Gorus FK. High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40years. The Belgian Diabetes Registry. J Clin Endocrinol Metab 1995: 80: 846-851.
45. Sera Y, Kawasaki E, Abiru N et al. Autoantibodies to multiple islet autoantigens in patients with abrupt onset type 1 diabetes and diabetes diagnosed with urinary glucose screening. J Autoimmun 1999: 13: 257-265.
46. Sabbah E, Savola K, Kulmala P et al. Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. The Childhood Diabetes in Finland Study Group. J Clin Endocrinol Metab 1999: 84: 1534-1539.
47. Kulmala P, Savola K, Petersen JS et al. Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. a population-based study. The Childhood Diabetes in Finland Study Group. J Clin Invest 1998: 101: 327-336.
48. Ziegler AG, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: The 2-year analysis of the German BABYDIAB Study. Diabetes 1999: 48: 460-468.
49. Orban T, Sosenko JM, Cuthbertson D et al. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2009: 32: 2269-2274.