메뉴 건너뛰기




Volumn 59, Issue 4, 2010, Pages 759-774

Banting lecture 2009: An unfinished journey: Molecular pathogenesis to prevention of type 1A diabetes

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; B LYMPHOCYTE ANTIBODY; CD20 ANTIBODY; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; INSULIN; INSULIN ANTIBODY; INSULIN DERIVATIVE; INSULIN PEPTIDE B: 9 23; NICOTINAMIDE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; PLACEBO; SULFONYLUREA; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

EID: 77951169178     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-1855     Document Type: Review
Times cited : (84)

References (185)
  • 2
    • 25644456144 scopus 로고    scopus 로고
    • Mortality in childhood-onset type 1 diabetes: A population-based study
    • DOI 10.2337/diacare.28.10.2384
    • Dahlquist G, Källén B. Mortality in childhood-onset type 1 diabetes: a population-based study. Diabetes Care 2005;28:2384-2387 (Pubitemid 41384281)
    • (2005) Diabetes Care , vol.28 , Issue.10 , pp. 2384-2387
    • Dahlquist, G.1    Kallen, B.2
  • 3
    • 70449516720 scopus 로고    scopus 로고
    • Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (The FinnDiane Study)
    • Makinen VP, Forsblom C, Thorn LM, Waden J, Kaski K, Ala-Korpela M, Groop PH. Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (The FinnDiane Study). Cardiovasc Diabetologia 2009;8:54
    • (2009) Cardiovasc Diabetologia , vol.8 , pp. 54
    • Makinen, V.P.1    Forsblom, C.2    Thorn, L.M.3    Waden, J.4    Kaski, K.5    Ala-Korpela, M.6    Groop, P.H.7
  • 4
    • 65649106226 scopus 로고    scopus 로고
    • Continuous glucose monitoring in type 1 diabetes mellitus
    • Tamborlane WV, Beck RW. Continuous glucose monitoring in type 1 diabetes mellitus. Lancet 2009;373:1744-1746
    • (2009) Lancet , vol.373 , pp. 1744-1746
    • Tamborlane, W.V.1    Beck, R.W.2
  • 5
    • 37149049051 scopus 로고    scopus 로고
    • Continuous home monitoring of glucose: Improved glycemic control with real-life use of continuous glucose sensors in adult subjects with type 1 diabetes
    • Garg SK, Kelly WC, Voelmle MK, Ritchie PJ, Gottlieb PA, McFann KK, Ellis SL. Continuous home monitoring of glucose: improved glycemic control with real-life use of continuous glucose sensors in adult subjects with type 1 diabetes. Diabetes Care 2007;30:3023-3025
    • (2007) Diabetes Care , vol.30 , pp. 3023-3025
    • Garg, S.K.1    Kelly, W.C.2    Voelmle, M.K.3    Ritchie, P.J.4    Gottlieb, P.A.5    McFann, K.K.6    Ellis, S.L.7
  • 7
    • 33645083494 scopus 로고    scopus 로고
    • Pancreas versus islet transplantation in diabetes mellitus: How to allocate deceased donor pancreata?
    • Kandaswamy R, Sutherland DE. Pancreas versus islet transplantation in diabetes mellitus: How to allocate deceased donor pancreata? Transplant Proc 2006;38:365-367
    • (2006) Transplant Proc , vol.38 , pp. 365-367
    • Kandaswamy, R.1    Sutherland, D.E.2
  • 8
    • 33646008879 scopus 로고    scopus 로고
    • Advances in pancreatic islet transplantation in humans
    • Nanji SA, Shapiro AM. Advances in pancreatic islet transplantation in humans. Diabetes Obes Metab 2006;8:15-25
    • (2006) Diabetes Obes Metab , vol.8 , pp. 15-25
    • Nanji, S.A.1    Shapiro, A.M.2
  • 10
    • 49949152047 scopus 로고    scopus 로고
    • Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after pancreas transplantation
    • Laughlin E, Burke G, Pugliese A, Falk B, Nepom G. Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after pancreas transplantation. Clin Immunol 2008;128:23-30
    • (2008) Clin Immunol , vol.128 , pp. 23-30
    • Laughlin, E.1    Burke, G.2    Pugliese, A.3    Falk, B.4    Nepom, G.5
  • 12
    • 0022646067 scopus 로고
    • The NOD mouse: Recessive diabetogenic gene in the major histocompatibility complex
    • Hattori M, Buse JB, Jackson RA, Glimcher L, Dorf ME, Minami M, Makino S, Moriwaki K, Kuzuya H, Imura H, Seidman JG, Eisenbarth, GS. The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science 1986;231:733-735 (Pubitemid 16104046)
    • (1986) Science , vol.231 , Issue.4739 , pp. 733-735
    • Hattori, M.1    Buse, J.B.2    Jackson, R.A.3
  • 14
    • 33646401825 scopus 로고    scopus 로고
    • An immunologic homunculus for type 1 diabetes
    • Homann D, Eisenbarth GS. An immunologic homunculus for type 1 diabetes. J Clin Invest 2006;116:1212-1215
    • (2006) J Clin Invest , vol.116 , pp. 1212-1215
    • Homann, D.1    Eisenbarth, G.S.2
  • 16
    • 5444222000 scopus 로고    scopus 로고
    • Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
    • DOI 10.1038/ni1120
    • Jaeckel E, Lipes MA, von Boehmer H. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat Immunol 2004;5:1028-1035 (Pubitemid 41057722)
    • (2004) Nature Immunology , vol.5 , Issue.10 , pp. 1028-1035
    • Jaeckel, E.1    Lipes, M.A.2    Von Boehmer, H.3
  • 18
    • 38649120073 scopus 로고    scopus 로고
    • Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice
    • Fukushima K, Abiru N, Nagayama Y, Kobayashi M, Satoh T, Nakahara M, Kawasaki E, Yamasaki H, Ueha S, Matsushima K, Liu E, Eguchi K. Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice. Biochem Biophys Res Commun 2008;367:719-724
    • (2008) Biochem Biophys Res Commun , vol.367 , pp. 719-724
    • Fukushima, K.1    Abiru, N.2    Nagayama, Y.3    Kobayashi, M.4    Satoh, T.5    Nakahara, M.6    Kawasaki, E.7    Yamasaki, H.8    Ueha, S.9    Matsushima, K.10    Liu, E.11    Eguchi, K.12
  • 20
    • 39149118342 scopus 로고    scopus 로고
    • Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?
    • Suri A, Levisetti MG, Unanue ER. Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity? Curr Opin Immunol 2008;20:105-110
    • (2008) Curr Opin Immunol , vol.20 , pp. 105-110
    • Suri, A.1    Levisetti, M.G.2    Unanue, E.R.3
  • 21
    • 33646430866 scopus 로고    scopus 로고
    • TGF-beta signaling is required for the function of insulin-reactive T regulatory cells
    • Du W, Wong FS, Li MO, Peng J, Qi H, Flavell RA, Sherwin R, Wen L. TGF-beta signaling is required for the function of insulin-reactive T regulatory cells. J Clin Invest 2006;116:1360-1370
    • (2006) J Clin Invest , vol.116 , pp. 1360-1370
    • Du, W.1    Wong, F.S.2    Li, M.O.3    Peng, J.4    Qi, H.5    Flavell, R.A.6    Sherwin, R.7    Wen, L.8
  • 22
    • 0028145676 scopus 로고
    • Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice
    • DOI 10.1002/eji.1830240820
    • Wegmann DR, Norbury-Glaser M, Daniel D. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur J Immunol 1994;24:1853-1857 (Pubitemid 24237557)
    • (1994) European Journal of Immunology , vol.24 , Issue.8 , pp. 1853-1857
    • Wegmann, D.R.1    Norbury-Glaser, M.2    Daniel, D.3
  • 23
    • 0028914351 scopus 로고
    • Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice
    • Daniel D, Gill RG, Schloot N, Wegmann D. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol 1995;25:1056-1062
    • (1995) Eur J Immunol , vol.25 , pp. 1056-1062
    • Daniel, D.1    Gill, R.G.2    Schloot, N.3    Wegmann, D.4
  • 26
    • 16244374292 scopus 로고    scopus 로고
    • The good turned ugly: Immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice
    • DiLorenzo TP, Serreze DV: The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice. Immunol Rev 2005;204:250-263
    • (2005) Immunol Rev , vol.204 , pp. 250-263
    • DiLorenzo, T.P.1    Serreze, D.V.2
  • 29
    • 0942290492 scopus 로고    scopus 로고
    • IA-2 is not required for the development of diabetes in NOD mice [7]
    • DOI 10.1007/s00125-003-1252-z
    • Kubosaki A, Miura J, Notkins AL. IA-2 is not required for the development of diabetes in NOD mice. Diabetologia 2004;47:149-150 (Pubitemid 38141956)
    • (2004) Diabetologia , vol.47 , Issue.1 , pp. 149-150
    • Kubosaki, A.1    Miura, J.2    Notkins, A.L.3
  • 30
    • 3042704212 scopus 로고    scopus 로고
    • Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice
    • DOI 10.2337/diabetes.53.7.1684
    • Kubosaki A, Gross S, Miura J, Saeki K, Zhu M, Nakamura S, Hendriks W, Notkins AL. Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice. Diabetes 2004;53:1684-1691 (Pubitemid 38857025)
    • (2004) Diabetes , vol.53 , Issue.7 , pp. 1684-1691
    • Kubosaki, A.1    Gross, S.2    Miura, J.3    Saeki, K.4    Zhu, M.5    Nakamura, S.6    Hendriks, W.7    Notkins, A.L.8
  • 31
    • 0038152841 scopus 로고    scopus 로고
    • Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein
    • DOI 10.1084/jem.20030266
    • Brimnes MK, Bonifaz L, Steinman RM, Moran TM. Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein. J Exp Med 2003;198:133-144 (Pubitemid 36870193)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.1 , pp. 133-144
    • Brimnes, M.K.1    Bonifaz, L.2    Steinman, R.M.3    Moran, T.M.4
  • 36
    • 20944441042 scopus 로고    scopus 로고
    • Prevention of diabetes by manipulation of anti-IGRP autoimmunity: High efficiency of a low-affinity peptide
    • DOI 10.1038/nm1250
    • Han B, Serra P, Amrani A, Yamanouchi J, Marée AF, Edelstein-Keshet L, Santamaria P. Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide. Nat Med 2005;11: 645-652 (Pubitemid 40868305)
    • (2005) Nature Medicine , vol.11 , Issue.6 , pp. 645-652
    • Han, B.1    Serra, P.2    Amrani, A.3    Yamanouchi, J.4    Maree, A.F.M.5    Edelstein-Keshet, L.6    Santamaria, P.7
  • 37
    • 34248210131 scopus 로고    scopus 로고
    • + T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice
    • DOI 10.2337/db06-0543
    • Pop SM, Wong CP, He Q, Wang Y, Wallet MA, Goudy KS, Tisch R. The type and frequency of immunoregulatory CD4+ T cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice. Diabetes 2007;56:1395-1402 (Pubitemid 46715604)
    • (2007) Diabetes , vol.56 , Issue.5 , pp. 1395-1402
    • Pop, S.M.1    Wong, C.P.2    He, Q.3    Wang, Y.4    Wallet, M.A.5    Goudy, K.S.6    Tisch, R.7
  • 38
    • 0242486680 scopus 로고    scopus 로고
    • + regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells
    • DOI 10.1016/S0896-8411(03)00114-8
    • Mukherjee R, Chaturvedi P, Qin HY, Singh B. CD4+CD25+ regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells. J Autoimmun 2003;21:221-237 (Pubitemid 37410111)
    • (2003) Journal of Autoimmunity , vol.21 , Issue.3 , pp. 221-237
    • Mukherjee, R.1    Chaturvedi, P.2    Qin, H.-Y.3    Singh, B.4
  • 39
    • 39449126502 scopus 로고    scopus 로고
    • + regulatory T cell: A jack of all trades, master of regulation
    • DOI 10.1038/ni1572, PII NI1572
    • Tang Q, Bluestone JA. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 2008;9:239-244 (Pubitemid 351267321)
    • (2008) Nature Immunology , vol.9 , Issue.3 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 40
    • 62149094732 scopus 로고    scopus 로고
    • Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes
    • Kanazawa Y, Shimada A, Oikawa Y, Okubo Y, Tada A, Imai T, Miyazaki J, Itoh H. Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes. J Autoimmun 2009;32:104-109
    • (2009) J Autoimmun , vol.32 , pp. 104-109
    • Kanazawa, Y.1    Shimada, A.2    Oikawa, Y.3    Okubo, Y.4    Tada, A.5    Imai, T.6    Miyazaki, J.7    Itoh, H.8
  • 41
    • 33646392755 scopus 로고    scopus 로고
    • Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
    • Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von Herrath M. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest 2006;116:1371-1381
    • (2006) J Clin Invest , vol.116 , pp. 1371-1381
    • Bresson, D.1    Togher, L.2    Rodrigo, E.3    Chen, Y.4    Bluestone, J.A.5    Herold, K.C.6    Von Herrath, M.7
  • 44
    • 0033012832 scopus 로고    scopus 로고
    • Immunologic "vaccination" for the prevention of autoimmune diabetes mellitus (type 1A)
    • Simone EA, Wegmann DR, Eisenbarth GS. Immunologic "vaccination" for the prevention of autoimmune diabetes mellitus (type 1A). Diabetes Care 1999;22(Suppl. 2):B7-B15
    • (1999) Diabetes Care , vol.22 , Issue.SUPPL. 2
    • Simone, E.A.1    Wegmann, D.R.2    Eisenbarth, G.S.3
  • 46
    • 4243595317 scopus 로고    scopus 로고
    • Induction of autoantibodies to native insulin in normal and NOD derived mice following immunization with the immunodominant self-B-chain insulin peptide B:9-23
    • Abstract.
    • Abiru N, Yu L, Wegmann D, Eisenbarth GS: Induction of autoantibodies to native insulin in normal and NOD derived mice following immunization with the immunodominant self-B-chain insulin peptide B:9-23 (Abstract). Diabetes 2000;49(Suppl. 1):A232
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Abiru, N.1    Yu, L.2    Wegmann, D.3    Eisenbarth, G.S.4
  • 47
    • 0034987197 scopus 로고    scopus 로고
    • Peptide and major histocompatibility complex-specific breaking of humoral tolerance to native insulin with the B9-23 peptide in diabetes-prone and normal mice
    • Abiru N, Maniatis AK, Yu L, Miao D, Moriyama H, Wegmann D, Eisenbarth GS. Peptide and MHC specific breaking of humoral tolerance to native insulin with the B:9-23 peptide in diabetes prone and normal mice. Diabetes 2001;50:1274-1281 (Pubitemid 32500159)
    • (2001) Diabetes , vol.50 , Issue.6 , pp. 1274-1281
    • Abiru, N.1    Maniatis, A.K.2    Yu, L.3    Miao, D.4    Moriyama, H.5    Wegmann, D.6    Eisenbarth, G.S.7
  • 48
    • 33845710661 scopus 로고    scopus 로고
    • Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouse
    • DOI 10.1196/annals.1375.020, Immunology of Diabetes IV: Progress in Our Understanding
    • Devendra D, Miao D, Nakayama M, Eisenbarth GS, Liu E: Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouse. Ann N Y Acad Sci 2006;1079:135-137 (Pubitemid 44968713)
    • (2006) Annals of the New York Academy of Sciences , vol.1079 , pp. 135-137
    • Devendra, D.1    Miao, D.2    Nakayama, M.3    Eisenbarth, G.S.4    Liu, E.5
  • 49
    • 84857421659 scopus 로고    scopus 로고
    • Primer immunology and autoimmunity
    • article online, Available from Accessed 20 February 2010
    • Eisenbarth SG, Homann D. Primer immunology and autoimmunity. In Type I Diabetes: Molecular, Cellular and Clinical Immunology [article online], 2009. Available from http://www.uchsc.edu/misc/diabetes/books. html. Accessed 20 February 2010
    • (2009) Type I Diabetes: Molecular, Cellular and Clinical Immunology
    • Eisenbarth, S.G.1    Homann, D.2
  • 59
    • 45249120203 scopus 로고    scopus 로고
    • Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: Variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species
    • DOI 10.1042/BST0360312
    • Rainbow DB, Esposito L, Howlett SK, Hunter KM, Todd JA, Peterson LB, Wicker LS. Commonality in the genetic control of type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species. Biochem Soc Trans 2008;36:312-315 (Pubitemid 351839322)
    • (2008) Biochemical Society Transactions , vol.36 , Issue.3 , pp. 312-315
    • Rainbow, D.B.1    Esposito, L.2    Howlett, S.K.3    Hunter, K.M.4    Todd, J.A.5    Peterson, L.B.6    Wicker, L.S.7
  • 61
    • 0022617990 scopus 로고
    • Type I diabetes mellitus. a chronic autoimmune disease
    • Eisenbarth GS. Type I diabetes mellitus: a chronic autoimmune disease. N Engl J Med 1986;314:1360-1368 (Pubitemid 16122469)
    • (1986) New England Journal of Medicine , vol.314 , Issue.21 , pp. 1360-1368
    • Eisenbarth, G.S.1
  • 62
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • DOI 10.1016/S0140-6736(01)05415-0
    • Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001;358:221-229 (Pubitemid 32718550)
    • (2001) Lancet , vol.358 , Issue.9277 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 64
    • 0029995958 scopus 로고    scopus 로고
    • Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
    • Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase HP, Eisenbarth GS. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 1996;45:926-933
    • (1996) Diabetes , vol.45 , pp. 926-933
    • Verge, C.F.1    Gianani, R.2    Kawasaki, E.3    Yu, L.4    Pietropaolo, M.5    Jackson, R.A.6    Chase, H.P.7    Eisenbarth, G.S.8
  • 65
    • 33845883000 scopus 로고    scopus 로고
    • Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization Program
    • DOI 10.1016/j.clim.2006.09.004, PII S1521661606008758
    • Achenbach P, Schlosser M, Williams AJ, Yu L, Mueller PW, Bingley PJ, Bonifacio E. Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization Program. Clin Immunol 2007;122:85-90 (Pubitemid 46026696)
    • (2007) Clinical Immunology , vol.122 , Issue.1 , pp. 85-90
    • Achenbach, P.1    Schlosser, M.2    Williams, A.J.K.3    Yu, L.4    Mueller, P.W.5    Bingley, P.J.6    Bonifacio, E.7
  • 66
    • 38149011472 scopus 로고    scopus 로고
    • Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT)
    • European Nicotinamide Diabetes Intervention Trial Group.
    • Bingley PJ, Mahon JL, Gale EA, European Nicotinamide Diabetes Intervention Trial Group. Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT). Diabetes Care 2008;31:146-150
    • (2008) Diabetes Care , vol.31 , pp. 146-150
    • Bingley, P.J.1    Mahon, J.L.2    Gale, E.A.3
  • 67
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with type 1 diabetes: The diabetes prevention trial-type 1
    • DOI 10.2337/diacare.28.5.1068
    • Skyler JS, Krischer JP, Wolfsdorf J, Cowie C, Palmer JP, Greenbaum C, Cuthbertson D, Rafkin-Mervis LE, Chase HP, Leschek E. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1. Diabetes Care 2005;28:1068-1076 (Pubitemid 40616615)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1068-1076
    • Skyler, J.S.1
  • 69
    • 33747662305 scopus 로고    scopus 로고
    • Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
    • Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab 2006;91:2843-2850
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2843-2850
    • Perheentupa, J.1
  • 70
    • 2342458361 scopus 로고    scopus 로고
    • Autoimmune polyendocrine syndromes
    • Eisenbarth GS, Gottlieb PA. Autoimmune polyendocrine syndromes. N Engl J Med 2004;350:2068-2079
    • (2004) N Engl J Med , vol.350 , pp. 2068-2079
    • Eisenbarth, G.S.1    Gottlieb, P.A.2
  • 72
    • 33845983223 scopus 로고    scopus 로고
    • Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning
    • DOI 10.1182/blood-2006-05-025072
    • Rao A, Kamani N, Filipovich A, Lee SM, Davies SM, Dalal J, Shenoy S. Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning. Blood 2007;109:383-385 (Pubitemid 46053081)
    • (2007) Blood , vol.109 , Issue.1 , pp. 383-385
    • Rao, A.1    Kamani, N.2    Filipovich, A.3    Lee, S.M.4    Davies, S.M.5    Dalal, J.6    Shenoy, S.7
  • 75
    • 34548285420 scopus 로고    scopus 로고
    • Modulation of Aire regulates the expression of tissue-restricted antigens
    • DOI 10.1016/j.molimm.2007.05.014, PII S0161589007002192
    • Kont V, Laan M, Kisand K, Merits A, Scott HS, Peterson P. Modulation of Aire regulates the expression of tissue-restricted antigens. Molecular Immunology 2008;45:25-33 (Pubitemid 47331653)
    • (2008) Molecular Immunology , vol.45 , Issue.1 , pp. 25-33
    • Kont, V.1    Laan, M.2    Kisand, K.3    Merits, A.4    Scott, H.S.5    Peterson, P.6
  • 79
    • 0016062612 scopus 로고
    • Addison's disease - Clinical studies: A report of 108 cases
    • Nerup J. Addison's disease - clinical studies: a report of 108 cases. Acta Endocrinol 1974;76:127-141
    • (1974) Acta Endocrinol , vol.76 , pp. 127-141
    • Nerup, J.1
  • 80
    • 3543015625 scopus 로고    scopus 로고
    • Autoimmune polyglandular syndrome type 2: The tip of an iceberg?
    • Betterle C, Lazzarotto F, Presotto F. Autoimmune polyglandular syndrome type 2: the tip of an iceberg? Clin Exp Immunol 2004;137:225-233
    • (2004) Clin Exp Immunol , vol.137 , pp. 225-233
    • Betterle, C.1    Lazzarotto, F.2    Presotto, F.3
  • 83
    • 33646052603 scopus 로고    scopus 로고
    • Clinical review: Type 1 diabetes-associated autoimmunity: Natural history, genetic associations, and screening
    • Barker JM. Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening. J Clin Endocrinol Metab 2006;91:1210-1217
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1210-1217
    • Barker, J.M.1
  • 84
    • 33646052603 scopus 로고    scopus 로고
    • Clinical review: Type 1 diabetes-associated autoimmunity: Natural history, genetic associations and screening
    • Barker JM. Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations and screening. J Clin Endocrinol Metab 2006;91:1210-1217
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1210-1217
    • Barker, J.M.1
  • 87
    • 14244260204 scopus 로고    scopus 로고
    • Expression of beta-cell autoimmunity does not differ between potential dizygotic twins and siblings of patients with type 1 diabetes
    • DPT-1 Study Group
    • Redondo MJ, Fain PR, Krischer JP, Yu L, Cuthbertson D, Winter WE, Eisenbarth GS, DPT-1 Study Group. Expression of beta-cell autoimmunity does not differ between potential dizygotic twins and siblings of patients with type 1 diabetes. J Autoimmun 2004;23:275-279
    • (2004) J Autoimmun , vol.23 , pp. 275-279
    • Redondo, M.J.1    Fain, P.R.2    Krischer, J.P.3    Yu, L.4    Cuthbertson, D.5    Winter, W.E.6    Eisenbarth, G.S.7
  • 88
    • 4043091960 scopus 로고    scopus 로고
    • Diabetes Autoimmunity Study in the Young. Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    • Barker JM, Barriga KJ, Yu L, Miao D, Erlich HA, Norris JM, Eisenbarth GS, Rewers M, Diabetes Autoimmunity Study in the Young. Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab 2004;89:3896-3902
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3896-3902
    • Barker, J.M.1    Barriga, K.J.2    Yu, L.3    Miao, D.4    Erlich, H.A.5    Norris, J.M.6    Eisenbarth, G.S.7    Rewers, M.8
  • 96
    • 58549090910 scopus 로고    scopus 로고
    • Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A
    • Howson JM, Walker NM, Clayton D, Todd JA. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab 2009; 11(Suppl. 1):31-45
    • (2009) Diabetes Obes Metab , vol.11 , Issue.SUPPL. 1 , pp. 31-45
    • Howson, J.M.1    Walker, N.M.2    Clayton, D.3    Todd, J.A.4
  • 97
    • 67649979852 scopus 로고    scopus 로고
    • Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes
    • Type 1 Diabetes Genetics Consortium.
    • Baschal EE, Aly TA, Jasinski JM, Steck AK, Noble JA, Erlich HA, Eisenbarth GS, Type 1 Diabetes Genetics Consortium. Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes. Clin Immunol 2009;132:203-214
    • (2009) Clin Immunol , vol.132 , pp. 203-214
    • Baschal, E.E.1    Aly, T.A.2    Jasinski, J.M.3    Steck, A.K.4    Noble, J.A.5    Erlich, H.A.6    Eisenbarth, G.S.7
  • 98
    • 0021151532 scopus 로고
    • Extended major histocompatibility complex haplotypes in type I diabetes mellitus
    • Raum D, Awdeh Z, Yunis EJ, Alper CA, Gabbay KH. Extended major histocompatibility complex haplotypes in type I diabetes mellitus. J Clin Invest 1984;74:449-454 (Pubitemid 14053992)
    • (1984) Journal of Clinical Investigation , vol.74 , Issue.2 , pp. 449-454
    • Raum, D.1    Awdeh, Z.2    Yunis, E.3
  • 104
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • DOI 10.1038/ng0397-293
    • Pugliese A, Zeller M, Fernandez A Jr, Zalcberg LJ, Bartlett RJ, Ricordi C, Pietropaolo M, Eisenbarth GS, Bennett ST, Patel DD. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 1997;15:293-297 (Pubitemid 27098726)
    • (1997) Nature Genetics , vol.15 , Issue.3 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez Jr., A.3    Zalcberg, L.J.4    Bartlett, R.J.5    Ricordi, C.6    Pietropaolo, M.7    Eisenbarth, G.S.8    Bennett, S.T.9    Patel, D.D.10
  • 110
    • 33845931200 scopus 로고    scopus 로고
    • Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects [1]
    • DOI 10.1007/s00125-006-0506-y
    • Field SF, Howson JM, Smyth DJ, Walker NM, Dunger DB, Todd JA. Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects. Diabetologia 2007;50:212-213 (Pubitemid 46035870)
    • (2007) Diabetologia , vol.50 , Issue.1 , pp. 212-213
    • Field, S.F.1    Howson, J.M.M.2    Smyth, D.J.3    Walker, N.M.4    Dunger, D.B.5    Todd, J.A.6
  • 111
    • 59749087957 scopus 로고    scopus 로고
    • Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes
    • Yu J, Steck AK, Babu S, Yu L, Miao D, McFann K, Hutton J, Eisenbarth GS, Klingensmith G. Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes. J Clin Endocrinol Metab 2009;94:504-510
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 504-510
    • Yu, J.1    Steck, A.K.2    Babu, S.3    Yu, L.4    Miao, D.5    McFann, K.6    Hutton, J.7    Eisenbarth, G.S.8    Klingensmith, G.9
  • 113
    • 48449092954 scopus 로고    scopus 로고
    • Genetic similarities between latent autoimmune diabetes and type 1 and type 2 diabetes
    • Steck AK, Eisenbarth GS. Genetic similarities between latent autoimmune diabetes and type 1 and type 2 diabetes. Diabetes 2008;57:1160-1162
    • (2008) Diabetes , vol.57 , pp. 1160-1162
    • Steck, A.K.1    Eisenbarth, G.S.2
  • 116
  • 119
    • 67049159857 scopus 로고    scopus 로고
    • Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study
    • EURODIAB Study Group.
    • Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G, EURODIAB Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009;373:2027-2033
    • (2009) Lancet , vol.373 , pp. 2027-2033
    • Patterson, C.C.1    Dahlquist, G.G.2    Gyürüs, E.3    Green, A.4    Soltész, G.5
  • 120
    • 43849096855 scopus 로고    scopus 로고
    • Time trends in the incidence of type 1 diabetes in Finnish children: A cohort study
    • DOI 10.1016/S0140-6736(08)60765-5, PII S0140673608607655
    • Harjutsalo V, Sjöberg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 2008;371:1777-1782 (Pubitemid 351697953)
    • (2008) The Lancet , vol.371 , Issue.9626 , pp. 1777-1782
    • Harjutsalo, V.1    Sjoberg, L.2    Tuomilehto, J.3
  • 122
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002;347:911-920
    • (2002) N Engl J Med , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 123
    • 0035988197 scopus 로고    scopus 로고
    • A missing link in the hygiene hypothesis?
    • Gale EA. A missing link in the hygiene hypothesis? Diabetologia 2002;45: 588-594
    • (2002) Diabetologia , vol.45 , pp. 588-594
    • Gale, E.A.1
  • 125
    • 34447120854 scopus 로고    scopus 로고
    • To boldly go - Or to go too boldly? The accelerator hypothesis revisited
    • Gale EA. To boldly go - or to go too boldly? The accelerator hypothesis revisited. Diabetologia 2007;50:1571-1575
    • (2007) Diabetologia , vol.50 , pp. 1571-1575
    • Gale, E.A.1
  • 128
    • 11144298970 scopus 로고    scopus 로고
    • Insulin resistance is a risk factor for progression to Type 1 diabetes
    • DOI 10.1007/s00125-004-1507-3
    • Fourlanos S, Narendran P, Byrnes GB, Colman PG, Harrison LC. Insulin resistance is a risk factor for progression to type 1 diabetes. Diabetologia 2004;47:1661-1667 (Pubitemid 40022398)
    • (2004) Diabetologia , vol.47 , Issue.10 , pp. 1661-1667
    • Fourlanos, S.1    Narendran, P.2    Byrnes, G.B.3    Colman, P.G.4    Harrison, L.C.5
  • 130
    • 37449007676 scopus 로고    scopus 로고
    • High incidence of type 1 diabetes mellitus during or shortly after treatment with pegylated interferon alpha for chronic hepatitis C virus infection
    • Schreuder TC, Gelderblom HC, Weegink CJ, Hamann D, Reesink HW, Devries JH, Hoekstra JB, Jansen PL: High incidence of type 1 diabetes mellitus during or shortly after treatment with pegylated interferon alpha for chronic hepatitis C virus infection. Liver Int 2008;28:39-46
    • (2008) Liver Int , vol.28 , pp. 39-46
    • Schreuder, T.C.1    Gelderblom, H.C.2    Weegink, C.J.3    Hamann, D.4    Reesink, H.W.5    Devries, J.H.6    Hoekstra, J.B.7    Jansen, P.L.8
  • 133
    • 0033959371 scopus 로고    scopus 로고
    • Worldwide differences in the incidence of insulin autoimmune syndrome (Hirata disease) with respect to the evolution of HLA-DR4 alleles
    • DOI 10.1016/S0198-8859(99)00144-5, PII S0198885999001445
    • Uchigata Y, Hirata Y, Omori Y, Iwamoto Y, Tokunaga K. Worldwide differences in the incidence of insulin autoimmune syndrome (Hirata disease) with respect to the evolution of HLA-DR4 alleles. Hum Immunol 2000;61:154-157 (Pubitemid 30075237)
    • (2000) Human Immunology , vol.61 , Issue.2 , pp. 154-157
    • Uchigata, Y.1    Hirata, Y.2    Omori, Y.3    Iwamoto, Y.4    Tokunaga, K.5
  • 134
    • 0026498340 scopus 로고
    • Frequent induction of insulin autoantibodies by D-penicillamine in patients with rheumatoid arthritis
    • Vardi P, Brik R, Barzilai D, Lorber M, Scharf Y. Frequent induction of insulin autoantibodies by D-penicillamine in patients with rheumatoid arthritis. J Rheumatol 1992;19:1527-1530
    • (1992) J Rheumatol , vol.19 , pp. 1527-1530
    • Vardi, P.1    Brik, R.2    Barzilai, D.3    Lorber, M.4    Scharf, Y.5
  • 135
    • 33846049960 scopus 로고    scopus 로고
    • Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome
    • DOI 10.1016/j.diabres.2006.07.005, PII S0168822706003032
    • Furukawa N, Miyamura N, Nishida K, Motoshima H, Taketa K, Araki E. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-367 (Pubitemid 46074207)
    • (2007) Diabetes Research and Clinical Practice , vol.75 , Issue.3 , pp. 366-367
    • Furukawa, N.1    Miyamura, N.2    Nishida, K.3    Motoshima, H.4    Taketa, K.5    Araki, E.6
  • 140
    • 0642307067 scopus 로고    scopus 로고
    • Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: A large, population-based, case-control study
    • Stene LC, Joner G, Norwegian Childhood Diabetes Study Group. Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. Am J Clin Nutr 2003;78:1128-1134 (Pubitemid 39663453)
    • (2003) American Journal of Clinical Nutrition , vol.78 , Issue.6 , pp. 1128-1134
    • Stene, L.C.1    Joner, G.2
  • 142
    • 40749100302 scopus 로고    scopus 로고
    • Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics
    • Wang X, Jia S, Geoffrey R, Alemzadeh R, Ghosh S, Hessner MJ. Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics. J Immunol 2008;180:1929-1937
    • (2008) J Immunol , vol.180 , pp. 1929-1937
    • Wang, X.1    Jia, S.2    Geoffrey, R.3    Alemzadeh, R.4    Ghosh, S.5    Hessner, M.J.6
  • 147
    • 33846190681 scopus 로고    scopus 로고
    • TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat
    • Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA. TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J Immunol 2007;178:693-701 (Pubitemid 46095141)
    • (2007) Journal of Immunology , vol.178 , Issue.2 , pp. 693-701
    • Zipris, D.1    Lien, E.2    Nair, A.3    Xie, J.X.4    Greiner, D.L.5    Mordes, J.P.6    Rossini, A.A.7
  • 149
    • 0016261369 scopus 로고
    • Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
    • Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974;2:1279-1283
    • (1974) Lancet , vol.2 , pp. 1279-1283
    • Bottazzo, G.F.1    Florin-Christensen, A.2    Doniach, D.3
  • 154
    • 4344690190 scopus 로고    scopus 로고
    • Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
    • DOI 10.1172/JCI200421307
    • Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E. Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 2004;114: 589-597 (Pubitemid 39572109)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.4 , pp. 589-597
    • Achenbach, P.1    Koczwara, K.2    Knopff, A.3    Naserke, H.4    Ziegler, A.-G.5    Bonifacio, E.6
  • 157
    • 41149084500 scopus 로고    scopus 로고
    • Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes
    • DOI 10.1038/ncpendmet0778, PII NCPENDMET0778
    • Murphy R, Ellard S, Hattersley AT. Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. Nat Clin Pract Endocrinol Metab 2008;4:200-213 (Pubitemid 351430925)
    • (2008) Nature Clinical Practice Endocrinology and Metabolism , vol.4 , Issue.4 , pp. 200-213
    • Murphy, R.1    Ellard, S.2    Hattersley, A.T.3
  • 161
    • 35248878595 scopus 로고    scopus 로고
    • Accepting clocks that tell time poorly: Fluid-phase versus standard ELISA autoantibody assays
    • DOI 10.1016/j.clim.2007.08.005, PII S1521661607013216
    • Liu E, Eisenbarth GS. Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays. Clin Immunol 2007;125:120-126 (Pubitemid 47562903)
    • (2007) Clinical Immunology , vol.125 , Issue.2 , pp. 120-126
    • Liu, E.1    Eisenbarth, G.S.2
  • 163
    • 0037408360 scopus 로고    scopus 로고
    • Diabetes antibody standardization program: First assay proficiency evaluation
    • DOI 10.2337/diabetes.52.5.1128
    • Bingley PJ, Bonifacio E, Mueller PW. Diabetes Antibody Standardization Program: first assay proficiency evaluation. Diabetes 2003;52:1128-1136 (Pubitemid 36523346)
    • (2003) Diabetes , vol.52 , Issue.5 , pp. 1128-1136
    • Bingley, P.J.1    Bonifacio, E.2    Mueller, P.W.3
  • 164
    • 33845634821 scopus 로고    scopus 로고
    • Pre-type 1 diabetes dysmetabolism: Maximal sensitivity achieved with both oral and intravenous glucose tolerance testing
    • DPT-1 Study Group.
    • Barker JM, McFann K, Harrison LC, Fourlanos S, Krischer J, Cuthbertson D, Chase HP, Eisenbarth GS, DPT-1 Study Group. Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing. J Pediatr 2007;150:31-36
    • (2007) J Pediatr , vol.150 , pp. 31-36
    • Barker, J.M.1    McFann, K.2    Harrison, L.C.3    Fourlanos, S.4    Krischer, J.5    Cuthbertson, D.6    Chase, H.P.7    Eisenbarth, G.S.8
  • 166
    • 33750140236 scopus 로고    scopus 로고
    • Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    • DOI 10.1111/j.1399-5448.2006.00198.x
    • Stene LC, Barriga K, Hoffman M, Kean J, Klingensmith G, Norris JM, Erlich HA, Eisenbarth GS, Rewers M. Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). Pediatr Diabetes 2006;7:247-253 (Pubitemid 44593924)
    • (2006) Pediatric Diabetes , vol.7 , Issue.5 , pp. 247-253
    • Stene, L.C.1    Barriga, K.2    Hoffman, M.3    Kean, J.4    Klingensmith, G.5    Norris, J.M.6    Erlich, H.A.7    Eisenbarth, G.S.8    Rewers, M.9
  • 167
    • 0025730698 scopus 로고
    • The immunobiology of T cells with invariant gamma delta antigen receptors
    • Allison JP, Havran WL. The immunobiology of T cells with invariant gamma delta antigen receptors. Annu Rev Immunol 1991;9:679-705
    • (1991) Annu Rev Immunol , vol.9 , pp. 679-705
    • Allison, J.P.1    Havran, W.L.2
  • 169
    • 27744603796 scopus 로고    scopus 로고
    • Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: Indirect evidence for islet regeneration?
    • Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC. Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 2005;48:2221-2228
    • (2005) Diabetologia , vol.48 , pp. 2221-2228
    • Meier, J.J.1    Bhushan, A.2    Butler, A.E.3    Rizza, R.A.4    Butler, P.C.5
  • 173
    • 0002679649 scopus 로고
    • Pathology of the pancreas in diabetes mellitus
    • 13th ed. Kahn CR, Weir GC, Eds. Philadelphia, Lea & Febiger
    • Foulis AK, Clark A: Pathology of the pancreas in diabetes mellitus. In Joslin's Diabetes Mellitus. 13th ed. Kahn CR, Weir GC, Eds. Philadelphia, Lea & Febiger, 1994, p. 265-281
    • (1994) Joslin's Diabetes Mellitus , pp. 265-281
    • Foulis, A.K.1    Clark, A.2
  • 175
    • 20044375937 scopus 로고    scopus 로고
    • A single course of anti-CD3 monoclonal antibody hOKT3γ1(ala-ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
    • DOI 10.2337/diabetes.54.6.1763
    • Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA. A single course of anti-CD3 monoclonal antibody hOKT3γ1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 2005;54:1763-1769 (Pubitemid 40770766)
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1763-1769
    • Herold, K.C.1    Gitelman, S.E.2    Masharani, U.3    Hagopian, W.4    Bisikirska, B.5    Donaldson, D.6    Rother, K.7    Diamond, B.8    Harlan, D.M.9    Bluestone, J.A.10
  • 178
    • 33646401140 scopus 로고    scopus 로고
    • Progression to type 1 diabetes in islet T cell antibody-positive relatives in the European Nicotinamide Diabetes Intervention Trial: The role of additional immune, genetic and metabolic markers of risk
    • European Nicotinamide Diabetes Intervention Trial (ENDIT) Group.
    • Bingley PJ, Gale EA, European Nicotinamide Diabetes Intervention Trial (ENDIT) Group. Progression to type 1 diabetes in islet T cell antibody-positive relatives in the European Nicotinamide Diabetes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk. Diabetologia 2006;49:881-890
    • (2006) Diabetologia , vol.49 , pp. 881-890
    • Bingley, P.J.1    Gale, E.A.2
  • 182
    • 59249093047 scopus 로고    scopus 로고
    • Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies
    • El Fassi D, Banga JP, Gilbert JA, Padoa C, Hegedüs L, Nielsen CH. Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies. Clin Immunol 2009;130: 252-258
    • (2009) Clin Immunol , vol.130 , pp. 252-258
    • El Fassi, D.1    Banga, J.P.2    Gilbert, J.A.3    Padoa, C.4    Hegedüs, L.5    Nielsen, C.H.6
  • 183
    • 33947726341 scopus 로고    scopus 로고
    • Moving towards efficient therapies in type 1 diabetes: To combine or not to combine?
    • Bresson D, von Herrath M. Moving towards efficient therapies in type 1 diabetes: to combine or not to combine? Autoimmun Rev 2007;6:315-322
    • (2007) Autoimmun Rev , vol.6 , pp. 315-322
    • Bresson, D.1    Von Herrath, M.2
  • 184
    • 0035113444 scopus 로고    scopus 로고
    • Rapid assays for detection of anti-islet autoantibodies: Implications for organ donor screening
    • DOI 10.1006/jaut.2000.0457
    • Maniatis AK, Yu L, Miao D, Nelson K, Eisenbarth GS. Rapid assays for detection of anti-islet autoantibodies: implications for organ donor screening. J Autoimmun 2001;16:71-76 (Pubitemid 32174176)
    • (2001) Journal of Autoimmunity , vol.16 , Issue.1 , pp. 71-76
    • Maniatis, A.K.1    Yu, L.2    Miao, D.3    Nelson, K.4    Eisenbarth, G.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.