Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 7, 2014, Pages 2656-2661

  Zhang, Li ^a   Crawford, Frances ^b,c,d   Yu, Liping ^a   Michels, Aaron ^a   Nakayama, Maki ^a,d   Davidson, Howard W ^a,d   Kappler, John W ^b,c,d   Eisenbarth, George S ^a,d  

^a UNIVERSITY OF COLORADO DENVER   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c DEPARTMENT OF MEDICINE   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen processing; Immunotherapy

Indexed keywords

AMINO ACID; AUTOANTIBODY; EPITOPE; IMMUNOGLOBULIN G1; INSULIN; INSULIN ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 287; RECOMBINANT PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; IMMUNIZATION; IMMUNOTHERAPY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET CELL; PRIORITY JOURNAL;

ANTIGEN PROCESSING; IMMUNOTHERAPY;

ANIMALS; ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, ION EXCHANGE; DIABETES MELLITUS, TYPE 1; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOTHERAPY; INSULIN; MICE; MICE, INBRED NOD; MULTIPROTEIN COMPLEXES; PEPTIDE FRAGMENTS; STATISTICS, NONPARAMETRIC; SURFACE PLASMON RESONANCE;

EID: 84894354624     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323436111     Document Type: Article

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