Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes

Pediatric Diabetes

Volumn 13, Issue 7, 2012, Pages 564-571

  Redondo, Maria J ^a   Rodriguez, Luisa M ^a   Escalante, Mirna ^a   O'Brian Smith, E ^a   Balasubramanyam, Ashok ^a   Haymond, Morey W ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Beta cell function; BMI; C peptide; Obesity; T1D

Indexed keywords

C PEPTIDE;

AFRICAN AMERICAN; ARTICLE; BODY MASS; BODY WEIGHT; CELL FUNCTION; CHILD; CROSS-SECTIONAL STUDY; DIABETIC KETOACIDOSIS; EUROPEAN AMERICAN; FEMALE; HISPANIC; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; OBESITY; PANCREAS ISLET BETA CELL; PEDIATRICS; PRIORITY JOURNAL; SCHOOL CHILD; UNDERWEIGHT;

AFRICAN AMERICANS; AUTOANTIBODIES; BLOOD GLUCOSE; BODY MASS INDEX; C-PEPTIDE; CHILD; DIABETES MELLITUS, TYPE 1; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HISPANIC AMERICANS; HUMANS; INSULIN-SECRETING CELLS; MALE; OBESITY; OVERWEIGHT; PUBERTY;

EID: 84868197291     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/j.1399-5448.2012.00875.x     Document Type: Article

References (40)

1. Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 2010: 464: 1293-1300.
2. Bonifacio E, Ziegler AG. Advances in the prediction and natural history of type 1 diabetes. Endocrinol Metab Clin North Am 2010: 39: 513-525.
3. Mortensen HB, Swift PG, Holl Rw et al. Hvidoere Study Group on Childhood Diabetes. Multinational study in children and adolescents with newly diagnosed type 1 diabetes: association of age, ketoacidosis, HLA status, and autoantibodies on residual beta-cell function and glycemic control 12months after diagnosis. Pediatr Diabetes 2010: 11: 218-226.
4. Wilking TJ. The accelerator hypothesis: weight gain as the missing link between type 1 and type 2 diabetes. Diabetologia 2001: 44: 914-922.
5. Fourlanos S, Narendran P, Byrnes GB, Colman PG, Harrison LC. Insulin resistance is a risk factor for progression to type 1 diabetes. Diabetologia 2004: 47: 1661-1667.
6. Kordonouri O, Hartmann R. Higher body weight is associated with earlier onset of T1Din children: confirming the "Accelerator Hypothesis". Diabetic Medicine 2005: 22: 1778-1784.
7. Knerr I, Wolf J, Reinehr T et al. DPV Scientific Initiative of Germany and Austria. The 'accelerator hypothesis': relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9, 248 German and Austrian children with T1Dmellitus. Diabetologia 2005: 48: 2501-2504.
8. Evertsen J, Alemzadeh R, Wang X. Increasing incidence of pediatric T1Dmellitus in Southeastern Wisconsin: relationship with body weight at diagnosis. PloS One 2009: 4: 6873.
9. Betts P, Mulligan J, Ward P, Smith B, Wilkin T. Increasing body weight predicts the earlier onset of insulin-dependant diabetes in childhood: testing the 'accelerator hypothesis'. Diabet Med 2005: 22: 144-151.
10. Kibirige M, Metcalf B, Renuka R, Wilkin TJ. Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes. Diabetes Care 2003: 26: 2865-2870.
11. Dabelea D, D'Agostino RB Jr, Mayer-Davis EJ, et al. SEARCH for Diabetes in Youth Study Group. Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes. Diabetes Care 2006: 29: 290-294.
12. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA 2012: 307: 483-490.
13. Libman IM, Pietropaolo M, Arslanian SA, LaPorte RE, Becker DJ. Changing prevalence of overweight children and adolescents at onset of insulin-treated diabetes. Diabetes Care 2003: 26: 2871-2875.
14. Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J. Incidence of childhood T1Dworldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 2000: 23: 1516-1526.
15. Patterson CC, Dahlquist GG, Gyurus E, Green A, Soltesz G. Incidence trends for childhood T1Din Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009: 373: 2027-2033.
16. Weets I, De Leeuw IH, Du Caju MV et al. Belgian Diabetes Registry. The incidence of T1Din the age group 0-39years has not increased in Antwerp (Belgium) between 1989 and 2000: evidence for earlier disease manifestation. Diabetes Care 2002: 25: 840-846.
17. Vehik K, Hamman RF, Lezotte D et al. Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes. Diabetes Care 2008: 31: 1392-1396.
18. Ljungkrantz M, Ludvigsson J, Samuelsson U. Type 1 diabetes: increased height and weight gains in early childhood. Pediatr Diabetes 2008: 9: 50-56.
19. Lamb MM, Yin X, Zerbe GO et al. Height growth velocity, islet autoimmunity and T1Ddevelopment: the Diabetes Autoimmunity Study in the Young. Diabetologia 2009: 52: 2064-2071.
20. Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith GJ, Dabelea D. Childhood growth and age at diagnosis with T1Din Colorado young people. Diabet Med 2009: 26: 961-967.
21. Bingley PJ, Mahon JL, Gale EA, European Nicotinamide Diabetes Intervention Trial Group. Insulin resistance and progression to T1Din the European Nicotinamide Diabetes Intervention Trial (ENDIT). Diabetes Care 2008: 31: 146-150.
22. Greenbaum CJ, Anderson AM, Dolan LM et al. SEARCH Study Group. Preservation of beta-cell function in autoantibody-positive youth with diabetes. Diabetes Care 2009: 32: 1839-1844.
23. Gale EA. To boldly go-or to go too boldly? The accelerator hypothesis revisited. Diabetologia 2007: 50: 1571-1575.
24. Wilkin TJ. Diabetes: 1 and 2, or one and the same? Progress with the accelerator hypothesis. Pediatr Diabetes 2008: 9: 23-32.
25. Fourlanos S, Harrison LC, Colman PG. The accelerator hypothesis and increasing incidence of type 1 diabetes. Curr Opin Endocrinol Diabetes Obes 2008: 15: 321-325.
26. Wilkin TJ. The accelerator hypothesis: a review of the evidence for insulin resistance as the basis for type I as well as type II diabetes. Int J Obes (Lond) 2009: 33: 716-726.
27. Booker C. The accelerator hypothesis: insulin resistance as the central cause of type1 and type 2 diabetes. Int J Obes (London) 2010: 34: 210-211.
28. The DCCT Research Group. Effect of age, duration and treatment of insulin-dependent diabetes mellitus on residual beta-cell function: observations during eligibility testing for the Diabetes Control and Complications Trial (DCCT). J Clin Endocrinol Metab 1987: 65: 30-36.
29. The Diabetes Control and Complications Trial Research Group. Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. Ann Intern Med 1998: 128: 517-523.
30. Ogden CL, Flegal KM. Changes in terminology for childhood overweight and obesity. Natl Health Stat Rep 2010: 25: 1-8.
31. Kleinbaum D, Klein M, eds. Logistic Regression, A Self Learning Text, 2nd edn. Springer-Verlag, 2002. ISBN: 0-387-95397-3.
32. Andersen R, ed. Modern Methods for Robust Regression. Paper Series on Quantitative Applications in the Social Sciences. Thousand Oaks, California: SAGE Publications, Inc., 2008.
33. Barker LE, Kirtland KA, Gregg EW, Geiss LS, Thompson TJ. Geographic distribution of diagnosed diabetes in the U.S. A diabetes belt. Am J Prev Med 2011: 40: 434-439.
34. Palmer JP, Fleming GA, Greenbaum CJ et al. C-peptide is the appropriate outcome measure for T1Dclinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes 2004: 53: 250-264.
35. Bjork E, Kampe O, Karlsson FA et al. Glucose regulation of the autoantigen GAD65 in human pancreatic islets. J Clin Endocrinol Metab 1992: 75: 1574-1576.
36. Dhalquist G. Can we slow the rising incidence of childhood-onset autoimmune diabetes? The overload hypothesis. Diabetologia 2006: 49: 20-24.
37. Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006: 116: 1902-1912.
38. Ziegler AG, Meier-Stiegen F, Winkler C, Bonifacio E, the TEENDIAB Study Group. Prospective evaluation of risk factors for the development of islet autoimmunity and T1Dduring puberty - TEENDIAB: study design. Pediatr Diabetes 2011 doi: 10.1111/j.1399-5448.2011.00763.x.
39. Keenan HA, Sun JK, Levine J et al. Diabetes. Residual insulin production and pancreatic ß-cell turnover after 50years of diabetes: Joslin Medalist Study. Diabetes 2010: 59: 2846-2853.
40. Zeitler P. Approach to the obese adolescent with new-onset diabetes. Clin Endocrinol Metab 2010: 95: 5163-5170.