Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice

Diabetes/Metabolism Research and Reviews

Volumn 27, Issue 8, 2011, Pages 784-789

  Zhang, Li ^a   Stadinski, Brian D ^b   Michels, Aaron ^a   Kappler, John W ^b   Eisenbarth, George S ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Antigen presentation; I A g7; Insulin peptide B:9 23; Prevention; Type 1 diabetes

Indexed keywords

ARGININE; AUTOANTIBODY; GLUTAMIC ACID; INSULIN; INSULIN ANTIBODY; INSULIN PEPTIDE; MUTANT PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; IMMUNIZATION; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TARGETING; T LYMPHOCYTE;

ANIMALS; AUTOANTIGENS; DIABETES MELLITUS, TYPE 1; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DQ ANTIGENS; INSULIN; MICE; MICE, INBRED NOD; PEPTIDE FRAGMENTS;

EID: 80855147966     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1252     Document Type: Article

References (40)

1. Simone E, Daniel D, Schloot N, et al. T cell receptor restriction of diabetogenic autoimmune NOD T cells. Proc Natl Acad Sci U S A 1997; 94: 2518-2521.
2. Abiru N, Maniatis AK, Yu L, et al. Peptide and MHC specific breaking of humoral tolerance to native insulin with the B:9-23 peptide in diabetes prone and normal mice. Diabetes 2001; 50: 1274-1281.
3. Lieberman SM, DiLorenzo TP. A comprehensive guide to antibody and T-cell responses in type 1 diabetes. Tissue Antigens 2003; 62: 359-377.
4. Michels AW, Nakayama M. The anti-insulin trimolecular complex in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes 2010; 17(4): 329-334.
5. Stadinski B, Kappler J, Eisenbarth GS. Molecular targeting of islet autoantigens. Immunity 2010; 32: 446-456.
6. Yi W, Seth NP, Martillotti T, Wucherpfennig KW, Sant'Angelo DB, Denzin LK. Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest 2010; 120: 1324-1336.
7. Erlich H, Valdes AM, Noble J, et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008; 57: 1084-1092.
8. Aly T, Ide A, Humphrey K, et al. Genetic prediction of autoimmunity: Initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetes. J Autoimmun 2005; 25: 40-45.
9. Wicker LS, Clark J, Fraser HI, et al. Type 1 diabetes genes and pathways shared by humans and NOD mice. J Autoimmun 2005; 25:(Suppl): 29-33.
10. Dardenne M, Lepault F, Bendelac A, Bach JF. Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning. Eur J Immunol 1989; 19: 889-895.
11. Muir A, Peck A, Clare-Salzler M, et al. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription. J Clin Invest 1995; 95: 628-634.
12. Coon B, An LL, Whitton JL, von Herrath MG. DNA immunization to prevent autoimmune diabetes. J Clin Invest 1999; 104: 189-194.
13. Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H. Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med 2003; 197: 1635-1644.
14. Thebault-Baumont K, Dubois-LaForgue D, Krief P, et al. Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice. J Clin Invest 2003; 111: 851-857.
15. Moriyama H, Abiru N, Paronen J, et al. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc Natl Acad Sci U S A 2003; 100: 10376-10381.
16. Martin-Pagola A, Pileggi A, Zahr E, et al. Insulin2 gene (Ins2) transcription by NOD bone marrow-derived cells does not influence autoimmune diabetes development in NOD-Ins2 knockout mice. Scand J Immunol 2009; 70: 439-446.
17. Daniel D, Gill RG, Schloot N, Wegmann D. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol 1995; 25: 1056-1062.
18. Wegmann DR, Norbury-Glaser M, Daniel D. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur J Immunol 1994; 24: 1853-1857.
19. Kobayashi M, Jasinski J, Liu E, et al. Conserved T cell receptor alpha-chain induces insulin autoantibodies. Proc Natl Acad Sci U S A 2008; 105: 10090-10094.
20. Nakayama M, Abiru N, Moriyama H, et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005; 435: 220-223.
21. Jasinski JM, Yu L, Nakayama M, et al. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes. 2006; 55: 1978-1984.
22. Fukushima K, Abiru N, Nagayama Y, et al. Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4 + Foxp3+ regulatory T cells in the islets in non-obese diabetic mice. Biochem Biophys Res Commun 2008; 367: 719-724.
23. Suri A, Unanue ER. The murine diabetogenic class II histocompatibility molecule I-A(g7): structural and functional properties and specificity of peptide selection. Adv Immunol 2005; 88: 235-265.
24. g7 β chain in peptide binding and antigen recognition by T cells. Int Immunol 1998; 9: 1523-1526.
25. Levisetti MG, Suri A, Petzold SJ, Unanue ER. The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form. J Immunol 2007; 178: 6051-6057.
26. Stadinski BD, Zhang L, Crawford F, Marrack P, Eisenbarth GS, Kappler JW. Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci U S A 2010; 107: 10978-10983.
27. Crawford F, Jordan KR, Stadinski B, et al. Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands. Immunol Rev 2006; 210: 156-170.
28. Wang Y, Rubtsov A, Heiser R, et al. Using a baculovirus display library to identify MHC class I mimotopes. Proc Natl Acad Sci U S A 2005; 102: 2476-2481.
29. Zhang L, Jasinski JM, Kobayashi M, et al. Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4 × 04 anti-insulin B:9-23 alpha chains. J Autoimmun 2009; 33(1): 42-49.
30. Karttunen J, Shastri N. Measurement of ligand-induced activation in single viable T cells using the lacZ reporter gene. Proc Natl Acad Sci U S A 1991; 88: 3972-3976.
31. Babaya N, Liu E, Miao D, Li M, Yu L, Eisenbarth GS. Murine high specificity/sensitivity competitive europium insulin autoantibody assay. Diabetes Technol Ther 2009; 11: 227-233.
32. Stadinski BD, Delong T, Reisdorph N, et al. Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol 2010; 11: 225-231.
33. Todd JA, Bell JI, McDevitt HO. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 1987; 329: 599-604.
34. Todd JA, Bell JI, McDevitt HO. A molecular basis for genetic susceptibility to insulin dependent diabetes mellitus. TIG 1988; 4: 129-134.
35. Latek RR, Suri A, Petzold SJ, et al. Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice. Immunity 2000; 12: 699-710.
36. Corper AL, Stratmann T, Apostolopoulos V, et al. A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes. Science 2000; 288: 505-511.
37. Higashide T, Kawamura T, Nagata M, et al. T cell epitope mapping study with insulin overlapping peptides using ELISPOT assay in Japanese children and adolescents with type 1 diabetes. Pediatr Res 2006; 59: 445-450.
38. Alleva DG, Crowe PD, Jin L, et al. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J Clin Invest 2001; 107: 173-180.
39. Hassainya Y, Garcia-Pons F, Kratzer R, et al. Identification of naturally processed HLA-A2-restricted proinsulin epitopes by reverse immunology. Diabetes 2005; 54: 2053-2059.
40. Zhang L, Nakayama M, Eisenbarth GS. Insulin as an autoantigen in NOD/human diabetes. Curr Opin Immunol 2008; 20(1): 111-118.