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Volumn 17, Issue 4, 2010, Pages 329-334

The anti-insulin trimolecular complex in type 1 diabetes

Author keywords

autoimmunity; diabetes; human leukocyte antigen; insulin; T cell receptor

Indexed keywords

AUTOANTIGEN; INSULIN ANTIBODY; T LYMPHOCYTE RECEPTOR; AUTOANTIBODY; INSULIN; LYMPHOCYTE ANTIGEN RECEPTOR; MACROMOLECULE;

EID: 77955773620     PISSN: 1752296X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MED.0b013e32833aba41     Document Type: Review
Times cited : (19)

References (63)
  • 1
    • 43849096855 scopus 로고    scopus 로고
    • Time trends in the incidence of type 1 diabetes in Finnish children: A cohort study
    • Harjutsalo V, Sjoberg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 2008; 371:1777-1782.
    • (2008) Lancet , vol.371 , pp. 1777-1782
    • Harjutsalo, V.1    Sjoberg, L.2    Tuomilehto, J.3
  • 2
    • 0033912572 scopus 로고    scopus 로고
    • Application and interpretation of transmission/disequilibrium tests: Transmission of HLA-DQ haplotypes to unaffected siblings in 526 families with type 1 diabetes
    • Lie BA, Ronningen KS, Akselsen HE, et al. Application and interpretation of transmission/disequilibrium tests: transmission of HLA-DQ haplotypes to unaffected siblings in 526 families with type 1 diabetes. Am J Hum Genet 2000; 66:740-743.
    • (2000) Am J Hum Genet , vol.66 , pp. 740-743
    • Lie, B.A.1    Ronningen, K.S.2    Akselsen, H.E.3
  • 3
    • 0035380479 scopus 로고    scopus 로고
    • Structure of a human insulin peptide/ HLA-DQ8 complex and susceptibility to type 1 diabetes
    • Lee KH, Wucherpfennig KW, Wiley DC. Structure of a human insulin peptide/ HLA-DQ8 complex and susceptibility to type 1 diabetes. Nature Immunol 2001; 2:501-507.
    • (2001) Nature Immunol , vol.2 , pp. 501-507
    • Lee, K.H.1    Wucherpfennig, K.W.2    Wiley, D.C.3
  • 4
    • 0034697101 scopus 로고    scopus 로고
    • A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes
    • Corper AL, Stratmann T, Apostolopoulos V, et al. A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes. Science 2000; 288:505-511.
    • (2000) Science , vol.288 , pp. 505-511
    • Corper, A.L.1    Stratmann, T.2    Apostolopoulos, V.3
  • 5
    • 0036467345 scopus 로고    scopus 로고
    • In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket
    • Suri A, Vidavsky I, van der DK, et al. In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket. J Immunol 2002; 168:1235-1243.
    • (2002) J Immunol , vol.168 , pp. 1235-1243
    • Suri, A.1    Vidavsky Van Der, I.D.K.2
  • 6
    • 23644433712 scopus 로고    scopus 로고
    • Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity
    • Suri A, Walters JJ, Gross ML, Unanue ER. Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity. J Clin Invest 2005; 115:2268-2276.
    • (2005) J Clin Invest , Issue.115 , pp. 2268-2276
    • Suri, A.1    Walters, J.J.2    Gross, M.L.3    Unanue, E.R.4
  • 7
    • 44849130871 scopus 로고    scopus 로고
    • First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules
    • Suri A, Walters JJ, Rohrs HW, et al. First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules. J Immunol 2008; 180:3849-3856.
    • (2008) J Immunol , vol.180 , pp. 3849-3856
    • Suri, A.1    Walters, J.J.2    Rohrs, H.W.3
  • 8
    • 42449144715 scopus 로고    scopus 로고
    • HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: Analysis of the type 1 diabetes genetics consortium families
    • Erlich H, Valdes AM, Noble J, et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008; 57:1084-1092.
    • (2008) Diabetes , vol.57 , pp. 1084-1092
    • Erlich, H.1    Valdes, A.M.2    Noble, J.3
  • 9
    • 0033005328 scopus 로고    scopus 로고
    • Impaired binding of a DQ2 and DQ8- binding HSV VP16 peptide to a DQA1-0501/DQB1-0302 trans class II heterodimer
    • Reichstetter S, Kwok WW, Nepom GT. Impaired binding of a DQ2 and DQ8- binding HSV VP16 peptide to a DQA1-0501/DQB1-0302 trans class II heterodimer. Tissue Antigens 1999; 53:101-105.
    • (1999) Tissue Antigens , vol.53 , pp. 101-105
    • Reichstetter, S.1    Kwok, W.W.2    Nepom, G.T.3
  • 10
    • 33746694192 scopus 로고    scopus 로고
    • HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease
    • Tollefsen S, Arentz-Hansen H, Fleckenstein B, et al. HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. J Clin Invest 2006; 116:2226-2236.
    • (2006) J Clin Invest , vol.116 , pp. 2226-2236
    • Tollefsen, S.1    Arentz-Hansen, H.2    Fleckenstein, B.3
  • 11
    • 33748305619 scopus 로고    scopus 로고
    • Combination of HLA-A24, -DQA1-03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: Longitudinal study of residual beta-cell function
    • Nakanishi K, Inoko H. Combination of HLA-A24, -DQA1-03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell function. Diabetes 2006; 55:1862-1868.
    • (2006) Diabetes , vol.55 , pp. 1862-1868
    • Nakanishi, K.1    Inoko, H.2
  • 12
    • 36849012027 scopus 로고    scopus 로고
    • Localization of type 1 diabetes susceptibility to the MHC class i genes HLA-B and HLA-A
    • Nejentsev S, Howson JM, Walker NM, et al. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007; 450:887-892.
    • (2007) Nature , vol.450 , pp. 887-892
    • Nejentsev, S.1    Howson, J.M.2    Walker, N.M.3
  • 13
    • 40949086474 scopus 로고    scopus 로고
    • Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex
    • Aly TA, Baschal EE, Jahromi MM, et al. Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex. Diabetes 2008; 57:770-776.
    • (2008) Diabetes , vol.57 , pp. 770-776
    • Aly, T.A.1    Baschal, E.E.2    Jahromi, M.M.3
  • 14
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    • Todd JA, Walker NM, Cooper JD, et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007; 39:857-864.
    • (2007) Nat Genet , vol.39 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3
  • 15
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type i diabetes
    • Pugliese A, Zeller M, Fernandez A, et al. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type I diabetes. Nat Genet 1997; 15:293-297.
    • (1997) Nat Genet , vol.15 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez, A.3
  • 16
    • 0036315824 scopus 로고    scopus 로고
    • Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: The mechanism by which the IDDM2 locus may predispose to diabetes
    • Chentoufi AA, Polychronakos C. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 2002; 51:1383-1390.
    • (2002) Diabetes , vol.51 , pp. 1383-1390
    • Chentoufi, A.A.1    Polychronakos, C.2
  • 17
    • 0021019885 scopus 로고
    • Insulin antibodies in insulindependent diabetics before insulin treatment
    • Palmer JP, Asplin CM, Clemons P, et al. Insulin antibodies in insulindependent diabetics before insulin treatment. Science 1983; 222:1337-1339.
    • (1983) Science , vol.222 , pp. 1337-1339
    • Palmer, J.P.1    Asplin, C.M.2    Clemons, P.3
  • 18
    • 4344690190 scopus 로고    scopus 로고
    • Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
    • Achenbach P, Koczwara K, Knopff A, et al. Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 2004; 114:589-597.
    • (2004) J Clin Invest , vol.114 , pp. 589-597
    • Achenbach, P.1    Koczwara, K.2    Knopff, A.3
  • 19
    • 0035142467 scopus 로고    scopus 로고
    • A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin
    • Alleva DG, Crowe PD, Jin L, et al. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J Clin Invest 2001; 107:173-180.
    • (2001) J Clin Invest , vol.107 , pp. 173-180
    • Alleva, D.G.1    Crowe, P.D.2    Jin, L.3
  • 20
    • 18744385526 scopus 로고    scopus 로고
    • Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
    • Kent SC, Chen Y, Bregoli L, et al. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005; 435:224-228.
    • (2005) Nature , vol.435 , pp. 224-228
    • Kent, S.C.1    Chen, Y.2    Bregoli, L.3
  • 21
    • 27744524215 scopus 로고    scopus 로고
    • The insulin A-chain epitope recognized by human T cells is posttranslationally modified
    • Mannering SI, Harrison LC, Williamson NA, et al. The insulin A-chain epitope recognized by human T cells is posttranslationally modified. J Exp Med 2005; 202:1191-1197.
    • (2005) J Exp Med , vol.202 , pp. 1191-1197
    • Mannering, S.I.1    Harrison, L.C.2    Williamson, N.A.3
  • 22
    • 64649084572 scopus 로고    scopus 로고
    • The A-chain of insulin is a hotspot for CD4 T cell epitopes in human type 1 diabetes
    • Mannering SI, Pang SH, Williamson NA, et al. The A-chain of insulin is a hotspot for CD4 T cell epitopes in human type 1 diabetes. Clin Exp Immunol 2009; 156:226-231.
    • (2009) Clin Exp Immunol , vol.156 , pp. 226-231
    • Mannering, S.I.1    Pang, S.H.2    Williamson, N.A.3
  • 23
    • 29444433680 scopus 로고    scopus 로고
    • Autoreactive CD8 T cells associated with {beta} cell destruction in type 1 diabetes
    • Pinkse GG, Tysma OH, Bergen CA, et al. Autoreactive CD8 T cells associated with {beta} cell destruction in type 1 diabetes. Proc Natl Acad Sci U S A 2005; 102:18425-18430.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18425-18430
    • Pinkse, G.G.1    Tysma, O.H.2    Bergen, C.A.3
  • 24
    • 21344433224 scopus 로고    scopus 로고
    • Identification of naturally processed HLA-A2 - Restricted proinsulin epitopes by reverse immunology
    • Hassainya Y, Garcia-Pons F, Kratzer R, et al. Identification of naturally processed HLA-A2 - Restricted proinsulin epitopes by reverse immunology. Diabetes 2005; 54:2053-2059.
    • (2005) Diabetes , vol.54 , pp. 2053-2059
    • Hassainya, Y.1    Garcia-Pons, F.2    Kratzer, R.3
  • 25
    • 23044455740 scopus 로고    scopus 로고
    • Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients
    • Toma A, Haddouk S, Briand JP, et al. Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. Proc Natl Acad Sci U S A 2005; 102:10581-10586.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10581-10586
    • Toma, A.1    Haddouk, S.2    Briand, J.P.3
  • 26
    • 55849116389 scopus 로고    scopus 로고
    • CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
    • Skowera A, Ellis RJ, Varela-Calvino R, et al. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest 2008; 118:3390-3402.
    • (2008) J Clin Invest , vol.118 , pp. 3390-3402
    • Skowera, A.1    Ellis, R.J.2    Varela-Calvino, R.3
  • 27
    • 76249103112 scopus 로고    scopus 로고
    • Ins2 deficiency augments spontaneous HLAA-0201-restricted T cell responses to insulin
    • Jarchum I, DiLorenzo TP. Ins2 deficiency augments spontaneous HLAA-0201-restricted T cell responses to insulin. J Immunol 2010; 184:658-665.
    • (2010) J Immunol , vol.184 , pp. 658-665
    • Jarchum, I.1    Dilorenzo, T.P.2
  • 28
    • 0028145676 scopus 로고
    • Insulin-specific T cells are a predominant component of islet infiltrates in prediabetic NOD mice
    • Wegmann DR, Norbury-Glaser M, Daniel D. Insulin-specific T cells are a predominant component of islet infiltrates in prediabetic NOD mice. Eur J Immunol 1994; 24:1853-1857.
    • (1994) Eur J Immunol , vol.24 , pp. 1853-1857
    • Wegmann, D.R.1    Norbury-Glaser, M.2    Daniel, D.3
  • 29
    • 0036721796 scopus 로고    scopus 로고
    • T cell response to preproinsulin i and II in the nonobese diabetic mouse
    • Halbout P, Briand JP, Becourt C, et al. T cell response to preproinsulin I and II in the nonobese diabetic mouse. J Immunol 2002; 169:2436-2443.
    • (2002) J Immunol , vol.169 , pp. 2436-2443
    • Halbout, P.1    Briand, J.P.2    Becourt, C.3
  • 30
    • 34248233148 scopus 로고    scopus 로고
    • The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form
    • Levisetti MG, Suri A, Petzold SJ, Unanue ER. The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form. J Immunol 2007; 178:6051-6057.
    • (2007) J Immunol , vol.178 , pp. 6051-6057
    • Levisetti, M.G.1    Suri, A.2    Petzold, S.J.3    Unanue, E.R.4
  • 31
    • 0028914351 scopus 로고
    • Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice
    • Daniel D, Gill RG, Schloot N, Wegmann D. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol 1995; 25:1056-1062.
    • (1995) Eur J Immunol , vol.25 , pp. 1056-1062
    • Daniel, D.1    Gill, R.G.2    Schloot, N.3    Wegmann, D.4
  • 32
    • 33747067459 scopus 로고    scopus 로고
    • Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout
    • Jasinski JM, Yu L, Nakayama M, et al. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes 2006; 55:1978-1984.
    • (2006) Diabetes , vol.55 , pp. 1978-1984
    • Jasinski, J.M.1    Yu, L.2    Nakayama, M.3
  • 33
    • 77949872804 scopus 로고    scopus 로고
    • Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes
    • Mohan JF, Levisetti MG, Calderon B, et al. Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes. Nat Immunol 2010; 11:350-354.
    • (2010) Nat Immunol , vol.11 , pp. 350-354
    • Mohan, J.F.1    Levisetti, M.G.2    Calderon, B.3
  • 34
    • 0030069688 scopus 로고    scopus 로고
    • Protection of Nonobese Diabetic Mice from Diabetes by Intranasal or Subcutaneous Administration of Insulin Peptide B-(9-23)
    • Daniel D, Wegmann DR. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci USA 1996; 93:956-960.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 956-960
    • Daniel, D.1    Wegmann, D.R.2
  • 35
    • 0036300542 scopus 로고    scopus 로고
    • Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide
    • Alleva DG, Gaur A, Jin L, et al. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes 2002; 51:2126-2134.
    • (2002) Diabetes , Issue.51 , pp. 2126-2134
    • Alleva, D.G.1    Gaur, A.2    Jin, L.3
  • 36
    • 34848817986 scopus 로고    scopus 로고
    • Altered B: 9 23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes
    • Kobayashi M, Abiru N, Arakawa T, et al. Altered B:9 23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes. J Immunol 2007; 179:2082-2088.
    • (2007) J Immunol , Issue.179 , pp. 2082-2088
    • Kobayashi, M.1    Abiru, N.2    Arakawa, T.3
  • 37
    • 0031025574 scopus 로고    scopus 로고
    • Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice
    • French MB, Allison J, Cram DS, et al. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 1996; 46:34-39.
    • (1996) Diabetes , vol.46 , pp. 34-39
    • French, M.B.1    Allison, J.2    Cram, D.S.3
  • 38
    • 5444222000 scopus 로고    scopus 로고
    • Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
    • Jaeckel E, Lipes MA, von Boehmer H. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat Immunol 2004; 5:1028-1035.
    • (2004) Nat Immunol , vol.5 , pp. 1028-1035
    • Jaeckel, E.1    Ma, L.2    Von Boehmer, H.3
  • 39
    • 0038204841 scopus 로고    scopus 로고
    • Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase
    • Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H. Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med 2003; 197:1635-1644.
    • (2003) J Exp Med , vol.197 , pp. 1635-1644
    • Jaeckel, E.1    Klein, L.2    Martin-Orozco, N.3    Von Boehmer, H.4
  • 40
    • 33845316086 scopus 로고    scopus 로고
    • Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP
    • Krishnamurthy B, Dudek NL, McKenzie MD, et al. Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. J Clin Invest 2006; 116:3258-3265.
    • (2006) J Clin Invest , vol.116 , pp. 3258-3265
    • Krishnamurthy, B.1    Dudek, N.L.2    McKenzie, M.D.3
  • 41
    • 70349194383 scopus 로고    scopus 로고
    • Thymus-specific deletion of insulin induces autoimmune diabetes
    • Fan Y, Rudert WA, Grupillo M, et al. Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J 2009; 28:2812-2824.
    • (2009) EMBO J , vol.28 , pp. 2812-2824
    • Fan, Y.1    Rudert, W.A.2    Grupillo, M.3
  • 42
    • 18744366947 scopus 로고    scopus 로고
    • Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    • Nakayama M, Abiru N, Moriyama H, et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005; 435:220-223.
    • (2005) Nature , vol.435 , pp. 220-223
    • Nakayama, M.1    Abiru, N.2    Moriyama, H.3
  • 43
    • 27844611983 scopus 로고    scopus 로고
    • Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout
    • Nakayama M, Babaya N, Miao D, et al. Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout. J Autoimmun 2005; 25:193-198.
    • (2005) J Autoimmun , vol.25 , pp. 193-198
    • Nakayama, M.1    Babaya, N.2    Miao, D.3
  • 44
    • 34447134722 scopus 로고    scopus 로고
    • Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity
    • Nakayama M, Beilke JN, Jasinski JM, et al. Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. J Clin Invest 2007; 117:1835-1843.
    • (2007) J Clin Invest , vol.117 , pp. 1835-1843
    • Nakayama, M.1    Beilke, J.N.2    Jasinski, J.M.3
  • 45
    • 0035500757 scopus 로고    scopus 로고
    • Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes
    • Chen W, Bergerot I, Elliott JF, et al. Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes. J Immunol 2001; 167:4926-4935.
    • (2001) J Immunol , vol.167 , pp. 4926-4935
    • Chen, W.1    Bergerot, I.2    Elliott, J.F.3
  • 46
    • 33646392755 scopus 로고    scopus 로고
    • Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
    • Bresson D, Togher L, Rodrigo E, et al. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Investig 2006; 116:1371-1381.
    • (2006) J Clin Investig , vol.116 , pp. 1371-1381
    • Bresson, D.1    Togher, L.2    Rodrigo, E.3
  • 47
    • 48249157055 scopus 로고    scopus 로고
    • Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice
    • Levisetti MG, Lewis DM, Suri A, Unanue ER. Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice. Diabetes 2008; 57:1852-1860.
    • (2008) Diabetes , vol.57 , pp. 1852-1860
    • Levisetti, M.G.1    Lewis, D.M.2    Suri, A.3    Unanue, E.R.4
  • 48
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson MS, Venanzi ES, Klein L, et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002; 298:1395-1401.
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3
  • 49
    • 49449093723 scopus 로고    scopus 로고
    • Deletional tolerance mediated by extrathymic Aire-expressing cells
    • Gardner JM, DeVoss JJ, Friedman RS, et al. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science 2008; 321:843-847.
    • (2008) Science , vol.321 , pp. 843-847
    • Gardner, J.M.1    Devoss, J.J.2    Friedman, R.S.3
  • 50
    • 69049109653 scopus 로고    scopus 로고
    • Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes
    • Yip L, Su L, Sheng D, et al. Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol 2009; 10:1026-1033.
    • (2009) Nat Immunol , vol.10 , pp. 1026-1033
    • Yip, L.1    Su, L.2    Sheng, D.3
  • 51
    • 23644439438 scopus 로고    scopus 로고
    • Pathogenic T-cell clones in autoimmune diabetes: More lessons from the NOD mouse
    • 123-162
    • Haskins K. Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse. Adv Immunol 2005; 87:123-162; 123-162
    • (2005) Adv Immunol , vol.87 , pp. 123-162
    • Haskins, K.1
  • 52
    • 76949098835 scopus 로고    scopus 로고
    • Chromogranin A is an autoantigen in type 1 diabetes
    • Stadinski BD, Delong T, Reisdorph N, et al. Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol 2010; 11:225-231.
    • (2010) Nat Immunol , vol.11 , pp. 225-231
    • Stadinski, B.D.1    Delong, T.2    Reisdorph, N.3
  • 53
    • 33646417368 scopus 로고    scopus 로고
    • Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas
    • Dogra RS, Vaidyanathan P, Prabakar KR, et al. Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas. Diabetol 2006; 49:953-957.
    • (2006) Diabetol , vol.49 , pp. 953-957
    • Dogra, R.S.1    Vaidyanathan, P.2    Prabakar, K.R.3
  • 54
    • 0030962478 scopus 로고    scopus 로고
    • T cell receptor restriction of diabetogenic autoimmune NOD T cells
    • Simone E, Daniel D, Schloot N, et al. T cell receptor restriction of diabetogenic autoimmune NOD T cells. Proc Natl Acad Sci USA 1997; 94:2518-2521.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2518-2521
    • Simone, E.1    Daniel, D.2    Schloot, N.3
  • 55
    • 48249109500 scopus 로고    scopus 로고
    • Conserved T cell receptor alpha-chain induces insulin autoantibodies
    • Kobayashi M, Jasinski J, Liu E, et al. Conserved T cell receptor alpha-chain induces insulin autoantibodies. Proc Natl Acad Sci U S A 2008; 105:10090-10094.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10090-10094
    • Kobayashi, M.1    Jasinski, J.2    Liu, E.3
  • 56
    • 3242768392 scopus 로고    scopus 로고
    • GAD65-specific CD4 T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes
    • Reijonen H, Mallone R, Heninger AK, et al. GAD65-specific CD4 T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes. Diabetes 2004; 53:1987-1994.
    • (2004) Diabetes , vol.53 , pp. 1987-1994
    • Reijonen, H.1    Mallone, R.2    Heninger, A.K.3
  • 57
    • 68949125346 scopus 로고    scopus 로고
    • Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms
    • Gebe JA, Yue BB, Unrath KA, et al. Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms. J Immunol 2009; 183:59-65.
    • (2009) J Immunol , vol.183 , pp. 59-65
    • Gebe, J.A.1    Yue, B.B.2    Unrath, K.A.3
  • 58
    • 18244392426 scopus 로고    scopus 로고
    • Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor
    • Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW. Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nat Immunol 2005; 6:490-496.
    • (2005) Nat Immunol , vol.6 , pp. 490-496
    • Hahn, M.1    Nicholson, M.J.2    Pyrdol, J.3    Wucherpfennig, K.W.4
  • 59
    • 26644468528 scopus 로고    scopus 로고
    • Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule
    • Li Y, Huang Y, Lue J, et al. Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. EMBO J 2005; 24:2968-2979.
    • (2005) EMBO J , vol.24 , pp. 2968-2979
    • Li, Y.1    Huang, Y.2    Lue, J.3
  • 60
    • 12444298109 scopus 로고    scopus 로고
    • Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: Insights into MHC bias and antigen specificity
    • Maynard J, Petersson K, Wilson DH, et al. Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity 2005; 22:81-92.
    • (2005) Immunity , vol.22 , pp. 81-92
    • Maynard, J.1    Petersson, K.2    Wilson, D.H.3
  • 61
    • 34548128306 scopus 로고    scopus 로고
    • Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction codon
    • Feng D, Bond CJ, Ely LK, et al. Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction codon. Nat Immunol 2007; 8:975-983.
    • (2007) Nat Immunol , vol.8 , pp. 975-983
    • Feng, D.1    Bond, C.J.2    Ely, L.K.3
  • 62
    • 70349745490 scopus 로고    scopus 로고
    • T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event
    • Lennon GP, Bettini M, Burton AR, et al. T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity 2009; 31:643-653.
    • (2009) Immunity , vol.31 , pp. 643-653
    • Lennon, G.P.1    Bettini, M.2    Burton, A.R.3
  • 63
    • 73349085255 scopus 로고    scopus 로고
    • Tisch R. beta cell-specific CD4 T cell clonotypes in peripheral blood and the pancreatic islets are distinct
    • Li L, He Q, Garland A, et al. Tisch R. beta cell-specific CD4 T cell clonotypes in peripheral blood and the pancreatic islets are distinct. J Immunol 2009; 183:7585-7591.
    • (2009) J Immunol , vol.183 , pp. 7585-7591
    • Li, L.1    He, Q.2    Garland, A.3


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