-
1
-
-
43849096855
-
Time trends in the incidence of type 1 diabetes in Finnish children: A cohort study
-
Harjutsalo V, Sjoberg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 2008; 371:1777-1782.
-
(2008)
Lancet
, vol.371
, pp. 1777-1782
-
-
Harjutsalo, V.1
Sjoberg, L.2
Tuomilehto, J.3
-
2
-
-
0033912572
-
Application and interpretation of transmission/disequilibrium tests: Transmission of HLA-DQ haplotypes to unaffected siblings in 526 families with type 1 diabetes
-
Lie BA, Ronningen KS, Akselsen HE, et al. Application and interpretation of transmission/disequilibrium tests: transmission of HLA-DQ haplotypes to unaffected siblings in 526 families with type 1 diabetes. Am J Hum Genet 2000; 66:740-743.
-
(2000)
Am J Hum Genet
, vol.66
, pp. 740-743
-
-
Lie, B.A.1
Ronningen, K.S.2
Akselsen, H.E.3
-
3
-
-
0035380479
-
Structure of a human insulin peptide/ HLA-DQ8 complex and susceptibility to type 1 diabetes
-
Lee KH, Wucherpfennig KW, Wiley DC. Structure of a human insulin peptide/ HLA-DQ8 complex and susceptibility to type 1 diabetes. Nature Immunol 2001; 2:501-507.
-
(2001)
Nature Immunol
, vol.2
, pp. 501-507
-
-
Lee, K.H.1
Wucherpfennig, K.W.2
Wiley, D.C.3
-
4
-
-
0034697101
-
A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes
-
Corper AL, Stratmann T, Apostolopoulos V, et al. A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes. Science 2000; 288:505-511.
-
(2000)
Science
, vol.288
, pp. 505-511
-
-
Corper, A.L.1
Stratmann, T.2
Apostolopoulos, V.3
-
5
-
-
0036467345
-
In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket
-
Suri A, Vidavsky I, van der DK, et al. In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket. J Immunol 2002; 168:1235-1243.
-
(2002)
J Immunol
, vol.168
, pp. 1235-1243
-
-
Suri, A.1
Vidavsky Van Der, I.D.K.2
-
6
-
-
23644433712
-
Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity
-
Suri A, Walters JJ, Gross ML, Unanue ER. Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity. J Clin Invest 2005; 115:2268-2276.
-
(2005)
J Clin Invest
, Issue.115
, pp. 2268-2276
-
-
Suri, A.1
Walters, J.J.2
Gross, M.L.3
Unanue, E.R.4
-
7
-
-
44849130871
-
First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules
-
Suri A, Walters JJ, Rohrs HW, et al. First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules. J Immunol 2008; 180:3849-3856.
-
(2008)
J Immunol
, vol.180
, pp. 3849-3856
-
-
Suri, A.1
Walters, J.J.2
Rohrs, H.W.3
-
8
-
-
42449144715
-
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: Analysis of the type 1 diabetes genetics consortium families
-
Erlich H, Valdes AM, Noble J, et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008; 57:1084-1092.
-
(2008)
Diabetes
, vol.57
, pp. 1084-1092
-
-
Erlich, H.1
Valdes, A.M.2
Noble, J.3
-
9
-
-
0033005328
-
Impaired binding of a DQ2 and DQ8- binding HSV VP16 peptide to a DQA1-0501/DQB1-0302 trans class II heterodimer
-
Reichstetter S, Kwok WW, Nepom GT. Impaired binding of a DQ2 and DQ8- binding HSV VP16 peptide to a DQA1-0501/DQB1-0302 trans class II heterodimer. Tissue Antigens 1999; 53:101-105.
-
(1999)
Tissue Antigens
, vol.53
, pp. 101-105
-
-
Reichstetter, S.1
Kwok, W.W.2
Nepom, G.T.3
-
10
-
-
33746694192
-
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease
-
Tollefsen S, Arentz-Hansen H, Fleckenstein B, et al. HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. J Clin Invest 2006; 116:2226-2236.
-
(2006)
J Clin Invest
, vol.116
, pp. 2226-2236
-
-
Tollefsen, S.1
Arentz-Hansen, H.2
Fleckenstein, B.3
-
11
-
-
33748305619
-
Combination of HLA-A24, -DQA1-03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: Longitudinal study of residual beta-cell function
-
Nakanishi K, Inoko H. Combination of HLA-A24, -DQA1-03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell function. Diabetes 2006; 55:1862-1868.
-
(2006)
Diabetes
, vol.55
, pp. 1862-1868
-
-
Nakanishi, K.1
Inoko, H.2
-
12
-
-
36849012027
-
Localization of type 1 diabetes susceptibility to the MHC class i genes HLA-B and HLA-A
-
Nejentsev S, Howson JM, Walker NM, et al. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007; 450:887-892.
-
(2007)
Nature
, vol.450
, pp. 887-892
-
-
Nejentsev, S.1
Howson, J.M.2
Walker, N.M.3
-
13
-
-
40949086474
-
Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex
-
Aly TA, Baschal EE, Jahromi MM, et al. Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex. Diabetes 2008; 57:770-776.
-
(2008)
Diabetes
, vol.57
, pp. 770-776
-
-
Aly, T.A.1
Baschal, E.E.2
Jahromi, M.M.3
-
14
-
-
34347341846
-
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
-
Todd JA, Walker NM, Cooper JD, et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007; 39:857-864.
-
(2007)
Nat Genet
, vol.39
, pp. 857-864
-
-
Todd, J.A.1
Walker, N.M.2
Cooper, J.D.3
-
15
-
-
18244421874
-
The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type i diabetes
-
Pugliese A, Zeller M, Fernandez A, et al. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type I diabetes. Nat Genet 1997; 15:293-297.
-
(1997)
Nat Genet
, vol.15
, pp. 293-297
-
-
Pugliese, A.1
Zeller, M.2
Fernandez, A.3
-
16
-
-
0036315824
-
Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: The mechanism by which the IDDM2 locus may predispose to diabetes
-
Chentoufi AA, Polychronakos C. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 2002; 51:1383-1390.
-
(2002)
Diabetes
, vol.51
, pp. 1383-1390
-
-
Chentoufi, A.A.1
Polychronakos, C.2
-
17
-
-
0021019885
-
Insulin antibodies in insulindependent diabetics before insulin treatment
-
Palmer JP, Asplin CM, Clemons P, et al. Insulin antibodies in insulindependent diabetics before insulin treatment. Science 1983; 222:1337-1339.
-
(1983)
Science
, vol.222
, pp. 1337-1339
-
-
Palmer, J.P.1
Asplin, C.M.2
Clemons, P.3
-
18
-
-
4344690190
-
Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
-
Achenbach P, Koczwara K, Knopff A, et al. Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 2004; 114:589-597.
-
(2004)
J Clin Invest
, vol.114
, pp. 589-597
-
-
Achenbach, P.1
Koczwara, K.2
Knopff, A.3
-
19
-
-
0035142467
-
A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin
-
Alleva DG, Crowe PD, Jin L, et al. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J Clin Invest 2001; 107:173-180.
-
(2001)
J Clin Invest
, vol.107
, pp. 173-180
-
-
Alleva, D.G.1
Crowe, P.D.2
Jin, L.3
-
20
-
-
18744385526
-
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
-
Kent SC, Chen Y, Bregoli L, et al. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005; 435:224-228.
-
(2005)
Nature
, vol.435
, pp. 224-228
-
-
Kent, S.C.1
Chen, Y.2
Bregoli, L.3
-
21
-
-
27744524215
-
The insulin A-chain epitope recognized by human T cells is posttranslationally modified
-
Mannering SI, Harrison LC, Williamson NA, et al. The insulin A-chain epitope recognized by human T cells is posttranslationally modified. J Exp Med 2005; 202:1191-1197.
-
(2005)
J Exp Med
, vol.202
, pp. 1191-1197
-
-
Mannering, S.I.1
Harrison, L.C.2
Williamson, N.A.3
-
22
-
-
64649084572
-
The A-chain of insulin is a hotspot for CD4 T cell epitopes in human type 1 diabetes
-
Mannering SI, Pang SH, Williamson NA, et al. The A-chain of insulin is a hotspot for CD4 T cell epitopes in human type 1 diabetes. Clin Exp Immunol 2009; 156:226-231.
-
(2009)
Clin Exp Immunol
, vol.156
, pp. 226-231
-
-
Mannering, S.I.1
Pang, S.H.2
Williamson, N.A.3
-
23
-
-
29444433680
-
Autoreactive CD8 T cells associated with {beta} cell destruction in type 1 diabetes
-
Pinkse GG, Tysma OH, Bergen CA, et al. Autoreactive CD8 T cells associated with {beta} cell destruction in type 1 diabetes. Proc Natl Acad Sci U S A 2005; 102:18425-18430.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 18425-18430
-
-
Pinkse, G.G.1
Tysma, O.H.2
Bergen, C.A.3
-
24
-
-
21344433224
-
Identification of naturally processed HLA-A2 - Restricted proinsulin epitopes by reverse immunology
-
Hassainya Y, Garcia-Pons F, Kratzer R, et al. Identification of naturally processed HLA-A2 - Restricted proinsulin epitopes by reverse immunology. Diabetes 2005; 54:2053-2059.
-
(2005)
Diabetes
, vol.54
, pp. 2053-2059
-
-
Hassainya, Y.1
Garcia-Pons, F.2
Kratzer, R.3
-
25
-
-
23044455740
-
Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients
-
Toma A, Haddouk S, Briand JP, et al. Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. Proc Natl Acad Sci U S A 2005; 102:10581-10586.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 10581-10586
-
-
Toma, A.1
Haddouk, S.2
Briand, J.P.3
-
26
-
-
55849116389
-
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
-
Skowera A, Ellis RJ, Varela-Calvino R, et al. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest 2008; 118:3390-3402.
-
(2008)
J Clin Invest
, vol.118
, pp. 3390-3402
-
-
Skowera, A.1
Ellis, R.J.2
Varela-Calvino, R.3
-
27
-
-
76249103112
-
Ins2 deficiency augments spontaneous HLAA-0201-restricted T cell responses to insulin
-
Jarchum I, DiLorenzo TP. Ins2 deficiency augments spontaneous HLAA-0201-restricted T cell responses to insulin. J Immunol 2010; 184:658-665.
-
(2010)
J Immunol
, vol.184
, pp. 658-665
-
-
Jarchum, I.1
Dilorenzo, T.P.2
-
28
-
-
0028145676
-
Insulin-specific T cells are a predominant component of islet infiltrates in prediabetic NOD mice
-
Wegmann DR, Norbury-Glaser M, Daniel D. Insulin-specific T cells are a predominant component of islet infiltrates in prediabetic NOD mice. Eur J Immunol 1994; 24:1853-1857.
-
(1994)
Eur J Immunol
, vol.24
, pp. 1853-1857
-
-
Wegmann, D.R.1
Norbury-Glaser, M.2
Daniel, D.3
-
29
-
-
0036721796
-
T cell response to preproinsulin i and II in the nonobese diabetic mouse
-
Halbout P, Briand JP, Becourt C, et al. T cell response to preproinsulin I and II in the nonobese diabetic mouse. J Immunol 2002; 169:2436-2443.
-
(2002)
J Immunol
, vol.169
, pp. 2436-2443
-
-
Halbout, P.1
Briand, J.P.2
Becourt, C.3
-
30
-
-
34248233148
-
The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form
-
Levisetti MG, Suri A, Petzold SJ, Unanue ER. The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form. J Immunol 2007; 178:6051-6057.
-
(2007)
J Immunol
, vol.178
, pp. 6051-6057
-
-
Levisetti, M.G.1
Suri, A.2
Petzold, S.J.3
Unanue, E.R.4
-
31
-
-
0028914351
-
Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice
-
Daniel D, Gill RG, Schloot N, Wegmann D. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol 1995; 25:1056-1062.
-
(1995)
Eur J Immunol
, vol.25
, pp. 1056-1062
-
-
Daniel, D.1
Gill, R.G.2
Schloot, N.3
Wegmann, D.4
-
32
-
-
33747067459
-
Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout
-
Jasinski JM, Yu L, Nakayama M, et al. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes 2006; 55:1978-1984.
-
(2006)
Diabetes
, vol.55
, pp. 1978-1984
-
-
Jasinski, J.M.1
Yu, L.2
Nakayama, M.3
-
33
-
-
77949872804
-
Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes
-
Mohan JF, Levisetti MG, Calderon B, et al. Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes. Nat Immunol 2010; 11:350-354.
-
(2010)
Nat Immunol
, vol.11
, pp. 350-354
-
-
Mohan, J.F.1
Levisetti, M.G.2
Calderon, B.3
-
34
-
-
0030069688
-
Protection of Nonobese Diabetic Mice from Diabetes by Intranasal or Subcutaneous Administration of Insulin Peptide B-(9-23)
-
Daniel D, Wegmann DR. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci USA 1996; 93:956-960.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 956-960
-
-
Daniel, D.1
Wegmann, D.R.2
-
35
-
-
0036300542
-
Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide
-
Alleva DG, Gaur A, Jin L, et al. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes 2002; 51:2126-2134.
-
(2002)
Diabetes
, Issue.51
, pp. 2126-2134
-
-
Alleva, D.G.1
Gaur, A.2
Jin, L.3
-
36
-
-
34848817986
-
Altered B: 9 23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes
-
Kobayashi M, Abiru N, Arakawa T, et al. Altered B:9 23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes. J Immunol 2007; 179:2082-2088.
-
(2007)
J Immunol
, Issue.179
, pp. 2082-2088
-
-
Kobayashi, M.1
Abiru, N.2
Arakawa, T.3
-
37
-
-
0031025574
-
Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice
-
French MB, Allison J, Cram DS, et al. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 1996; 46:34-39.
-
(1996)
Diabetes
, vol.46
, pp. 34-39
-
-
French, M.B.1
Allison, J.2
Cram, D.S.3
-
38
-
-
5444222000
-
Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
-
Jaeckel E, Lipes MA, von Boehmer H. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat Immunol 2004; 5:1028-1035.
-
(2004)
Nat Immunol
, vol.5
, pp. 1028-1035
-
-
Jaeckel, E.1
Ma, L.2
Von Boehmer, H.3
-
39
-
-
0038204841
-
Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase
-
Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H. Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med 2003; 197:1635-1644.
-
(2003)
J Exp Med
, vol.197
, pp. 1635-1644
-
-
Jaeckel, E.1
Klein, L.2
Martin-Orozco, N.3
Von Boehmer, H.4
-
40
-
-
33845316086
-
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP
-
Krishnamurthy B, Dudek NL, McKenzie MD, et al. Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. J Clin Invest 2006; 116:3258-3265.
-
(2006)
J Clin Invest
, vol.116
, pp. 3258-3265
-
-
Krishnamurthy, B.1
Dudek, N.L.2
McKenzie, M.D.3
-
41
-
-
70349194383
-
Thymus-specific deletion of insulin induces autoimmune diabetes
-
Fan Y, Rudert WA, Grupillo M, et al. Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J 2009; 28:2812-2824.
-
(2009)
EMBO J
, vol.28
, pp. 2812-2824
-
-
Fan, Y.1
Rudert, W.A.2
Grupillo, M.3
-
42
-
-
18744366947
-
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
-
Nakayama M, Abiru N, Moriyama H, et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005; 435:220-223.
-
(2005)
Nature
, vol.435
, pp. 220-223
-
-
Nakayama, M.1
Abiru, N.2
Moriyama, H.3
-
43
-
-
27844611983
-
Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout
-
Nakayama M, Babaya N, Miao D, et al. Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout. J Autoimmun 2005; 25:193-198.
-
(2005)
J Autoimmun
, vol.25
, pp. 193-198
-
-
Nakayama, M.1
Babaya, N.2
Miao, D.3
-
44
-
-
34447134722
-
Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity
-
Nakayama M, Beilke JN, Jasinski JM, et al. Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. J Clin Invest 2007; 117:1835-1843.
-
(2007)
J Clin Invest
, vol.117
, pp. 1835-1843
-
-
Nakayama, M.1
Beilke, J.N.2
Jasinski, J.M.3
-
45
-
-
0035500757
-
Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes
-
Chen W, Bergerot I, Elliott JF, et al. Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes. J Immunol 2001; 167:4926-4935.
-
(2001)
J Immunol
, vol.167
, pp. 4926-4935
-
-
Chen, W.1
Bergerot, I.2
Elliott, J.F.3
-
46
-
-
33646392755
-
Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
-
Bresson D, Togher L, Rodrigo E, et al. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Investig 2006; 116:1371-1381.
-
(2006)
J Clin Investig
, vol.116
, pp. 1371-1381
-
-
Bresson, D.1
Togher, L.2
Rodrigo, E.3
-
47
-
-
48249157055
-
Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice
-
Levisetti MG, Lewis DM, Suri A, Unanue ER. Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice. Diabetes 2008; 57:1852-1860.
-
(2008)
Diabetes
, vol.57
, pp. 1852-1860
-
-
Levisetti, M.G.1
Lewis, D.M.2
Suri, A.3
Unanue, E.R.4
-
48
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the aire protein
-
Anderson MS, Venanzi ES, Klein L, et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002; 298:1395-1401.
-
(2002)
Science
, vol.298
, pp. 1395-1401
-
-
Anderson, M.S.1
Venanzi, E.S.2
Klein, L.3
-
49
-
-
49449093723
-
Deletional tolerance mediated by extrathymic Aire-expressing cells
-
Gardner JM, DeVoss JJ, Friedman RS, et al. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science 2008; 321:843-847.
-
(2008)
Science
, vol.321
, pp. 843-847
-
-
Gardner, J.M.1
Devoss, J.J.2
Friedman, R.S.3
-
50
-
-
69049109653
-
Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes
-
Yip L, Su L, Sheng D, et al. Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol 2009; 10:1026-1033.
-
(2009)
Nat Immunol
, vol.10
, pp. 1026-1033
-
-
Yip, L.1
Su, L.2
Sheng, D.3
-
51
-
-
23644439438
-
Pathogenic T-cell clones in autoimmune diabetes: More lessons from the NOD mouse
-
123-162
-
Haskins K. Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse. Adv Immunol 2005; 87:123-162; 123-162
-
(2005)
Adv Immunol
, vol.87
, pp. 123-162
-
-
Haskins, K.1
-
52
-
-
76949098835
-
Chromogranin A is an autoantigen in type 1 diabetes
-
Stadinski BD, Delong T, Reisdorph N, et al. Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol 2010; 11:225-231.
-
(2010)
Nat Immunol
, vol.11
, pp. 225-231
-
-
Stadinski, B.D.1
Delong, T.2
Reisdorph, N.3
-
53
-
-
33646417368
-
Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas
-
Dogra RS, Vaidyanathan P, Prabakar KR, et al. Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas. Diabetol 2006; 49:953-957.
-
(2006)
Diabetol
, vol.49
, pp. 953-957
-
-
Dogra, R.S.1
Vaidyanathan, P.2
Prabakar, K.R.3
-
54
-
-
0030962478
-
T cell receptor restriction of diabetogenic autoimmune NOD T cells
-
Simone E, Daniel D, Schloot N, et al. T cell receptor restriction of diabetogenic autoimmune NOD T cells. Proc Natl Acad Sci USA 1997; 94:2518-2521.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2518-2521
-
-
Simone, E.1
Daniel, D.2
Schloot, N.3
-
55
-
-
48249109500
-
Conserved T cell receptor alpha-chain induces insulin autoantibodies
-
Kobayashi M, Jasinski J, Liu E, et al. Conserved T cell receptor alpha-chain induces insulin autoantibodies. Proc Natl Acad Sci U S A 2008; 105:10090-10094.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 10090-10094
-
-
Kobayashi, M.1
Jasinski, J.2
Liu, E.3
-
56
-
-
3242768392
-
GAD65-specific CD4 T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes
-
Reijonen H, Mallone R, Heninger AK, et al. GAD65-specific CD4 T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes. Diabetes 2004; 53:1987-1994.
-
(2004)
Diabetes
, vol.53
, pp. 1987-1994
-
-
Reijonen, H.1
Mallone, R.2
Heninger, A.K.3
-
57
-
-
68949125346
-
Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms
-
Gebe JA, Yue BB, Unrath KA, et al. Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms. J Immunol 2009; 183:59-65.
-
(2009)
J Immunol
, vol.183
, pp. 59-65
-
-
Gebe, J.A.1
Yue, B.B.2
Unrath, K.A.3
-
58
-
-
18244392426
-
Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor
-
Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW. Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nat Immunol 2005; 6:490-496.
-
(2005)
Nat Immunol
, vol.6
, pp. 490-496
-
-
Hahn, M.1
Nicholson, M.J.2
Pyrdol, J.3
Wucherpfennig, K.W.4
-
59
-
-
26644468528
-
Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule
-
Li Y, Huang Y, Lue J, et al. Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. EMBO J 2005; 24:2968-2979.
-
(2005)
EMBO J
, vol.24
, pp. 2968-2979
-
-
Li, Y.1
Huang, Y.2
Lue, J.3
-
60
-
-
12444298109
-
Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: Insights into MHC bias and antigen specificity
-
Maynard J, Petersson K, Wilson DH, et al. Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity 2005; 22:81-92.
-
(2005)
Immunity
, vol.22
, pp. 81-92
-
-
Maynard, J.1
Petersson, K.2
Wilson, D.H.3
-
61
-
-
34548128306
-
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction codon
-
Feng D, Bond CJ, Ely LK, et al. Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction codon. Nat Immunol 2007; 8:975-983.
-
(2007)
Nat Immunol
, vol.8
, pp. 975-983
-
-
Feng, D.1
Bond, C.J.2
Ely, L.K.3
-
62
-
-
70349745490
-
T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event
-
Lennon GP, Bettini M, Burton AR, et al. T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity 2009; 31:643-653.
-
(2009)
Immunity
, vol.31
, pp. 643-653
-
-
Lennon, G.P.1
Bettini, M.2
Burton, A.R.3
-
63
-
-
73349085255
-
Tisch R. beta cell-specific CD4 T cell clonotypes in peripheral blood and the pancreatic islets are distinct
-
Li L, He Q, Garland A, et al. Tisch R. beta cell-specific CD4 T cell clonotypes in peripheral blood and the pancreatic islets are distinct. J Immunol 2009; 183:7585-7591.
-
(2009)
J Immunol
, vol.183
, pp. 7585-7591
-
-
Li, L.1
He, Q.2
Garland, A.3
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