Extended family history of type 1 diabetes and phenotype and genotype of newly diagnosed children

Diabetes Care

Volumn 36, Issue 2, 2013, Pages 348-354

  Parkkola, Anna ^a   HäRKÖNEN, Taina ^a   RYHäNEN, Samppa J ^a   Ilonen, Jorma ^b,c   Knip, Mikael ^a,d,e  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d FOLKHÄLSAN RESEARCH CENTER   (Finland)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A ANTIGEN; HLA DQ8 ANTIGEN; HLA DR4 ANTIGEN; HLA DR5 ANTIGEN; HLA DR6 ANTIGEN; HLA DR7 ANTIGEN; INSULIN ANTIBODY;

ADOLESCENT; ANALYSIS OF VARIANCE; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; CHILD; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; FAMILY HISTORY; FEMALE; GENE MUTATION; GENOTYPE; GLUCOSE BLOOD LEVEL; HAPLOTYPE; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET BETA CELL; PHENOTYPE; PRESCHOOL CHILD; QUESTIONNAIRE; SCHOOL CHILD; SEX DIFFERENCE;

3-HYDROXYBUTYRIC ACID; ADOLESCENT; AUTOANTIBODIES; AUTOIMMUNITY; BLOOD GLUCOSE; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FAMILY; FEMALE; GENOTYPE; HLA-DQ ANTIGENS; HUMANS; INFANT; INFANT, NEWBORN; MALE; PHENOTYPE;

EID: 84873830631     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-0445     Document Type: Article

References (32)

1. Weires MB, Tausch B, Haug PJ, Edwards CQ, Wetter T, Cannon-Albright LA. Familiality of diabetes mellitus. Exp Clin Endocrinol Diabetes 2007;115:634-640
2. Nielsen NM, Westergaard T, Frisch M, et al. Type 1 diabetes and multiple sclerosis: a Danish population-based cohort study. Arch Neurol 2006;63:1001-1004
3. Harjutsalo V, Reunanen A, Tuomilehto J. Differential transmission of type 1 diabetes from diabetic fathers and mothers to their offspring. Diabetes 2006;55:1517-1524
4. Tuomilehto J, Podar T, Tuomilehto-Wolf E, Virtala E. Evidence for importance of gender and birth cohort for risk of IDDM in offspring of IDDM parents. Diabetologia 1995;38:975-982
5. Sipetic S, Vlajinac H, Kocev N, Marinkovic J, Radmanovic S, Denic L. Family history and risk of type 1 diabetes mellitus. Acta Diabetol 2002;39:111-115
6. Hemminki K, Li X, Sundquist J, Sundquist K. Familial association between type 1 diabetes and other autoimmune and related diseases. Diabetologia 2009;52:1820-1828
7. Allen C, Palta M, DAlessio DJ. Risk of diabetes in siblings and other relatives of IDDM subjects. Diabetes 1991;40:831-836
8. Veijola R, Reijonen H, Vähäsalo P, et al. HLA-DQB1-defined genetic susceptibility, beta cell autoimmunity, and metabolic characteristics in familial and nonfamilial insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group. J Clin Invest 1996;98:2489-2495
9. Dahlquist GG, Mustonen LR. Clinical onset characteristics of familial versus non-familial cases in a large population-based cohort of childhood-onset diabetes patients. Diabetes Care 1995;18:852-854
10. Dahlquist G, Mustonen L; Swedish Childhood Diabetes Study Group. Analysis of 20 years of prospective registration of childhood onset diabetes time trends and birth cohort effects. Acta Paediatr 2000;89:1231-1237
11. Roche EF, Menon A, Gill D, Hoey H. Clinical presentation of type 1 diabetes. Pediatr Diabetes 2005;6:75-78
12. Familial risk of type I diabetes in European children. The Eurodiab Ace Study Group and the Eurodiab Ace Substudy 2 Study Group. Diabetologia 1998;41:1151-1156
13. Lebenthal Y, de Vries L, Phillip M, LazarL. Familial type 1 diabetes mellitus-gender distribution and age at onset of diabetes distinguish between parent-offspring and sib-pair subgroups. Pediatr Diabetes 2010;11:403-411
14. Lorenzen T, Pociot F, Hougaard P, Nerup J. Long-term risk of IDDM in first-degree relatives of patients with IDDM. Diabetologia 1994;37:321-327
15. Akesson K, Nyström L, Färnkvist L, Ostman J, Lernmark A, Kockum I. Increased risk of diabetes among relatives of female insulin-treated patients diagnosed at 15-34 years of age. Diabet Med 2005;22:1551-1557
16. Warram JH, Krolewski AS, Gottlieb MS, Kahn CR. Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N EnglJ Med 1984;311:149-152
17. Alhonen S, Korhonen S, Tapanainen P, Knip M, Veijola R. Extended family history of diabetes and autoimmune diseases in children with and without type 1 diabetes. Diabetes Care 2011;34:115-117
18. Douek IF, Gillespie KM, Dix RJ, Bingley PJ, Gale EA. Three generations of autoimmune diabetes: an extended family study. Diabetologia 2003;46:1313-1318
19. Barone B, Rodacki M, Zajdenverg L, et al. Family history of type 2 diabetes is increased in patients with type 1 diabetes. Diabetes Res Clin Pract 2008;82:e1-e4
20. Anderson CE, Hodge SE, Rubin R, et al. A search for heterogeneity in insulin dependent diabetes mellitus (IDDM): HLA and autoimmune studies in simplex, multiplex and multigenerational families. Metabolism 1983;32:471-477
21. O'Leary LA, Dorman JS, LaPorte RE, et al. Familial and sporadic insulin-dependent diabetes: evidence for heterogeneous etiologies? Diabetes Res Clin Pract 1991;14: 183-190
22. Svejgaard A, Jakobsen BK, Platz P, et al. HLA associations in insulin-dependent diabetes: search for heterogeneity in different groups of patients from a homogeneous population. Tissue Antigens 1986;28:237-244
23. Ilonen J, Reijonen H, Herva E, et al. Rapid HLA-DQB1 genotyping for four alleles in the assessment of risk for IDDM in the Finnish population. The Childhood Diabetes in Finland (DiMe) Study Group. Diabetes Care 1996;19:795-800
24. Pociot F, Rønningen KS, Bergholdt R, et al.; Danish Study Group of Diabetes in Childhood. Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetesdevidence for polygenicity in man. Autoimmunity 1994; 19:169-178
25. Hekkala A, Reunanen A, Koski M, Knip M, Veijola R; Finnish Pediatric Diabetes Register. Age-related differences in the frequency of ketoacidosis at diagnosis of type 1 diabetes in children and adolescents. Diabetes Care 2010;33:1500-1502
26. Hermann R, Turpeinen H, Laine AP, et al. HLA DR-DQ-encodedgenetic determinants of childhood-onset type 1 diabetes in Finland: an analysis of 622 nuclear families. Tissue Antigens 2003;62:162-169
27. Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974;2:1279-1283
28. Ronkainen MS, Hämäläinen AM, Koskela P, Akerblom HK, Knip M; Finnish Trigr Study Group. Pregnancy induces non-immunoglobulin insulin-binding activity in both maternal and cord blood serum. Clin Exp Immunol 2001;124:190-196
29. Savola K, Sabbah E, Kulmala P, Vähäsalo P, Ilonen J, Knip M. Autoantibodies associated with type I diabetes mellitus persist after diagnosis in children. Dia-betologia 1998;41:1293-1297
30. Savola K, Bonifacio E, Sabbah E, et al. IA-2 antibodies a sensitive marker of IDDM with clinical onset in childhood and adolescence. Childhood Diabetes in Finland Study Group. Diabetologia 1998;41:424-429
31. Douek IF, Gillespie KM, Bingley PJ, Gale EA. Diabetes in the parents of children with type I diabetes. Diabetologia 2002;45:495-501
32. Guo SW, Tuomilehto J. Preferential transmission of type 1 diabetes from parents to offspring: fact or artifact? Genet Epidemiol 2002;23:323-334