Avidity-dependent programming of autoreactive T cells in T1D

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Durinovic Belló, Ivana ^a   Gersuk, Vivian H ^a   Ni, Chester ^a   Wu, Rebecca ^a   Thorpe, Jerill ^a   Jospe, Nicholas ^b   Sanda, Srinath ^a   Greenbaum, Carla J ^a   Nepom, Gerald T ^a,c  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; INSULIN; NUCLEAR RECEPTOR NUR77; PROINSULIN; AUTOANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN BINDING; T LYMPHOCYTE RECEPTOR;

ADULT; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; BINDING AFFINITY; CD4+ T LYMPHOCYTE; CELL FATE; CELL SELECTION; CELL SPECIFICITY; CONTROLLED STUDY; DIABETOGENESIS; EARLY RESPONSE GENE; FEMALE; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NR4A GENE; SIGNAL TRANSDUCTION; THYMUS; TRANSCRIPTION REGULATION; UPREGULATION; VARIABLE NUMBER OF TANDEM REPEAT; CASE CONTROL STUDY; GENE EXPRESSION PROFILING; GENETICS; GENOTYPE; IMMUNOLOGY; METABOLISM; MIDDLE AGED; T LYMPHOCYTE SUBPOPULATION; YOUNG ADULT;

ADULT; AUTOANTIGENS; AUTOIMMUNITY; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION PROFILING; GENOTYPE; HUMANS; INSULIN; MALE; MIDDLE AGED; PROINSULIN; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 84901300488     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098074     Document Type: Article

References (31)

1. Durinovic-Bello I, Boehm BO, Ziegler AG (2002) Predominantly recognized proinsulin T helper cell epitopes in individuals with and without islet cell autoimmunity. J Autoimmun 18(1): 55-66. (Pubitemid 34252594)
2. Arif S, Tree TI, Astill TP, Tremble JM, Bishop AJ, et al. (2004) Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest 113(3): 451-463. (Pubitemid 38544189)
3. Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, et al. (2005) Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435(7039): 220-223. (Pubitemid 40685949)
4. Durinovic-Bello I, Hummel M, Ziegler A-G (1996) Cellular immune response to diverse islet cell antigens in IDDM. Diabetes 45: 795-800. (Pubitemid 26166775)
5. Bennett ST, Lucassen AM, Gough SC, Powell EE, Undlien DE, et al. (1995) Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet 9(3): 284-292.
6. Pugliese A, Zeller M, Fernandez A Jr, Zalcberg LJ, Bartlett RJ, et al. (1997) The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 15(3): 293-297. (Pubitemid 27098726)
7. Durinovic-Bello I, Wu RP, Gersuk VH, Sanda S, Shilling HG, et al. (2010) Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin. Genes Immun 11(2): 188-193.
8. Fukui Y, Ishimoto T, Utsuyama M, Gyotoku T, Koga T, et al. (1997) Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus. Immunity 6: 401-410. (Pubitemid 27208195)
9. Sebzda E, Wallace VA, Mayer J, Yeung RS, Mak TW, et al. (1994) Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263(5153): 1615-1618. (Pubitemid 24128366)
10. Baldwin TA, Hogquist KA (2007) Transcriptional analysis of clonal deletion in vivo. J Immunol 179(2): 837-844.
11. Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, et al. (2013) Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis. Nat Immunol 14(3): 230-237.
12. Nepom GT (2012) MHC class II tetramers. J Immunol 188(6): 2477-2482.
13. Danke NA, Yang J, Greenbaum C, Kwok WW (2005) Comparative study of GAD65-specific CD4 + T cells in healthy and type 1 diabetic subjects. J Autoimmun 25(4): 303-311. (Pubitemid 41642977)
14. Yang J, Danke N, Roti M, Huston L, Greenbaum C, et al. (2008) CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope. J Autoimmun 31(1): 30-41.
15. Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, et al. (1997) Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet 15(3):2 89-292.
16. Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, et al. (2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23(5): 479-490. (Pubitemid 41587888)
17. Starr TK, Jameson SC, Hogquist KA (2003) Positive and negative selection of T cells. Annu Rev Immunol 21: 139-176. (Pubitemid 37174529)
18. Gebe JA, Yue BB, Unrath KA, Falk BA, Nepom GT (2009) Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms. J Immunol 183(1): 59-65.
19. Macian F, Garcia-Cozar F, Im SH, Horton HF, Byrne MC, et al. (2002) Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109(6): 719-731. (Pubitemid 34722268)
20. Collins S, Lutz MA, Zarek PE, Anders RA, Kersh GJ, et al. (2008) Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. Eur J Immunol 238(2): 528-536.
21. Zehn D, Bevan MJ (2006) T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 25(2): 261-270. (Pubitemid 44224142)
22. Liu GY, Fairchild PJ, Smith RM, Prowle JR, Kioussis D, et al. (1995) Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity 3(4): 407-415.
23. James EA, Kwok WW (2008) Low-affinity major histocompatibility complex-binding peptides in type 1 diabetes. Diabetes 57(7): 1788-1789.
24. Monti P, Scirpoli M, Rigamonti A, Mayr A, Jaeger A, et al. (2007) Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes. J Immunol 179(9): 5785-5792.
25. Gersuk VH, Nepom GT (2006) A real-time PCR approach for rapid high resolution subtyping of HLA-DRB1*04. J Immunol Methods 317(1-2): 64-70. (Pubitemid 44809203)
26. Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, et al. (2004) Remapping the insulin gene/IDDM2 locus in type 1 diabetes. Diabetes 53(7): 1884-1889. (Pubitemid 38857048)
27. Stead JD, Buard J, Todd JA, Jeffreys AJ (2000) Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes. Hum Mol Genet 9(20): 2929-2935. (Pubitemid 32000766)
28. Novak EJ, Liu AW, Nepom GT, Kwok WW (1999) MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen. J Clin Invest 104: R63-R67. (Pubitemid 30053194)
29. Durinovic-Bello I, Rosinger S, Olson JA, Congia M, Ahmad RC, et al. (2006) DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype. Proc Natl Acad Sci U S A 103(31): 11683-11688. (Pubitemid 44182511)
30. James EA, LaFond R, Durinovic-Bello I, Kwok W (2009) Visualizing antigen specific CD4+ T cells using MHC class II tetramers. J Vis Exp Mar 6: (25).
31. McDavid A, Finak G, Chattopadyay PK, Dominguez M, Lamoreaux L, et al. (2013) Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments. Bioinformatics 29(4): 461-467.