메뉴 건너뛰기




Volumn 47, Issue 10, 2015, Pages 2113-2126

Autophagy and amino acid metabolism in the brain: Implications for epilepsy

Author keywords

Epilepsy; Glutamine; Ketogenic diet; Leucine; Macroautophagy; mTOR

Indexed keywords

2 OXOISOVALERATE DEHYDROGENASE (LIPOAMIDE); 4 AMINOBUTYRIC ACID; ALANINE; GLUTAMIC ACID; GLUTAMINE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; HISTIDINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; METHIONINE; PROLINE; RAPAMYCIN; SUCCINYL COENZYME A SYNTHETASE; TRYPTOPHAN; TUBERIN; TYROSINE; AMINO ACID;

EID: 84942430203     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-014-1822-z     Document Type: Review
Times cited : (28)

References (120)
  • 3
    • 34249786877 scopus 로고    scopus 로고
    • Glutamine in the central nervous system: Function and dysfunction
    • 1:CAS:528:DC%2BD28Xht1WgsL3P 17127302
    • Albrecht J, Sonnewald U, Waagepetersen HS, Schousboe A (2007) Glutamine in the central nervous system: function and dysfunction. Front Biosci 12:332-343
    • (2007) Front Biosci , vol.12 , pp. 332-343
    • Albrecht, J.1    Sonnewald, U.2    Waagepetersen, H.S.3    Schousboe, A.4
  • 5
    • 33745893228 scopus 로고    scopus 로고
    • The glutamate/GABA-glutamine cycle: Aspects of transport, neurotransmitter homeostasis and ammonia transfer
    • 1:CAS:528:DC%2BD28XovFGhsL4%3D 16787421
    • Bak LK, Schousboe A, Waagepetersen HS (2006) The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer. J Neurochem 98:641-653
    • (2006) J Neurochem , vol.98 , pp. 641-653
    • Bak, L.K.1    Schousboe, A.2    Waagepetersen, H.S.3
  • 6
    • 77954237882 scopus 로고    scopus 로고
    • Network organization of the human autophagy system
    • 2901998 1:CAS:528:DC%2BC3cXns1Gis7Y%3D 20562859
    • Behrends C, Sowa ME, Gygi SP, Harper JW (2010) Network organization of the human autophagy system. Nature 466:68-76
    • (2010) Nature , vol.466 , pp. 68-76
    • Behrends, C.1    Sowa, M.E.2    Gygi, S.P.3    Harper, J.W.4
  • 7
    • 84861663288 scopus 로고    scopus 로고
    • Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner
    • 3364179 1:CAS:528:DC%2BC38XotlWrsLw%3D 22496425
    • Bejarano E, Girao H, Yuste A, Patel B, Marques C, Spray DC, Pereira P, Cuervo AM (2012) Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner. Mol Biol Cell 23:2156-2169
    • (2012) Mol Biol Cell , vol.23 , pp. 2156-2169
    • Bejarano, E.1    Girao, H.2    Yuste, A.3    Patel, B.4    Marques, C.5    Spray, D.C.6    Pereira, P.7    Cuervo, A.M.8
  • 9
    • 0021707433 scopus 로고
    • Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
    • 1:CAS:528:DyaL2cXmt1yjt7k%3D 6149259
    • Benveniste H, Drejer J, Schousboe A, Diemer NH (1984) Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43:1369-1374
    • (1984) J Neurochem , vol.43 , pp. 1369-1374
    • Benveniste, H.1    Drejer, J.2    Schousboe, A.3    Diemer, N.H.4
  • 10
    • 0028079585 scopus 로고
    • Endocrine and amino acid regulation of liver macroautophagy and proteolytic function
    • 1:CAS:528:DyaK2cXhsF2ltb0%3D 8304450
    • Bergamini E, Del Roso A, Gori Z, Masiello P, Masini M, Pollera M (1994) Endocrine and amino acid regulation of liver macroautophagy and proteolytic function. Am J Physiol 266:G118-G122
    • (1994) Am J Physiol , vol.266 , pp. G118-G122
    • Bergamini, E.1    Del Roso, A.2    Gori, Z.3    Masiello, P.4    Masini, M.5    Pollera, M.6
  • 11
    • 35948982621 scopus 로고    scopus 로고
    • The role of autophagy in aging: Its essential part in the anti-aging mechanism of caloric restriction
    • 1:CAS:528:DC%2BD2sXhsVGqu7bP 17934054
    • Bergamini E, Cavallini G, Donati A, Gori Z (2007) The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restriction. Ann N Y Acad Sci 1114:69-78
    • (2007) Ann N y Acad Sci , vol.1114 , pp. 69-78
    • Bergamini, E.1    Cavallini, G.2    Donati, A.3    Gori, Z.4
  • 12
    • 0028899789 scopus 로고
    • Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
    • 1:CAS:528:DyaK2MXjsV2kt7s%3D 7836465
    • Blommaart EF, Luiken JJ, Blommaart PJ, van Woerkom GM, Meijer AJ (1995) Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem 270:2320-2326
    • (1995) J Biol Chem , vol.270 , pp. 2320-2326
    • Blommaart, E.F.1    Luiken, J.J.2    Blommaart, P.J.3    Van Woerkom, G.M.4    Meijer, A.J.5
  • 13
    • 67649962153 scopus 로고    scopus 로고
    • Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit
    • 2740923 1:CAS:528:DC%2BD1MXosFeksb0%3D 19571121
    • Blouet C, Jo YH, Li X, Schwartz GJ (2009) Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. J Neurosci 29:8302-8311
    • (2009) J Neurosci , vol.29 , pp. 8302-8311
    • Blouet, C.1    Jo, Y.H.2    Li, X.3    Schwartz, G.J.4
  • 14
    • 13044258426 scopus 로고    scopus 로고
    • Selective expression of the large neutral amino acid transporter at the blood-brain barrier
    • 18415 1:CAS:528:DyaK1MXmvVGjtrw%3D 10518579
    • Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM (1999) Selective expression of the large neutral amino acid transporter at the blood-brain barrier. Proc Natl Acad Sci USA 96:12079-12084
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12079-12084
    • Boado, R.J.1    Li, J.Y.2    Nagaya, M.3    Zhang, C.4    Pardridge, W.M.5
  • 15
    • 49049096562 scopus 로고    scopus 로고
    • Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
    • 2676733 1:CAS:528:DC%2BD1cXot1OqtLk%3D 18596167
    • Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA (2008) Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci 28:6926-6937
    • (2008) J Neurosci , vol.28 , pp. 6926-6937
    • Boland, B.1    Kumar, A.2    Lee, S.3    Platt, F.M.4    Wegiel, J.5    Yu, W.H.6    Nixon, R.A.7
  • 16
    • 84880376355 scopus 로고    scopus 로고
    • Emerging regulation and functions of autophagy
    • 1:CAS:528:DC%2BC3sXhtVehurzO 23817233
    • Boya P, Reggiori F, Codogno P (2013) Emerging regulation and functions of autophagy. Nat Cell Biol 15:713-720
    • (2013) Nat Cell Biol , vol.15 , pp. 713-720
    • Boya, P.1    Reggiori, F.2    Codogno, P.3
  • 17
    • 79951531485 scopus 로고    scopus 로고
    • Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
    • 3073836 1:CAS:528:DC%2BC3MXit1antbw%3D 21307269
    • Buckmaster PS, Lew FH (2011) Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J Neurosci 31:2337-2347
    • (2011) J Neurosci , vol.31 , pp. 2337-2347
    • Buckmaster, P.S.1    Lew, F.H.2
  • 20
    • 84894353191 scopus 로고    scopus 로고
    • Long-distance mechanism of neurotransmitter recycling mediated by glial network facilitates visual function in Drosophila
    • 3932938 1:CAS:528:DC%2BC2cXivFaju7o%3D 24550312
    • Chaturvedi R, Reddig K, Li HS (2014) Long-distance mechanism of neurotransmitter recycling mediated by glial network facilitates visual function in Drosophila. Proc Natl Acad Sci USA 111:2812-2817
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 2812-2817
    • Chaturvedi, R.1    Reddig, K.2    Li, H.S.3
  • 21
    • 0034633653 scopus 로고    scopus 로고
    • The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics
    • 17239 1:CAS:528:DC%2BD3cXnsF2qsLk%3D 10984509
    • Chen L, Wang H, Vicini S, Olsen RW (2000) The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics. Proc Natl Acad Sci USA 97:11557-11562
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11557-11562
    • Chen, L.1    Wang, H.2    Vicini, S.3    Olsen, R.W.4
  • 22
    • 84863095997 scopus 로고    scopus 로고
    • Expression of mitochondrial branched-chain aminotransferase and alpha-keto-acid dehydrogenase in rat brain: Implications for neurotransmitter metabolism
    • 3361127 1:CAS:528:DC%2BC38XptV2itbc%3D 22654736
    • Cole JT, Sweatt AJ, Hutson SM (2012) Expression of mitochondrial branched-chain aminotransferase and alpha-keto-acid dehydrogenase in rat brain: implications for neurotransmitter metabolism. Front Neuroanat 6:18
    • (2012) Front Neuroanat , vol.6 , pp. 18
    • Cole, J.T.1    Sweatt, A.J.2    Hutson, S.M.3
  • 23
    • 84856953003 scopus 로고    scopus 로고
    • Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation
    • 3278575 1:CAS:528:DC%2BC38XhsVeisb8%3D 22285542
    • Coupe B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG (2012) Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation. Cell Metab 15:247-255
    • (2012) Cell Metab , vol.15 , pp. 247-255
    • Coupe, B.1    Ishii, Y.2    Dietrich, M.O.3    Komatsu, M.4    Horvath, T.L.5    Bouret, S.G.6
  • 25
    • 84894212463 scopus 로고    scopus 로고
    • Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
    • 4346203 1:CAS:528:DC%2BC2cXisFelsbs%3D 24529380
    • Demetriades C, Doumpas N, Teleman AA (2014) Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell 156:786-799
    • (2014) Cell , vol.156 , pp. 786-799
    • Demetriades, C.1    Doumpas, N.2    Teleman, A.A.3
  • 26
    • 0014148066 scopus 로고
    • Participation of lysosomes in cellular autophagy induced in rat liver by glucagon
    • 2107130 1:STN:280:DyaF1c%2FktVemsQ%3D%3D 6055998
    • Deter RL, Baudhuin P, De Duve C (1967) Participation of lysosomes in cellular autophagy induced in rat liver by glucagon. J Cell Biol 35:C11-C16
    • (1967) J Cell Biol , vol.35 , pp. C11-C16
    • Deter, R.L.1    Baudhuin, P.2    De Duve, C.3
  • 27
    • 84865531819 scopus 로고    scopus 로고
    • Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder
    • 3435187 22826245
    • Di Malta C, Fryer JD, Settembre C, Ballabio A (2012) Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder. Proc Natl Acad Sci USA 109:E2334-E2342
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. E2334-E2342
    • Di Malta, C.1    Fryer, J.D.2    Settembre, C.3    Ballabio, A.4
  • 29
    • 80053476420 scopus 로고    scopus 로고
    • The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
    • 21460621
    • Egan D, Kim J, Shaw RJ, Guan KL (2011a) The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy 7:643-644
    • (2011) Autophagy , vol.7 , pp. 643-644
    • Egan, D.1    Kim, J.2    Shaw, R.J.3    Guan, K.L.4
  • 31
    • 77953861522 scopus 로고    scopus 로고
    • Ammonia derived from glutaminolysis is a diffusible regulator of autophagy
    • 20424262
    • Eng CH, Yu K, Lucas J, White E, Abraham RT (2010) Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Sci Signal 3:ra31
    • (2010) Sci Signal , vol.3 , pp. ra31
    • Eng, C.H.1    Yu, K.2    Lucas, J.3    White, E.4    Abraham, R.T.5
  • 32
    • 0029833561 scopus 로고    scopus 로고
    • Regulation of GABA level in rat brain synaptosomes: Fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies
    • 1:CAS:528:DyaK28Xnt1Squ7Y%3D 8931464
    • Erecinska M, Nelson D, Daikhin Y, Yudkoff M (1996) Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies. J Neurochem 67:2325-2334
    • (1996) J Neurochem , vol.67 , pp. 2325-2334
    • Erecinska, M.1    Nelson, D.2    Daikhin, Y.3    Yudkoff, M.4
  • 33
    • 84882677526 scopus 로고    scopus 로고
    • Large neutral amino acids: Dietary effects on brain neurochemistry and function
    • 1:CAS:528:DC%2BC3sXht1Oit77F 22677921
    • Fernstrom JD (2013) Large neutral amino acids: dietary effects on brain neurochemistry and function. Amino Acids 45:419-430
    • (2013) Amino Acids , vol.45 , pp. 419-430
    • Fernstrom, J.D.1
  • 34
    • 21844440290 scopus 로고    scopus 로고
    • Ketone bodies stimulate chaperone-mediated autophagy
    • 1:CAS:528:DC%2BD2MXlslyksLs%3D 15883160
    • Finn PF, Dice JF (2005) Ketone bodies stimulate chaperone-mediated autophagy. J Biol Chem 280:25864-25870
    • (2005) J Biol Chem , vol.280 , pp. 25864-25870
    • Finn, P.F.1    Dice, J.F.2
  • 38
    • 3242727927 scopus 로고    scopus 로고
    • Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency
    • 1:CAS:528:DC%2BD2cXlslOqu7s%3D 15262267
    • Gupta M, Polinsky M, Senephansiri H, Snead OC, Jansen EE, Jakobs C, Gibson KM (2004) Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency. Neurobiol Dis 16:556-562
    • (2004) Neurobiol Dis , vol.16 , pp. 556-562
    • Gupta, M.1    Polinsky, M.2    Senephansiri, H.3    Snead, O.C.4    Jansen, E.E.5    Jakobs, C.6    Gibson, K.M.7
  • 40
    • 84862777407 scopus 로고    scopus 로고
    • Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
    • 1:CAS:528:DC%2BC38Xkt1Gnsbw%3D 22424946
    • Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH, Kim S (2012) Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 149:410-424
    • (2012) Cell , vol.149 , pp. 410-424
    • Han, J.M.1    Jeong, S.J.2    Park, M.C.3    Kim, G.4    Kwon, N.H.5    Kim, H.K.6    Ha, S.H.7    Ryu, S.H.8    Kim, S.9
  • 41
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • 1:CAS:528:DyaK1cXjs1Oqs74%3D 9603962
    • Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J (1998) Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 273:14484-14494
    • (1998) J Biol Chem , vol.273 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 43
    • 84875265574 scopus 로고    scopus 로고
    • Harnessing the power of metabolism for seizure prevention: Focus on dietary treatments
    • 3562425 23110824
    • Hartman AL, Stafstrom CE (2013) Harnessing the power of metabolism for seizure prevention: focus on dietary treatments. Epilepsy Behav 26:266-272
    • (2013) Epilepsy Behav , vol.26 , pp. 266-272
    • Hartman, A.L.1    Stafstrom, C.E.2
  • 44
    • 84867249241 scopus 로고    scopus 로고
    • Exercise induces autophagy in peripheral tissues and in the brain
    • 3463459 1:CAS:528:DC%2BC3sXisVGgtr8%3D 22892563
    • He C, Sumpter R Jr, Levine B (2012) Exercise induces autophagy in peripheral tissues and in the brain. Autophagy 8:1548-1551
    • (2012) Autophagy , vol.8 , pp. 1548-1551
    • He, C.1    Sumpter, R.2    Levine, B.3
  • 46
    • 77955845741 scopus 로고    scopus 로고
    • Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
    • 2926303 1:CAS:528:DC%2BC3cXhtVGrt7zP 20566381
    • Huang X, Zhang H, Yang J, Wu J, McMahon J, Lin Y, Cao Z, Gruenthal M, Huang Y (2010) Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy. Neurobiol Dis 40:193-199
    • (2010) Neurobiol Dis , vol.40 , pp. 193-199
    • Huang, X.1    Zhang, H.2    Yang, J.3    Wu, J.4    McMahon, J.5    Lin, Y.6    Cao, Z.7    Gruenthal, M.8    Huang, Y.9
  • 47
    • 0035095315 scopus 로고    scopus 로고
    • Function of leucine in excitatory neurotransmitter metabolism in the central nervous system
    • 1:STN:280:DC%2BD3M3hs1agtA%3D%3D 11238772
    • Hutson SM, Lieth E, LaNoue KF (2001) Function of leucine in excitatory neurotransmitter metabolism in the central nervous system. J Nutr 131:846S-850S
    • (2001) J Nutr , vol.131 , pp. 846S-850S
    • Hutson, S.M.1    Lieth, E.2    LaNoue, K.F.3
  • 48
    • 0038682500 scopus 로고    scopus 로고
    • Amino acid transporters: Roles in amino acid sensing and signalling in animal cells
    • 1223487 1:CAS:528:DC%2BD3sXkvVentrg%3D 12879880
    • Hyde R, Taylor PM, Hundal HS (2003) Amino acid transporters: roles in amino acid sensing and signalling in animal cells. Biochem J 373:1-18
    • (2003) Biochem J , vol.373 , pp. 1-18
    • Hyde, R.1    Taylor, P.M.2    Hundal, H.S.3
  • 50
    • 0038050536 scopus 로고    scopus 로고
    • Amino acids as regulators of proteolysis
    • 1:CAS:528:DC%2BD3sXksFeqsbw%3D 12771364
    • Kadowaki M, Kanazawa T (2003) Amino acids as regulators of proteolysis. J Nutr 133:2052S-2056S
    • (2003) J Nutr , vol.133 , pp. 2052S-2056S
    • Kadowaki, M.1    Kanazawa, T.2
  • 51
    • 0034617273 scopus 로고    scopus 로고
    • Transport properties of a system y + L neutral and basic amino acid transporter. Insights into the mechanisms of substrate recognition
    • 1:CAS:528:DC%2BD3cXkvVyht7o%3D 10777485
    • Kanai Y, Fukasawa Y, Cha SH, Segawa H, Chairoungdua A, Kim DK, Matsuo H, Kim JY, Miyamoto K, Takeda E, Endou H (2000) Transport properties of a system y + L neutral and basic amino acid transporter. Insights into the mechanisms of substrate recognition. J Biol Chem 275:20787-20793
    • (2000) J Biol Chem , vol.275 , pp. 20787-20793
    • Kanai, Y.1    Fukasawa, Y.2    Cha, S.H.3    Segawa, H.4    Chairoungdua, A.5    Kim, D.K.6    Matsuo, H.7    Kim, J.Y.8    Miyamoto, K.9    Takeda, E.10    Endou, H.11
  • 55
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • 3987946 1:CAS:528:DC%2BC3MXhtlamtb0%3D 21258367
    • Kim J, Kundu M, Viollet B, Guan KL (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13:132-141
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 59
    • 79960352475 scopus 로고    scopus 로고
    • The monoamine neurotransmitter disorders: An expanding range of neurological syndromes
    • 1:CAS:528:DC%2BC3MXptlyqsb4%3D 21777827
    • Kurian MA, Gissen P, Smith M, Heales S Jr, Clayton PT (2011) The monoamine neurotransmitter disorders: an expanding range of neurological syndromes. Lancet Neurol 10:721-733
    • (2011) Lancet Neurol , vol.10 , pp. 721-733
    • Kurian, M.A.1    Gissen, P.2    Smith, M.3    Heales, S.4    Clayton, P.T.5
  • 60
    • 0034305620 scopus 로고    scopus 로고
    • Phosphate-activated glutaminase and mitochondrial glutamine transport in the brain
    • 1:CAS:528:DC%2BD3cXns1eiur4%3D 11059811
    • Kvamme E, Roberg B, Torgner IA (2000) Phosphate-activated glutaminase and mitochondrial glutamine transport in the brain. Neurochem Res 25:1407-1419
    • (2000) Neurochem Res , vol.25 , pp. 1407-1419
    • Kvamme, E.1    Roberg, B.2    Torgner, I.A.3
  • 61
    • 34047154536 scopus 로고    scopus 로고
    • ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase
    • 1852764 1:CAS:528:DC%2BD2sXjs1yqtLY%3D 17347671
    • Lee SB, Kim S, Lee J, Park J, Lee G, Kim Y, Kim JM, Chung J (2007) ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase. EMBO Rep 8:360-365
    • (2007) EMBO Rep , vol.8 , pp. 360-365
    • Lee, S.B.1    Kim, S.2    Lee, J.3    Park, J.4    Lee, G.5    Kim, Y.6    Kim, J.M.7    Chung, J.8
  • 62
    • 78149476877 scopus 로고    scopus 로고
    • The association of AMPK with ULK1 regulates autophagy
    • 2972217 21072212
    • Lee JW, Park S, Takahashi Y, Wang HG (2010) The association of AMPK with ULK1 regulates autophagy. PLoS ONE 5:e15394
    • (2010) PLoS ONE , vol.5 , pp. e15394
    • Lee, J.W.1    Park, S.2    Takahashi, Y.3    Wang, H.G.4
  • 63
    • 0025801462 scopus 로고
    • Leucine: Effector of phosphate activated glutaminase in rat cerebral cortex
    • 1:CAS:528:DyaK3MXktVGrtL8%3D 2052140
    • Lellos V, Tselentis V, Galanopoulos E, Philippidis H, Palaiologos G (1991) Leucine: effector of phosphate activated glutaminase in rat cerebral cortex. Neurochem Res 16:67-71
    • (1991) Neurochem Res , vol.16 , pp. 67-71
    • Lellos, V.1    Tselentis, V.2    Galanopoulos, E.3    Philippidis, H.4    Palaiologos, G.5
  • 64
    • 0022509201 scopus 로고
    • In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis
    • 1:CAS:528:DyaL28XmtVegsL0%3D 3790989
    • Lerma J, Herranz AS, Herreras O, Abraira V, Martin del Rio R (1986) In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis. Brain Res 384:145-155
    • (1986) Brain Res , vol.384 , pp. 145-155
    • Lerma, J.1    Herranz, A.S.2    Herreras, O.3    Abraira, V.4    Martin Del Rio, R.5
  • 67
  • 68
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • 1:CAS:528:DC%2BD2MXht1emuro%3D 15680329
    • Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120:237-248
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6    Thompson, C.B.7
  • 69
    • 33644934376 scopus 로고    scopus 로고
    • Specific distribution of gabarap, gec1/gabarap Like 1, gate16/gabarap Like 2, lc3 messenger RNAs in rat brain areas by quantitative real-time PCR
    • 16458273
    • Mansuy-Schlick V, Tolle F, Delage-Mourroux R, Fraichard A, Risold PY, Jouvenot M (2006) Specific distribution of gabarap, gec1/gabarap Like 1, gate16/gabarap Like 2, lc3 messenger RNAs in rat brain areas by quantitative real-time PCR. Brain Res 1073-1074:83-87
    • (2006) Brain Res , vol.1073-1074 , pp. 83-87
    • Mansuy-Schlick, V.1    Tolle, F.2    Delage-Mourroux, R.3    Fraichard, A.4    Risold, P.Y.5    Jouvenot, M.6
  • 71
    • 79957877029 scopus 로고    scopus 로고
    • The impact of dietary energy intake on cognitive aging
    • 2874403 20552045
    • Mattson MP (2010) The impact of dietary energy intake on cognitive aging. Front Aging Neurosci 2:5
    • (2010) Front Aging Neurosci , vol.2 , pp. 5
    • Mattson, M.P.1
  • 72
    • 79952570329 scopus 로고    scopus 로고
    • The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway
    • 3076631 1:CAS:528:DC%2BC3MXnvVaquro%3D 21371020
    • McDaniel SS, Rensing NR, Thio LL, Yamada KA, Wong M (2011) The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway. Epilepsia 52:e7-e11
    • (2011) Epilepsia , vol.52 , pp. e7-e11
    • McDaniel, S.S.1    Rensing, N.R.2    Thio, L.L.3    Yamada, K.A.4    Wong, M.5
  • 73
    • 80052290024 scopus 로고    scopus 로고
    • Glutamate dehydrogenase in brain mitochondria: Do lipid modifications and transient metabolon formation influence enzyme activity?
    • 3459329 1:CAS:528:DC%2BC3MXhtV2nurvO 21771624
    • McKenna MC (2011) Glutamate dehydrogenase in brain mitochondria: do lipid modifications and transient metabolon formation influence enzyme activity? Neurochem Int 59:525-533
    • (2011) Neurochem Int , vol.59 , pp. 525-533
    • McKenna, M.C.1
  • 74
    • 84868592137 scopus 로고    scopus 로고
    • Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis
    • 3501684 1:CAS:528:DC%2BC38Xhs1ygtrjF 23136410
    • McMahon J, Huang X, Yang J, Komatsu M, Yue Z, Qian J, Zhu X, Huang Y (2012) Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis. J Neurosci 32:15704-15714
    • (2012) J Neurosci , vol.32 , pp. 15704-15714
    • McMahon, J.1    Huang, X.2    Yang, J.3    Komatsu, M.4    Yue, Z.5    Qian, J.6    Zhu, X.7    Huang, Y.8
  • 75
    • 84881474333 scopus 로고    scopus 로고
    • Role of the mTOR signaling pathway in epilepsy
    • 1:CAS:528:DC%2BC3sXpslCrs7w%3D 23773767
    • Meng XF, Yu JT, Song JH, Chi S, Tan L (2013) Role of the mTOR signaling pathway in epilepsy. J Neurol Sci 332:4-15
    • (2013) J Neurol Sci , vol.332 , pp. 4-15
    • Meng, X.F.1    Yu, J.T.2    Song, J.H.3    Chi, S.4    Tan, L.5
  • 76
    • 1542283812 scopus 로고    scopus 로고
    • In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
    • 363084 1:CAS:528:DC%2BD2cXitlGhu7g%3D 14699058
    • Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15:1101-1111
    • (2004) Mol Biol Cell , vol.15 , pp. 1101-1111
    • Mizushima, N.1    Yamamoto, A.2    Matsui, M.3    Yoshimori, T.4    Ohsumi, Y.5
  • 77
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • 2670399 1:CAS:528:DC%2BD1cXisFWjt78%3D 18305538
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069-1075
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 78
    • 0023065242 scopus 로고
    • Intracellular protein catabolism and its control during nutrient deprivation and supply
    • 1:CAS:528:DyaL2sXkvFGksrc%3D 3300746
    • Mortimore GE, Poso AR (1987) Intracellular protein catabolism and its control during nutrient deprivation and supply. Annu Rev Nutr 7:539-564
    • (1987) Annu Rev Nutr , vol.7 , pp. 539-564
    • Mortimore, G.E.1    Poso, A.R.2
  • 79
    • 0017697151 scopus 로고
    • Induction of autophagy by amino-acid deprivation in perfused rat liver
    • 1:STN:280:DyaE1c%2FltFWnug%3D%3D 927529
    • Mortimore GE, Schworer CM (1977) Induction of autophagy by amino-acid deprivation in perfused rat liver. Nature 270:174-176
    • (1977) Nature , vol.270 , pp. 174-176
    • Mortimore, G.E.1    Schworer, C.M.2
  • 80
    • 0028120314 scopus 로고
    • Leucine-specific binding of photoreactive Leu7-MAP to a high molecular weight protein on the plasma membrane of the isolated rat hepatocyte
    • 1:CAS:528:DyaK2cXlslKisL0%3D 8074656
    • Mortimore GE, Wert JJ Jr, Miotto G, Venerando R, Kadowaki M (1994) Leucine-specific binding of photoreactive Leu7-MAP to a high molecular weight protein on the plasma membrane of the isolated rat hepatocyte. Biochem Biophys Res Commun 203:200-208
    • (1994) Biochem Biophys Res Commun , vol.203 , pp. 200-208
    • Mortimore, G.E.1    Wert, J.J.2    Miotto, G.3    Venerando, R.4    Kadowaki, M.5
  • 81
    • 84880567639 scopus 로고    scopus 로고
    • Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle
    • 3774374 1:CAS:528:DC%2BC3sXhtFeksLjJ 23744068
    • Naito T, Kuma A, Mizushima N (2013) Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle. J Biol Chem 288:21074-21081
    • (2013) J Biol Chem , vol.288 , pp. 21074-21081
    • Naito, T.1    Kuma, A.2    Mizushima, N.3
  • 84
    • 84882254367 scopus 로고    scopus 로고
    • The role of autophagy in neurodegenerative disease
    • Nixon RA (2014) The role of autophagy in neurodegenerative disease. Nat Med 19:983-997
    • (2014) Nat Med , vol.19 , pp. 983-997
    • Nixon, R.A.1
  • 87
    • 0035936814 scopus 로고    scopus 로고
    • Regulation of the activity of branched-chain 2-oxo acid dehydrogenase (BCODH) complex by binding BCODH kinase
    • 1:CAS:528:DC%2BD3MXhsFShsrk%3D 11226417
    • Obayashi M, Sato Y, Harris RA, Shimomura Y (2001) Regulation of the activity of branched-chain 2-oxo acid dehydrogenase (BCODH) complex by binding BCODH kinase. FEBS Lett 491:50-54
    • (2001) FEBS Lett , vol.491 , pp. 50-54
    • Obayashi, M.1    Sato, Y.2    Harris, R.A.3    Shimomura, Y.4
  • 88
    • 24744441497 scopus 로고    scopus 로고
    • Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation
    • 1:CAS:528:DC%2BD2MXpslaqu7c%3D 16027116
    • Onodera J, Ohsumi Y (2005) Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem 280:31582-31586
    • (2005) J Biol Chem , vol.280 , pp. 31582-31586
    • Onodera, J.1    Ohsumi, Y.2
  • 89
    • 84898041750 scopus 로고    scopus 로고
    • Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle
    • 3986127 1:CAS:528:DC%2BC2cXkvVGku7s%3D 24706914
    • Patel AB, Lai JC, Chowdhury GM, Hyder F, Rothman DL, Shulman RG, Behar KL (2014) Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle. Proc Natl Acad Sci USA 111:5385-5390
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 5385-5390
    • Patel, A.B.1    Lai, J.C.2    Chowdhury, G.M.3    Hyder, F.4    Rothman, D.L.5    Shulman, R.G.6    Behar, K.L.7
  • 90
    • 0001437616 scopus 로고    scopus 로고
    • Bidirectional modulation of insulin action by amino acids
    • 508730 1:CAS:528:DyaK1cXitleksbk%3D 9525995
    • Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CR (1998) Bidirectional modulation of insulin action by amino acids. J Clin Invest 101:1519-1529
    • (1998) J Clin Invest , vol.101 , pp. 1519-1529
    • Patti, M.E.1    Brambilla, E.2    Luzi, L.3    Landaker, E.J.4    Kahn, C.R.5
  • 91
    • 64249112098 scopus 로고    scopus 로고
    • Branched-chain 2-oxoacid transamination increases GABA-shunt metabolism and insulin secretion in isolated islets
    • 1:CAS:528:DC%2BD1MXjs1yntLw%3D 19173679
    • Pizarro-Delgado J, Hernandez-Fisac I, Martin-Del-Rio R, Tamarit-Rodriguez J (2009) Branched-chain 2-oxoacid transamination increases GABA-shunt metabolism and insulin secretion in isolated islets. Biochem J 419:359-368
    • (2009) Biochem J , vol.419 , pp. 359-368
    • Pizarro-Delgado, J.1    Hernandez-Fisac, I.2    Martin-Del-Rio, R.3    Tamarit-Rodriguez, J.4
  • 92
    • 79958184395 scopus 로고    scopus 로고
    • A pulse rapamycin therapy for infantile spasms and associated cognitive decline
    • 3114281 1:CAS:528:DC%2BC3MXnsFWhtbY%3D 21504792
    • Raffo E, Coppola A, Ono T, Briggs SW, Galanopoulou AS (2011) A pulse rapamycin therapy for infantile spasms and associated cognitive decline. Neurobiol Dis 43:322-329
    • (2011) Neurobiol Dis , vol.43 , pp. 322-329
    • Raffo, E.1    Coppola, A.2    Ono, T.3    Briggs, S.W.4    Galanopoulou, A.S.5
  • 93
    • 79953136700 scopus 로고    scopus 로고
    • Autophagy and lipids: Tightening the knot
    • 1:CAS:528:DC%2BC3cXhsFCgt73L 20730586
    • Rodriguez-Navarro JA, Cuervo AM (2010) Autophagy and lipids: tightening the knot. Semin Immunopathol 32:343-353
    • (2010) Semin Immunopathol , vol.32 , pp. 343-353
    • Rodriguez-Navarro, J.A.1    Cuervo, A.M.2
  • 96
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM (2008) Ragulator-rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141:290-303
    • (2008) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 98
  • 100
    • 84873276759 scopus 로고    scopus 로고
    • Central leucine sensing in the control of energy homeostasis
    • 3568262 1:CAS:528:DC%2BC3sXhs1WmsA%3D%3D 23391241
    • Schwartz GJ (2013) Central leucine sensing in the control of energy homeostasis. Endocrinol Metab Clin North Am 42:81-87
    • (2013) Endocrinol Metab Clin North Am , vol.42 , pp. 81-87
    • Schwartz, G.J.1
  • 102
    • 33947591870 scopus 로고    scopus 로고
    • Branched chain keto-acids exert biphasic effects on alpha-ketoglutarate-stimulated respiration in intact rat liver mitochondria
    • 1:CAS:528:DC%2BD2sXjtlymsbY%3D 17342410
    • Shestopalov AI, Kristal BS (2007) Branched chain keto-acids exert biphasic effects on alpha-ketoglutarate-stimulated respiration in intact rat liver mitochondria. Neurochem Res 32:947-951
    • (2007) Neurochem Res , vol.32 , pp. 947-951
    • Shestopalov, A.I.1    Kristal, B.S.2
  • 103
    • 79955631150 scopus 로고    scopus 로고
    • Autophagy in the cellular energetic balance
    • Singh R, Cuervo AM (2013) Autophagy in the cellular energetic balance. Cell Metab 13:495-504
    • (2013) Cell Metab , vol.13 , pp. 495-504
    • Singh, R.1    Cuervo, A.M.2
  • 104
    • 84856303217 scopus 로고    scopus 로고
    • The role of glutamate dehydrogenase in mammalian ammonia metabolism
    • 1:CAS:528:DC%2BC3MXhs1GhtL3M 22038055
    • Spanaki C, Plaitakis A (2012) The role of glutamate dehydrogenase in mammalian ammonia metabolism. Neurotox Res 21:117-127
    • (2012) Neurotox Res , vol.21 , pp. 117-127
    • Spanaki, C.1    Plaitakis, A.2
  • 105
    • 84896731458 scopus 로고    scopus 로고
    • A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release
    • 4001919 1:CAS:528:DC%2BC2cXivFCnsrY%3D 24559677
    • Tani H, Dulla CG, Farzampour Z, Taylor-Weiner A, Huguenard JR, Reimer RJ (2014) A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release. Neuron 81:888-900
    • (2014) Neuron , vol.81 , pp. 888-900
    • Tani, H.1    Dulla, C.G.2    Farzampour, Z.3    Taylor-Weiner, A.4    Huguenard, J.R.5    Reimer, R.J.6
  • 106
    • 79960226234 scopus 로고    scopus 로고
    • Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease
    • 1:CAS:528:DC%2BC3MXptVOjsrc%3D 21684337
    • Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K (2011) Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease. Neurobiol Dis 43:690-697
    • (2011) Neurobiol Dis , vol.43 , pp. 690-697
    • Tanji, K.1    Mori, F.2    Kakita, A.3    Takahashi, H.4    Wakabayashi, K.5
  • 107
    • 41049092706 scopus 로고    scopus 로고
    • Autophagic neuron death in neonatal brain ischemia/hypoxia
    • 1:CAS:528:DC%2BD1cXntFyntLk%3D 18212531
    • Uchiyama Y, Koike M, Shibata M (2008) Autophagic neuron death in neonatal brain ischemia/hypoxia. Autophagy 4:404-408
    • (2008) Autophagy , vol.4 , pp. 404-408
    • Uchiyama, Y.1    Koike, M.2    Shibata, M.3
  • 109
    • 0141676472 scopus 로고    scopus 로고
    • Compartmentation of glutamine, glutamate, and GABA metabolism in neurons and astrocytes: Functional implications
    • 1:CAS:528:DC%2BD3sXoslajsbc%3D 14580123
    • Waagepetersen HS, Sonnewald U, Schousboe A (2003) Compartmentation of glutamine, glutamate, and GABA metabolism in neurons and astrocytes: functional implications. Neuroscientist 9:398-403
    • (2003) Neuroscientist , vol.9 , pp. 398-403
    • Waagepetersen, H.S.1    Sonnewald, U.2    Schousboe, A.3
  • 110
    • 77954116814 scopus 로고    scopus 로고
    • Autophagy gone awry in neurodegenerative diseases
    • Wong E, Cuervo AM (2011) Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13:805-811
    • (2011) Nat Neurosci , vol.13 , pp. 805-811
    • Wong, E.1    Cuervo, A.M.2
  • 112
    • 84896722838 scopus 로고    scopus 로고
    • MTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits
    • 1:CAS:528:DC%2BC2cXkslWjurY%3D 24525424
    • Yang F, Chu X, Yin M, Liu X, Yuan H, Niu Y, Fu L (2014) mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits. Behav Brain Res 264:82-90
    • (2014) Behav Brain Res , vol.264 , pp. 82-90
    • Yang, F.1    Chu, X.2    Yin, M.3    Liu, X.4    Yuan, H.5    Niu, Y.6    Fu, L.7
  • 113
    • 4344689871 scopus 로고    scopus 로고
    • Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: Implications for beta-amyloid peptide over-production and localization in Alzheimer's disease
    • 1:CAS:528:DC%2BD2cXmvFelsr4%3D 15325590
    • Yu WH, Kumar A, Peterhoff C, Shapiro Kulnane L, Uchiyama Y, Lamb BT, Cuervo AM, Nixon RA (2004) Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. Int J Biochem Cell Biol 36:2531-2540
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2531-2540
    • Yu, W.H.1    Kumar, A.2    Peterhoff, C.3    Shapiro Kulnane, L.4    Uchiyama, Y.5    Lamb, B.T.6    Cuervo, A.M.7    Nixon, R.A.8
  • 115
    • 55349091074 scopus 로고    scopus 로고
    • Ketosis and brain handling of glutamate, glutamine, and GABA
    • 2722878 19049594
    • Yudkoff M, Daikhin Y, Horyn O, Nissim I (2008) Ketosis and brain handling of glutamate, glutamine, and GABA. Epilepsia 49(Suppl 8):73-75
    • (2008) Epilepsia , vol.49 , pp. 73-75
    • Yudkoff, M.1    Daikhin, Y.2    Horyn, O.3    Nissim, I.4
  • 116
    • 0035577775 scopus 로고    scopus 로고
    • Differential expression of glutamate dehydrogenase in cultured neurons and astrocytes from mouse cerebellum and cerebral cortex
    • 1:CAS:528:DC%2BD3MXpt1Sgt7Y%3D 11746418
    • Zaganas I, Waagepetersen HS, Georgopoulos P, Sonnewald U, Plaitakis A, Schousboe A (2001) Differential expression of glutamate dehydrogenase in cultured neurons and astrocytes from mouse cerebellum and cerebral cortex. J Neurosci Res 66:909-913
    • (2001) J Neurosci Res , vol.66 , pp. 909-913
    • Zaganas, I.1    Waagepetersen, H.S.2    Georgopoulos, P.3    Sonnewald, U.4    Plaitakis, A.5    Schousboe, A.6
  • 117
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • 3937593 1:CAS:528:DC%2BD1cXmsFGqt7c%3D 18389497
    • Zeng LH, Xu L, Gutmann DH, Wong M (2008) Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol 63:444-453
    • (2008) Ann Neurol , vol.63 , pp. 444-453
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4
  • 118
    • 77953367327 scopus 로고    scopus 로고
    • Developing antiepileptogenic drugs for acquired epilepsy: Targeting the mammalian target of rapamycin (mTOR) pathway
    • 2858431 1:CAS:528:DC%2BD1MXhsVOktrfK 20419051
    • Zeng LH, Rensing NR, Wong M (2009a) Developing antiepileptogenic drugs for acquired epilepsy: targeting the mammalian target of rapamycin (mTOR) pathway. Mol Cell Pharmacol 1:124-129
    • (2009) Mol Cell Pharmacol , vol.1 , pp. 124-129
    • Zeng, L.H.1    Rensing, N.R.2    Wong, M.3
  • 119
    • 66149169973 scopus 로고    scopus 로고
    • The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    • 2727061 1:CAS:528:DC%2BD1MXmvVGisL0%3D 19474323
    • Zeng LH, Rensing NR, Wong M (2009b) The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J Neurosci 29:6964-6972
    • (2009) J Neurosci , vol.29 , pp. 6964-6972
    • Zeng, L.H.1    Rensing, N.R.2    Wong, M.3
  • 120
    • 77954146395 scopus 로고    scopus 로고
    • Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): A double-edged sword?
    • Zeng LH, McDaniel S, Rensing NR, Wong M (2011) Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): a double-edged sword? Cell Cycle 9:2281-2285
    • (2011) Cell Cycle , vol.9 , pp. 2281-2285
    • Zeng, L.H.1    McDaniel, S.2    Rensing, N.R.3    Wong, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.