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Volumn 42, Issue 1, 2013, Pages 81-87

Central Leucine Sensing in the Control of Energy Homeostasis

Author keywords

Brainstem; Diabetes; Food intake; Hypothalamus; Leucine; Nutrient sensing; Obesity; Rapamycin

Indexed keywords

INSULIN RECEPTOR; LEUCINE;

EID: 84873276759     PISSN: 08898529     EISSN: 15584410     Source Type: Journal    
DOI: 10.1016/j.ecl.2012.12.001     Document Type: Review
Times cited : (24)

References (18)
  • 1
    • 67649962153 scopus 로고    scopus 로고
    • Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit
    • Blouet C., Jo Y.H., Li X., et al. Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. J Neurosci 2009, 29:8302-8311.
    • (2009) J Neurosci , vol.29 , pp. 8302-8311
    • Blouet, C.1    Jo, Y.H.2    Li, X.3
  • 2
    • 0025741116 scopus 로고
    • The blood-brain barrier and the regulation of amino acid uptake and availability to brain
    • Smith Q.R. The blood-brain barrier and the regulation of amino acid uptake and availability to brain. Adv Exp Med Biol 1991, 291:55-71.
    • (1991) Adv Exp Med Biol , vol.291 , pp. 55-71
    • Smith, Q.R.1
  • 3
    • 0032971333 scopus 로고    scopus 로고
    • Structural requirement of leucine for activation of p70 S6 kinase
    • Shigemitsu K., Tsujishita Y., Miyake H., et al. Structural requirement of leucine for activation of p70 S6 kinase. FEBS Lett 1999, 447:303-306.
    • (1999) FEBS Lett , vol.447 , pp. 303-306
    • Shigemitsu, K.1    Tsujishita, Y.2    Miyake, H.3
  • 4
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • Um S.H., Frigerio F., Watanabe M., et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004, 431:200-205.
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3
  • 5
    • 63449111894 scopus 로고    scopus 로고
    • A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
    • Newgard C.B., An J., Bain J.R., et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009, 9:311-326.
    • (2009) Cell Metab , vol.9 , pp. 311-326
    • Newgard, C.B.1    An, J.2    Bain, J.R.3
  • 6
    • 34249680883 scopus 로고    scopus 로고
    • Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms
    • Zhang Y., Guo K., LeBlanc R.E., et al. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 2007, 56:1647-1654.
    • (2007) Diabetes , vol.56 , pp. 1647-1654
    • Zhang, Y.1    Guo, K.2    LeBlanc, R.E.3
  • 7
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • Obici S., Feng Z., Karkanias G., et al. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 2002, 5:566-572.
    • (2002) Nat Neurosci , vol.5 , pp. 566-572
    • Obici, S.1    Feng, Z.2    Karkanias, G.3
  • 8
    • 48749105887 scopus 로고    scopus 로고
    • Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
    • Ono H., Pocai A., Wang Y., et al. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. J Clin Invest 2008, 118:2959-2968.
    • (2008) J Clin Invest , vol.118 , pp. 2959-2968
    • Ono, H.1    Pocai, A.2    Wang, Y.3
  • 9
    • 84555195141 scopus 로고    scopus 로고
    • Hypothalamic leucine metabolism regulates liver glucose production
    • Su Y., Lam T.K., He W., et al. Hypothalamic leucine metabolism regulates liver glucose production. Diabetes 2012, 61:85-93.
    • (2012) Diabetes , vol.61 , pp. 85-93
    • Su, Y.1    Lam, T.K.2    He, W.3
  • 10
    • 33646582664 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling regulates food intake
    • Cota D., Proulx K., Smith K.A., et al. Hypothalamic mTOR signaling regulates food intake. Science 2006, 312:927-930.
    • (2006) Science , vol.312 , pp. 927-930
    • Cota, D.1    Proulx, K.2    Smith, K.A.3
  • 11
    • 56449115916 scopus 로고    scopus 로고
    • Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis
    • Blouet C., Ono H., Schwartz G.J. Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. Cell Metab 2008, 8:459-467.
    • (2008) Cell Metab , vol.8 , pp. 459-467
    • Blouet, C.1    Ono, H.2    Schwartz, G.J.3
  • 12
    • 33750363301 scopus 로고    scopus 로고
    • Brainstem mechanisms integrating gut-derived satiety signals and descending forebrain information in the control of meal size
    • Berthoud H.R., Sutton G.M., Townsend R.L., et al. Brainstem mechanisms integrating gut-derived satiety signals and descending forebrain information in the control of meal size. Physiol Behav 2006, 89:517-524.
    • (2006) Physiol Behav , vol.89 , pp. 517-524
    • Berthoud, H.R.1    Sutton, G.M.2    Townsend, R.L.3
  • 13
    • 77649212149 scopus 로고    scopus 로고
    • Brainstem integrative function in the central nervous system control of food intake
    • Schwartz G.J. Brainstem integrative function in the central nervous system control of food intake. Forum Nutr 2010, 63:141-151.
    • (2010) Forum Nutr , vol.63 , pp. 141-151
    • Schwartz, G.J.1
  • 14
    • 3042819531 scopus 로고    scopus 로고
    • Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
    • Blevins J.E., Schwartz M.W., Baskin D.G. Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size. Am J Physiol Regul Integr Comp Physiol 2004, 287:R87-R96.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287
    • Blevins, J.E.1    Schwartz, M.W.2    Baskin, D.G.3
  • 15
    • 84865714588 scopus 로고    scopus 로고
    • Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance
    • Grill H.J., Hayes M.R. Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance. Cell Metab 2012, 16:296-309.
    • (2012) Cell Metab , vol.16 , pp. 296-309
    • Grill, H.J.1    Hayes, M.R.2
  • 16
    • 84871405563 scopus 로고    scopus 로고
    • Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding
    • Blouet C., Schwartz G.J. Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding. Cell Metab 2012, 16:579-587.
    • (2012) Cell Metab , vol.16 , pp. 579-587
    • Blouet, C.1    Schwartz, G.J.2
  • 17
    • 23844542825 scopus 로고    scopus 로고
    • Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus
    • Sutton G.M., Duos B., Patterson L.M., et al. Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus. Endocrinology 2005, 146:3739-3747.
    • (2005) Endocrinology , vol.146 , pp. 3739-3747
    • Sutton, G.M.1    Duos, B.2    Patterson, L.M.3
  • 18
    • 0036854550 scopus 로고    scopus 로고
    • Central melanocortin receptor agonist reduces spontaneous and scheduled meal size but does not augment duodenal preload-induced feeding inhibition
    • Azzara A.V., Sokolnicki J.P., Schwartz G.J. Central melanocortin receptor agonist reduces spontaneous and scheduled meal size but does not augment duodenal preload-induced feeding inhibition. Physiol Behav 2002, 77:411-416.
    • (2002) Physiol Behav , vol.77 , pp. 411-416
    • Azzara, A.V.1    Sokolnicki, J.P.2    Schwartz, G.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.