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Volumn 4, Issue 11, 2013, Pages

Measurement of autophagy flux in the nervous system in vivo

Author keywords

Adeno associated vector (AAV); Autophagy; Autophagy flux; Microtubule associated protein 1 light chain 3 (LC3); Nervous system

Indexed keywords

PARVOVIRUS VECTOR; RAPAMYCIN; TREHALOSE;

EID: 84889575041     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.421     Document Type: Article
Times cited : (97)

References (48)
  • 1
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069-1075
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 2
    • 84875892111 scopus 로고    scopus 로고
    • Autophagy as a stress-response and quality-control mechanism: Implications for cell injury and human disease
    • Murrow L, Debnath J. Autophagy as a stress-response and quality-control mechanism: Implications for cell injury and human disease. Annu Rev Pathol 2012; 8: 105-137
    • (2012) Annu Rev Pathol , vol.8 , pp. 105-137
    • Murrow, L.1    Debnath, J.2
  • 3
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer G, Marino G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010; 40: 280-293
    • (2010) Mol Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Marino, G.2    Levine, B.3
  • 5
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441: 880-884
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3    Murata, S.4    Iwata, J.5    Tanida, I.6
  • 6
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441: 885-889
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3    Yamamoto, A.4    Nakahara, Y.5    Suzuki-Migishima, R.6
  • 7
    • 79954425809 scopus 로고    scopus 로고
    • Protein folding stress in neurodegenerative diseases: A glimpse into the ER
    • Matus S, Glimcher LH, Hetz C. Protein folding stress in neurodegenerative diseases: A glimpse into the ER. Curr Opin Cell Biol 2011; 23: 239-252
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 239-252
    • Matus, S.1    Glimcher, L.H.2    Hetz, C.3
  • 9
    • 79954417611 scopus 로고    scopus 로고
    • Autophagy for tissue homeostasis and neuroprotection
    • Marino G, Madeo F, Kroemer G. Autophagy for tissue homeostasis and neuroprotection. Curr Opin Cell Biol 2011; 23: 198-206
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 198-206
    • Marino, G.1    Madeo, F.2    Kroemer, G.3
  • 10
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010; 140: 313-326
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 11
    • 45749114895 scopus 로고    scopus 로고
    • The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
    • Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 2008; 118: 2190-2199
    • (2008) J Clin Invest , vol.118 , pp. 2190-2199
    • Pickford, F.1    Masliah, E.2    Britschgi, M.3    Lucin, K.4    Narasimhan, R.5    Jaeger, P.A.6
  • 12
    • 77953693051 scopus 로고    scopus 로고
    • Dynein-And activity-dependent retrograde transport of autophagosomes in neuronal axons
    • Katsumata K, Nishiyama J, Inoue T, Mizushima N, Takeda J, Yuzaki M. Dynein-And activity-dependent retrograde transport of autophagosomes in neuronal axons. Autophagy 2010; 6: 378-385
    • (2010) Autophagy , vol.6 , pp. 378-385
    • Katsumata, K.1    Nishiyama, J.2    Inoue, T.3    Mizushima, N.4    Takeda, J.5    Yuzaki, M.6
  • 14
    • 1542283812 scopus 로고    scopus 로고
    • In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
    • Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15: 1101-1111
    • (2004) Mol Biol Cell , vol.15 , pp. 1101-1111
    • Mizushima, N.1    Yamamoto, A.2    Matsui, M.3    Yoshimori, T.4    Ohsumi, Y.5
  • 15
    • 80052353946 scopus 로고    scopus 로고
    • In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis
    • Tian F, Morimoto N, Liu W, Ohta Y, Deguchi K, Miyazaki K, et al. In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis. Autophagy 2011; 7: 985-992
    • (2011) Autophagy , vol.7 , pp. 985-992
    • Tian, F.1    Morimoto, N.2    Liu, W.3    Ohta, Y.4    Deguchi, K.5    Miyazaki, K.6
  • 16
    • 84934440488 scopus 로고    scopus 로고
    • Autophagosomes in gfp-lc3 transgenic mice
    • Mizushima N, Kuma A. Autophagosomes in GFP-LC3 Transgenic Mice. Methods Mol Biol 2008; 445: 119-124
    • (2008) Methods Mol Biol , vol.445 , pp. 119-124
    • Mizushima, N.1    Kuma, A.2
  • 17
    • 34548259958 scopus 로고    scopus 로고
    • P62/sqstm1 binds directly to atg8/lc3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282: 24131-24145
    • (2007) J Biol Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5    Outzen, H.6
  • 18
    • 0035203152 scopus 로고    scopus 로고
    • Widespread gene delivery and structure-specific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-Associated virus vector
    • Passini MA, Wolfe JH. Widespread gene delivery and structure-specific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-Associated virus vector. J Virol 2001; 75: 12382-12392
    • (2001) J Virol , vol.75 , pp. 12382-12392
    • Passini, M.A.1    Wolfe, J.H.2
  • 19
    • 80054879102 scopus 로고    scopus 로고
    • Delivery of therapeutic agents through intracerebroventricular (ICV) and intravenous (IV) injection in mice
    • doi:10.3791/2968
    • Glascock JJ, Osman EY, Coady TH, Rose FF, Shababi M, Lorson CL. Delivery of therapeutic agents through intracerebroventricular (ICV) and intravenous (IV) injection in mice. J Vis Experiments 2011; 56: E2968, doi:10.3791/2968
    • (2011) J Vis Experiments , vol.56
    • Glascock, J.J.1    Osman, E.Y.2    Coady, T.H.3    Rose, F.F.4    Shababi, M.5    Lorson, C.L.6
  • 21
    • 84865749298 scopus 로고    scopus 로고
    • Rapamycin delays disease onset and prevents prp plaque deposition in a mouse model of gerstmann-straussler-scheinker disease
    • Cortes CJ, Qin K, Cook J, Solanki A, Mastrianni JA. Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Straussler-Scheinker disease. J Neurosci 2012; 32: 12396-12405
    • (2012) J Neurosci , vol.32 , pp. 12396-12405
    • Cortes, C.J.1    Qin, K.2    Cook, J.3    Solanki, A.4    Mastrianni, J.A.5
  • 22
    • 2642586352 scopus 로고    scopus 로고
    • Inhibition of mtor induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of huntington disease
    • Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nature Genet 2004; 36: 585-595
    • (2004) Nature Genet , vol.36 , pp. 585-595
    • Ravikumar, B.1    Vacher, C.2    Berger, Z.3    Davies, J.E.4    Luo, S.5    Oroz, L.G.6
  • 23
    • 57649227693 scopus 로고    scopus 로고
    • Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
    • Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine- expanded huntingtin and related proteinopathies. Cell Death Differ 2009; 16: 46-56
    • (2009) Cell Death Differ , vol.16 , pp. 46-56
    • Sarkar, S.1    Ravikumar, B.2    Floto, R.A.3    Rubinsztein, D.C.4
  • 25
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mtor complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 2010; 40: 310-322
    • (2010) Mol Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 26
    • 84863210676 scopus 로고    scopus 로고
    • Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy
    • Schaeffer V, Lavenir I, Ozcelik S, Tolnay M, Winkler DT, Goedert M. Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy. Brain 2012; 135: 2169-2177
    • (2012) Brain , vol.135 , pp. 2169-2177
    • Schaeffer, V.1    Lavenir, I.2    Ozcelik, S.3    Tolnay, M.4    Winkler, D.T.5    Goedert, M.6
  • 27
    • 77954955573 scopus 로고    scopus 로고
    • Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
    • Rodriguez-Navarro JA, Rodriguez L, Casarejos MJ, Solano RM, Gomez A, Perucho J, et al. Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation. Neurobiol Dis 2010; 39: 423-438
    • (2010) Neurobiol Dis , vol.39 , pp. 423-438
    • Rodriguez-Navarro, J.A.1    Rodriguez, L.2    Casarejos, M.J.3    Solano, R.M.4    Gomez, A.5    Perucho, J.6
  • 28
    • 29644437591 scopus 로고    scopus 로고
    • Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy
    • Davies JE, Sarkar S, Rubinsztein DC. Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. Hum Mol Genet 2006; 15: 23-31
    • (2006) Hum Mol Genet , vol.15 , pp. 23-31
    • Davies, J.E.1    Sarkar, S.2    Rubinsztein, D.C.3
  • 29
    • 34247161367 scopus 로고    scopus 로고
    • Trehalose, a novel mTORindependent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
    • Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC. Trehalose, a novel mTORindependent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 2007; 282: 5641-5652
    • (2007) J Biol Chem , vol.282 , pp. 5641-5652
    • Sarkar, S.1    Davies, J.E.2    Huang, Z.3    Tunnacliffe, A.4    Rubinsztein, D.C.5
  • 30
    • 84884294596 scopus 로고    scopus 로고
    • Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons
    • Castillo K, Nassif M, Valenzuela V, Rojas F, Matus S, Mercado G, et al. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy 2013; 9: 1-13
    • (2013) Autophagy , vol.9 , pp. 1-13
    • Castillo, K.1    Nassif, M.2    Valenzuela, V.3    Rojas, F.4    Matus, S.5    Mercado, G.6
  • 31
    • 84857858536 scopus 로고    scopus 로고
    • Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
    • Maday S, Wallace KE, Holzbaur EL. Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. J Cell Biol 2012; 196: 407-417
    • (2012) J Cell Biol , vol.196 , pp. 407-417
    • Maday, S.1    Wallace, K.E.2    Holzbaur, E.L.3
  • 32
    • 58149483522 scopus 로고    scopus 로고
    • Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death
    • Kanno H, Ozawa H, Sekiguchi A, Itoi E. Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death. Neurobiol Dis 2009; 33: 143-148
    • (2009) Neurobiol Dis , vol.33 , pp. 143-148
    • Kanno, H.1    Ozawa, H.2    Sekiguchi, A.3    Itoi, E.4
  • 33
    • 84858407568 scopus 로고    scopus 로고
    • Rapamycin promotes autophagy and reduces neural tissue damage and locomotor impairment after spinal cord injury in mice
    • Sekiguchi A, Kanno H, Ozawa H, Yamaya S, Itoi E. Rapamycin promotes autophagy and reduces neural tissue damage and locomotor impairment after spinal cord injury in mice. J Neurotrauma 2012; 29: 946-956
    • (2012) J Neurotrauma , vol.29 , pp. 946-956
    • Sekiguchi, A.1    Kanno, H.2    Ozawa, H.3    Yamaya, S.4    Itoi, E.5
  • 34
    • 80053970026 scopus 로고    scopus 로고
    • Induction of autophagy and autophagic cell death in damaged neural tissue after acute spinal cord injury in mice
    • Kanno H, Ozawa H, Sekiguchi A, Yamaya S, Itoi E. Induction of autophagy and autophagic cell death in damaged neural tissue after acute spinal cord injury in mice. Spine (Phila Pa 1976) 2011; 36: E1427-E1434
    • (2011) Spine (Phila Pa 1976 , vol.36
    • Kanno, H.1    Ozawa, H.2    Sekiguchi, A.3    Yamaya, S.4    Itoi, E.5
  • 35
    • 84858800745 scopus 로고    scopus 로고
    • Autophagy is activated in injured neurons and inhibited by methylprednisolone after experimental spinal cord injury
    • Chen HC, Fong TH, Lee AW, Chiu WT. Autophagy is activated in injured neurons and inhibited by methylprednisolone after experimental spinal cord injury. Spine (Phila Pa 1976) 2012; 37: 470-475
    • (2012) Spine (Phila Pa 1976 , vol.37 , pp. 470-475
    • Chen, H.C.1    Fong, T.H.2    Lee, A.W.3    Chiu, W.T.4
  • 37
    • 82855169507 scopus 로고    scopus 로고
    • Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: Functional analysis of p62 and autophagy in hypoxic neuronal cells
    • Tanabe F, Yone K, Kawabata N, Sakakima H, Matsuda F, Ishidou Y, et al. Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: Functional analysis of p62 and autophagy in hypoxic neuronal cells. Autophagy 2011; 7: 1462-1471
    • (2011) Autophagy , vol.7 , pp. 1462-1471
    • Tanabe, F.1    Yone, K.2    Kawabata, N.3    Sakakima, H.4    Matsuda, F.5    Ishidou, Y.6
  • 38
    • 80052777066 scopus 로고    scopus 로고
    • Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons
    • Penas C, Font-Nieves M, Fores J, Petegnief V, Planas A, Navarro X, et al. Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons. Cell Death Differ 2011; 18: 1617-1627
    • (2011) Cell Death Differ , vol.18 , pp. 1617-1627
    • Penas, C.1    Font-Nieves, M.2    Fores, J.3    Petegnief, V.4    Planas, A.5    Navarro, X.6
  • 40
    • 78751565419 scopus 로고    scopus 로고
    • Axonal degeneration is mediated by the mitochondrial permeability transition pore
    • Barrientos SA, Martinez NW, Yoo S, Jara JS, Zamorano S, Hetz C, et al. Axonal degeneration is mediated by the mitochondrial permeability transition pore. J Neurosci 2011; 31: 966-978
    • (2011) J Neurosci , vol.31 , pp. 966-978
    • Barrientos, S.A.1    Martinez, N.W.2    Yoo, S.3    Jara, J.S.4    Zamorano, S.5    Hetz, C.6
  • 42
    • 0021673488 scopus 로고
    • Suppression of experimental allergic encephalomyelitis (eae) with liposome-encapsulated protease inhibitor: Therapy through the blood-brain barrier
    • Osanai T, Nagai Y. Suppression of experimental allergic encephalomyelitis (EAE) with liposome-encapsulated protease inhibitor: Therapy through the blood-brain barrier. Neurochem Res 1984; 9: 1407-1416
    • (1984) Neurochem Res , vol.9 , pp. 1407-1416
    • Osanai, T.1    Nagai, Y.2
  • 43
  • 44
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005; 308: 1314-1318
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 45
    • 0033971439 scopus 로고    scopus 로고
    • A method for the preparation of highly purified adeno-Associated virus using affinity column chromatography, protease digestion and solvent extraction
    • Anderson R, Macdonald I, Corbett T, Whiteway A, Prentice HG. A method for the preparation of highly purified adeno-Associated virus using affinity column chromatography, protease digestion and solvent extraction. J Virol Methods 2000; 85: 23-34
    • (2000) J Virol Methods , vol.85 , pp. 23-34
    • Anderson, R.1    Macdonald, I.2    Corbett, T.3    Whiteway, A.4    Prentice, H.G.5
  • 46
    • 80051937261 scopus 로고    scopus 로고
    • MMP2-9 cleavage of dystroglycan alters the size and molecular composition of Schwann cell domains
    • Court FA, Zambroni D, Pavoni E, Colombelli C, Baragli C, Figlia G, et al. MMP2-9 cleavage of dystroglycan alters the size and molecular composition of Schwann cell domains. J Neurosci 2011; 31: 12208-12217
    • (2011) J Neurosci , vol.31 , pp. 12208-12217
    • Court, F.A.1    Zambroni, D.2    Pavoni, E.3    Colombelli, C.4    Baragli, C.5    Figlia, G.6
  • 47
    • 79960736536 scopus 로고    scopus 로고
    • Morphological evidence for a transport of ribosomes from Schwann cells to regenerating axons
    • Court FA, Midha R, Cisterna BA, Grochmal J, Shakhbazau A, Hendriks WT, et al. Morphological evidence for a transport of ribosomes from Schwann cells to regenerating axons. Glia 2011; 59: 1529-1539
    • (2011) Glia , vol.59 , pp. 1529-1539
    • Court, F.A.1    Midha, R.2    Cisterna, B.A.3    Grochmal, J.4    Shakhbazau, A.5    Hendriks, W.T.6
  • 48
    • 80455173839 scopus 로고    scopus 로고
    • BAX inhibitor-1 regulates autophagy by controlling the IRE1alpha branch of the unfolded protein response
    • Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, et al. BAX inhibitor-1 regulates autophagy by controlling the IRE1alpha branch of the unfolded protein response. Embo J 2011; 30: 4465-4478
    • (2011) Embo J , vol.30 , pp. 4465-4478
    • Castillo, K.1    Rojas-Rivera, D.2    Lisbona, F.3    Caballero, B.4    Nassif, M.5    Court, F.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.