Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 35, 2012, Pages

  Di Malta, Chiara ^a,b,c,d   Fryer, John D ^e   Settembre, Carmine ^a,b,c   Ballabio, Andrea ^a,b,c,f  

^a TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c TEXAS CHILDREN S HOSPITAL   (United States)

^d OPEN UNIVERSITY   (United Kingdom)

^e MAYO GRADUATE SCHOOL   (United States)

^f UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Brain; Glia; Lysosome

Indexed keywords

SULFATASE; SULFATASE MODIFYING FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTOPHAGY; BRAIN CELL; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; EX VIVO STUDY; EXON; GENE DELETION; GENE MUTATION; GLIA; IN VIVO STUDY; LYSOSOME STORAGE DISEASE; MOUSE; MULTIPLE SULFATASE DEFICIENCY; NERVE CELL; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ASTROCYTES; CELL COMMUNICATION; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; CEREBRAL CORTEX; LYSOSOMAL STORAGE DISEASES, NERVOUS SYSTEM; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON; MULTIPLE SULFATASE DEFICIENCY DISEASE; NERVE DEGENERATION; NEURONS; PURKINJE CELLS; SULFATASES;

MUS;

EID: 84865531819     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1209577109     Document Type: Article

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