MTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits

Behavioural Brain Research

Volumn 264, Issue , 2014, Pages 82-90

  Yang, Fengying ^a   Chu, Xiaolei ^b   Yin, Miaomiao ^c   Liu, Xiaolei ^a   Yuan, Hairui ^a   Niu, Yanmei ^a   Fu, Li ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b TIANJIN HOSPITAL   (China)

^c TIANJIN HUANHU HOSPITAL   (China)

Author keywords

Autophagy; Caloric restriction; Cognition; Hippocampus; Mammalian target of rapamycin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ADULT; AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BRAIN LEVEL; BRAIN REGION; CALORIC RESTRICTION; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATIONAL STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HIPPOCAMPUS; LIFE EXTENSION; MALE; MIDDLE AGED; MOUSE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AUTOPHAGY; CALORIC RESTRICTION; COGNITION; HIPPOCAMPUS; MAMMALIAN TARGET OF RAPAMYCIN;

AGE FACTORS; AGING; ANIMALS; AUTOPHAGY; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALORIC RESTRICTION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; FOOD DEPRIVATION; GENE EXPRESSION REGULATION; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS; TIME FACTORS;

EID: 84896722838     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2014.02.005     Document Type: Article

References (46)

1. Abbott A. Cognition: the brain's decline. Nature 2012, 492:S4-S5.
2. Wilson R.S., Krueger K.R., Arnold S.E., Schneider J.A., Kelly J.F., Barnes L.L., et al. Loneliness and risk of Alzheimer disease. Arch Gen Psychiatry 2007, 64:234-240.
3. Caballero B., Coto-Montes A. An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain. Histol Histopathol 2012, 27:263-275.
4. Yang Z., Klionsky D.J. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010, 22:124-131.
5. Tanaka Y., Kume S., Kitada M., Kanasaki K., Uzu T., Maegawa H., et al. Autophagy as a therapeutic target in diabetic nephropathy. Exp Diabetes Res 2012, 2012:628978.
6. Jia H., Kast R.J., Steffan J.S., Thomas E.A. Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems. Hum Mol Genet 2012, 21:5280-5293.
7. Osellame L.D., Rahim A.A., Hargreaves I.P., Gegg M.E., Richard-Londt A., Brandner S., et al. Mitochondria and quality control defects in a mouse model of Gaucher disease - links to Parkinson's disease. Cell Metab 2013, 17:941-953.
8. Wolfe D.M., Lee J.H., Kumar A., Lee S., Orenstein S.J., Nixon R.A. Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur J Neurosci 2013, 37:1949-1961.
9. Maiese K., Chong Z.Z., Shang Y.C., Wang S. mTOR: on target for novel therapeutic strategies in the nervous system. Trends Mol Med 2013, 19:51-60.
10. Troca-Marín J.A., Alves-Sampaio A., Montesinos M.L. An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of Down's syndrome. J Neurosci 2011, 31:9445-9455.
11. Ma X.M., Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 2009, 10:307-318.
12. Harrison D.E., Strong R., Sharp Z.D., Nelson J.F., Astle C.M., Flurkey K., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460:392-395.
13. Urbanska M., Gozdz A., Swiech L.J., Jaworski J. Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons. J Biol Chem 2012, 287:30240-30256.
14. Yang P.C., Yang C.H., Huang C.C., Hsu K.S. Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity. J Biol Chem 2008, 283:2631-2643.
15. Chung J.H., Manganiello V., Dyck J.R. Resveratrol as a calorie restriction mimetic: therapeutic implications. Trends Cell Biol 2012, 22:546-554.
16. Smith D.L., Nagy T.R., Allison D.B. Calorie restriction: what recent results suggest for the future of ageing research. Eur J Clin Invest 2010, 40:440-450.
17. Blagosklonny M.V. Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans). Cell Cycle 2010, 9:683-688.
18. Morselli E., Maiuri M.C., Markaki M., Megalou E., Pasparaki A., Palikaras K., et al. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 2010, 1:e10.
19. Wu P., Jiang C., Shen Q., Hu Y. Systematic gene expression profile of hypothalamus in calorie-restricted mice implicates the involvement of mTOR signaling in neuroprotective activity. Mech Ageing Dev 2009, 130:602-610.
20. Adams M.M., Shi L., Linville M.C., Forbes M.E., Long A.B., Bennett C., et al. Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability. Exp Neurol 2008, 211:141-149.
21. Dal-Pan A., Pifferi F., Marchal J., Picq J.L., Aujard F. Cognitive performances are selectively enhanced during chronic caloric restriction or resveratrol supplementation in a primate. PLoS ONE 2011, 6:e16581. RESTRIKAL Consortium.
22. Sharma S., Rakoczy S., Brown-Borg H. Assessment of spatial memory in mice. Life Sci 2010, 87:521-536.
23. Beauquis J., Vinuesa A., Pomilio C., Pavía P., Galván V., Saravia F. Neuronal glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer's disease. Hippocampus 2013, [Epub ahead of print].
24. Demontis F., Perrimon N. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell 2010, 143:813-825.
25. Liuzzi J.P., Yoo C. Role of zinc in the regulation of autophagy during ethanol exposure in human hepatoma cells. Biol Trace Elem Res 2013, 156:350-356.
26. Wirawan E., Lippens S., Vanden Berghe T., Romagnoli A., Fimia G.M., Piacentini M., et al. Beclin1: a role in membrane dynamics and beyond. Autophagy 2012, 8:6-17.
27. Wang M., Miller R.A. Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress. Aging Cell 2012, 11:668-674.
28. Abidin I., Eysel U.T., Lessmann V., Mittmann T. Impaired GABAergic inhibition in the visual cortex of brain-derived neurotrophic factor heterozygous knockout mice. J Physiol 2008, 586:1885-1901.
29. Yamada M.K., Nakanishi K., Ohba S., Nakamura T., Ikegaya Y., Nishiyama N., et al. Brain-derived neurotrophic factor promotes the maturation of GABAergic mechanisms in cultured hippocampal neurons. J Neurosci 2002, 22:7580-7585.
30. Jin X., Hu H., Mathers P.H., Agmon A. Brain-derived neurotrophic factor mediates activity-dependent dendritic growth in nonpyramidal neocortical interneurons in developing organotypic cultures. J Neurosci 2003, 23:5662-5673.
31. Tanaka J., Horiike Y., Matsuzaki M., Miyazaki T., Ellis-Davies G.C., Kasai H. Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science 2008, 319:1683-1687.
32. Tai H.C., Serrano-Pozo A., Hashimoto T., Frosch M.P., Spires-Jones T.L., Hyman B.T. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am J Pathol 2012, 181:1426-1435.
33. Butler D., Nixon R.A., Bahr B.A. Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases. Autophagy 2006, 2:234-237.
34. Gottlieb R.A., Carreira R.S. Autophagy in health and disease. 5. Mitophagy as a way of life. Am J Physiol Cell Physiol 2010, 299:C203-C210.
35. Jung C.H., Jun C.B., Ro S.H., Kim Y.M., Otto N.M., Cao J., et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009, 20:1992-2003.
36. Koren I., Reem E., Kimchi A. Autophagy gets a brake: DAP1, a novel mTOR substrate, is activated to suppress the autophagic process. Autophagy 2010, 6:1179-1180.
37. McAlpine F., Williamson L.E., Tooze S.A., Chan E.Y. Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2. Autophagy 2013, 9:361-373.
38. Selman C., Tullet J.M., Wieser D., Irvine E., Lingard S.J., Choudhury A.I., et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009, 326:140-144.
39. Salminen A., Kaarniranta K. NF-kappaB signaling in the aging process. J Clin Immunol 2009, 29:397-405.
40. Lee I.H., Cao L., Mostoslavsky R., Lombard D.B., Liu J., Bruns N.E., et al. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A 2008, 105:3374-3379.
41. Ehninger D., Han S., Shilyansky C., Zhou Y., Li W., Kwiatkowski D.J., et al. Reversal of learning deficits in a Tsc2± mouse model of tuberous sclerosis. Nat Med 2008, 14:843-848.
42. Sharma A., Hoeffer C.A., Takayasu Y., Miyawaki T., McBride S.M., Klann E., et al. Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci 2010, 30:694-702.
43. Jaworski J., Spangler S., Seeburg D.P., Hoogenraad C.C., Sheng M. Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway. J Neurosci 2005, 25:11300-11312.
44. Bekinschtein P., Cammarota M., Katche C., Slipczuk L., Rossato J.I., Goldin A., et al. BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci U S A 2008, 105:2711-2716.
45. Eiland L., McEwen B.S. Early life stress followed by subsequent adult chronic stress potentiates anxiety and blunts hippocampal structural remodeling. Hippocampus 2012, 22:82-91.
46. Laplante M., Sabatini D.M. mTOR signaling in growth control and disease. Cell 2012, 149:274-293.