메뉴 건너뛰기




Volumn 72, Issue 19, 2015, Pages 3637-3652

Airway hydration and COPD

Author keywords

Airway surface liquid; CFTR; Cystic fibrosis; ENaC; Mucus; Tobacco smoke

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BIOLOGICAL MARKER; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ION CHANNEL; TOBACCO SMOKE; CFTR PROTEIN, HUMAN; SODIUM CHANNEL;

EID: 84941423127     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-1946-7     Document Type: Review
Times cited : (64)

References (240)
  • 1
    • 33845338724 scopus 로고    scopus 로고
    • Projections of global mortality and burden of disease from 2002 to 2030
    • 10.1371/journal.pmed.0030442
    • Mathers CD, Loncar D (2011) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3(11): e442. doi: 10.1371/journal.pmed.0030442
    • (2011) PLoS Med , vol.3 , Issue.11 , pp. e442
    • Mathers, C.D.1    Loncar, D.2
  • 2
    • 84893771777 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of chronic obstructive pulmonary disease
    • Barnes PJ (2014) Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clin Chest Med 35(1):71-86
    • (2014) Clin Chest Med , vol.35 , Issue.1 , pp. 71-86
    • Barnes, P.J.1
  • 3
    • 1542713396 scopus 로고    scopus 로고
    • Alpha1-antitrypsin deficiency. 2: Genetic aspects of alpha(1)-antitrypsin deficiency: Phenotypes and genetic modifiers of emphysema risk
    • 1:STN:280:DC%2BD2c%2Fps1amsw%3D%3D
    • DeMeo DL, Silverman EK (2004) Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk. Thorax 59(3):259-264
    • (2004) Thorax , vol.59 , Issue.3 , pp. 259-264
    • DeMeo, D.L.1    Silverman, E.K.2
  • 4
    • 84873353231 scopus 로고    scopus 로고
    • Chronic bronchitis and chronic obstructive pulmonary disease
    • Kim V, Criner GJ (2012) Chronic bronchitis and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 187(3):228-237
    • (2012) Am J Respir Crit Care Med , vol.187 , Issue.3 , pp. 228-237
    • Kim, V.1    Criner, G.J.2
  • 5
    • 2942720573 scopus 로고    scopus 로고
    • The nature of small-airway obstruction in chronic obstructive pulmonary disease
    • 1:CAS:528:DC%2BD2cXltFGgur4%3D
    • Hogg JC et al (2004) The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350(26):2645-2653
    • (2004) N Engl J Med , vol.350 , Issue.26 , pp. 2645-2653
    • Hogg, J.C.1
  • 6
    • 0026641782 scopus 로고
    • The spectrum of cystic fibrosis mutations
    • 1:CAS:528:DyaK3sXpvFSqug%3D%3D
    • Tsui LC (1992) The spectrum of cystic fibrosis mutations. Trends Genet 8(11):392-398
    • (1992) Trends Genet , vol.8 , Issue.11 , pp. 392-398
    • Tsui, L.C.1
  • 7
    • 0027550821 scopus 로고
    • The cystic fibrosis gene and its product CFTR
    • 1:CAS:528:DyaK2cXltFWrtQ%3D%3D
    • Harris A, Argent BE (1993) The cystic fibrosis gene and its product CFTR. Semin Cell Biol 4(1):37-44
    • (1993) Semin Cell Biol , vol.4 , Issue.1 , pp. 37-44
    • Harris, A.1    Argent, B.E.2
  • 8
    • 1542267080 scopus 로고    scopus 로고
    • State of the art: Why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection?
    • Chmiel JF, Davis PB (2003) State of the art: why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection? Respir Res 4:8
    • (2003) Respir Res , vol.4 , pp. 8
    • Chmiel, J.F.1    Davis, P.B.2
  • 10
    • 84885575144 scopus 로고    scopus 로고
    • Cigarette smoke and CFTR: Implications in the pathogenesis of COPD
    • 1:CAS:528:DC%2BC3sXhslejurrM
    • Rab A et al (2013) Cigarette smoke and CFTR: implications in the pathogenesis of COPD. Am J Physiol Lung Cell Mol Physiol 305(8):L530-L541
    • (2013) Am J Physiol Lung Cell Mol Physiol , vol.305 , Issue.8 , pp. L530-L541
    • Rab, A.1
  • 11
    • 36148930617 scopus 로고    scopus 로고
    • Liquid movement across the surface epithelium of large airways
    • 1:CAS:528:DC%2BD2sXhtlGht7vM
    • Chambers LA, Rollins BM, Tarran R (2007) Liquid movement across the surface epithelium of large airways. Respir Physiol Neurobiol 159(3):256-270
    • (2007) Respir Physiol Neurobiol , vol.159 , Issue.3 , pp. 256-270
    • Chambers, L.A.1    Rollins, B.M.2    Tarran, R.3
  • 12
    • 84901617618 scopus 로고    scopus 로고
    • Cystic fibrosis: An inherited disease affecting mucin-producing organs
    • 1:CAS:528:DC%2BC2cXmt1Wkur4%3D
    • Ehre C, Ridley C, Thornton DJ (2014) Cystic fibrosis: an inherited disease affecting mucin-producing organs. Int J Biochem Cell Biol 52:136-145
    • (2014) Int J Biochem Cell Biol , vol.52 , pp. 136-145
    • Ehre, C.1    Ridley, C.2    Thornton, D.J.3
  • 13
    • 11144221941 scopus 로고    scopus 로고
    • Relationship of airway epithelial ion transport to chronic bronchitis
    • 1:CAS:528:DC%2BD2cXhs1Wlu7w%3D
    • Boucher RC (2004) Relationship of airway epithelial ion transport to chronic bronchitis. Proc Am Thorac Soc 1(1):66-70
    • (2004) Proc Am Thorac Soc , vol.1 , Issue.1 , pp. 66-70
    • Boucher, R.C.1
  • 14
    • 84856557879 scopus 로고    scopus 로고
    • Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration
    • 1:CAS:528:DC%2BC38XitFOgu7g%3D
    • Clunes LA et al (2012) Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. FASEB J 26(2):533-545
    • (2012) FASEB J , vol.26 , Issue.2 , pp. 533-545
    • Clunes, L.A.1
  • 15
    • 0345701470 scopus 로고    scopus 로고
    • Not 15 but 50% of smokers develop COPD? - Report from the obstructive lung disease in Northern Sweden studies
    • 1:STN:280:DC%2BD3s%2Fns1KksQ%3D%3D
    • Lundback B et al (2003) Not 15 but 50% of smokers develop COPD? - report from the obstructive lung disease in Northern Sweden studies. Respir Med 97(2):115-122
    • (2003) Respir Med , vol.97 , Issue.2 , pp. 115-122
    • Lundback, B.1
  • 16
    • 0036778538 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease surveillance - United States, 1971-2000
    • Mannino DM et al (2002) Chronic obstructive pulmonary disease surveillance - United States, 1971-2000. Respir Care 47(10):1184-1199
    • (2002) Respir Care , vol.47 , Issue.10 , pp. 1184-1199
    • Mannino, D.M.1
  • 17
    • 79959321052 scopus 로고    scopus 로고
    • Outdoor air pollution and respiratory health in patients with COPD
    • Peacock JL et al (2011) Outdoor air pollution and respiratory health in patients with COPD. Thorax 66(7):591-596
    • (2011) Thorax , vol.66 , Issue.7 , pp. 591-596
    • Peacock, J.L.1
  • 18
    • 0034954094 scopus 로고    scopus 로고
    • Urban air pollution and chronic obstructive pulmonary disease: A review
    • 1:CAS:528:DC%2BD3MXmtlGjsLc%3D
    • Sunyer J (2001) Urban air pollution and chronic obstructive pulmonary disease: a review. Eur Respir J 17(5):1024-1033
    • (2001) Eur Respir J , vol.17 , Issue.5 , pp. 1024-1033
    • Sunyer, J.1
  • 19
    • 77949824795 scopus 로고    scopus 로고
    • COPD and chronic bronchitis risk of indoor air pollution from solid fuel: A systematic review and meta-analysis
    • Kurmi OP et al (2010) COPD and chronic bronchitis risk of indoor air pollution from solid fuel: a systematic review and meta-analysis. Thorax 65(3):221-228
    • (2010) Thorax , vol.65 , Issue.3 , pp. 221-228
    • Kurmi, O.P.1
  • 20
    • 84891926417 scopus 로고    scopus 로고
    • Ambient air pollution: A cause of COPD?
    • Schikowski T et al (2013) Ambient air pollution: a cause of COPD? Eur Respir J 43(1):250-263
    • (2013) Eur Respir J , vol.43 , Issue.1 , pp. 250-263
    • Schikowski, T.1
  • 21
    • 34548222188 scopus 로고    scopus 로고
    • Global burden of COPD: Risk factors, prevalence, and future trends
    • Mannino DM, Buist AS (2007) Global burden of COPD: risk factors, prevalence, and future trends. Lancet 370(9589):765-773
    • (2007) Lancet , vol.370 , Issue.9589 , pp. 765-773
    • Mannino, D.M.1    Buist, A.S.2
  • 22
    • 69149102202 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease in non-smokers
    • Salvi SS, Barnes PJ (2009) Chronic obstructive pulmonary disease in non-smokers. Lancet 374(9691):733-743
    • (2009) Lancet , vol.374 , Issue.9691 , pp. 733-743
    • Salvi, S.S.1    Barnes, P.J.2
  • 23
    • 84875674428 scopus 로고    scopus 로고
    • The electrophoretic alpha1-globulin pattern of serum in alpha1-antitrypsin deficiency. 1963
    • Laurell CB, Eriksson S (2013) The electrophoretic alpha1-globulin pattern of serum in alpha1-antitrypsin deficiency. 1963. COPD 10(Suppl 1):3-8
    • (2013) COPD , vol.10 , pp. 3-8
    • Laurell, C.B.1    Eriksson, S.2
  • 24
    • 48949095935 scopus 로고    scopus 로고
    • SERPINA1 gene variants in individuals from the general population with reduced alpha1-antitrypsin concentrations
    • 1:CAS:528:DC%2BD1cXpt12gtbc%3D
    • Zorzetto M et al (2008) SERPINA1 gene variants in individuals from the general population with reduced alpha1-antitrypsin concentrations. Clin Chem 54(8):1331-1338
    • (2008) Clin Chem , vol.54 , Issue.8 , pp. 1331-1338
    • Zorzetto, M.1
  • 25
    • 20744450475 scopus 로고    scopus 로고
    • Alpha1-antitrypsin deficiency
    • 1:CAS:528:DC%2BD2MXlsFCrsrk%3D
    • Stoller JK, Aboussouan LS (2005) Alpha1-antitrypsin deficiency. Lancet 365(9478):2225-2236
    • (2005) Lancet , vol.365 , Issue.9478 , pp. 2225-2236
    • Stoller, J.K.1    Aboussouan, L.S.2
  • 26
    • 0023840928 scopus 로고
    • Emphysema of early onset associated with a complete deficiency of alpha-1-antitrypsin (null homozygotes)
    • 1:STN:280:DyaL1c7jt1Sksw%3D%3D
    • Cox DW, Levison H (1988) Emphysema of early onset associated with a complete deficiency of alpha-1-antitrypsin (null homozygotes). Am Rev Respir Dis 137(2):371-375
    • (1988) Am Rev Respir Dis , vol.137 , Issue.2 , pp. 371-375
    • Cox, D.W.1    Levison, H.2
  • 27
    • 0023795389 scopus 로고
    • Clinical features and history of the destructive lung disease associated with alpha-1-antitrypsin deficiency of adults with pulmonary symptoms
    • 1:STN:280:DyaL1M%2FmtVOjsA%3D%3D
    • Brantly ML et al (1988) Clinical features and history of the destructive lung disease associated with alpha-1-antitrypsin deficiency of adults with pulmonary symptoms. Am Rev Respir Dis 138(2):327-336
    • (1988) Am Rev Respir Dis , vol.138 , Issue.2 , pp. 327-336
    • Brantly, M.L.1
  • 28
    • 0035891572 scopus 로고    scopus 로고
    • Longitudinal changes in physiological, radiological, and health status measurements in alpha(1)-antitrypsin deficiency and factors associated with decline
    • 1:STN:280:DC%2BD3Mnosl2ksw%3D%3D
    • Dowson LJ, Guest PJ, Stockley RA (2001) Longitudinal changes in physiological, radiological, and health status measurements in alpha(1)-antitrypsin deficiency and factors associated with decline. Am J Respir Crit Care Med 164(10 Pt 1):1805-1809
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.10 , pp. 1805-1809
    • Dowson, L.J.1    Guest, P.J.2    Stockley, R.A.3
  • 29
    • 34047166052 scopus 로고    scopus 로고
    • Airway surface dehydration in cystic fibrosis: Pathogenesis and therapy
    • 1:CAS:528:DC%2BD2sXisV2jsbo%3D
    • Boucher RC (2007) Airway surface dehydration in cystic fibrosis: pathogenesis and therapy. Annu Rev Med 58:157-170
    • (2007) Annu Rev Med , vol.58 , pp. 157-170
    • Boucher, R.C.1
  • 30
    • 84905655597 scopus 로고    scopus 로고
    • CFTR: Cystic fibrosis and beyond
    • 1:CAS:528:DC%2BC2cXitFSitbfO
    • Mall MA, Hartl D (2014) CFTR: cystic fibrosis and beyond. Eur Respir J 44(4):1042-1054
    • (2014) Eur Respir J , vol.44 , Issue.4 , pp. 1042-1054
    • Mall, M.A.1    Hartl, D.2
  • 31
    • 0031040975 scopus 로고    scopus 로고
    • Pathogenesis of bacterial bronchitis in cystic fibrosis
    • 1:STN:280:DyaK2s7lsFCitA%3D%3D (discussion 95-96, 123-126)
    • Smith A (1997) Pathogenesis of bacterial bronchitis in cystic fibrosis. Pediatr Infect Dis J 16(1):91-95 (discussion 95-96, 123-126)
    • (1997) Pediatr Infect Dis J , vol.16 , Issue.1 , pp. 91-95
    • Smith, A.1
  • 32
    • 0035891636 scopus 로고    scopus 로고
    • Remodeling in response to infection and injury. Airway inflammation and hypersecretion of mucus in smoking subjects with chronic obstructive pulmonary disease
    • 1:STN:280:DC%2BD3MnovVSjsA%3D%3D
    • Maestrelli P et al (2001) Remodeling in response to infection and injury. Airway inflammation and hypersecretion of mucus in smoking subjects with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 164(10):S76-S80
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.10 , pp. S76-S80
    • Maestrelli, P.1
  • 33
    • 0024805189 scopus 로고
    • Intraluminal airway inflammation in chronic bronchitis. Characterization and correlation with clinical parameters
    • 1:STN:280:DyaK3c7gtlahsA%3D%3D
    • Thompson AB et al (1989) Intraluminal airway inflammation in chronic bronchitis. Characterization and correlation with clinical parameters. Am Rev Respir Dis 140(6):1527-1537
    • (1989) Am Rev Respir Dis , vol.140 , Issue.6 , pp. 1527-1537
    • Thompson, A.B.1
  • 34
    • 0036167851 scopus 로고    scopus 로고
    • Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
    • 1:CAS:528:DC%2BD38XhtV2isLo%3D
    • Worlitzsch D et al (2002) Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest 109(3):317-325
    • (2002) J Clin Invest , vol.109 , Issue.3 , pp. 317-325
    • Worlitzsch, D.1
  • 35
    • 4344675455 scopus 로고    scopus 로고
    • Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
    • Hogg JC (2004) Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 364(9435):709-721
    • (2004) Lancet , vol.364 , Issue.9435 , pp. 709-721
    • Hogg, J.C.1
  • 36
    • 0014424329 scopus 로고
    • Site and nature of airway obstruction in chronic obstructive lung disease
    • 1:STN:280:DyaF1c3jvF2hug%3D%3D
    • Hogg JC, Macklem PT, Thurlbeck WM (1968) Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med 278(25):1355-1360
    • (1968) N Engl J Med , vol.278 , Issue.25 , pp. 1355-1360
    • Hogg, J.C.1    Macklem, P.T.2    Thurlbeck, W.M.3
  • 37
    • 0036194724 scopus 로고    scopus 로고
    • Mucus clearance as a primary innate defense mechanism for mammalian airways
    • 1:CAS:528:DC%2BD38XitVeqt78%3D
    • Knowles MR, Boucher RC (2002) Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 109(5):571-577
    • (2002) J Clin Invest , vol.109 , Issue.5 , pp. 571-577
    • Knowles, M.R.1    Boucher, R.C.2
  • 38
    • 33846261443 scopus 로고    scopus 로고
    • Mucociliary clearance - A critical upper airway host defense mechanism and methods of assessment
    • Antunes MB, Cohen NA (2007) Mucociliary clearance - a critical upper airway host defense mechanism and methods of assessment. Curr Opin Allergy Clin Immunol 7(1):5-10
    • (2007) Curr Opin Allergy Clin Immunol , vol.7 , Issue.1 , pp. 5-10
    • Antunes, M.B.1    Cohen, N.A.2
  • 39
    • 78651527775 scopus 로고    scopus 로고
    • Analysis of the proteome of human airway epithelial secretions
    • 1:CAS:528:DC%2BC3MXhslyitr8%3D
    • Ali M et al (2011) Analysis of the proteome of human airway epithelial secretions. Proteome Sci 9:4
    • (2011) Proteome Sci , vol.9 , pp. 4
    • Ali, M.1
  • 40
    • 0021348692 scopus 로고
    • Respiratory tract infections: Intrinsic risk factors
    • 1:STN:280:DyaL2c3gtVanug%3D%3D
    • Pennington JE (1984) Respiratory tract infections: intrinsic risk factors. Am J Med 76(5A):34-41
    • (1984) Am J Med , vol.76 , Issue.5 A , pp. 34-41
    • Pennington, J.E.1
  • 41
    • 33644628486 scopus 로고    scopus 로고
    • Antimicrobial proteins and polypeptides in pulmonary innate defence
    • Rogan MP et al (2006) Antimicrobial proteins and polypeptides in pulmonary innate defence. Respir Res 7:29
    • (2006) Respir Res , vol.7 , pp. 29
    • Rogan, M.P.1
  • 42
    • 33751234251 scopus 로고    scopus 로고
    • Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease
    • 1:CAS:528:DC%2BD28Xht1Okt7vK
    • Puchelle E et al (2006) Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease. Proc Am Thorac Soc 3(8):726-733
    • (2006) Proc Am Thorac Soc , vol.3 , Issue.8 , pp. 726-733
    • Puchelle, E.1
  • 43
    • 43549093774 scopus 로고    scopus 로고
    • Structure and function of the polymeric mucins in airways mucus
    • 1:CAS:528:DC%2BD1cXkt1eqt7o%3D
    • Thornton DJ, Rousseau K, McGuckin MA (2008) Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol 70:459-486
    • (2008) Annu Rev Physiol , vol.70 , pp. 459-486
    • Thornton, D.J.1    Rousseau, K.2    McGuckin, M.A.3
  • 44
    • 33745595399 scopus 로고    scopus 로고
    • Effective mucus clearance is essential for respiratory health
    • 1:CAS:528:DC%2BD28Xms1Cksrs%3D
    • Randell SH, Boucher RC (2006) Effective mucus clearance is essential for respiratory health. Am J Respir Cell Mol Biol 35(1):20-28
    • (2006) Am J Respir Cell Mol Biol , vol.35 , Issue.1 , pp. 20-28
    • Randell, S.H.1    Boucher, R.C.2
  • 45
    • 78649735324 scopus 로고    scopus 로고
    • Airway mucus function and dysfunction
    • 1:CAS:528:DC%2BC3cXhsFaisrjL
    • Fahy JV, Dickey BF (2010) Airway mucus function and dysfunction. N Engl J Med 363(23):2233-2247
    • (2010) N Engl J Med , vol.363 , Issue.23 , pp. 2233-2247
    • Fahy, J.V.1    Dickey, B.F.2
  • 46
    • 0018401153 scopus 로고
    • Control of mucus secretion and ion transport in airways
    • 1:CAS:528:DyaE1MXhs1Ggsbw%3D
    • Nadel JA, Davis B, Phipps RJ (1979) Control of mucus secretion and ion transport in airways. Annu Rev Physiol 41:369-381
    • (1979) Annu Rev Physiol , vol.41 , pp. 369-381
    • Nadel, J.A.1    Davis, B.2    Phipps, R.J.3
  • 47
    • 0034885192 scopus 로고    scopus 로고
    • The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition
    • 1:CAS:528:DC%2BD3MXmsVyltrY%3D
    • Tarran R et al (2001) The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition. J Gen Physiol 118(2):223-236
    • (2001) J Gen Physiol , vol.118 , Issue.2 , pp. 223-236
    • Tarran, R.1
  • 48
    • 0034885663 scopus 로고    scopus 로고
    • The CF salt controversy: In vivo observations and therapeutic approaches
    • 1:CAS:528:DC%2BD3MXls1Wnu7Y%3D
    • Tarran R et al (2001) The CF salt controversy: in vivo observations and therapeutic approaches. Mol Cell 8(1):149-158
    • (2001) Mol Cell , vol.8 , Issue.1 , pp. 149-158
    • Tarran, R.1
  • 49
    • 0014034646 scopus 로고
    • Cilia and mucus transport as determinants of the response of lung to air pollutants
    • 1:STN:280:DyaF2s%2Fos1yhsQ%3D%3D
    • Kilburn KH (1967) Cilia and mucus transport as determinants of the response of lung to air pollutants. Arch Environ Health 14(1):77-91
    • (1967) Arch Environ Health , vol.14 , Issue.1 , pp. 77-91
    • Kilburn, K.H.1
  • 50
    • 0024846317 scopus 로고
    • The interaction of inhaled toxicants with respiratory tract clearance mechanisms
    • 1:CAS:528:DyaK38Xnslyrtw%3D%3D
    • Schlesinger RB (1990) The interaction of inhaled toxicants with respiratory tract clearance mechanisms. Crit Rev Toxicol 20(4):257-286
    • (1990) Crit Rev Toxicol , vol.20 , Issue.4 , pp. 257-286
    • Schlesinger, R.B.1
  • 51
    • 60149089459 scopus 로고    scopus 로고
    • Barrier properties of mucus
    • 1:CAS:528:DC%2BD1MXit1Ohtrs%3D
    • Cone RA (2009) Barrier properties of mucus. Adv Drug Deliv Rev 61(2):75-85
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.2 , pp. 75-85
    • Cone, R.A.1
  • 52
    • 0034802398 scopus 로고    scopus 로고
    • Respiratory fluid mechanics and transport processes
    • 1:CAS:528:DC%2BD3MXmsFKqur0%3D
    • Grotberg JB (2001) Respiratory fluid mechanics and transport processes. Annu Rev Biomed Eng 3:421-457
    • (2001) Annu Rev Biomed Eng , vol.3 , pp. 421-457
    • Grotberg, J.B.1
  • 53
    • 33645964965 scopus 로고    scopus 로고
    • Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress
    • 1:CAS:528:DC%2BD28XksFWks7Y%3D
    • Tarran R, Button B, Boucher RC (2006) Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress. Annu Rev Physiol 68:543-561
    • (2006) Annu Rev Physiol , vol.68 , pp. 543-561
    • Tarran, R.1    Button, B.2    Boucher, R.C.3
  • 54
    • 84865305392 scopus 로고    scopus 로고
    • A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia
    • 1:CAS:528:DC%2BC38Xht1ahu7nO
    • Button B et al (2012) A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science 337(6097):937-941
    • (2012) Science , vol.337 , Issue.6097 , pp. 937-941
    • Button, B.1
  • 55
    • 84864591396 scopus 로고    scopus 로고
    • Mapping the protein domain structures of the respiratory mucins: A mucin proteome coverage study
    • 1:CAS:528:DC%2BC38XnvFKqtbc%3D
    • Cao R et al (2012) Mapping the protein domain structures of the respiratory mucins: a mucin proteome coverage study. J Proteome Res 11(8):4013-4023
    • (2012) J Proteome Res , vol.11 , Issue.8 , pp. 4013-4023
    • Cao, R.1
  • 56
    • 84874102944 scopus 로고    scopus 로고
    • Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways
    • 1:CAS:528:DC%2BC38Xht1Kku7rE
    • Kesimer M et al (2013) Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways. Mucosal Immunol 6(2):379-392
    • (2013) Mucosal Immunol , vol.6 , Issue.2 , pp. 379-392
    • Kesimer, M.1
  • 57
    • 84903759350 scopus 로고    scopus 로고
    • Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure
    • 1:CAS:528:DC%2BC2cXhtFOht77F
    • Henderson AG et al (2014) Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. J Clin Invest 124(7):3047-3060
    • (2014) J Clin Invest , vol.124 , Issue.7 , pp. 3047-3060
    • Henderson, A.G.1
  • 58
    • 0029150812 scopus 로고
    • Chronic mucus hypersecretion in COPD and death from pulmonary infection
    • 1:STN:280:DyaK28%2FoslGntg%3D%3D
    • Prescott E, Lange P, Vestbo J (1995) Chronic mucus hypersecretion in COPD and death from pulmonary infection. Eur Respir J 8(8):1333-1338
    • (1995) Eur Respir J , vol.8 , Issue.8 , pp. 1333-1338
    • Prescott, E.1    Lange, P.2    Vestbo, J.3
  • 59
    • 0027956153 scopus 로고
    • Airway goblet cells: Responsive and adaptable front-line defenders
    • 1:STN:280:DyaK2M%2FoslOmtA%3D%3D
    • Rogers DF (1994) Airway goblet cells: responsive and adaptable front-line defenders. Eur Respir J 7(9):1690-1706
    • (1994) Eur Respir J , vol.7 , Issue.9 , pp. 1690-1706
    • Rogers, D.F.1
  • 60
    • 32444442905 scopus 로고    scopus 로고
    • Mucus in chronic airway diseases: Sorting out the sticky details
    • 1:CAS:528:DC%2BD28Xht1Sru7Y%3D
    • Cohn L (2006) Mucus in chronic airway diseases: sorting out the sticky details. J Clin Invest 116(2):306-308
    • (2006) J Clin Invest , vol.116 , Issue.2 , pp. 306-308
    • Cohn, L.1
  • 61
    • 32444436464 scopus 로고    scopus 로고
    • Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
    • 1:CAS:528:DC%2BD28Xht1Sru7c%3D
    • Tyner JW et al (2006) Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. J Clin Invest 116(2):309-321
    • (2006) J Clin Invest , vol.116 , Issue.2 , pp. 309-321
    • Tyner, J.W.1
  • 62
    • 0037292365 scopus 로고    scopus 로고
    • Preliminary pharmacological characterisation of an interleukin-13-enhanced calcium-activated chloride conductance in the human airway epithelium
    • 1:CAS:528:DC%2BD3sXhsVSltr4%3D
    • Atherton H et al (2003) Preliminary pharmacological characterisation of an interleukin-13-enhanced calcium-activated chloride conductance in the human airway epithelium. Naunyn Schmiedebergs Arch Pharmacol 367(2):214-217
    • (2003) Naunyn Schmiedebergs Arch Pharmacol , vol.367 , Issue.2 , pp. 214-217
    • Atherton, H.1
  • 63
    • 84892563951 scopus 로고    scopus 로고
    • Muc5b is required for airway defence
    • 1:CAS:528:DC%2BC2cXotFGluw%3D%3D
    • Roy MG et al (2014) Muc5b is required for airway defence. Nature 505(7483):412-416
    • (2014) Nature , vol.505 , Issue.7483 , pp. 412-416
    • Roy, M.G.1
  • 64
    • 0347123435 scopus 로고    scopus 로고
    • Mucins in cancer: Protection and control of the cell surface
    • 1:CAS:528:DC%2BD3sXpvVGnu7w%3D
    • Hollingsworth MA, Swanson BJ (2004) Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer 4(1):45-60
    • (2004) Nat Rev Cancer , vol.4 , Issue.1 , pp. 45-60
    • Hollingsworth, M.A.1    Swanson, B.J.2
  • 65
    • 43549083496 scopus 로고    scopus 로고
    • Regulated airway goblet cell mucin secretion
    • 1:CAS:528:DC%2BD1cXkt1eqt7s%3D
    • Davis CW, Dickey BF (2008) Regulated airway goblet cell mucin secretion. Annu Rev Physiol 70:487-512
    • (2008) Annu Rev Physiol , vol.70 , pp. 487-512
    • Davis, C.W.1    Dickey, B.F.2
  • 66
    • 0028954215 scopus 로고
    • Signal transduction, packaging and secretion of mucins
    • 1:CAS:528:DyaK2MXksVeqsb4%3D
    • Forstner G (1995) Signal transduction, packaging and secretion of mucins. Annu Rev Physiol 57:585-605
    • (1995) Annu Rev Physiol , vol.57 , pp. 585-605
    • Forstner, G.1
  • 67
    • 43549126011 scopus 로고    scopus 로고
    • Structure and function of the cell surface (tethered) mucins
    • 1:CAS:528:DC%2BD1cXkt1eqt70%3D
    • Hattrup CL, Gendler SJ (2008) Structure and function of the cell surface (tethered) mucins. Annu Rev Physiol 70:431-457
    • (2008) Annu Rev Physiol , vol.70 , pp. 431-457
    • Hattrup, C.L.1    Gendler, S.J.2
  • 68
    • 33644620356 scopus 로고    scopus 로고
    • Respiratory tract mucin genes and mucin glycoproteins in health and disease
    • 1:CAS:528:DC%2BD28XhtlKntr8%3D
    • Rose MC, Voynow JA (2006) Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 86(1):245-278
    • (2006) Physiol Rev , vol.86 , Issue.1 , pp. 245-278
    • Rose, M.C.1    Voynow, J.A.2
  • 69
    • 0029756477 scopus 로고    scopus 로고
    • P2u purinoceptor regulation of mucin secretion in SPOC1 cells, a goblet cell line from the airways
    • 1:CAS:528:DyaK28XktVylurw%3D
    • Abdullah LH et al (1996) P2u purinoceptor regulation of mucin secretion in SPOC1 cells, a goblet cell line from the airways. Biochem J 316(Pt 3):943-951
    • (1996) Biochem J , vol.316 , pp. 943-951
    • Abdullah, L.H.1
  • 70
    • 0030749551 scopus 로고    scopus 로고
    • 2+ activation of mucin secretion in airway goblet cells
    • 1:CAS:528:DyaK2sXlt1Sqsr8%3D
    • 2+ activation of mucin secretion in airway goblet cells. Am J Physiol 273(1 Pt 1):L201-L210
    • (1997) Am J Physiol , vol.273 , Issue.1 , pp. L201-L210
    • Abdullah, L.H.1
  • 71
    • 78649647597 scopus 로고    scopus 로고
    • 3(-) transport in mucin secretion: Lessons from cystic fibrosis
    • 1:CAS:528:DC%2BC3cXhs1aisbrK
    • 3(-) transport in mucin secretion: lessons from cystic fibrosis. Am J Physiol Cell Physiol 299(6):C1222-C1233
    • (2010) Am J Physiol Cell Physiol , vol.299 , Issue.6 , pp. C1222-C1233
    • Quinton, P.M.1
  • 72
    • 0025306375 scopus 로고
    • Goblet cells secretion and mucogenesis
    • 1:STN:280:DyaK3c3jtlOmsg%3D%3D
    • Verdugo P (1990) Goblet cells secretion and mucogenesis. Annu Rev Physiol 52:157-176
    • (1990) Annu Rev Physiol , vol.52 , pp. 157-176
    • Verdugo, P.1
  • 73
    • 33847289649 scopus 로고    scopus 로고
    • Cystic fibrosis and other respiratory diseases of impaired mucus clearance
    • 1:CAS:528:DC%2BD2sXkt1SrtL8%3D
    • Livraghi A, Randell SH (2007) Cystic fibrosis and other respiratory diseases of impaired mucus clearance. Toxicol Pathol 35(1):116-129
    • (2007) Toxicol Pathol , vol.35 , Issue.1 , pp. 116-129
    • Livraghi, A.1    Randell, S.H.2
  • 74
    • 70449098259 scopus 로고    scopus 로고
    • Planar cell polarity signaling: The developing cell's compass
    • Vladar EK, Antic D, Axelrod JD (2009) Planar cell polarity signaling: the developing cell's compass. Cold Spring Harb Perspect Biol 1(3):a002964
    • (2009) Cold Spring Harb Perspect Biol , vol.1 , Issue.3 , pp. a002964
    • Vladar, E.K.1    Antic, D.2    Axelrod, J.D.3
  • 75
    • 1642350333 scopus 로고    scopus 로고
    • Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells
    • 1:CAS:528:DC%2BD2cXjtlans7o%3D
    • You Y et al (2004) Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 286(4):L650-L657
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286 , Issue.4 , pp. L650-L657
    • You, Y.1
  • 76
    • 2342417378 scopus 로고    scopus 로고
    • Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells
    • 1:CAS:528:DC%2BD2cXjs1ygur8%3D
    • Gomperts BN, Gong-Cooper X, Hackett BP (2004) Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J Cell Sci 117(Pt 8):1329-1337
    • (2004) J Cell Sci , vol.117 , pp. 1329-1337
    • Gomperts, B.N.1    Gong-Cooper, X.2    Hackett, B.P.3
  • 77
    • 0036618084 scopus 로고    scopus 로고
    • A proteomic analysis of human cilia: Identification of novel components
    • 1:CAS:528:DC%2BD38XmsV2jt7c%3D
    • Ostrowski LE et al (2002) A proteomic analysis of human cilia: identification of novel components. Mol Cell Proteomics 1(6):451-465
    • (2002) Mol Cell Proteomics , vol.1 , Issue.6 , pp. 451-465
    • Ostrowski, L.E.1
  • 78
    • 33947384151 scopus 로고    scopus 로고
    • Overview of structure and function of mammalian cilia
    • 1:CAS:528:DC%2BD2sXltVaksLw%3D
    • Satir P, Christensen ST (2007) Overview of structure and function of mammalian cilia. Annu Rev Physiol 69:377-400
    • (2007) Annu Rev Physiol , vol.69 , pp. 377-400
    • Satir, P.1    Christensen, S.T.2
  • 79
    • 54049094727 scopus 로고    scopus 로고
    • Coupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling
    • 1:CAS:528:DC%2BD1cXht12rtr7K
    • Davis CW, Lazarowski E (2008) Coupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling. Respir Physiol Neurobiol 163(1-3):208-213
    • (2008) Respir Physiol Neurobiol , vol.163 , Issue.1-3 , pp. 208-213
    • Davis, C.W.1    Lazarowski, E.2
  • 80
    • 22144464040 scopus 로고    scopus 로고
    • ATP regulation of ciliary beat frequency in rat tracheal and distal airway epithelium
    • 1:CAS:528:DC%2BD2MXovVOnu7c%3D
    • Hayashi T et al (2005) ATP regulation of ciliary beat frequency in rat tracheal and distal airway epithelium. Exp Physiol 90(4):535-544
    • (2005) Exp Physiol , vol.90 , Issue.4 , pp. 535-544
    • Hayashi, T.1
  • 81
    • 0029957910 scopus 로고    scopus 로고
    • Purinergic stimulation of rabbit ciliated airway epithelia: Control by multiple calcium sources
    • 1:CAS:528:DyaK28XnsVyqtro%3D
    • Korngreen A, Priel Z (1996) Purinergic stimulation of rabbit ciliated airway epithelia: control by multiple calcium sources. J Physiol 497(Pt 1):53-66
    • (1996) J Physiol , vol.497 , pp. 53-66
    • Korngreen, A.1    Priel, Z.2
  • 82
    • 65749098350 scopus 로고    scopus 로고
    • Purinergic receptors in airway epithelia
    • 1:CAS:528:DC%2BD1MXms1Ogsr4%3D
    • Lazarowski ER, Boucher RC (2009) Purinergic receptors in airway epithelia. Curr Opin Pharmacol 9(3):262-267
    • (2009) Curr Opin Pharmacol , vol.9 , Issue.3 , pp. 262-267
    • Lazarowski, E.R.1    Boucher, R.C.2
  • 83
    • 0037082217 scopus 로고    scopus 로고
    • Prolonged increase in ciliary beat frequency after short-term purinergic stimulation in human airway epithelial cells
    • 1:CAS:528:DC%2BD38XislGnu7w%3D
    • Lieb T et al (2002) Prolonged increase in ciliary beat frequency after short-term purinergic stimulation in human airway epithelial cells. J Physiol 538(Pt 2):633-646
    • (2002) J Physiol , vol.538 , pp. 633-646
    • Lieb, T.1
  • 84
    • 0027291291 scopus 로고
    • Modulation of airway epithelial cell ciliary beat frequency by nitric oxide
    • 1:CAS:528:DyaK3sXhvVylsbY%3D
    • Jain B et al (1993) Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem Biophys Res Commun 191(1):83-88
    • (1993) Biochem Biophys Res Commun , vol.191 , Issue.1 , pp. 83-88
    • Jain, B.1
  • 85
    • 80052624280 scopus 로고    scopus 로고
    • Regulation of ciliary beat frequency by the nitric oxide signaling pathway in mouse nasal and tracheal epithelial cells
    • 1:CAS:528:DC%2BC3MXhtFGlsbvF
    • Jiao J et al (2011) Regulation of ciliary beat frequency by the nitric oxide signaling pathway in mouse nasal and tracheal epithelial cells. Exp Cell Res 317(17):2548-2553
    • (2011) Exp Cell Res , vol.317 , Issue.17 , pp. 2548-2553
    • Jiao, J.1
  • 86
    • 0033844950 scopus 로고    scopus 로고
    • Regulation of ciliary beat frequency by the nitric oxide-cyclic guanosine monophosphate signaling pathway in rat airway epithelial cells
    • 1:CAS:528:DC%2BD3cXmt1OgtbY%3D
    • Li D et al (2000) Regulation of ciliary beat frequency by the nitric oxide-cyclic guanosine monophosphate signaling pathway in rat airway epithelial cells. Am J Respir Cell Mol Biol 23(2):175-181
    • (2000) Am J Respir Cell Mol Biol , vol.23 , Issue.2 , pp. 175-181
    • Li, D.1
  • 87
    • 0029943168 scopus 로고    scopus 로고
    • Dual signal transduction mechanisms modulate ciliary beat frequency in upper airway epithelium
    • 1:CAS:528:DyaK28Xjt1Gqs7s%3D
    • Yang B, Schlosser RJ, McCaffrey TV (1996) Dual signal transduction mechanisms modulate ciliary beat frequency in upper airway epithelium. Am J Physiol 270(5 Pt 1):L745-L751
    • (1996) Am J Physiol , vol.270 , Issue.5 , pp. L745-L751
    • Yang, B.1    Schlosser, R.J.2    McCaffrey, T.V.3
  • 88
    • 84934876748 scopus 로고    scopus 로고
    • Nucleotide-mediated airway clearance
    • 1:CAS:528:DC%2BC38XhtlGrur3K
    • Schmid A et al (2011) Nucleotide-mediated airway clearance. Subcell Biochem 55:95-138
    • (2011) Subcell Biochem , vol.55 , pp. 95-138
    • Schmid, A.1
  • 89
    • 33947367829 scopus 로고    scopus 로고
    • Regulation of mammalian ciliary beating
    • 1:CAS:528:DC%2BD2sXltVaksL0%3D
    • Salathe M (2007) Regulation of mammalian ciliary beating. Annu Rev Physiol 69:401-422
    • (2007) Annu Rev Physiol , vol.69 , pp. 401-422
    • Salathe, M.1
  • 90
    • 77953242207 scopus 로고    scopus 로고
    • Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor
    • 1:CAS:528:DC%2BC3cXhsVKrtLjP
    • Wyatt TA et al (2010) Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor. Am J Respir Cell Mol Biol 42(6):706-715
    • (2010) Am J Respir Cell Mol Biol , vol.42 , Issue.6 , pp. 706-715
    • Wyatt, T.A.1
  • 91
    • 0024234657 scopus 로고
    • Role of absorptive and secretory processes in hydration of the airway surface
    • 1:CAS:528:DyaL1MXlsVOqsA%3D%3D
    • Frizzell RA (1988) Role of absorptive and secretory processes in hydration of the airway surface. Am Rev Respir Dis 138(6 Pt 2):S3-S6
    • (1988) Am Rev Respir Dis , vol.138 , Issue.6 , pp. S3-S6
    • Frizzell, R.A.1
  • 92
    • 36348979793 scopus 로고    scopus 로고
    • Sodium channels and cystic fibrosis
    • 1:CAS:528:DC%2BD2sXhsVGqtLzJ
    • Donaldson SH, Boucher RC (2007) Sodium channels and cystic fibrosis. Chest 132(5):1631-1636
    • (2007) Chest , vol.132 , Issue.5 , pp. 1631-1636
    • Donaldson, S.H.1    Boucher, R.C.2
  • 93
    • 84885679220 scopus 로고    scopus 로고
    • Proteases, cystic fibrosis and the epithelial sodium channel (ENaC)
    • 1:CAS:528:DC%2BC3sXitVOjs7s%3D
    • Thibodeau PH, Butterworth MB (2013) Proteases, cystic fibrosis and the epithelial sodium channel (ENaC). Cell Tissue Res 351(2):309-323
    • (2013) Cell Tissue Res , vol.351 , Issue.2 , pp. 309-323
    • Thibodeau, P.H.1    Butterworth, M.B.2
  • 94
    • 70349335993 scopus 로고    scopus 로고
    • Adenosine receptors, cystic fibrosis, and airway hydration
    • 1:CAS:528:DC%2BD1MXhs1SktrzP
    • Com G, Clancy JP (2009) Adenosine receptors, cystic fibrosis, and airway hydration. Handb Exp Pharmacol 193:363-381
    • (2009) Handb Exp Pharmacol , vol.193 , pp. 363-381
    • Com, G.1    Clancy, J.P.2
  • 95
    • 36249004984 scopus 로고    scopus 로고
    • Ion and liquid transport across the bronchiolar epithelium
    • 1:CAS:528:DC%2BD2sXhtlGht7vJ
    • Blouquit-Laye S, Chinet T (2007) Ion and liquid transport across the bronchiolar epithelium. Respir Physiol Neurobiol 159(3):278-282
    • (2007) Respir Physiol Neurobiol , vol.159 , Issue.3 , pp. 278-282
    • Blouquit-Laye, S.1    Chinet, T.2
  • 97
    • 15544371839 scopus 로고    scopus 로고
    • Assembly of functional CFTR chloride channels
    • 1:CAS:528:DC%2BD2MXjsFeks7s%3D
    • Riordan JR (2005) Assembly of functional CFTR chloride channels. Annu Rev Physiol 67:701-718
    • (2005) Annu Rev Physiol , vol.67 , pp. 701-718
    • Riordan, J.R.1
  • 98
    • 0026532895 scopus 로고
    • Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)
    • 1:CAS:528:DyaK38XhvFajtLs%3D
    • Bear CE et al (1992) Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR). Cell 68(4):809-818
    • (1992) Cell , vol.68 , Issue.4 , pp. 809-818
    • Bear, C.E.1
  • 99
    • 0025885376 scopus 로고
    • - channel in CHO cells stably expressing the cystic fibrosis gene
    • 1:STN:280:DyaK3Mzis1Squw%3D%3D
    • - channel in CHO cells stably expressing the cystic fibrosis gene. Nature 352(6336):628-631
    • (1991) Nature , vol.352 , Issue.6336 , pp. 628-631
    • Tabcharani, J.A.1
  • 100
    • 0023782863 scopus 로고
    • Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells
    • 1:STN:280:DyaL1M7htV2mtg%3D%3D
    • Gray MA, Greenwell JR, Argent BE (1988) Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells. J Membr Biol 105(2):131-142
    • (1988) J Membr Biol , vol.105 , Issue.2 , pp. 131-142
    • Gray, M.A.1    Greenwell, J.R.2    Argent, B.E.3
  • 101
    • 0025987020 scopus 로고
    • Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel
    • 1:CAS:528:DyaK3MXmtVGitLs%3D
    • Cheng SH et al (1991) Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel. Cell 66(5):1027-1036
    • (1991) Cell , vol.66 , Issue.5 , pp. 1027-1036
    • Cheng, S.H.1
  • 102
    • 34548853133 scopus 로고    scopus 로고
    • Structure and mechanism of ABC transporter proteins
    • 1:CAS:528:DC%2BD2sXhtFSltb3L
    • Hollenstein K, Dawson RJ, Locher KP (2007) Structure and mechanism of ABC transporter proteins. Curr Opin Struct Biol 17(4):412-418
    • (2007) Curr Opin Struct Biol , vol.17 , Issue.4 , pp. 412-418
    • Hollenstein, K.1    Dawson, R.J.2    Locher, K.P.3
  • 103
    • 0027958441 scopus 로고
    • + channel is made of three homologous subunits
    • 1:CAS:528:DyaK2cXitlymsL4%3D
    • + channel is made of three homologous subunits. Nature 367(6462):463-467
    • (1994) Nature , vol.367 , Issue.6462 , pp. 463-467
    • Canessa, C.M.1
  • 104
    • 34548813656 scopus 로고    scopus 로고
    • Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH
    • 1:CAS:528:DC%2BD2sXhtVKiu7vE
    • Jasti J et al (2007) Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature 449(7160):316-323
    • (2007) Nature , vol.449 , Issue.7160 , pp. 316-323
    • Jasti, J.1
  • 105
    • 0141621280 scopus 로고    scopus 로고
    • + channel involves proteolytic processing of the alpha- and gamma-subunits
    • 1:CAS:528:DC%2BD3sXnsV2mtb8%3D
    • + channel involves proteolytic processing of the alpha- and gamma-subunits. J Biol Chem 278(39):37073-37082
    • (2003) J Biol Chem , vol.278 , Issue.39 , pp. 37073-37082
    • Hughey, R.P.1
  • 106
    • 68949094195 scopus 로고    scopus 로고
    • ENaC at the cutting edge: Regulation of epithelial sodium channels by proteases
    • 1:CAS:528:DC%2BD1MXovFWrs7g%3D
    • Kleyman TR, Carattino MD, Hughey RP (2009) ENaC at the cutting edge: regulation of epithelial sodium channels by proteases. J Biol Chem 284(31):20447-20451
    • (2009) J Biol Chem , vol.284 , Issue.31 , pp. 20447-20451
    • Kleyman, T.R.1    Carattino, M.D.2    Hughey, R.P.3
  • 107
    • 0030731428 scopus 로고    scopus 로고
    • + channel (ENaC) by ubiquitination
    • 1:CAS:528:DyaK2sXnslWksbk%3D
    • + channel (ENaC) by ubiquitination. The EMBO Journal 16(21):6325-6336
    • (1997) The EMBO Journal , vol.16 , Issue.21 , pp. 6325-6336
    • Staub, O.1
  • 108
    • 79952764514 scopus 로고    scopus 로고
    • Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease
    • 1:CAS:528:DC%2BC3MXislyjuro%3D
    • Kimura T et al (2011) Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci USA 108(8):3216-3221
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.8 , pp. 3216-3221
    • Kimura, T.1
  • 109
    • 0033525780 scopus 로고    scopus 로고
    • Cystic fibrosis and the salt controversy
    • 1:CAS:528:DyaK1MXitVChsrw%3D
    • Guggino WB (1999) Cystic fibrosis and the salt controversy. Cell 96(5):607-610
    • (1999) Cell , vol.96 , Issue.5 , pp. 607-610
    • Guggino, W.B.1
  • 110
    • 84884284486 scopus 로고    scopus 로고
    • Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease?
    • 1:CAS:528:DC%2BC3sXhsVCrurzI
    • Hobbs CA, Da Tan C, Tarran R (2013) Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease? J Physiol 591(Pt 18):4377-4387
    • (2013) J Physiol , vol.591 , pp. 4377-4387
    • Hobbs, C.A.1    Da Tan, C.2    Tarran, R.3
  • 111
    • 0037274990 scopus 로고    scopus 로고
    • ENaC-CFTR interactions: The role of electrical coupling of ion fluxes explored in an epithelial cell model
    • 1:CAS:528:DC%2BD3sXis1GnsbY%3D
    • Horisberger JD (2003) ENaC-CFTR interactions: the role of electrical coupling of ion fluxes explored in an epithelial cell model. Pflugers Arch 445(4):522-528
    • (2003) Pflugers Arch , vol.445 , Issue.4 , pp. 522-528
    • Horisberger, J.D.1
  • 112
    • 0028309683 scopus 로고
    • Human airway ion transport. Part one
    • 1:STN:280:DyaK2c3pslymtw%3D%3D
    • Boucher RC (1994) Human airway ion transport. Part one. Am J Respir Crit Care Med 150(1):271-281
    • (1994) Am J Respir Crit Care Med , vol.150 , Issue.1 , pp. 271-281
    • Boucher, R.C.1
  • 113
    • 0030814886 scopus 로고    scopus 로고
    • Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects
    • 1:CAS:528:DyaK2sXnsVymtbk%3D
    • Knowles MR et al (1997) Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects. J Clin Invest 100(10):2588-2595
    • (1997) J Clin Invest , vol.100 , Issue.10 , pp. 2588-2595
    • Knowles, M.R.1
  • 114
    • 0035412021 scopus 로고    scopus 로고
    • Regulation and functional significance of airway surface liquid pH
    • 1:STN:280:DC%2BD387jvFehsg%3D%3D
    • Coakley RD, Boucher RC (2001) Regulation and functional significance of airway surface liquid pH. Jop 2(4 Suppl):294-300
    • (2001) Jop , vol.2 , Issue.4 , pp. 294-300
    • Coakley, R.D.1    Boucher, R.C.2
  • 115
    • 67650488822 scopus 로고    scopus 로고
    • SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage
    • 1:CAS:528:DC%2BD1MXptVahsbs%3D
    • Garcia-Caballero A et al (2009) SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage. Proc Natl Acad Sci USA 106(27):11412-11417
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.27 , pp. 11412-11417
    • Garcia-Caballero, A.1
  • 116
    • 4344619319 scopus 로고    scopus 로고
    • Nucleotide release provides a mechanism for airway surface liquid homeostasis
    • 1:CAS:528:DC%2BD2cXmvFCmtr4%3D
    • Lazarowski ER et al (2004) Nucleotide release provides a mechanism for airway surface liquid homeostasis. J Biol Chem 279(35):36855-36864
    • (2004) J Biol Chem , vol.279 , Issue.35 , pp. 36855-36864
    • Lazarowski, E.R.1
  • 117
    • 84879974863 scopus 로고    scopus 로고
    • Mechanosensitive ATP release maintains proper mucus hydration of airways
    • Button B et al (2013) Mechanosensitive ATP release maintains proper mucus hydration of airways. Sci Signa 6(279):ra46
    • (2013) Sci Signa , vol.6 , Issue.279 , pp. ra46
    • Button, B.1
  • 118
    • 54049116737 scopus 로고    scopus 로고
    • Role of mechanical stress in regulating airway surface hydration and mucus clearance rates
    • Button B, Boucher RC (2008) Role of mechanical stress in regulating airway surface hydration and mucus clearance rates. Respir Physiol Neurobiol 163(1-3):189-201
    • (2008) Respir Physiol Neurobiol , vol.163 , Issue.1-3 , pp. 189-201
    • Button, B.1    Boucher, R.C.2
  • 119
    • 77950810893 scopus 로고    scopus 로고
    • + channel and airway surface liquid volume by serine proteases
    • 1:CAS:528:DC%2BC3cXmtFKktbY%3D
    • + channel and airway surface liquid volume by serine proteases. Pflugers Arch 460(1):1-17
    • (2010) Pflugers Arch , vol.460 , Issue.1 , pp. 1-17
    • Gaillard, E.A.1
  • 120
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    • 1:CAS:528:DyaK1MXjslyktg%3D%3D
    • Matsui H et al (1998) Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95(7):1005-1015
    • (1998) Cell , vol.95 , Issue.7 , pp. 1005-1015
    • Matsui, H.1
  • 121
    • 11244283223 scopus 로고    scopus 로고
    • + transport via hydrolysis of PIP2
    • 1:CAS:528:DC%2BD2MXitVGgsg%3D%3D
    • + transport via hydrolysis of PIP2. FASEB J 19(1):142-143
    • (2005) FASEB J , vol.19 , Issue.1 , pp. 142-143
    • Kunzelmann, K.1
  • 122
    • 58149335369 scopus 로고    scopus 로고
    • Physiologic regulation of the epithelial sodium channel by phosphatidylinositides
    • 1:CAS:528:DC%2BD1cXhtVejtbfP
    • Pochynyuk O, Bugaj V, Stockand JD (2008) Physiologic regulation of the epithelial sodium channel by phosphatidylinositides. Curr Opin Nephrol Hypertens 17(5):533-540
    • (2008) Curr Opin Nephrol Hypertens , vol.17 , Issue.5 , pp. 533-540
    • Pochynyuk, O.1    Bugaj, V.2    Stockand, J.D.3
  • 123
    • 0037023759 scopus 로고    scopus 로고
    • Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates epithelial sodium channel activity in A6 cells
    • 1:CAS:528:DC%2BD38XivVektr8%3D
    • Yue G, Malik B, Eaton DC (2002) Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates epithelial sodium channel activity in A6 cells. J Biol Chem 277(14):11965-11969
    • (2002) J Biol Chem , vol.277 , Issue.14 , pp. 11965-11969
    • Yue, G.1    Malik, B.2    Eaton, D.C.3
  • 124
    • 84890393972 scopus 로고    scopus 로고
    • Identification of SPLUNC1's ENaC-Inhibitory Domain Yields Novel Strategies to Treat Sodium Hyperabsorption in Cystic Fibrosis Airway Cultures. Am J Physiol Lung Cell Mol Physiol
    • Hobbs CA et al (2013) Identification of SPLUNC1's ENaC-Inhibitory Domain Yields Novel Strategies to Treat Sodium Hyperabsorption in Cystic Fibrosis Airway Cultures. Am J Physiol Lung Cell Mol Physiol
    • (2013)
    • Hobbs, C.A.1
  • 125
    • 77952891046 scopus 로고    scopus 로고
    • SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes
    • 1:CAS:528:DC%2BC3cXhsFyrtb%2FP
    • Rollins BM et al (2010) SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes. Channels (Austin) 4(4):255-259
    • (2010) Channels (Austin) , vol.4 , Issue.4 , pp. 255-259
    • Rollins, B.M.1
  • 126
    • 84885084821 scopus 로고    scopus 로고
    • Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways
    • 1:CAS:528:DC%2BC3sXhs1SqtbjN
    • Garland AL et al (2013) Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Proc Natl Acad Sci USA 110(40):15973-15978
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.40 , pp. 15973-15978
    • Garland, A.L.1
  • 127
    • 84861384708 scopus 로고    scopus 로고
    • Acid and base secretion in freshly excised nasal tissue from cystic fibrosis patients with DeltaF508 mutation
    • Cho DY et al (2011) Acid and base secretion in freshly excised nasal tissue from cystic fibrosis patients with DeltaF508 mutation. Int Forum Allergy Rhinol 1(2):123-127
    • (2011) Int Forum Allergy Rhinol , vol.1 , Issue.2 , pp. 123-127
    • Cho, D.Y.1
  • 128
    • 84901608363 scopus 로고    scopus 로고
    • Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration
    • 1:CAS:528:DC%2BC2cXkvV2qtb4%3D
    • Tarran R, Redinbo MR (2014) Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration. Int J Biochem Cell Biol 52:130-135
    • (2014) Int J Biochem Cell Biol , vol.52 , pp. 130-135
    • Tarran, R.1    Redinbo, M.R.2
  • 129
    • 0037428391 scopus 로고    scopus 로고
    • Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts
    • 1:CAS:528:DC%2BD3sXnvVSi
    • Di YP et al (2003) Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts. J Biol Chem 278(2):1165-1173
    • (2003) J Biol Chem , vol.278 , Issue.2 , pp. 1165-1173
    • Di, Y.P.1
  • 130
    • 58549087743 scopus 로고    scopus 로고
    • Assessment of the CFTR and ENaC association
    • 1:CAS:528:DC%2BD1MXntVynsQ%3D%3D
    • Berdiev BK, Qadri YJ, Benos DJ (2009) Assessment of the CFTR and ENaC association. Mol BioSyst 5(2):123-127
    • (2009) Mol BioSyst , vol.5 , Issue.2 , pp. 123-127
    • Berdiev, B.K.1    Qadri, Y.J.2    Benos, D.J.3
  • 131
    • 84861470533 scopus 로고    scopus 로고
    • Airway epithelial cells - Hyperabsorption in CF?
    • 1:CAS:528:DC%2BC38XovVanurc%3D
    • Kunzelmann K, Schreiber R (2012) Airway epithelial cells - hyperabsorption in CF? Int J Biochem Cell Biol 44(8):1232-1235
    • (2012) Int J Biochem Cell Biol , vol.44 , Issue.8 , pp. 1232-1235
    • Kunzelmann, K.1    Schreiber, R.2
  • 132
    • 0022973473 scopus 로고
    • + transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation
    • 1:CAS:528:DyaL28Xmt1eqtrY%3D
    • + transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. J Clin Invest 78(5):1245-1252
    • (1986) J Clin Invest , vol.78 , Issue.5 , pp. 1245-1252
    • Boucher, R.C.1
  • 133
    • 0031024767 scopus 로고    scopus 로고
    • + currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator
    • 1:CAS:528:DyaK2sXktl2gsw%3D%3D
    • + currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator. FEBS Lett 400(3):341-344
    • (1997) FEBS Lett , vol.400 , Issue.3 , pp. 341-344
    • Kunzelmann, K.1
  • 134
    • 0028982894 scopus 로고
    • CFTR as a cAMP-dependent regulator of sodium channels
    • 1:CAS:528:DyaK2MXnsVagsrk%3D
    • Stutts MJ et al (1995) CFTR as a cAMP-dependent regulator of sodium channels. Science 269(5225):847-850
    • (1995) Science , vol.269 , Issue.5225 , pp. 847-850
    • Stutts, M.J.1
  • 135
    • 80053376536 scopus 로고    scopus 로고
    • Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung
    • 1:CAS:528:DC%2BC3MXhtlersbbN
    • Lazrak A et al (2011) Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung. Am J Physiol Lung Cell Mol Physiol 301(4):L557-L567
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.301 , Issue.4 , pp. L557-L567
    • Lazrak, A.1
  • 136
    • 84881494429 scopus 로고    scopus 로고
    • Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD
    • 1:CAS:528:DC%2BC3sXhsVCqtrnL
    • Dransfield MT et al (2013) Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD. Chest 144(2):498-506
    • (2013) Chest , vol.144 , Issue.2 , pp. 498-506
    • Dransfield, M.T.1
  • 137
    • 0030879756 scopus 로고    scopus 로고
    • An epithelial serine protease activates the amiloride-sensitive sodium channel
    • 1:CAS:528:DyaK2sXmslWgu7s%3D
    • Vallet V et al (1997) An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature 389(6651):607-610
    • (1997) Nature , vol.389 , Issue.6651 , pp. 607-610
    • Vallet, V.1
  • 139
    • 84918789823 scopus 로고    scopus 로고
    • + hyperabsorption in cystic fibrosis airway epithelial cultures
    • 1:CAS:528:DC%2BC2cXitVamsLfE
    • + hyperabsorption in cystic fibrosis airway epithelial cultures. J Physiol 592(Pt 23):5251-5268
    • (2014) J Physiol , vol.592 , pp. 5251-5268
    • Tan, C.D.1
  • 140
    • 84865758196 scopus 로고    scopus 로고
    • Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity
    • 1:CAS:528:DC%2BC38Xht1yqtrfI
    • Alli AA et al (2012) Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity. J Biol Chem 287(36):30073-30083
    • (2012) J Biol Chem , vol.287 , Issue.36 , pp. 30073-30083
    • Alli, A.A.1
  • 141
    • 84866527762 scopus 로고    scopus 로고
    • Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa
    • 1:CAS:528:DC%2BC38XhtlyqsrvK
    • Butterworth MB et al (2012) Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa. J Biol Chem 287(39):32556-32565
    • (2012) J Biol Chem , vol.287 , Issue.39 , pp. 32556-32565
    • Butterworth, M.B.1
  • 142
    • 84879291920 scopus 로고    scopus 로고
    • The neutrophil in chronic obstructive pulmonary disease
    • 1:CAS:528:DC%2BC3sXnsl2hsb0%3D
    • Hoenderdos K, Condliffe A (2013) The neutrophil in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 48(5):531-539
    • (2013) Am J Respir Cell Mol Biol , vol.48 , Issue.5 , pp. 531-539
    • Hoenderdos, K.1    Condliffe, A.2
  • 143
    • 21244481615 scopus 로고    scopus 로고
    • Analysis of complex mixtures-cigarette smoke
    • 1:CAS:528:DC%2BD2MXhtVGmsbnF
    • Borgerding M, Klus H (2005) Analysis of complex mixtures-cigarette smoke. Exp Toxicol Pathol 57(Suppl 1):43-73
    • (2005) Exp Toxicol Pathol , vol.57 , pp. 43-73
    • Borgerding, M.1    Klus, H.2
  • 144
    • 0031194463 scopus 로고    scopus 로고
    • The changing cigarette
    • 1:CAS:528:DyaK2sXltlKlurs%3D
    • Hoffmann D, Djordjevic MV, Hoffmann I (1997) The changing cigarette. Prev Med 26(4):427-434
    • (1997) Prev Med , vol.26 , Issue.4 , pp. 427-434
    • Hoffmann, D.1    Djordjevic, M.V.2    Hoffmann, I.3
  • 145
    • 79953279642 scopus 로고    scopus 로고
    • Hazardous compounds in tobacco smoke
    • Talhout R et al (2011) Hazardous compounds in tobacco smoke. Int J Environ Res Public Health 8(2):613-628
    • (2011) Int J Environ Res Public Health , vol.8 , Issue.2 , pp. 613-628
    • Talhout, R.1
  • 146
    • 70350643671 scopus 로고    scopus 로고
    • Chemical analysis of cigarette smoke particulate generated in the MSB-01 in vitro whole smoke exposure system
    • 1:CAS:528:DC%2BD1MXhtFGlsbnE
    • Scian MJ et al (2009) Chemical analysis of cigarette smoke particulate generated in the MSB-01 in vitro whole smoke exposure system. Inhal Toxicol 21(12):1040-1052
    • (2009) Inhal Toxicol , vol.21 , Issue.12 , pp. 1040-1052
    • Scian, M.J.1
  • 147
    • 4143062086 scopus 로고    scopus 로고
    • Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke
    • 1:STN:280:DC%2BD3srotVGisA%3D%3D
    • Fowles J, Dybing E (2003) Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob Control 12(4):424-430
    • (2003) Tob Control , vol.12 , Issue.4 , pp. 424-430
    • Fowles, J.1    Dybing, E.2
  • 148
    • 0027937573 scopus 로고
    • Effects of cigarette smoke on epithelial cells of the respiratory tract
    • 1:STN:280:DyaK2cznvVWhsA%3D%3D
    • Dye JA, Adler KB (1994) Effects of cigarette smoke on epithelial cells of the respiratory tract. Thorax 49(8):825-834
    • (1994) Thorax , vol.49 , Issue.8 , pp. 825-834
    • Dye, J.A.1    Adler, K.B.2
  • 149
    • 84862516080 scopus 로고    scopus 로고
    • Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects
    • Yaghi A et al (2012) Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects. Respir Med 106(8):1139-1147
    • (2012) Respir Med , vol.106 , Issue.8 , pp. 1139-1147
    • Yaghi, A.1
  • 150
    • 0031865163 scopus 로고    scopus 로고
    • Age, smoking and nasal ciliary beat frequency
    • 1:STN:280:DyaK1czjtlKkug%3D%3D
    • Agius AM, Smallman LA, Pahor AL (1998) Age, smoking and nasal ciliary beat frequency. Clin Otolaryngol Allied Sci 23(3):227-230
    • (1998) Clin Otolaryngol Allied Sci , vol.23 , Issue.3 , pp. 227-230
    • Agius, A.M.1    Smallman, L.A.2    Pahor, A.L.3
  • 151
    • 0033807630 scopus 로고    scopus 로고
    • Acetaldehyde-stimulated PKC activity in airway epithelial cells treated with smoke extract from normal and smokeless cigarettes
    • 1:CAS:528:DC%2BD3cXntVSms7w%3D
    • Wyatt TA et al (2000) Acetaldehyde-stimulated PKC activity in airway epithelial cells treated with smoke extract from normal and smokeless cigarettes. Proc Soc Exp Biol Med 225(1):91-97
    • (2000) Proc Soc Exp Biol Med , vol.225 , Issue.1 , pp. 91-97
    • Wyatt, T.A.1
  • 152
    • 67650330215 scopus 로고    scopus 로고
    • Cigarette smoke exposure impairs respiratory epithelial ciliogenesis
    • Tamashiro E et al (2009) Cigarette smoke exposure impairs respiratory epithelial ciliogenesis. Am J Rhinol Allergy 23(2):117-122
    • (2009) Am J Rhinol Allergy , vol.23 , Issue.2 , pp. 117-122
    • Tamashiro, E.1
  • 153
    • 84890025789 scopus 로고    scopus 로고
    • Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction
    • 1:CAS:528:DC%2BC3sXhvFSqurzK
    • Lam HC et al (2013) Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest 123(12):5212-5230
    • (2013) J Clin Invest , vol.123 , Issue.12 , pp. 5212-5230
    • Lam, H.C.1
  • 154
    • 0028920130 scopus 로고
    • Ciliary abnormalities in bronchial epithelium of smokers, ex-smokers, and nonsmokers
    • 1:STN:280:DyaK2M7oslCjuw%3D%3D
    • Verra F et al (1995) Ciliary abnormalities in bronchial epithelium of smokers, ex-smokers, and nonsmokers. Am J Respir Crit Care Med 151(3 Pt 1):630-634
    • (1995) Am J Respir Crit Care Med , vol.151 , Issue.3 , pp. 630-634
    • Verra, F.1
  • 155
    • 0018343201 scopus 로고
    • Changes in bronchial epithelium in relation to cigarette smoking, 1955-1960 vs. 1970-1977
    • 1:STN:280:DyaE1M%2Fptl2juw%3D%3D
    • Auerbach O, Hammond EC, Garfinkel L (1979) Changes in bronchial epithelium in relation to cigarette smoking, 1955-1960 vs. 1970-1977. N Engl J Med 300(8):381-385
    • (1979) N Engl J Med , vol.300 , Issue.8 , pp. 381-385
    • Auerbach, O.1    Hammond, E.C.2    Garfinkel, L.3
  • 156
    • 77954063235 scopus 로고    scopus 로고
    • Smoking is associated with shortened airway cilia
    • Leopold PL et al (2009) Smoking is associated with shortened airway cilia. PLoS One 4(12):e8157
    • (2009) PLoS One , vol.4 , Issue.12 , pp. e8157
    • Leopold, P.L.1
  • 157
    • 0020600295 scopus 로고
    • Abnormalities of bronchial cilia in patients with chronic bronchitis: An ultrastructural and quantitative analysis
    • 1:STN:280:DyaL3s3ntVSgsQ%3D%3D
    • Lungarella G, Fonzi L, Ermini G (1983) Abnormalities of bronchial cilia in patients with chronic bronchitis: an ultrastructural and quantitative analysis. Lung 161(3):147-156
    • (1983) Lung , vol.161 , Issue.3 , pp. 147-156
    • Lungarella, G.1    Fonzi, L.2    Ermini, G.3
  • 158
    • 0028014332 scopus 로고
    • Smoke and viral infection cause cilia loss detectable by bronchoalveolar lavage cytology and dynein ELISA
    • 1:STN:280:DyaK2c7lsV2rsw%3D%3D
    • Sisson JH et al (1994) Smoke and viral infection cause cilia loss detectable by bronchoalveolar lavage cytology and dynein ELISA. Am J Respir Crit Care Med 149(1):205-213
    • (1994) Am J Respir Crit Care Med , vol.149 , Issue.1 , pp. 205-213
    • Sisson, J.H.1
  • 159
    • 0000700007 scopus 로고
    • Components of cigarette smoke with ciliary-depressant activity. Their selective removal by filters containing activated charcoal granules
    • 1:STN:280:DyaF2c%2FhvVOmsw%3D%3D
    • Kensler CJ, Battista SP (1963) Components of cigarette smoke with ciliary-depressant activity. Their selective removal by filters containing activated charcoal granules. N Engl J Med 269:1161-1166
    • (1963) N Engl J Med , vol.269 , pp. 1161-1166
    • Kensler, C.J.1    Battista, S.P.2
  • 160
    • 33646540731 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers
    • 1:CAS:528:DC%2BD28XmslSrsbY%3D
    • Cantin AM et al (2006) Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers. Am J Respir Crit Care Med 173(10):1139-1144
    • (2006) Am J Respir Crit Care Med , vol.173 , Issue.10 , pp. 1139-1144
    • Cantin, A.M.1
  • 161
    • 84923902575 scopus 로고    scopus 로고
    • Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR
    • 10.1016/j.bbagen.2015.02.004 1:CAS:528:DC%2BC2MXjtVShurs%3D
    • Xu X et al (2015) Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR. Biochim Biophys Acta 1850(6):1224-1232. doi: 10.1016/j.bbagen.2015.02.004
    • (2015) Biochim Biophys Acta , vol.1850 , Issue.6 , pp. 1224-1232
    • Xu, X.1
  • 162
    • 84896273138 scopus 로고    scopus 로고
    • 2+ release leads to cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction
    • 1:CAS:528:DC%2BC2cXktlWmtb0%3D
    • 2+ release leads to cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction. J Biol Chem 289(11):7671-7681
    • (2014) J Biol Chem , vol.289 , Issue.11 , pp. 7671-7681
    • Rasmussen, J.E.1
  • 163
    • 0037023764 scopus 로고    scopus 로고
    • A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator
    • 1:CAS:528:DC%2BD38XivVeksrY%3D
    • Gelman MS, Kannegaard ES, Kopito RR (2002) A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator. J Biol Chem 277(14):11709-11714
    • (2002) J Biol Chem , vol.277 , Issue.14 , pp. 11709-11714
    • Gelman, M.S.1    Kannegaard, E.S.2    Kopito, R.R.3
  • 164
    • 0032576605 scopus 로고    scopus 로고
    • Aggresomes: A cellular response to misfolded proteins
    • 1:CAS:528:DyaK1MXisFCrtA%3D%3D
    • Johnston JA, Ward CL, Kopito RR (1998) Aggresomes: a cellular response to misfolded proteins. J Cell Biol 143(7):1883-1898
    • (1998) J Cell Biol , vol.143 , Issue.7 , pp. 1883-1898
    • Johnston, J.A.1    Ward, C.L.2    Kopito, R.R.3
  • 165
    • 12144287602 scopus 로고    scopus 로고
    • Misfolding diverts CFTR from recycling to degradation: Quality control at early endosomes
    • 1:CAS:528:DC%2BD2cXitleqsLY%3D
    • Sharma M et al (2004) Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. J Cell Biol 164(6):923-933
    • (2004) J Cell Biol , vol.164 , Issue.6 , pp. 923-933
    • Sharma, M.1
  • 166
    • 77955607650 scopus 로고    scopus 로고
    • Peripheral protein quality control removes unfolded CFTR from the plasma membrane
    • 1:CAS:528:DC%2BC3cXpvV2hsro%3D
    • Okiyoneda T et al (2010) Peripheral protein quality control removes unfolded CFTR from the plasma membrane. Science 329(5993):805-810
    • (2010) Science , vol.329 , Issue.5993 , pp. 805-810
    • Okiyoneda, T.1
  • 167
    • 33746675669 scopus 로고    scopus 로고
    • Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator
    • 1:CAS:528:DC%2BD28XosFGjur8%3D
    • Younger JM et al (2006) Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator. Cell 126(3):571-582
    • (2006) Cell , vol.126 , Issue.3 , pp. 571-582
    • Younger, J.M.1
  • 168
    • 38949113159 scopus 로고    scopus 로고
    • Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease
    • 1:CAS:528:DC%2BD1cXhsFSjtLc%3D
    • Stevens JF, Maier CS (2008) Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease. Mol Nutr Food Res 52(1):7-25
    • (2008) Mol Nutr Food Res , vol.52 , Issue.1 , pp. 7-25
    • Stevens, J.F.1    Maier, C.S.2
  • 169
    • 65949095199 scopus 로고    scopus 로고
    • Mutagenicity and sequence specificity of acrolein-DNA adducts
    • 1:CAS:528:DC%2BD1MXmtFGlug%3D%3D
    • Wang HT et al (2009) Mutagenicity and sequence specificity of acrolein-DNA adducts. Chem Res Toxicol 22(3):511-517
    • (2009) Chem Res Toxicol , vol.22 , Issue.3 , pp. 511-517
    • Wang, H.T.1
  • 170
    • 0036949669 scopus 로고    scopus 로고
    • Smoking-related DNA and protein adducts in human tissues
    • 1:CAS:528:DC%2BD3sXhtV2jsr8%3D
    • Phillips DH (2002) Smoking-related DNA and protein adducts in human tissues. Carcinogenesis 23(12):1979-2004
    • (2002) Carcinogenesis , vol.23 , Issue.12 , pp. 1979-2004
    • Phillips, D.H.1
  • 171
    • 84890050882 scopus 로고    scopus 로고
    • Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function
    • 1:CAS:528:DC%2BC2cXhtVKqsLs%3D
    • Raju SV et al (2013) Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function. Am J Respir Crit Care Med 188(11):1321-1330
    • (2013) Am J Respir Crit Care Med , vol.188 , Issue.11 , pp. 1321-1330
    • Raju, S.V.1
  • 172
    • 84893369191 scopus 로고    scopus 로고
    • Aqueous cigarette smoke extract induces a voltage-dependent inhibition of CFTR expressed in Xenopus oocytes
    • 1:CAS:528:DC%2BC2cXjs1ymsr0%3D
    • Moran AR et al (2014) Aqueous cigarette smoke extract induces a voltage-dependent inhibition of CFTR expressed in Xenopus oocytes. Am J Physiol Lung Cell Mol Physiol 306(3):L284-L291
    • (2014) Am J Physiol Lung Cell Mol Physiol , vol.306 , Issue.3 , pp. L284-L291
    • Moran, A.R.1
  • 173
    • 0032731843 scopus 로고    scopus 로고
    • CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands
    • 1:CAS:528:DyaK1MXntFCju74%3D
    • Ballard ST et al (1999) CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands. Am J Physiol 277(4 Pt 1):L694-L699
    • (1999) Am J Physiol , vol.277 , Issue.4 , pp. L694-L699
    • Ballard, S.T.1
  • 174
    • 0037291973 scopus 로고    scopus 로고
    • CFTR and bicarbonate secretion by [correction of to] epithelial cells
    • 1:CAS:528:DC%2BD3sXhsFaisb4%3D
    • Hug MJ, Tamada T, Bridges RJ (2003) CFTR and bicarbonate secretion by [correction of to] epithelial cells. News Physiol Sci 18:38-42
    • (2003) News Physiol Sci , vol.18 , pp. 38-42
    • Hug, M.J.1    Tamada, T.2    Bridges, R.J.3
  • 175
    • 0020646254 scopus 로고
    • Electron-spin resonance study of mainstream and sidestream cigarette smoke: Nature of the free radicals in gas-phase smoke and in cigarette tar
    • 1:CAS:528:DyaL3sXhvFehsr4%3D
    • Pryor WA, Prier DG, Church DF (1983) Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar. Environ Health Perspect 47:345-355
    • (1983) Environ Health Perspect , vol.47 , pp. 345-355
    • Pryor, W.A.1    Prier, D.G.2    Church, D.F.3
  • 176
    • 33644833034 scopus 로고    scopus 로고
    • Oxidant stress suppresses CFTR expression
    • 1:CAS:528:DC%2BD28XhsVSisr4%3D
    • Cantin AM et al (2006) Oxidant stress suppresses CFTR expression. Am J Physiol Cell Physiol 290(1):C262-C270
    • (2006) Am J Physiol Cell Physiol , vol.290 , Issue.1 , pp. C262-C270
    • Cantin, A.M.1
  • 177
    • 84870685948 scopus 로고    scopus 로고
    • MIR-101 and MIR-144 regulate the expression of the CFTR chloride channel in the lung
    • 1:CAS:528:DC%2BC38XhvVKqt7jF
    • Hassan F et al (2012) MiR-101 and miR-144 regulate the expression of the CFTR chloride channel in the lung. PLoS One 7(11):e50837
    • (2012) PLoS One , vol.7 , Issue.11 , pp. e50837
    • Hassan, F.1
  • 178
    • 84902735919 scopus 로고    scopus 로고
    • Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels
    • Hassan F et al (2014) Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels. Respir Res 15:69
    • (2014) Respir Res , vol.15 , pp. 69
    • Hassan, F.1
  • 179
    • 84863090252 scopus 로고    scopus 로고
    • A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease
    • 1:CAS:528:DC%2BC38XpvVCns7w%3D
    • Sloane PA et al (2012) A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease. PLoS One 7(6):e39809
    • (2012) PLoS One , vol.7 , Issue.6 , pp. e39809
    • Sloane, P.A.1
  • 180
    • 84920273225 scopus 로고    scopus 로고
    • Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition
    • Astrand AB et al (2015) Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition. Am J Physiol Lung Cell Mol Physiol 308(1):L22-L32
    • (2015) Am J Physiol Lung Cell Mol Physiol , vol.308 , Issue.1 , pp. L22-L32
    • Astrand, A.B.1
  • 181
    • 84930844766 scopus 로고    scopus 로고
    • Roflumilast combined with adenosine increases mucosal hydration in human airway epithelial cultures after cigarette smoke exposure
    • Tyrrell J et al (2015) Roflumilast combined with adenosine increases mucosal hydration in human airway epithelial cultures after cigarette smoke exposure. Am J Physiol Lung Cell Mol Physiol 308:L10068-L11077
    • (2015) Am J Physiol Lung Cell Mol Physiol , vol.308 , pp. L10068-L11077
    • Tyrrell, J.1
  • 182
    • 0016214706 scopus 로고
    • Nasal clearance in monozygotic twins
    • 1:STN:280:DyaE2M%2Fht1yrtQ%3D%3D
    • Andersen I et al (1974) Nasal clearance in monozygotic twins. Am Rev Respir Dis 110(3):301-305
    • (1974) Am Rev Respir Dis , vol.110 , Issue.3 , pp. 301-305
    • Andersen, I.1
  • 183
    • 0022480584 scopus 로고
    • Effect of cigarette smoking on nasal mucociliary clearance and ciliary beat frequency
    • 1:STN:280:DyaL2s%2FntVGlsQ%3D%3D
    • Stanley PJ et al (1986) Effect of cigarette smoking on nasal mucociliary clearance and ciliary beat frequency. Thorax 41(7):519-523
    • (1986) Thorax , vol.41 , Issue.7 , pp. 519-523
    • Stanley, P.J.1
  • 184
    • 0026514357 scopus 로고
    • Respiratory mucus from asymptomatic smokers is better hydrated and more easily cleared by mucociliary action
    • 1:STN:280:DyaK387ovFahsQ%3D%3D
    • Rubin BK et al (1992) Respiratory mucus from asymptomatic smokers is better hydrated and more easily cleared by mucociliary action. Am Rev Respir Dis 145(3):545-547
    • (1992) Am Rev Respir Dis , vol.145 , Issue.3 , pp. 545-547
    • Rubin, B.K.1
  • 185
    • 84895871605 scopus 로고    scopus 로고
    • A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease
    • Hill DB et al (2014) A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease. PLoS One 9(2):e87681
    • (2014) PLoS One , vol.9 , Issue.2 , pp. e87681
    • Hill, D.B.1
  • 186
    • 0024835905 scopus 로고
    • Immunohistopathologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. Implications for the pathogenesis of progressive lung deterioration
    • 1:STN:280:DyaK3c7gtlantg%3D%3D
    • Baltimore RS, Christie CD, Smith GJ (1989) Immunohistopathologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. Implications for the pathogenesis of progressive lung deterioration. Am Rev Respir Dis 140(6):1650-1661
    • (1989) Am Rev Respir Dis , vol.140 , Issue.6 , pp. 1650-1661
    • Baltimore, R.S.1    Christie, C.D.2    Smith, G.J.3
  • 187
    • 33845309114 scopus 로고    scopus 로고
    • A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms
    • 1:CAS:528:DC%2BD28XhtlWmur7J
    • Matsui H et al (2006) A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci USA 103(48):18131-18136
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.48 , pp. 18131-18136
    • Matsui, H.1
  • 188
    • 0018341940 scopus 로고
    • Hypersecretion of mucus glycoproteins in rat airways induced by tobacco smoke
    • 1:CAS:528:DyaL3MXlt1OitL8%3D
    • Coles SJ, Levine LR, Reid L (1979) Hypersecretion of mucus glycoproteins in rat airways induced by tobacco smoke. Am J Pathol 94(3):459-472
    • (1979) Am J Pathol , vol.94 , Issue.3 , pp. 459-472
    • Coles, S.J.1    Levine, L.R.2    Reid, L.3
  • 189
    • 0014663107 scopus 로고
    • Goblet cell increase in rat bronchial epithelium after exposure to cigarette and cigar tobacco smoke
    • 1:STN:280:DyaF1M%2Fnsl2mtw%3D%3D
    • Lamb D, Reid L (1969) Goblet cell increase in rat bronchial epithelium after exposure to cigarette and cigar tobacco smoke. Br Med J 1(5635):33-35
    • (1969) Br Med J , vol.1 , Issue.5635 , pp. 33-35
    • Lamb, D.1    Reid, L.2
  • 190
    • 0032746460 scopus 로고    scopus 로고
    • Control of mucin transcription by diverse injury-induced signaling pathways
    • 1:STN:280:DC%2BD3c%2FksFSiug%3D%3D
    • Basbaum C et al (1999) Control of mucin transcription by diverse injury-induced signaling pathways. Am J Respir Crit Care Med 160(5 Pt 2):S44-S48
    • (1999) Am J Respir Crit Care Med , vol.160 , Issue.5 , pp. S44-S48
    • Basbaum, C.1
  • 191
    • 0032900458 scopus 로고    scopus 로고
    • Regulation of human airway mucins by acrolein and inflammatory mediators
    • 1:CAS:528:DyaK1MXislCrs7k%3D
    • Borchers MT, Carty MP, Leikauf GD (1999) Regulation of human airway mucins by acrolein and inflammatory mediators. Am J Physiol 276(4 Pt 1):L549-L555
    • (1999) Am J Physiol , vol.276 , Issue.4 , pp. L549-L555
    • Borchers, M.T.1    Carty, M.P.2    Leikauf, G.D.3
  • 192
    • 0031977229 scopus 로고    scopus 로고
    • Acrolein-induced MUC5ac expression in rat airways
    • 1:CAS:528:DyaK1cXislyhtrY%3D
    • Borchers MT, Wert SE, Leikauf GD (1998) Acrolein-induced MUC5ac expression in rat airways. Am J Physiol 274(4 Pt 1):L573-L581
    • (1998) Am J Physiol , vol.274 , Issue.4 , pp. L573-L581
    • Borchers, M.T.1    Wert, S.E.2    Leikauf, G.D.3
  • 193
    • 42049101172 scopus 로고    scopus 로고
    • Mechanisms of cigarette smoke-induced COPD: Insights from animal models
    • 1:CAS:528:DC%2BD1cXkslOru7g%3D
    • Churg A, Cosio M, Wright JL (2008) Mechanisms of cigarette smoke-induced COPD: insights from animal models. Am J Physiol Lung Cell Mol Physiol 294(4):L612-L631
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294 , Issue.4 , pp. L612-L631
    • Churg, A.1    Cosio, M.2    Wright, J.L.3
  • 194
    • 33947156755 scopus 로고    scopus 로고
    • Effects of abstinence from tobacco: Etiology, animal models, epidemiology, and significance: A subjective review
    • Hughes JR (2007) Effects of abstinence from tobacco: etiology, animal models, epidemiology, and significance: a subjective review. Nicotine Tob Res 9(3):329-339
    • (2007) Nicotine Tob Res , vol.9 , Issue.3 , pp. 329-339
    • Hughes, J.R.1
  • 195
    • 0025372988 scopus 로고
    • Effects of mainstream and environmental tobacco smoke on the immune system in animals and humans: A review
    • 1:CAS:528:DyaK38Xnslyrtg%3D%3D
    • Johnson JD et al (1990) Effects of mainstream and environmental tobacco smoke on the immune system in animals and humans: a review. Crit Rev Toxicol 20(5):369-395
    • (1990) Crit Rev Toxicol , vol.20 , Issue.5 , pp. 369-395
    • Johnson, J.D.1
  • 196
    • 0037228085 scopus 로고    scopus 로고
    • Exposing ferrets to cigarette smoke and a pharmacological dose of beta-carotene supplementation enhance in vitro retinoic acid catabolism in lungs via induction of cytochrome P450 enzymes
    • 1:CAS:528:DC%2BD3sXjslehuw%3D%3D
    • Liu C, Russell RM, Wang XD (2003) Exposing ferrets to cigarette smoke and a pharmacological dose of beta-carotene supplementation enhance in vitro retinoic acid catabolism in lungs via induction of cytochrome P450 enzymes. J Nutr 133(1):173-179
    • (2003) J Nutr , vol.133 , Issue.1 , pp. 173-179
    • Liu, C.1    Russell, R.M.2    Wang, X.D.3
  • 197
    • 0030823772 scopus 로고    scopus 로고
    • Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
    • 1:CAS:528:DyaK2sXmt12qt7Y%3D
    • Hautamaki RD et al (1997) Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277(5334):2002-2004
    • (1997) Science , vol.277 , Issue.5334 , pp. 2002-2004
    • Hautamaki, R.D.1
  • 198
    • 0028047286 scopus 로고
    • Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in CFTR(-/-) mice
    • 1:CAS:528:DyaK2cXhtlWnsLk%3D
    • Clarke LL et al (1994) Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice. Proc Natl Acad Sci USA 91(2):479-483
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.2 , pp. 479-483
    • Clarke, L.L.1
  • 199
    • 0026649122 scopus 로고
    • An animal model for cystic fibrosis made by gene targeting
    • 1:CAS:528:DyaK38XlvV2ms7c%3D
    • Snouwaert JN et al (1992) An animal model for cystic fibrosis made by gene targeting. Science 257(5073):1083-1088
    • (1992) Science , vol.257 , Issue.5073 , pp. 1083-1088
    • Snouwaert, J.N.1
  • 200
    • 0020587312 scopus 로고
    • Mucociliary clearance in chronic sinusitis: Related human nasal clearance and in vitro bullfrog palate clearance
    • 1:STN:280:DyaL3s3lslOisA%3D%3D
    • Majima Y et al (1983) Mucociliary clearance in chronic sinusitis: related human nasal clearance and in vitro bullfrog palate clearance. Biorheology 20(2):251-262
    • (1983) Biorheology , vol.20 , Issue.2 , pp. 251-262
    • Majima, Y.1
  • 201
    • 45949094270 scopus 로고    scopus 로고
    • Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: Lessons from mouse models
    • 1:CAS:528:DC%2BD1cXjvFeiu7c%3D
    • Mall MA (2008) Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models. J Aerosol Med Pulm Drug Deliv 21(1):13-24
    • (2008) J Aerosol Med Pulm Drug Deliv , vol.21 , Issue.1 , pp. 13-24
    • Mall, M.A.1
  • 202
    • 2442718786 scopus 로고    scopus 로고
    • + absorption produces cystic fibrosis-like lung disease in mice
    • 1:CAS:528:DC%2BD2cXjsF2jtL8%3D
    • + absorption produces cystic fibrosis-like lung disease in mice. Nat Med 10(5):487-493
    • (2004) Nat Med , vol.10 , Issue.5 , pp. 487-493
    • Mall, M.1
  • 203
    • 30944452384 scopus 로고    scopus 로고
    • Mucus clearance and lung function in cystic fibrosis with hypertonic saline
    • 1:CAS:528:DC%2BD28Xls1Gkug%3D%3D
    • Donaldson SH et al (2006) Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N Engl J Med 354(3):241-250
    • (2006) N Engl J Med , vol.354 , Issue.3 , pp. 241-250
    • Donaldson, S.H.1
  • 204
    • 30944466084 scopus 로고    scopus 로고
    • A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis
    • 1:CAS:528:DC%2BD28XlsFGntA%3D%3D
    • Elkins MR et al (2006) A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med 354(3):229-240
    • (2006) N Engl J Med , vol.354 , Issue.3 , pp. 229-240
    • Elkins, M.R.1
  • 205
    • 0035891590 scopus 로고    scopus 로고
    • Airway response to inhaled hypertonic saline in patients with moderate to severe chronic obstructive pulmonary disease
    • 1:STN:280:DC%2BD38%2Flt1GlsQ%3D%3D
    • Taube C et al (2001) Airway response to inhaled hypertonic saline in patients with moderate to severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 164(10 Pt 1):1810-1815
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.10 , pp. 1810-1815
    • Taube, C.1
  • 206
    • 0032014985 scopus 로고    scopus 로고
    • Hypertonic saline resuscitation diminishes lung injury by suppressing neutrophil activation after hemorrhagic shock
    • 1:STN:280:DyaK1c7osVagtg%3D%3D
    • Angle N et al (1998) Hypertonic saline resuscitation diminishes lung injury by suppressing neutrophil activation after hemorrhagic shock. Shock 9(3):164-170
    • (1998) Shock , vol.9 , Issue.3 , pp. 164-170
    • Angle, N.1
  • 207
    • 0032213528 scopus 로고    scopus 로고
    • Regulation of murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in Chinese hamster ovary cells
    • 1:CAS:528:DyaK1cXnvFygu7c%3D
    • Lansdell KA et al (1998) Regulation of murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in Chinese hamster ovary cells. J Physiol 512(Pt 3):751-764
    • (1998) J Physiol , vol.512 , pp. 751-764
    • Lansdell, K.A.1
  • 208
    • 0025092468 scopus 로고
    • Anion selectivity and block of the small-conductance chloride channel on pancreatic duct cells
    • 1:CAS:528:DyaK3MXlvFCjuw%3D%3D
    • Gray MA et al (1990) Anion selectivity and block of the small-conductance chloride channel on pancreatic duct cells. Am J Physiol 259(5 Pt 1):C752-C761
    • (1990) Am J Physiol , vol.259 , Issue.5 , pp. C752-C761
    • Gray, M.A.1
  • 209
    • 0032743305 scopus 로고    scopus 로고
    • Defective function of the cystic fibrosis-causing missense mutation G551D is recovered by genistein
    • 1:CAS:528:DyaK1MXntFCjtrw%3D
    • Illek B et al (1999) Defective function of the cystic fibrosis-causing missense mutation G551D is recovered by genistein. Am J Physiol 277(4 Pt 1):C833-C839
    • (1999) Am J Physiol , vol.277 , Issue.4 , pp. C833-C839
    • Illek, B.1
  • 210
    • 73249114731 scopus 로고    scopus 로고
    • Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770
    • Van Goor F et al (2009) Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci USA 106(44):18825-18830
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.44 , pp. 18825-18830
    • Van Goor, F.1
  • 211
    • 0026325533 scopus 로고
    • Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation
    • 1:CAS:528:DyaK38Xls1OnsQ%3D%3D
    • Dalemans W et al (1991) Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation. Nature 354(6354):526-528
    • (1991) Nature , vol.354 , Issue.6354 , pp. 526-528
    • Dalemans, W.1
  • 212
    • 81755163563 scopus 로고    scopus 로고
    • Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
    • Van Goor F et al (2011) Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci USA 108(46):18843-18848
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.46 , pp. 18843-18848
    • Van Goor, F.1
  • 213
    • 84907223425 scopus 로고    scopus 로고
    • Potentiator ivacaftor abrogates pharmacological correction of DeltaF508 CFTR in cystic fibrosis
    • Cholon DM et al (2014) Potentiator ivacaftor abrogates pharmacological correction of DeltaF508 CFTR in cystic fibrosis. Sci Transl Med 6(246):246ra96
    • (2014) Sci Transl Med , vol.6 , Issue.246 , pp. 246ra96
    • Cholon, D.M.1
  • 214
    • 84895532370 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis
    • Lambert JA et al (2013) Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis. Am J Respir Cell Mol Biol 50(3):549-558
    • (2013) Am J Respir Cell Mol Biol , vol.50 , Issue.3 , pp. 549-558
    • Lambert, J.A.1
  • 215
    • 84906049219 scopus 로고    scopus 로고
    • Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: A network meta-analysis
    • Kew KM, Dias S, Cates CJ (2014) Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis. Cochrane Database Syst Rev 3:CD010844
    • (2014) Cochrane Database Syst Rev , vol.3 , pp. CD010844
    • Kew, K.M.1    Dias, S.2    Cates, C.J.3
  • 216
    • 0024465128 scopus 로고
    • Chloride secretory response of cystic fibrosis human airway epithelia. Preservation of calcium but not protein kinase C- and A-dependent mechanisms
    • 1:CAS:528:DyaL1MXmtlSisbk%3D
    • Boucher RC et al (1989) Chloride secretory response of cystic fibrosis human airway epithelia. Preservation of calcium but not protein kinase C- and A-dependent mechanisms. J Clin Invest 84(5):1424-1431
    • (1989) J Clin Invest , vol.84 , Issue.5 , pp. 1424-1431
    • Boucher, R.C.1
  • 217
    • 84901721726 scopus 로고    scopus 로고
    • Acute hyperkalemia associated with inhalation of a potent ENaC antagonist: Phase 1 trial of GS-9411
    • O'Riordan TG et al (2014) Acute hyperkalemia associated with inhalation of a potent ENaC antagonist: phase 1 trial of GS-9411. J Aerosol Med Pulm Drug Deliv 27(3):200-208
    • (2014) J Aerosol Med Pulm Drug Deliv , vol.27 , Issue.3 , pp. 200-208
    • O'Riordan, T.G.1
  • 218
    • 0024080294 scopus 로고
    • The mechanism of action of amiloride
    • 1:CAS:528:DyaL1MXisw%3D%3D
    • Kleyman TR, Cragoe EJ Jr (1988) The mechanism of action of amiloride. Semin Nephrol 8(3):242-248
    • (1988) Semin Nephrol , vol.8 , Issue.3 , pp. 242-248
    • Kleyman, T.R.1    Cragoe, E.J.2
  • 219
    • 78649480526 scopus 로고    scopus 로고
    • Emerging therapies for cystic fibrosis lung disease
    • 1:CAS:528:DC%2BC3cXhsVOgtL3M
    • Grasemann H, Ratjen F (2010) Emerging therapies for cystic fibrosis lung disease. Expert Opin Emerg Drugs 15(4):653-659
    • (2010) Expert Opin Emerg Drugs , vol.15 , Issue.4 , pp. 653-659
    • Grasemann, H.1    Ratjen, F.2
  • 220
    • 0030730947 scopus 로고    scopus 로고
    • Rapid life-threatening hyperkalemia after addition of amiloride HCl/hydrochlorothiazide to angiotensin-converting enzyme inhibitor therapy
    • 1:STN:280:DyaK1c%2FisFShsQ%3D%3D
    • Chiu TF et al (1997) Rapid life-threatening hyperkalemia after addition of amiloride HCl/hydrochlorothiazide to angiotensin-converting enzyme inhibitor therapy. Ann Emerg Med 30(5):612-615
    • (1997) Ann Emerg Med , vol.30 , Issue.5 , pp. 612-615
    • Chiu, T.F.1
  • 221
    • 84962223991 scopus 로고    scopus 로고
    • GS-5737, A novel epithelial sodium channel (ENaC) inhibitor: Results of a Phase 1 Safety and pharmacodynamic (PK) Study
    • O'Riordan TG et al (2013) GS-5737, A novel epithelial sodium channel (ENaC) inhibitor: results of a Phase 1 Safety and pharmacodynamic (PK) Study. Pediatr Pulmonol S36:290
    • (2013) Pediatr Pulmonol , vol.36 , pp. 290
    • O'Riordan, T.G.1
  • 222
    • 84962233866 scopus 로고    scopus 로고
    • A SPLUNC1-derived peptide reduces lung disease in scnn1b mice
    • Terryah s et al (2014) A SPLUNC1-derived peptide reduces lung disease in scnn1b mice. Pediatr Pulmonol S38:285
    • (2014) Pediatr Pulmonol , vol.38 , pp. 285
    • Terryah, S.1
  • 223
    • 84894278685 scopus 로고    scopus 로고
    • Multiple tobacco product use among adults in the United States: Cigarettes, cigars, electronic cigarettes, hookah, smokeless tobacco, and snus
    • Lee YO et al (2014) Multiple tobacco product use among adults in the United States: cigarettes, cigars, electronic cigarettes, hookah, smokeless tobacco, and snus. Prev Med 62:14-19
    • (2014) Prev Med , vol.62 , pp. 14-19
    • Lee, Y.O.1
  • 224
    • 84883046590 scopus 로고    scopus 로고
    • The regulatory challenge of electronic cigarettes
    • 1:CAS:528:DC%2BC3sXhtlags7jP
    • Benowitz NL, Goniewicz ML (2013) The regulatory challenge of electronic cigarettes. JAMA 310(7):685-686
    • (2013) JAMA , vol.310 , Issue.7 , pp. 685-686
    • Benowitz, N.L.1    Goniewicz, M.L.2
  • 225
    • 84867144735 scopus 로고    scopus 로고
    • Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality
    • 1:CAS:528:DC%2BC38XhsVCgu7fL
    • McAuley TR et al (2012) Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality. Inhal Toxicol 24(12):850-857
    • (2012) Inhal Toxicol , vol.24 , Issue.12 , pp. 850-857
    • McAuley, T.R.1
  • 226
    • 84907217555 scopus 로고    scopus 로고
    • Electronic cigarette liquid increases inflammation and virus infection in primary human airway epithelial cells
    • Wu Q et al (2014) Electronic cigarette liquid increases inflammation and virus infection in primary human airway epithelial cells. PLoS One 9(9):e108342
    • (2014) PLoS One , vol.9 , Issue.9 , pp. e108342
    • Wu, Q.1
  • 227
    • 0037592950 scopus 로고    scopus 로고
    • Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop
    • 1:CAS:528:DC%2BD3sXjsVKnurk%3D
    • Chen Y et al (2003) Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem 278(19):17036-17043
    • (2003) J Biol Chem , vol.278 , Issue.19 , pp. 17036-17043
    • Chen, Y.1
  • 228
    • 84921466573 scopus 로고    scopus 로고
    • Hidden formaldehyde in e-cigarette aerosols
    • 1:CAS:528:DC%2BC2MXhtVOgsrnK
    • Jensen RP et al (2015) Hidden formaldehyde in e-cigarette aerosols. N Engl J Med 372(4):392-394
    • (2015) N Engl J Med , vol.372 , Issue.4 , pp. 392-394
    • Jensen, R.P.1
  • 229
    • 84901812673 scopus 로고    scopus 로고
    • Candy flavorings in tobacco
    • 1:CAS:528:DC%2BC2MXnvVWqtb4%3D
    • Brown JE et al (2014) Candy flavorings in tobacco. N Engl J Med 370(23):2250-2252
    • (2014) N Engl J Med , vol.370 , Issue.23 , pp. 2250-2252
    • Brown, J.E.1
  • 230
    • 28444494709 scopus 로고    scopus 로고
    • New cigarette brands with flavors that appeal to youth: Tobacco marketing strategies
    • Carpenter CM et al (2005) New cigarette brands with flavors that appeal to youth: tobacco marketing strategies. Health Aff (Millwood) 24(6):1601-1610
    • (2005) Health Aff (Millwood) , vol.24 , Issue.6 , pp. 1601-1610
    • Carpenter, C.M.1
  • 231
    • 83755219949 scopus 로고    scopus 로고
    • Smokeless and flavored tobacco products in the US: 2009 Styles survey results
    • Regan AK, Dube SR, Arrazola R (2012) Smokeless and flavored tobacco products in the US: 2009 Styles survey results. Am J Prev Med 42(1):29-36
    • (2012) Am J Prev Med , vol.42 , Issue.1 , pp. 29-36
    • Regan, A.K.1    Dube, S.R.2    Arrazola, R.3
  • 232
    • 82655181351 scopus 로고    scopus 로고
    • Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
    • 1:CAS:528:DC%2BC3MXhs1Wlt7jJ
    • Willis DN et al (2011) Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. FASEB J 25(12):4434-4444
    • (2011) FASEB J , vol.25 , Issue.12 , pp. 4434-4444
    • Willis, D.N.1
  • 233
    • 82455192405 scopus 로고    scopus 로고
    • Menthol preference among smokers: Association with TRPA1 variants
    • 1:CAS:528:DC%2BC3MXhsFGjtrfK
    • Uhl GR et al (2011) Menthol preference among smokers: association with TRPA1 variants. Nicotine Tob Res 13(12):1311-1315
    • (2011) Nicotine Tob Res , vol.13 , Issue.12 , pp. 1311-1315
    • Uhl, G.R.1
  • 234
    • 84900323598 scopus 로고    scopus 로고
    • Diacetyl: Occurrence, analysis, and toxicity
    • 1:CAS:528:DC%2BC2cXmt1Gjtro%3D
    • Shibamoto T (2014) Diacetyl: occurrence, analysis, and toxicity. J Agric Food Chem 62(18):4048-4053
    • (2014) J Agric Food Chem , vol.62 , Issue.18 , pp. 4048-4053
    • Shibamoto, T.1
  • 235
    • 0036682184 scopus 로고    scopus 로고
    • Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant
    • Kreiss K et al (2002) Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N Engl J Med 347(5):330-338
    • (2002) N Engl J Med , vol.347 , Issue.5 , pp. 330-338
    • Kreiss, K.1
  • 236
  • 237
    • 84862286460 scopus 로고    scopus 로고
    • Patterns of tobacco use and dual use in US young adults: The missing link between youth prevention and adult cessation
    • Rath JM et al (2012) Patterns of tobacco use and dual use in US young adults: the missing link between youth prevention and adult cessation. J Environ Public Health 2012:679134
    • (2012) J Environ Public Health , vol.2012 , pp. 679134
    • Rath, J.M.1
  • 238
    • 67650245400 scopus 로고    scopus 로고
    • Measuring cigar use in adolescents: Inclusion of a brand-specific item
    • Terchek JJ et al (2009) Measuring cigar use in adolescents: inclusion of a brand-specific item. Nicotine Tob Res 11(7):842-846
    • (2009) Nicotine Tob Res , vol.11 , Issue.7 , pp. 842-846
    • Terchek, J.J.1
  • 239
    • 84900866624 scopus 로고    scopus 로고
    • Dynamics of soluble and cellular inflammatory markers in nasal lavage obtained from cystic fibrosis patients during intravenous antibiotic treatment
    • Hentschel J et al (2014) Dynamics of soluble and cellular inflammatory markers in nasal lavage obtained from cystic fibrosis patients during intravenous antibiotic treatment. BMC Pulm Med 14:82
    • (2014) BMC Pulm Med , vol.14 , pp. 82
    • Hentschel, J.1
  • 240
    • 0042131664 scopus 로고    scopus 로고
    • Induced sputum in the investigation of airway inflammation of COPD
    • 1:STN:280:DC%2BD3szoslartg%3D%3D
    • Tsoumakidou M, Tzanakis N, Siafakas NM (2003) Induced sputum in the investigation of airway inflammation of COPD. Respir Med 97(8):863-871
    • (2003) Respir Med , vol.97 , Issue.8 , pp. 863-871
    • Tsoumakidou, M.1    Tzanakis, N.2    Siafakas, N.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.