Hazardous compounds in tobacco smoke

International Journal of Environmental Research and Public Health

Volumn 8, Issue 2, 2011, Pages 613-628

  Talhout, Reinskje ^a   Schulz, Thomas ^b   Florek, Ewa ^c   van Benthem, Jan ^a   Wester, Piet ^a   Opperhuizen, Antoon ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^c POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Hoffmann list; Risk assessment; Smoke component; Tobacco product regulation; TTC

Indexed keywords

2 BUTANONE; ACETONE; ACETONITRILE; ACROLEIN; ACRYLAMIDE; ACRYLIC ACID; AMMONIA; ANILINE; ARSENIC; BENZENE; BENZO[A]PYRENE; BERYLLIUM; CADMIUM; CARBAZOLE DERIVATIVE; CARBON DISULFIDE; CARBON MONOXIDE; CARCINOGEN; CATECHOL; CHLOROFORM; CHLORPHENOTANE; CHROMIUM; COBALT; COPPER; CROTONALDEHYDE; HYDROQUINONE; METHYL CHLORIDE; PROPIONALDEHYDE; TOBACCO SMOKE; TOLUENE; UNINDEXED DRUG;

ARTICLE; CANCER RISK; CARCINOGENICITY; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CHEMICAL COMPOSITION; CIGARETTE SMOKING; HAZARD ASSESSMENT; HUMAN; LONG TERM EXPOSURE; LUNG DISEASE; MUTAGENICITY; RISK ASSESSMENT; TOBACCO INDUSTRY; TOXICITY TESTING;

NICOTIANA TABACUM;

EID: 79953279642     PISSN: None     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph8020613     Document Type: Article

References (49)

1. Hoffmann, D.; Hoffmann, I. Letters to the editor, tobacco smoke components. Beitr. Tabaksforsch. Int. 1998, 18, 49-52.
2. Thielen, A.; Klus, H.; Muller, L. Tobacco smoke: unraveling a controversial subject. Exp. Toxicol. Pathol. 2008, 60, 141-156.
3. Borgerding, M.; Klus, H. Analysis of complex mixtures-cigarette smoke. Exp. Toxicol. Pathol. 2005, 57, 43-73.
4. Fowles, J.; Dybing, E. Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob. Control 2003, 12, 424-430.
5. Ezzati, M.; Lopez, A.D. Estimates of global mortality attributable to smoking in 2000. Lancet 2003, 362, 847-852.
6. WHO Report on the Global Tobacco Epidemic: The MPOWER Package; WHO: Geneva, Switzerland, 2008; pp. 1-329.
7. Hatsukami, D.K.; Stead, L.F.; Gupta, P.C. Tobacco addiction. Lancet 2008, 371, 2027-2038.
8. Davis, R.M.; Wakefield, M.; Amos, A.; Gupta, P.C. The hitchhiker's guide to tobacco control: A global assessment of harms, remedies, and controversies. Annu. Rev. Public Health 2007, 28, 171-194.
9. The Health Consequences of Smoking: A Report of the Surgeon General; U.S. Department of Health and Human Services: Atlanta, GA, USA, 2004; pp. 1-910.
10. The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General; U.S. Department of Health and Human Services: Atlanta, GA, USA, 2006; pp. 1-709.
11. Hoffmann, D.; Hoffmann, I. The changing cigarette, 1950-1995. J. Toxicol. Environ. Health 1997, 50, 307-364.
12. Hoffmann, D.; Hoffmann, I.; El Bayoumy, K. The less harmful cigarette: A controversial issue. A tribute to Ernst L. Wynder. Chem. Res. Tox. 2001, 14, 767-790.
13. Burns, D.M.; Dybing, E.; Gray, N.; Hecht, S.; Anderson, C.; Sanner, T.; O'Connor, R.; Djordjevic, M.; Dresler, C.; Hainaut, P.; Jarvis, M.; Opperhuizen, A.; Straif, K. Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization TobReg proposal. Tob. Control 2008, 17, 132-141.
14. Rodgman, A.; Green, C.R. Toxic chemicals in cigarette mainstream smoke-hazard and hoopla. Beitr. Tabakforsch. Int. 2003, 20, 481-545.
15. Fowles, J.; Dybing, E. Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob. Control 2003, 12, 424-430.
16. Boyle, P.; Gray, N.; Henningfield, J.; Seffrin, J.; Zatonski, W. Tobacco: Science, Policy and Public Health; Oxford University Press: Oxford, UK, 2004; p. 798.
17. Jenkins, R.A.; Guerin, M.R.; Tomkins, B.A. The Chemistry of Environmental Tobacco Smoke: Composition and Measurement; Lewis: Washington, DC, USA, 1999; pp. 1-467.
18. WHO. Tobacco Smoking and Involuntary Smoking; IARC Press: Geneva, Switzerland, 2004.
19. Davis, D.L.; Nielsen, M.T. Tobacco: Production, Chemistry and Technology; Blackwell Science: Oxford, UK, 1999; pp. 1-467.
20. Changes in Cigarette-Related Disease Risk and Their Implication for Prevention and Control; National Institutes of Health, National Cancer Institute: Bethesda, MD, USA, 1997.
21. NCI Expert Committee. The FTC Cigarette Test Method for Determining Tar, Nicotine, and Carbon Monoxide Yields of U.S. Cigarettes; U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health: Bethesda, MD, USA, 1997.
22. Risk Associated with Smoking Cigarettes with Low Machine-Measured Yields of Tar and Nicotine; National Institutes of Health, National Cancer Institute: Bethesda, MD, USA, 2001.
23. Fowles, J.; Dybing, E. Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob. Control 2003, 12, 424-430.
24. Rodgman, A.; Perfetti, T.A. The Chemical Components of Tobacco and Tobacco Smoke; CRC Press: Boca Raton, FL, USA, 2009; pp. 1-1784.
25. Smith, C.J.; Livingston, S.D.; Doolittle, D.J. An international literature survey of "IARC Group I carcinogens" reported in mainstream cigarette smoke. Food Chem. Toxicol. 1997, 35, 1107-1130.
26. Smith, C.J.; Perfetti, T.A.; Rumple, M.A.; Rodgman, A.; Doolittle, D.J. 'IARC Group 2A carcinogens' reported in cigarette mainstream smoke. Food Chem. Toxicol. 2000, 38, 371-383.
27. Smith, C.J.; Perfetti, T.A.; Mullens, M.A.; Rodgman, A.; Doolittle, D.J. 'IARC Group 2B Carcinogens' reported in cigarette mainstream smoke. Food Chem. Toxicol. 2000, 38, 825-848.
28. The Scientific Basis of Tobacco Product Regulation; Second Report of a WHO Study Group Technical Report Series 951; WHO: Geneva, Switzerland, 2008.
29. Kroes, R.; Kleiner, J.; Renwick, A. The threshold of toxicological concern concept in risk assessment. Toxicol. Sci. 2005, 86, 226-230.
30. Munro, I.C.; Renwick, A.G.; Danielewska-Nikiel, B. The Threshold of Toxicological Concern (TTC) in risk assessment. Toxicol. Lett. 2008, 180, 151-156.
31. Escher, S.E.; Tluczkiewicz, I.; Batke, M.; Bitsch, A.; Melber, C.; Kroese, E.D.; Buist, H.E.; Mangelsdorf, I. Evaluation of inhalation TTC values with the database RepDose. Regul. Toxicol. Pharmacol. 2010, 58, 259-274.
32. Bitsch, A.; Jacobi, S.; Melber, C.; Wahnschaffe, U.; Simetska, N.; Mangelsdorf, I. REPDOSE: A database on repeated dose toxicity studies of commercial chemicals-A multifunctional tool. Regul. Toxicol. Pharmacol. 2006, 46, 202-210.
33. Carthew, P.; Clapp, C.; Gutsell, S. Exposure based waiving: The application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products. Food Chem. Toxicol. 2009, 47, 1287-1295.
34. Drew, R.; Frangos, J. The concentration of no toxicological concern (CoNTC): A risk assessment screening tool for air toxics. J. Toxicol. Environ. Health A 2007, 70, 1584-1593.
35. Price, P.S.; Hollnagel, H.M.; Zabik, J.M. Characterizing the noncancer toxicity of mixtures using concepts from the TTC and quantitative models of uncertainty in mixture toxicity. Risk Anal. 2009, 29, 1534-1548.
36. Richter, P.; Pechacek, T.; Swahn, M.; Wagman, V. Reducing levels of toxic chemicals in cigarette smoke: A new Healthy People 2010 objective. Public Health Rep. 2008, 123, 30-38.
37. Hatsukami, D.K.; Joseph, A.M.; Lesage, M.; Jensen, J.; Murphy, S.E.; Pentel, P.R.; Kotlyar, M.; Borgida, E.; Le, C.; Hecht, S.S. Developing the science base for reducing tobacco harm. Nicotine Tob. Res. 2007, 9, S537-S553.
38. Jarvis, M.J.; Boreham, R.; Primatesta, P.; Feyerabend, C.; Bryant, A. Nicotine yield from machine-smoked cigarettes and nicotine intakes in smokers: Evidence from a representative population survey. J. Natl. Cancer Inst. 2001, 93, 134-138.
39. Hammond, D.; Collishaw, N.E.; Callard, C. Secret science: tobacco industry research on smoking behaviour and cigarette toxicity. Lancet 2006, 367, 781-787.
40. Hammond, D.; Wiebel, F.; Kozlowski, L.T.; Borland, R.; Cummings, K.M.; O'Connor, R.J.; McNeill, A.; Connolly, G.N.; Arnott, D.; Fong, G.T. Revising the machine smoking regime for cigarette emissions: Implications for tobacco control policy. Tob. Control 2007, 16, 8-14.
41. Cummings, K.M.; Hyland, A.; Bansal, M.A.; Giovino, G.A. What do Marlboro Lights smokers know about low-tar cigarettes? Nicotine Tob. Res. 2004, 6, S323-S332.
42. Dunlop, S.M.; Romer, D. Relation between newspaper coverage of 'light' cigarette litigation and beliefs about 'lights' among American adolescents and young adults: the impact on risk perceptions and quitting intentions. Tob. Control 2010, 19, 267-273.
43. King, B.; Borland, R.; Fowles, J. Mainstream smoke emissions of Australian and Canadian cigarettes. Nicotine Tob. Res. 2007, 9, 835-844.
44. O'Connor, R.J.; Hurley, P.J. Existing technologies to reduce specific toxicant emissions in cigarette smoke. Tob. Control 2008, 17, i39-i48.
45. Stohs, S.J.; Bagchi, D.; Bagchi, M. Toxicity of trace elements in tobacco smoke. Inhal. Toxicol. 1997, 9, 867-890.
46. Talhout, R.; Opperhuizen, A.; van Amsterdam, J.G. Sugars as tobacco ingredient: Effects on mainstream smoke composition. Food Chem. Toxicol. 2006, 44, 1789-1798.
47. Talhout, R.; Opperhuizen, A.; van Amsterdam, J.G. Role of acetaldehyde in tobacco smoke addiction. Eur. Neuropsychopharmacol. 2007, 17, 627-636.
48. Fadel, H.H.; Farouk, A. Caramelization of maltose solution in presence of alanine. Amino Acids 2002, 22, 199-213.
49. SCENIHR. Addictiveness and Attractiveness of Tobacco Additives; European Union: Brussels, Belgium, 2010; pp. 1-119.