Chemical analysis of cigarette smoke particulate generated in the MSB-01 in vitro whole smoke exposure system

Inhalation Toxicology

Volumn 21, Issue 12, 2009, Pages 1040-1052

  Scian, Mariano J ^a   Oldham, Michael J ^b   Miller, John H ^c   Kane, David B ^b   Edmiston, Jeffery S ^b   McKinney, Willie J ^b  

^a Scientific Division   (United States)

^b Center for Research and Technology   (United States)

^c Philip Morris USA Research Center   (United States)

Author keywords

Chemical analysis; Cigarette smoke condensate; Exposure; In vitro

Indexed keywords

ACID; ALDEHYDE; CIGARETTE SMOKE CONDENSATE; FURAN DERIVATIVE; KETONE DERIVATIVE; NITROGEN; PHENOL DERIVATIVE;

AEROSOL; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CIGARETTE SMOKING; CONTROLLED STUDY; EXPOSURE; GRAVIMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INSTRUMENT; LIQUID CHROMATOGRAPHY; MAINSTREAM SMOKE; MASS SPECTROMETRY; MIMIC SMOKER 01; PARTICULATE MATTER; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

AEROSOLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MASS SPECTROMETRY; PARTICULATE MATTER; SMOKE; SPECTROPHOTOMETRY, ULTRAVIOLET; TERPENES; TOBACCO;

EID: 70350643671     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370802712705     Document Type: Article

References (56)

1. Adam T, Mitschke S, Streibel T, Baker RR, Zimmermann R. (2006a). Puff- by-puff resolved characterisation of cigarette mainstream smoke by single photon ionisation (SPI)-time-of-flight mass spectrometry (TOFMS): Comparison of the 2R4F research cigarette and pure Burley Virginia Oriental and Maryland tobacco cigarettes. Anal Chim Acta 572:219-229.
2. Adam T, Mitschke S, Streibel T, Baker RR, Zimmermann R. (2006b). Quantitative puff-by-puff-resolved characterization of selected toxic compounds in cigarette mainstream smoke. Chem Res Toxicol 19:511-520.
3. Adam T, Baker RR, Zimmermann R. (2007). Characterization of puff-by-puff resolved cigarette mainstream smoke by single photon ionization-timeof- flight mass spectrometry and principal component analysis. J Agric Food Chem 55:2055-2061.
4. Aufderheide M, Knebel JW, Ritter D. (2003). An improved in vitro model for testing the pulmonary toxicity of complex mixtures such as cigarette smoke. Exp Toxicol Pathol 55:51-57.
5. Baker RR, Massey ED, Smith G. (2004). An overview of the effects of tobacco ingredients on smoke chemistry and toxicity. Food Chem Toxicol 42(suppl):S53-S83. (Pubitemid 38456980)
6. Bombick BR, Murli H, Avalos JT, Bombick DW, Morgan WT, Putnam KP, Doolittle DJ. (1998a). Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 2. In vitro toxicology of mainstream smoke condensate. Food Chem Toxicol 36:183-190.
7. Bombick DW, Ayres PH, Putnam K, Bombick BR, Doolittle DJ. (1998b). Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 3. In vitro toxicity of whole smoke. Food Chem Toxicol 36:191-197. (Pubitemid 28435109)
8. Cai J, Liu B, Lin P, Su Q. (2003). Fast analysis of nicotine related alkaloids in tobacco and cigarette smoke by megabore capillary gas chromatography. J Chromatogr A 1017:187-193.
9. Carmines EL, Gaworski CL. (2005). Toxicological evaluation of glycerin as a cigarette ingredient. Food Chem Toxicol 43:1521-1539.
10. Chang P-T, Peters LK, Ueno Y. (1985). Particle size distribution of mainstream cigarette smoke undergoing dilution. Aerosol Sci Technol 4:191-207.
11. Chen PX, Moldoveanu SC. (2003). Mainstream smoke chemical analyses for 2R4F Kentucky reference cigarette. Beitr Tabakforsch Int 20:448-458.
12. Chouchane S, Wooten JB, Tewes FJ, Wittig A, Muller BP, Veltel D, Diekmann J. (2006). Involvement of semiquinone radicals in the in vitro cytotoxicity of cigarette mainstream smoke. Chem Res Toxicol 19:1602-1610.
13. Church D, Pryor W. (1985). Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 64:111-126.
14. Dalluge J, van Stee LL, Xu X, Williams J, Beens J, Vreuls RJ,Brinkman UA. (2002). Unravelling the composition of very complex samples by comprehensive gas chromatography coupled to time-of-flight mass spectrometry. Cigarette smoke. J Chromatogr A 974:169-184.
15. Dendo RI, Phalen RF, Mannix RC, Oldham MJ. (1998). Effects of breathing parameters on sidestream cigarette smoke deposition in a hollow tracheobronchial model. Am Ind Hyg Assoc J 59:381-387.
16. Ewing P, Blomgren B, Ryrfeldt A, Gerde P. (2006). Increasing exposure levels cause an abrupt change in the absorption and metabolism of acutely inhaled benzo(a)pyrene in the isolated ventilated and perfused lung of the rat. Toxicol Sci 91:332-340.
17. Gebel S, Muller T. (2001). The activity of NF-kappaB in Swiss 3T3 cells exposed to aqueous extracts of cigarette smoke is dependent on thioredoxin. Toxicol Sci 59:75-81.
18. Halliwell BB, Poulsen HE. (2006). Cigarette smoke and oxidative stress. Berlin: Springer.
19. Hoffmann D, Hoffmann I. (1997). The changing cigarette 1950-1995. J Toxicol Environ Health 50:307-364.
20. Hoffmann D, Wynder E. (1986). Chemical constituents and bioactivity of tobacco smoke. IARC Sci Publ 74:145-165.
21. International Organization for Standardization. (1999). ISO-3402. Tobacco and tobacco products-Atmosphere for conditioning and testing. Geneva: ISO.
22. International Organization for Standardization. (2000). ISO-3308. Routine analytical cigarette-smoking machine-Definitions and standard conditions. Geneva: ISO.
23. Kodama H, Fujimori T, Kato K. (1984). Glucosides of ionone-related compounds in several nicotiana species. Phytochemistry 23:583-585.
24. Kode A, Yang SR, Rahman I. (2006). Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respir Res 7:132.
25. Kulshreshtha NP, Moldoveanu SC. (2003). Analysis of pyridines in mainstream cigarette smoke. J Chromatogr 985:303-312.
26. Li R, Wang L, Li Q, Tong X, Tang G, Chen J. (2002). Analysis of volatile and semi-volatile composition in cut tobacco and total particulate matter of cigarettes with SPME-GC-MS. Fenxi Shiyanshi 21:31-35.
27. Lu X, Cai J, Kong H, Wu M, Hua R, Zhao M, Liu J, Xu G. (2003). Analysis of cigarette smoke condensates by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry I acidic fraction. Anal Chem 75:4441-4451.
28. Lu X, Zhao M, Kong H, Cai J, Wu J, Wu M, Hua R, Liu J, Xu G. (2004a). Characterization of cigarette smoke condensates by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry (GC × GC/TOFMS). Part 2: Basic fraction. J Sep Sci 27:101-109. (Pubitemid 38190196)
29. Lu X, Zhao M, Kong H, Cai J, Wu J, Wu M, Hua R, Liu J, Xu G. (2004b). Characterization of complex hydrocarbons in cigarette smoke condensate by gas chromatography-mass spectrometry and comprehensive twodimensional gas chromatography-time-of-flight mass spectrometry. J Chromatogr A 1043:265-273. (Pubitemid 38881593)
30. Matsukura M, Takahashi K, Kawamoto M, Ishiguro S, Matsushita H. (1985). Comparison of roasted tobacco volatiles with tobacco essential oil and cigarette smoke condensate. Agric Biol Chem 49:711-718.
31. Maunders H, Patwardhan S, Phillips J, Clack A, Richter A. (2007). Human bronchial epithelial cell transcriptome: Gene expression changes following acute exposure to whole cigarette smoke in vitro. Am J Physiol Lung Cell Mol Physiol 292:L1248-L1256.
32. McRae DD. (1990). The formation and evolution of cigarette smoke. In Recent advances in tobacco science. Symposium on the Formation and Evolution of Cigarette Smoke, 44th Tobacco Chemists' Research Conference, Winston-Salem, NC. 16:233-323.
33. Muller T, Gebel S. (1994). Heme oxygenase expression in Swiss 3T3 cells following exposure to aqueous cigarette smoke fractions. Carcinogenesis 15:67-72.
34. Novotny M, Merli F, Wiesler D, Saeed T. (1982). Composition of the basic fraction of marijuana and tobacco condensates: A comparative study by capillary GC/MS. Chromatographia 15:564-568.
35. Phalen RF, Oldham MJ. (2006). Aerosol dosimetry considerations. Clin Occup Environ Med 5:773-784.
36. Phalen RF, Cannon WC, Esparza D. (1976). Comparison of impaction centrifugal separation and electron microscopy for sizing cigarette smoke. In Fine particles, ed. B Liu, pp. 731-737. San Diego, CA: Academic Press.
37. Phalen RF, Oldham MJ, Nel AE. (2006). Tracheobronchial particle dose considerations for in vitro toxicology studies. Toxicol Sci 92:126-132.
38. Phillips J, Kluss B, Richter A, Massey E. (2005). Exposure of bronchial epithelial cells to whole cigarette smoke: Assessment of cellular responses. Altern Lab Anim 33:239-248.
39. Ritter D, Knebel J, Aufderheide M. (2004). Comparative assessment of toxicities of mainstream smoke from commercial cigarettes. Inhal Toxicol 16:691-700.
40. Rodgman A, Green CR. (2003). Toxic chemicals in cigarette mainstream smoke-hazard and hoopla. Beitr Tabakforsch Int 20:481-545.
41. Roemer E, Tewes FJ, Meisgen TJ, Veltel DJ, Carmines EL. (2002). Evaluation of the potential effects of ingredients added to cigarettes. Part 3: In vitro genotoxicity and cytotoxicity. Food Chem Toxicol 40:105-111. (Pubitemid 33132145)
42. Saint-Jalm Y, Moree-Testa P. (1980). Study of nitrogen-containing compounds in cigarette smoke by gas chromatography-mass spectrometry. J Chromatogr 198:188-192.
43. Schmeltz I, Hoffmann D. (1977). Nitrogen-containing compounds in tobacco and tobacco smoke. Chem Rev 77:295-311.
44. Schumacher JN, Green CR, Best FW, Newell MP. (1977). Smoke composition. An extensive investigation of the water-soluble portion of cigarette smoke. J Agric Food Chem 25:310-320.
45. Scian MJ, Oldham MJ, Kane DB, Edmiston JS, McKinney WJ. (2008). Characterization of a whole smoke in vitro exposure system (Burghart Mimic Smoker-01). Inhal Toxicol Nov 17:1. [Epub ahead of print]
46. Smith CJ, Hansch C. (2000). The relative toxicity of compounds in mainstream cigarette smoke condensate. Food Chem Toxicol 38:637-646.
47. Smith CJ, Perfetti TA, Rumple MA, Rodgman A, Doolittle DJ. (2000). "IARC group 2A Carcinogens" reported in cigarette mainstream smoke. Food Chem Toxicol 38:371-383. (Pubitemid 30155498)
48. Smith CJ, Perfetti TA, Morton MJ, Rodgman A, Garg R, Selassie CD, Hansch C. (2002). The relative toxicity of substituted phenols reported in cigarette mainstream smoke. Toxicol Sci 69:265-278.
49. Snook ME, Arrendale RF, Higman HC, Chortyk OT. (1978). Isolation of indoles and carbazoles from cigarette smoke condensate. Anal Chem 50:88-90.
50. Teeguarden JG, Hinderliter PM, Orr G, Thrall BD, Pounds JG. (2007). Particokinetics in vitro: Dosimetry considerations for in vitro nanoparticle toxicity assessments. Toxicol Sci 95:300-312.
51. Watson C, McCraw J, Polzin G, Ashley D, Barr D. (2004). Development of a method to assess cigarette smoke intake. Environ Sci Technol 38:248-253.
52. Wolz L, Krause G, Scherer G, Aufderheide M, Mohr U. (2002). In vitro genotoxicity assay of sidestream smoke using a human bronchial epithelial cell line. Food Chem Toxicol 40:845-850.
53. Yang H, Liu J, Li K, Yin X, Tan X, Wang J. (2001). Synthesis of 3-oxo-alpha-ionol ethyl carbonate and its conversion to megastigmatrienones in tobacco smoke. Beitr Tabakforsch Int 19:339-343.
54. Yi S, Hajaligol MR, Jeong SH. (2005). The prediction of the effects of tobacco type on smoke composition from the pyrolysis modeling of tobacco shreds. J Anal Appl Pyrolysis 7:181-192.
55. Yu R, Wu M, Lin S, Talbot P. (2006). Cigarette smoke toxicants alter growth and survival of cultured mammalian cells. Toxicol Sci 93:82-95.
56. Zhu S, Lu X, Xing J, Zhang S, Kong H, Xu G, Wu C. (2005). Comparison of comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry and gas chromatography-mass spectrometry for the analysis of tobacco essential oils. Anal Chim Acta 545:224-231. (Pubitemid 40898276)