Preliminary pharmacological characterisation of an interleukin-13-enhanced calcium-activated chloride conductance, in the human airway epithelium

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 367, Issue 2, 2003, Pages 214-217

  Atherton, Hazel ^a   Mesher, Jonathan ^a   Poll, Christopher T ^a   Danahay, Henry ^a  

^a Novartis Institutes for Biomedical Research   (United Kingdom)

Author keywords

Asthma; Human bronchial epithelial cells; Hypersecretion; Ion channel

Indexed keywords

4,4' DINITRO 2,2' STILBENEDISULFONIC ACID; 5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; INTERLEUKIN 13; IONOMYCIN; TAMOXIFEN; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE;

APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CALCIUM CELL LEVEL; CHLORIDE CONDUCTANCE; CHLORIDE TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; MEASUREMENT; MEMBRANE PERMEABILITY; MOLECULE; PHENOTYPE; RESPIRATORY EPITHELIUM; SHORT CIRCUIT CURRENT;

BRONCHI; CALCIUM; CELLS, CULTURED; CHLORIDE CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-13; PATCH-CLAMP TECHNIQUES; TIME FACTORS;

EID: 0037292365     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-002-0668-1     Document Type: Article

References (10)

1. Boucher RC (1994) Human airway ion transport. II. Am J Respir Crit Care Med 150:581-593
2. Danahay H, Atherton H, Jones G, Bridges RJ, Poll CT (2002) Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 282:L226-L236
3. - conductance in the apical membrane of murine tracheal epithelial cells. J Biol Chem 275:35028-35033
4. Galietta LJ, Pagesy P, Folli C, Caci E, Romio L, Costes B, Nicolis E, Cabrini G, Goossens M, Ravazzolo R, Zegarra-Moran O (2002) IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro. J Immunol 168:839-845
5. Galietta LJV, Folli C, Marchetti C, Romano L, Carpani D, Conese M, Zegarra-Moran O (2000) Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-γ. Am J Physiol 278:L1186-L1194
6. Gruber AD, Schreur KD, Ji HL, Fuller CM, Pauli BU (1999) Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland. Am J Physiol 276: C1261-C1270
7. Knowles MR, Olivier K, Noone P, Boucher RC (1995) Pharmacologic modulation of salt and water in the airway epithelium in cystic fibrosis. Am J Respir Crit Care Med 151:S65-S69
8. Lomax RB, Warhurst G, Sandle GI (1996) Characteristics of two basolateral potassium channel populations in human colonic crypts. Gut 38:243-247
9. Schultz BD, Singh AK, Devor DC, Bridges RJ (1999) Pharmacology of CFTR chloride channel activity. Physiol Rev 79:S109-S144
10. --channel blockers in the thick ascending limb of the loop of Henle. Structure activity relationship. Pflugers Arch 407 [Suppl 2]:128-141