Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration

FASEB Journal

Volumn 26, Issue 2, 2012, Pages 533-545

  Clunes, Lucy A ^a   Davies, Catrin M ^a   Coakley, Raymond D ^a   Aleksandrov, Andrei A ^a   Henderson, Ashley G ^a   Zeman, Kirby L ^a   Worthington, Erin N ^a   Gentzsch, Martina ^a   Kreda, Silvia M ^a   Cholon, Deborah ^a   Bennett, William D ^a   Riordan, John R ^a   Boucher, Richard C ^a   Tarran, Robert ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Aggresome; Chronic bronchitis; Ion channel; Lung disease

Indexed keywords

CIGARETTE SMOKE; DETERGENT; SODIUM CHLORIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR; VIMENTIN;

ADULT; AGGRESOME; AIRWAY SURFACE LIQUID; ANIMAL CELL; ARTICLE; BODY FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DEHYDRATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; ION TRANSPORT; LUNG FIBROSIS; LYSOSOME; MALE; MUCUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; REHYDRATION; SMOKING;

ADULT; AGED; ANIMALS; BASE SEQUENCE; BIOLOGICAL TRANSPORT, ACTIVE; BODY WATER; BRONCHITIS, CHRONIC; CASE-CONTROL STUDIES; CELLS, CULTURED; CRICETINAE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DNA PRIMERS; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; MUCOCILIARY CLEARANCE; RESPIRATORY MUCOSA; SALINE SOLUTION, HYPERTONIC; SMOKE; SMOKING; SOLUBILITY;

EID: 84856557879     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-192377     Document Type: Article

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