CFTR and bicarbonate secretion to epithelial cells

News in Physiological Sciences

Volumn 18, Issue 1, 2003, Pages 38-42

  Hug, Martin J ^a   Tamada, Tsutomu ^b   Bridges, Robert J ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CHLORINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AIRWAY; ANION EXCHANGE; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL SECRETION; EPITHELIUM CELL; HUMAN; METABOLISM; NONHUMAN; PANCREAS; PROTEIN FUNCTION; PROTEIN SECRETION;

EID: 0037291973     PISSN: 08861714     EISSN: None     Source Type: Journal    
DOI: 10.1152/nips.01412.2002     Document Type: Article

References (20)

1. Bro-Rasmussen F, Killmann SA, and Thaysen JH. The composition of pancreatic juice as compared to sweat, parotid saliva and tears. Acta Physiol Scand 37: 97-113, 1956.
2. - transport in mutations associated with cystic fibrosis. Nature 410: 94-97, 2001.
3. Devor DC, Bridges RJ, and Pilewski JM. Pharmacological modulation of ion transport across wild-type and ΔF508 CFTR-expressing human bronchial epithelia. Am J Physiol Cell Physiol 279: C461-C479, 2000.
4. Devor DC, Singh AK, Lambert LC, DeLuca A, Frizzell RA, and Bridges RJ. Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells. J Gen Physiol 113: 743-760, 1999.
5. Gray MA, Pollard CE, Harris A, Coleman L, Greenwell JR, and Argent BE. Anion selectivity and block of the small-conductance chloride channel on pancreatic duct cells. Am J Physiol Cell Physiol 259: C752-C761, 1990.
6. Illek B, Tam AW, Fischer H, and Machen TE. Anion selectivity of apical membrane conductance of Calu 3 human airway epithelium. Pflügers Arch 437: 812-822, 1999.
7. Ishiguro H, Steward MC, Wilson RW, and Case RM. Bicarbonate secretion in interlobular ducts from guinea-pig pancreas. J Physiol 495: 179-191, 1996.
8. Kopelman H, Corey M, Gaskin K, Durie P, Weizman Z, and Forstner G. Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid secretory defect in the cystic fibrosis pancreas. Gastroenterology 95: 349-355, 1988.
9. Lee MC, Penland CM, Widdicombe JH, and Wine JJ. Evidence that Calu-3 human airway cells secrete bicarbonate. Am J Physiol Lung Cell Mol Physiol 274: L450-L453, 1998.
10. - exchange. J Biol Chem 274: 3414-3421, 1999.
11. Linsdell P, Tabcharani JA, Rommens JM, Hou YX, Chang XB, Tsui LC, Riordan JR, and Hanrahan JW. Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to poly-atomic anions. J Gen Physiol 110: 355-364, 1997.
12. Lohi H, Kujala M, Kerkela E, Saarialho-Kere U, Kestila M, and Kere J. Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. Genomics 70: 102-112, 2000.
13. Novak I and Greger R. Properties of the luminal membrane of isolated perfused rat pancreatic ducts. Effect of cyclic AMP and blockers of chloride transport. Pflügers Arch 411: 546-553, 1988.
14. O'Reilly CM, Winpenny JP, Argent BE, and Gray MA. Cystic fibrosis transmembrane conductance regulator currents in guinea pig pancreatic duct cells: inhibition by bicarbonate ions. Gastroenterology 118: 1187-1196, 2000.
15. Poulsen JH, Fischer H, Illek B, and Machen TE. Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci USA 91: 5340-5344, 1994.
16. Pratha VS, Hogan DL, Martensson BA, Bernard J, Zhou R, and Isenberg JI. Identification of transport abnormalities in duodenal mucosa and duodenal enterocytes from patients with cystic fibrosis. Gastroenterology 118: 1051-1060, 2000.
17. Rosenstein BJ and Cutting GR. The diagnosis of cystic fibrosis: a consensus statement. Cystic Fibrosis Foundation Consensus Panel. J Pediatr 132: 589-595, 1998.
18. Smith JJ and Welsh MJ. cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia. J Clin Invest 89: 1148-1153, 1992.
19. - exchange activity in tracheal epithelial cells. Am J Physiol Cell Physiol 279: C62-C71, 2000.
20. Wine JJ. Cystic fibrosis: the 'bicarbonate before chloride' hypothesis. Curr Biol 11: R463-R466, 2001.