Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity

Journal of Biological Chemistry

Volumn 287, Issue 36, 2012, Pages 30073-30083

  Alli, Abdel A ^a   Song, John Z ^a   Al Khalili, Otor ^a   Bao, Hui Fang ^a   Ma, He Ping ^a   Alli, Alia A ^a   Eaton, Douglas C ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APICAL MEMBRANES; CATHEPSIN B; CYSTEINE PROTEASE; EPITHELIAL CELLS; EPITHELIAL SODIUM CHANNELS; EXTRACELLULAR LOOPS; EXTRACELLULAR VOLUMES; FUSION PROTEINS; IN-VITRO; INCLUSION BODIES; MASS SPECTROMETRY ANALYSIS; PATCH-CLAMP STUDIES; PROTEOLYTIC CLEAVAGE; RECYCLING ENDOSOMES; SINGLE CHANNELS; TWO-DIMENSIONAL GEL ELECTROPHORESIS; XENOPUS;

AMINO ACIDS; BLOOD PRESSURE; ELECTROPHORESIS; ELECTROPHYSIOLOGY; ESCHERICHIA COLI; MASS SPECTROMETRY; SODIUM;

RECOMBINANT PROTEINS;

CATHEPSIN B; EPITHELIAL SODIUM CHANNEL; GST ENAC ALPHA SUBUNIT FUSION PROTEIN; GST ENAC BETA SUBUNIT FUSION PROTEIN; GST ENAC GAMMA SUBUNIT FUSION PROTEIN; HYBRID PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; APICAL MEMBRANE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; XENOPUS;

ANIMALS; CATHEPSIN B; ENDOSOMES; EPITHELIAL SODIUM CHANNELS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GOLGI APPARATUS; HUMANS; PROTEIN STRUCTURE, SECONDARY; PROTEOLYSIS; RECOMBINANT FUSION PROTEINS; XENOPUS LAEVIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 84865758196     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.338574     Document Type: Article

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