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Volumn 11, Issue 8, 2015, Pages 462-474

A look behind the scenes: The risk and pathogenesis of primary osteoporosis

Author keywords

[No Author keywords available]

Indexed keywords

BLOSOZUMAB; CATHEPSIN K; DENOSUMAB; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; ODANACATIB; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROTEIN P53; PROTEIN P66; REACTIVE OXYGEN METABOLITE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; ROMOSOZUMAB; SEX HORMONE; TRANSCRIPTION FACTOR FOXO;

EID: 84938422411     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2015.48     Document Type: Review
Times cited : (222)

References (150)
  • 1
    • 69949136157 scopus 로고    scopus 로고
    • Excess mortality following hip fracture: A systematic epidemiological review
    • Abrahamsen, B., van Staa, T., Ariely, R., Olson, M. & Cooper, C. Excess mortality following hip fracture: a systematic epidemiological review. Osteoporos. Int. 20, 1633-1650 (2009).
    • (2009) Osteoporos. Int , vol.20 , pp. 1633-1650
    • Abrahamsen, B.1    Van Staa, T.2    Ariely, R.3    Olson, M.4    Cooper, C.5
  • 2
    • 84857922558 scopus 로고    scopus 로고
    • Osteoporosis frailty and fracture: Implications for case finding and therapy
    • van den Bergh, J. P., van Geel, T. A. & Geusens, P. P. Osteoporosis, frailty and fracture: implications for case finding and therapy. Nat. Rev. Rheumatol. 8, 163-172 (2012).
    • (2012) Nat. Rev. Rheumatol , vol.8 , pp. 163-172
    • Van Den Bergh, J.P.1    Van Geel, T.A.2    Geusens, P.P.3
  • 3
    • 0029243810 scopus 로고
    • How many women have osteoporosis now?
    • Melton, L. J. 3rd. How many women have osteoporosis now? J. Bone Miner. Res. 10, 175-177 (1995).
    • (1995) J. Bone Miner. Res , vol.10 , pp. 175-177
    • Melton, L.J.1
  • 4
    • 0028824564 scopus 로고
    • Direct clinical and welfare costs of osteoporotic fractures in elderly men and women
    • Randell, A., et al. Direct clinical and welfare costs of osteoporotic fractures in elderly men and women. Osteoporos. Int. 5, 427-432 (1995).
    • (1995) Osteoporos. Int , vol.5 , pp. 427-432
    • Randell, A.1
  • 5
    • 15044344862 scopus 로고    scopus 로고
    • Requirements for DXA for the management of osteoporosis in Europe
    • Kanis, J. A. & Johnell, O. Requirements for DXA for the management of osteoporosis in Europe. Osteoporos. Int. 16, 229-238 (2005).
    • (2005) Osteoporos. Int , vol.16 , pp. 229-238
    • Kanis, J.A.1    Johnell, O.2
  • 6
    • 0035227418 scopus 로고    scopus 로고
    • Acquisition of optimal bone mass in childhood and adolescence
    • Bachrach, L. K. Acquisition of optimal bone mass in childhood and adolescence. Trends Endocrinol. Metab. 12, 22-28 (2001).
    • (2001) Trends Endocrinol. Metab , vol.12 , pp. 22-28
    • Bachrach, L.K.1
  • 7
    • 84939886535 scopus 로고    scopus 로고
    • Osteocyte control of bone remodeling: Is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?
    • Sapir-Koren, R. & Livshits, G. Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles? Osteoporos. Int. (2014).
    • (2014) Osteoporos. Int.
    • Sapir-Koren, R.1    Livshits, G.2
  • 8
    • 84863633404 scopus 로고    scopus 로고
    • Osteoblastogenesis regulation signals in bone remodeling
    • Zuo, C., et al. Osteoblastogenesis regulation signals in bone remodeling. Osteoporos. Int. 23, 1653-1663 (2012).
    • (2012) Osteoporos. Int , vol.23 , pp. 1653-1663
    • Zuo, C.1
  • 9
    • 84907618334 scopus 로고    scopus 로고
    • The contribution of collagen crosslinks to bone strength
    • Garnero, P. The contribution of collagen crosslinks to bone strength. Bonekey Rep. 1, 182 (2012).
    • (2012) Bonekey Rep , vol.1 , pp. 182
    • Garnero, P.1
  • 10
    • 84906327430 scopus 로고    scopus 로고
    • Biological regulation of bone quality
    • Alliston, T. Biological regulation of bone quality. Curr. Osteoporos. Rep. 12, 366-375 (2014).
    • (2014) Curr. Osteoporos. Rep , vol.12 , pp. 366-375
    • Alliston, T.1
  • 11
    • 84865745554 scopus 로고    scopus 로고
    • Effects of bone matrix proteins on fracture and fragility in osteoporosis
    • Sroga, G. E. & Vashishth, D. Effects of bone matrix proteins on fracture and fragility in osteoporosis. Curr. Osteoporos. Rep. 10, 141-150 (2012).
    • (2012) Curr. Osteoporos. Rep , vol.10 , pp. 141-150
    • Sroga, G.E.1    Vashishth, D.2
  • 12
  • 13
    • 84899480054 scopus 로고    scopus 로고
    • Aging mechanisms in bone
    • Almeida, M. Aging mechanisms in bone. Bonekey Rep. 1, 102 (2012).
    • (2012) Bonekey Rep , vol.1 , pp. 102
    • Almeida, M.1
  • 14
    • 75149129597 scopus 로고    scopus 로고
    • From estrogen-centric to aging and oxidative stress: A revised perspective of the pathogenesis of osteoporosis
    • Manolagas, S. C. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr. Rev. 31, 266-300 (2010).
    • (2010) Endocr. Rev , vol.31 , pp. 266-300
    • Manolagas, S.C.1
  • 15
    • 0037123638 scopus 로고    scopus 로고
    • Premature aging in mice deficient in DNA repair and transcription
    • de Boer, J., et al. Premature aging in mice deficient in DNA repair and transcription. Science 296, 1276-1279 (2002).
    • (2002) Science , vol.296 , pp. 1276-1279
    • De Boer, J.1
  • 16
    • 0037011958 scopus 로고    scopus 로고
    • P53 mutant mice that display early ageing-associated phenotypes
    • Tyner, S. D., et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53 (2002).
    • (2002) Nature , vol.415 , pp. 45-53
    • Tyner, S.D.1
  • 17
    • 80055002537 scopus 로고    scopus 로고
    • Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking
    • Nojiri, H., et al. Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking. J. Bone Miner. Res. 26, 2682-2694 (2011).
    • (2011) J. Bone Miner. Res , vol.26 , pp. 2682-2694
    • Nojiri, H.1
  • 18
    • 78649688181 scopus 로고    scopus 로고
    • Reactive oxygen species on bone mineral density and mechanics in Cu, Zn superoxide dismutase (Sod1) knockout mice
    • Smietana, M. J., Arruda, E. M., Faulkner, J. A., Brooks, S. V. & Larkin, L. M. Reactive oxygen species on bone mineral density and mechanics in Cu, Zn superoxide dismutase (Sod1) knockout mice. Biochem. Biophys. Res. Commun. 403, 149-153 (2010).
    • (2010) Biochem. Biophys. Res. Commun , vol.403 , pp. 149-153
    • Smietana, M.J.1    Arruda, E.M.2    Faulkner, J.A.3    Brooks, S.V.4    Larkin, L.M.5
  • 19
    • 75149146587 scopus 로고    scopus 로고
    • FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice
    • Ambrogini, E., et al. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab. 11, 136-146 (2010).
    • (2010) Cell Metab , vol.11 , pp. 136-146
    • Ambrogini, E.1
  • 20
    • 79960575561 scopus 로고    scopus 로고
    • Unraveling the role of FoxOs in bone-insights from mouse models
    • Almeida, M. Unraveling the role of FoxOs in bone-insights from mouse models. Bone 49, 319-327 (2011).
    • (2011) Bone , vol.49 , pp. 319-327
    • Almeida, M.1
  • 21
    • 34848814178 scopus 로고    scopus 로고
    • Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor-to forkhead box O-mediated transcription
    • Almeida, M., Han, L., Martin-Millan, M., OBrien, C. A. & Manolagas, S. C. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor-to forkhead box O-mediated transcription. J. Biol. Chem. 282, 27298-27305 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 27298-27305
    • Almeida, M.1    Han, L.2    Martin-Millan, M.3    Obrien, C.A.4    Manolagas, S.C.5
  • 22
    • 18844382368 scopus 로고    scopus 로고
    • Functional interaction between β-catenin and FOXO in oxidative stress signaling
    • Essers, M. A., et al. Functional interaction between β-catenin and FOXO in oxidative stress signaling. Science 308, 1181-1184 (2005).
    • (2005) Science , vol.308 , pp. 1181-1184
    • Essers, M.A.1
  • 23
    • 0033581704 scopus 로고    scopus 로고
    • The p66shc adaptor protein controls oxidative stress response and life span in mammals
    • Migliaccio, E., et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402, 309-313 (1999).
    • (1999) Nature , vol.402 , pp. 309-313
    • Migliaccio, E.1
  • 24
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • Nemoto, S. & Finkel, T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 295, 2450-2452 (2002).
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 25
    • 22744447211 scopus 로고    scopus 로고
    • Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
    • Giorgio, M., et al. Electron. transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122, 221-233 (2005).
    • (2005) Cell , vol.122 , pp. 221-233
    • Giorgio, M.1
  • 26
    • 10744225848 scopus 로고    scopus 로고
    • P66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells
    • Pacini, S., et al. p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells. Mol. Cell Biol. 24, 1747-1757 (2004).
    • (2004) Mol. Cell Biol , vol.24 , pp. 1747-1757
    • Pacini, S.1
  • 27
    • 84961943473 scopus 로고    scopus 로고
    • Deletion of the redox amplifier p66shc decreases ROS production in murine bone and increases osteoblast resistance to oxidative stress and bone mass [abstract]
    • Bartell, S. M., et al. Deletion of the redox amplifier p66shc decreases ROS production in murine bone and increases osteoblast resistance to oxidative stress and bone mass [abstract]. J. Bone Miner. Res. 26 (Suppl. 1), S85 (2011).
    • (2011) J. Bone Miner. Res , vol.26 , pp. S85
    • Bartell, S.M.1
  • 28
    • 1042266548 scopus 로고    scopus 로고
    • Modulation of mammalian life span by the short isoform of p53
    • Maier, B., et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18, 306-319 (2004).
    • (2004) Genes Dev , vol.18 , pp. 306-319
    • Maier, B.1
  • 29
    • 29944437296 scopus 로고    scopus 로고
    • P53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling
    • Wang, X., et al. p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J. Cell Biol. 172, 115-125 (2006).
    • (2006) J. Cell Biol , vol.172 , pp. 115-125
    • Wang, X.1
  • 30
    • 84875860646 scopus 로고    scopus 로고
    • Dysfunctional osteocytes increase RANKL and promote cortical pore formation in their vicinity: A mechanistic explanation for the development of cortical porosity with age [abstract]
    • Jilka, R. L., et al. Dysfunctional osteocytes increase RANKL and promote cortical pore formation in their vicinity: a mechanistic explanation for the development of cortical porosity with age [abstract]. J. Bone Miner. Res. 27 (Suppl. 1), S348 (2012).
    • (2012) J. Bone Miner. Res , vol.27 , pp. S348
    • Jilka, R.L.1
  • 31
    • 84890899395 scopus 로고    scopus 로고
    • Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates bone porosity with age
    • Jilka, R. L., et al. Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates bone porosity with age. J. Bone Miner. Res. 29, 103-117 (2014).
    • (2014) J. Bone Miner. Res , vol.29 , pp. 103-117
    • Jilka, R.L.1
  • 33
    • 34848878406 scopus 로고    scopus 로고
    • Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids
    • Almeida, M., et al. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J. Biol. Chem. 282, 27285-27297 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 27285-27297
    • Almeida, M.1
  • 34
    • 0030884639 scopus 로고    scopus 로고
    • The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone
    • Tomkinson, A., Reeve, J., Shaw, R. W. & Noble, B. S. The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. J. Clin. Endocrinol. Metab. 82, 3128-3135 (1997).
    • (1997) J. Clin. Endocrinol. Metab , vol.82 , pp. 3128-3135
    • Tomkinson, A.1    Reeve, J.2    Shaw, R.W.3    Noble, B.S.4
  • 36
    • 78249262917 scopus 로고    scopus 로고
    • Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone
    • Busse, B., et al. Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone. Aging Cell 9, 1065-1075 (2010).
    • (2010) Aging Cell , vol.9 , pp. 1065-1075
    • Busse, B.1
  • 37
    • 84856959164 scopus 로고    scopus 로고
    • Increased proportion of hypermineralized osteocyte lacunae in osteoporotic and osteoarthritic human trabecular bone: Implications for bone remodeling
    • Carpentier, V. T., et al. Increased proportion of hypermineralized osteocyte lacunae in osteoporotic and osteoarthritic human trabecular bone: implications for bone remodeling. Bone 50, 688-694 (2012).
    • (2012) Bone , vol.50 , pp. 688-694
    • Carpentier, V.T.1
  • 38
    • 84888205228 scopus 로고    scopus 로고
    • The role of estrogen and androgen receptors in bone health and disease
    • Manolagas, S. C., OBrien, C. A. & Almeida, M. The role of estrogen and androgen receptors in bone health and disease. Nat. Rev. Endocrinol. 9, 699-712 (2013).
    • (2013) Nat. Rev. Endocrinol , vol.9 , pp. 699-712
    • Manolagas, S.C.1    Obrien, C.A.2    Almeida, M.3
  • 39
    • 0037778765 scopus 로고    scopus 로고
    • Periosteal bone formation-a neglected determinant of bone strength
    • Seeman, E. Periosteal bone formation-a neglected determinant of bone strength. N. Engl. J. Med. 349, 320-323 (2003).
    • (2003) N. Engl. J. Med , vol.349 , pp. 320-323
    • Seeman, E.1
  • 40
    • 75149165271 scopus 로고    scopus 로고
    • The estrogen receptor-α in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone
    • Martin-Millan, M., et al. The estrogen receptor-α in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol. Endocrinol. 24, 323-334 (2010).
    • (2010) Mol. Endocrinol , vol.24 , pp. 323-334
    • Martin-Millan, M.1
  • 41
    • 34548274444 scopus 로고    scopus 로고
    • Estrogen prevents bone loss via estrogen receptor α and induction of Fas ligand in osteoclasts
    • Nakamura, T., et al. Estrogen prevents bone loss via estrogen receptor α and induction of Fas ligand in osteoclasts. Cell 130, 811-823 (2007).
    • (2007) Cell , vol.130 , pp. 811-823
    • Nakamura, T.1
  • 42
    • 65549171025 scopus 로고    scopus 로고
    • Mineralization and bone resorption are regulated by the androgen receptor in male mice
    • Chiang, C., et al. Mineralization and bone resorption are regulated by the androgen receptor in male mice. J. Bone Miner. Res. 24, 621-631 (2009).
    • (2009) J. Bone Miner. Res , vol.24 , pp. 621-631
    • Chiang, C.1
  • 43
    • 34247192540 scopus 로고    scopus 로고
    • Osteoblast deletion of exon 3 of the androgen receptor gene results in trabecular bone loss in adult male mice
    • Notini, A. J., et al. Osteoblast deletion of exon 3 of the androgen receptor gene results in trabecular bone loss in adult male mice. J. Bone Miner. Res. 22, 347-356 (2007).
    • (2007) J. Bone Miner. Res , vol.22 , pp. 347-356
    • Notini, A.J.1
  • 44
    • 84869397973 scopus 로고    scopus 로고
    • Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: Evidence from targeted AR disruption in mouse osteocytes
    • Sinnesael, M., et al. Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: evidence from targeted AR disruption in mouse osteocytes. J. Bone Miner. Res. 27, 2535-2543 (2012).
    • (2012) J. Bone Miner. Res , vol.27 , pp. 2535-2543
    • Sinnesael, M.1
  • 45
    • 77953392432 scopus 로고    scopus 로고
    • Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERα
    • Almeida, M., et al. Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERα. J. Bone Miner. Res. 25, 769-781 (2010).
    • (2010) J. Bone Miner. Res. , vol.25 , pp. 769-781
    • Almeida, M.1
  • 46
    • 0035831020 scopus 로고    scopus 로고
    • Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity
    • Kousteni, S., et al. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104, 719-730 (2001).
    • (2001) Cell , vol.104 , pp. 719-730
    • Kousteni, S.1
  • 47
    • 0037174675 scopus 로고    scopus 로고
    • Reversal of bone loss in mice by nongenotropic signaling of sex steroids
    • Kousteni, S., et al. Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science 298, 843-846 (2002).
    • (2002) Science , vol.298 , pp. 843-846
    • Kousteni, S.1
  • 48
    • 84855514294 scopus 로고    scopus 로고
    • Pro-survival effects of 17β-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases i and II
    • Marathe, N., Rangaswami, H., Zhuang, S., Boss, G. R. & Pilz, R. B. Pro-survival effects of 17β-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases I and II. J. Biol. Chem. 287, 978-988 (2012).
    • (2012) J. Biol. Chem , vol.287 , pp. 978-988
    • Marathe, N.1    Rangaswami, H.2    Zhuang, S.3    Boss, G.R.4    Pilz, R.B.5
  • 49
    • 0037172407 scopus 로고    scopus 로고
    • Pathogenesis of bone fragility in women and men
    • Seeman, E. Pathogenesis of bone fragility in women and men. Lancet 359, 1841-1850 (2002).
    • (2002) Lancet , vol.359 , pp. 1841-1850
    • Seeman, E.1
  • 50
    • 26444515048 scopus 로고    scopus 로고
    • The decline of androgen levels in elderly men and its clinical and therapeutic implications
    • Kaufman, J. M. & Vermeulen, A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr. Rev. 26, 833-876 (2005).
    • (2005) Endocr. Rev , vol.26 , pp. 833-876
    • Kaufman, J.M.1    Vermeulen, A.2
  • 51
    • 84856962930 scopus 로고    scopus 로고
    • Bone turnover markers in peripheral blood and marrow plasma reflect trabecular bone loss but not endocortical expansion in aging mice
    • Shahnazari, M., et al. Bone turnover markers in peripheral blood and marrow plasma reflect trabecular bone loss but not endocortical expansion in aging mice. Bone 50, 628-637 (2012).
    • (2012) Bone , vol.50 , pp. 628-637
    • Shahnazari, M.1
  • 52
    • 78349252031 scopus 로고    scopus 로고
    • Effects of chronic estrogen treatment on modulating age-related bone loss in female mice
    • Syed, F. A., et al. Effects of chronic estrogen treatment on modulating age-related bone loss in female mice. J. Bone Miner. Res. 25, 2438-2446 (2010).
    • (2010) J. Bone Miner. Res , vol.25 , pp. 2438-2446
    • Syed, F.A.1
  • 53
    • 77952111123 scopus 로고    scopus 로고
    • Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: A cross-sectional study
    • Zebaze, R. M., et al. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet 375, 1729-1736 (2010).
    • (2010) Lancet , vol.375 , pp. 1729-1736
    • Zebaze, R.M.1
  • 54
    • 84875824593 scopus 로고    scopus 로고
    • For whom the bell tolls: Distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases
    • Manolagas, S. C. & Parfitt, A. M. For whom the bell tolls: distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases. Bone 54, 272-278 (2013).
    • (2013) Bone , vol.54 , pp. 272-278
    • Manolagas, S.C.1    Parfitt, A.M.2
  • 56
    • 84901346313 scopus 로고    scopus 로고
    • Autophagy-a key player in cellular and body metabolism
    • Kim, K. H. & Lee, M. S. Autophagy-a key player in cellular and body metabolism. Nat. Rev. Endocrinol. 10, 322-337 (2014).
    • (2014) Nat. Rev. Endocrinol , vol.10 , pp. 322-337
    • Kim, K.H.1    Lee, M.S.2
  • 57
    • 77954701060 scopus 로고    scopus 로고
    • Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD
    • Zhang, L., et al. Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD. J. Bone Miner. Res. 25, 1572-1580 (2010).
    • (2010) J. Bone Miner. Res , vol.25 , pp. 1572-1580
    • Zhang, L.1
  • 59
    • 70349669095 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    • Selman, C., et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326, 140-144 (2009).
    • (2009) Science , vol.326 , pp. 140-144
    • Selman, C.1
  • 60
    • 59749098315 scopus 로고    scopus 로고
    • Nutrient-dependent regulation of autophagy through the target of rapamycin pathway
    • Chang, Y. Y., et al. Nutrient-dependent regulation of autophagy through the target of rapamycin pathway. Biochem. Soc. Trans. 37, 232-236 (2009).
    • (2009) Biochem. Soc. Trans , vol.37 , pp. 232-236
    • Chang, Y.Y.1
  • 61
    • 83455173649 scopus 로고    scopus 로고
    • Autophagy proteins regulate the secretory component of osteoclastic bone resorption
    • DeSelm, C. J., et al. Autophagy proteins regulate the secretory component of osteoclastic bone resorption. Dev. Cell 21, 966-974 (2011).
    • (2011) Dev. Cell , vol.21 , pp. 966-974
    • DeSelm, C.J.1
  • 62
    • 84886819890 scopus 로고    scopus 로고
    • Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation
    • Liu, F., et al. Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation. J. Bone Miner. Res. 28, 2414-2430 (2013).
    • (2013) J. Bone Miner. Res , vol.28 , pp. 2414-2430
    • Liu, F.1
  • 63
    • 84879065741 scopus 로고    scopus 로고
    • Suppression of autophagy in osteocytes mimics skeletal aging
    • Onal, M., et al. Suppression of autophagy in osteocytes mimics skeletal aging. J. Biol. Chem. 288, 17432-17440 (2013).
    • (2013) J. Biol. Chem , vol.288 , pp. 17432-17440
    • Onal, M.1
  • 64
    • 84884262619 scopus 로고    scopus 로고
    • Dairy in adulthood: From foods to nutrient interactions on bone and skeletal muscle health
    • Bonjour, J. P., Kraenzlin, M., Levasseur, R., Warren, M. & Whiting, S. Dairy in adulthood: from foods to nutrient interactions on bone and skeletal muscle health. J. Am. Coll. Nutr. 32, 251-263 (2013).
    • (2013) J. Am. Coll. Nutr , vol.32 , pp. 251-263
    • Bonjour, J.P.1    Kraenzlin, M.2    Levasseur, R.3    Warren, M.4    Whiting, S.5
  • 66
    • 84904161132 scopus 로고    scopus 로고
    • Vitamin D: Direct effects of vitamin D metabolites on bone: Lessons from genetically modified mice
    • Eisman, J. A. & Bouillon, R. Vitamin D: direct effects of vitamin D metabolites on bone: lessons from genetically modified mice. Bonekey Rep. 3, 499 (2014).
    • (2014) Bonekey Rep , vol.3 , pp. 499
    • Eisman, J.A.1    Bouillon, R.2
  • 67
    • 84904052451 scopus 로고    scopus 로고
    • Antioxidants and human diseases
    • Rajendran, P., et al. Antioxidants and human diseases. Clin. Chim. Acta 436C, 332-347 (2014).
    • (2014) Clin. Chim. Acta , vol.436 , pp. 332-347
    • Rajendran, P.1
  • 68
    • 84870926998 scopus 로고    scopus 로고
    • Fruits and dietary phytochemicals in bone protection
    • Shen, C. L., et al. Fruits and dietary phytochemicals in bone protection. Nutr. Res. 32, 897-910 (2012).
    • (2012) Nutr. Res , vol.32 , pp. 897-910
    • Shen, C.L.1
  • 69
    • 84879466373 scopus 로고    scopus 로고
    • Fruit and vegetable intake and bone mass in Chinese adolescents, young and postmenopausal women
    • Li, J. J., et al. Fruit and vegetable intake and bone mass in Chinese adolescents, young and postmenopausal women. Public Health Nutr. 16, 78-86 (2013).
    • (2013) Public Health Nutr , vol.16 , pp. 78-86
    • Li, J.J.1
  • 70
    • 0033982885 scopus 로고    scopus 로고
    • Dietary influences on bone mass and bone metabolism: Further evidence of a positive link between fruit and vegetable consumption and bone health?
    • New, S. A., et al. Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am. J. Clin. Nutr. 71, 142-151 (2000).
    • (2000) Am. J. Clin. Nutr , vol.71 , pp. 142-151
    • New, S.A.1
  • 71
    • 33745622459 scopus 로고    scopus 로고
    • Fruit and vegetable intakes and bone mineral status: A cross sectional study in 5 age and sex cohorts
    • Prynne, C. J., et al. Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts. Am. J. Clin. Nutr. 83, 1420-1428 (2006).
    • (2006) Am. J. Clin. Nutr , vol.83 , pp. 1420-1428
    • Prynne, C.J.1
  • 72
    • 33845495859 scopus 로고    scopus 로고
    • Impact of seafood and fruit consumption on bone mineral density
    • Zalloua, P. A., et al. Impact of seafood and fruit consumption on bone mineral density. Maturitas 56, 1-11 (2007).
    • (2007) Maturitas , vol.56 , pp. 1-11
    • Zalloua, P.A.1
  • 73
    • 43549115702 scopus 로고    scopus 로고
    • Amount and type of protein influences bone health
    • Heaney, R. P. & Layman, D. K. Amount and type of protein influences bone health. Am. J. Clin. Nutr. 87, 1567S-1570S (2008).
    • (2008) Am. J. Clin. Nutr , vol.87 , pp. 1567S-1570S
    • Heaney, R.P.1    Layman, D.K.2
  • 74
    • 32944459496 scopus 로고    scopus 로고
    • Dietary protein content and the diets net acid load: Opposing effects on bone health
    • Sebastian, A. Dietary protein content and the diets net acid load: opposing effects on bone health. Am. J. Clin. Nutr. 82, 921-922 (2005).
    • (2005) Am. J. Clin. Nutr , vol.82 , pp. 921-922
    • Sebastian, A.1
  • 75
    • 84884254480 scopus 로고    scopus 로고
    • Nutritional disturbance in acid-base balance and osteoporosis: A hypothesis that disregards the essential homeostatic role of the kidney
    • Bonjour, J. P. Nutritional disturbance in acid-base balance and osteoporosis: a hypothesis that disregards the essential homeostatic role of the kidney. Br. J. Nutr. 110, 1168-1177 (2013).
    • (2013) Br. J. Nutr , vol.110 , pp. 1168-1177
    • Bonjour, J.P.1
  • 76
    • 0029774266 scopus 로고    scopus 로고
    • Metabolic alkalosis decreases bone calcium efflux by suppressing osteoclasts and stimulating osteoblasts
    • Bushinsky, D. A. Metabolic alkalosis decreases bone calcium efflux by suppressing osteoclasts and stimulating osteoblasts. Am. J. Physiol. 271, F216-F222 (1996).
    • (1996) Am. J. Physiol , vol.271 , pp. F216-F222
    • Bushinsky, D.A.1
  • 77
    • 0035005065 scopus 로고    scopus 로고
    • Oxidative stress and antioxidants in exercise
    • Leeuwenburgh, C. & Heinecke, J. W. Oxidative stress and antioxidants in exercise. Curr. Med. Chem. 8, 829-838 (2001).
    • (2001) Curr. Med. Chem , vol.8 , pp. 829-838
    • Leeuwenburgh, C.1    Heinecke, J.W.2
  • 78
    • 75149150013 scopus 로고    scopus 로고
    • Mechanical signals as anabolic agents in bone
    • Ozcivici, E., et al. Mechanical signals as anabolic agents in bone. Nat. Rev. Rheumatol. 6, 50-59 (2010).
    • (2010) Nat. Rev. Rheumatol , vol.6 , pp. 50-59
    • Ozcivici, E.1
  • 79
    • 77956461991 scopus 로고    scopus 로고
    • Osteocyte: The unrecognized side of bone tissue
    • Rochefort, G. Y., Pallu, S. & Benhamou, C. L. Osteocyte: the unrecognized side of bone tissue. Osteoporos. Int. 21, 1457-1469 (2010).
    • (2010) Osteoporos. Int , vol.21 , pp. 1457-1469
    • Rochefort, G.Y.1    Pallu, S.2    Benhamou, C.L.3
  • 80
    • 0035282968 scopus 로고    scopus 로고
    • Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
    • Balemans, W., et al. Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). Hum. Mol. Genet. 10, 537-543 (2001).
    • (2001) Hum. Mol. Genet , vol.10 , pp. 537-543
    • Balemans, W.1
  • 81
    • 18244403197 scopus 로고    scopus 로고
    • Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
    • Balemans, W., et al. Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease. J. Med. Genet. 39, 91-97 (2002).
    • (2002) J. Med. Genet , vol.39 , pp. 91-97
    • Balemans, W.1
  • 82
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • Li, X., et al. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J. Biol. Chem. 280, 19883-19887 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 19883-19887
    • Li, X.1
  • 83
    • 22844445934 scopus 로고    scopus 로고
    • SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    • Semenov, M., Tamai, K. & He, X. SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J. Biol. Chem. 280, 26770-26775 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 26770-26775
    • Semenov, M.1    Tamai, K.2    He, X.3
  • 84
    • 84886093793 scopus 로고    scopus 로고
    • The role of extracellular modulators of canonical Wnt signaling in bone metabolism and diseases
    • Boudin, E., Fijalkowski, I., Piters, E. & Van Hul, W. The role of extracellular modulators of canonical Wnt signaling in bone metabolism and diseases. Semin. Arthritis Rheum. 43, 220-240 (2013).
    • (2013) Semin. Arthritis Rheum , vol.43 , pp. 220-240
    • Boudin, E.1    Fijalkowski, I.2    Piters, E.3    Van Hul, W.4
  • 85
    • 84902679096 scopus 로고    scopus 로고
    • Wnt and the Wnt signaling pathway in bone development and disease
    • Wang, Y., et al. Wnt and the Wnt signaling pathway in bone development and disease. Front. Biosci. (Landmark Ed.) 19, 379-407 (2014).
    • (2014) Front. Biosci. (Landmark Ed.) , vol.19 , pp. 379-407
    • Wang, Y.1
  • 87
    • 79957504879 scopus 로고    scopus 로고
    • Effects of nutrition and alcohol consumption on bone loss
    • Ronis, M. J., Mercer, K. & Chen, J. R. Effects of nutrition and alcohol consumption on bone loss. Curr. Osteoporos. Rep. 9, 53-59 (2011).
    • (2011) Curr. Osteoporos. Rep , vol.9 , pp. 53-59
    • Ronis, M.J.1    Mercer, K.2    Chen, J.R.3
  • 88
    • 77953483918 scopus 로고    scopus 로고
    • A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/β-catenin signaling
    • Chen, J. R., et al. A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/β-catenin signaling. J. Bone Miner. Res. 25, 1117-1127 (2010).
    • (2010) J. Bone Miner. Res , vol.25 , pp. 1117-1127
    • Chen, J.R.1
  • 89
    • 37349060697 scopus 로고    scopus 로고
    • Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-?B ligand signaling cascade
    • Chen, J. R., Shankar, K., Nagarajan, S., Badger, T. M. & Ronis, M. J. Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-?B ligand signaling cascade. J. Pharmacol. Exp. Ther. 324, 50-59 (2008).
    • (2008) J. Pharmacol. Exp. Ther , vol.324 , pp. 50-59
    • Chen, J.R.1    Shankar, K.2    Nagarajan, S.3    Badger, T.M.4    Ronis, M.J.5
  • 90
    • 19944432683 scopus 로고    scopus 로고
    • Smoking and fracture risk: A meta-analysis
    • Kanis, J. A., et al. Smoking and fracture risk: a meta-analysis. Osteoporos. Int. 16, 155-162 (2005).
    • (2005) Osteoporos. Int , vol.16 , pp. 155-162
    • Kanis, J.A.1
  • 91
    • 0034968745 scopus 로고    scopus 로고
    • A meta-analysis of the effects of cigarette smoking on bone mineral density
    • Ward, K. D. & Klesges, R. C. A meta-analysis of the effects of cigarette smoking on bone mineral density. Calcif. Tissue Int. 68, 259-270 (2001).
    • (2001) Calcif. Tissue Int , vol.68 , pp. 259-270
    • Ward, K.D.1    Klesges, R.C.2
  • 92
    • 84864882479 scopus 로고    scopus 로고
    • The effects of smoking on bone metabolism
    • Yoon, V., Maalouf, N. M. & Sakhaee, K. The effects of smoking on bone metabolism. Osteoporos. Int. 23, 2081-2092 (2012).
    • (2012) Osteoporos. Int , vol.23 , pp. 2081-2092
    • Yoon, V.1    Maalouf, N.M.2    Sakhaee, K.3
  • 93
    • 84881524407 scopus 로고    scopus 로고
    • New genes in bone development: Whats new in osteogenesis imperfecta
    • Marini, J. C. & Blissett, A. R. New genes in bone development: whats new in osteogenesis imperfecta. J. Clin. Endocrinol. Metab. 98, 3095-3103 (2013).
    • (2013) J. Clin. Endocrinol. Metab , vol.98 , pp. 3095-3103
    • Marini, J.C.1    Blissett, A.R.2
  • 94
    • 0018416379 scopus 로고
    • Genetic heterogeneity in osteogenesis imperfecta
    • Sillence, D. O., Senn, A. & Danks, D. M. Genetic heterogeneity in osteogenesis imperfecta. J. Med. Genet. 16, 101-116 (1979).
    • (1979) J. Med. Genet , vol.16 , pp. 101-116
    • Sillence, D.O.1    Senn, A.2    Danks, D.M.3
  • 96
    • 84899980115 scopus 로고    scopus 로고
    • Osteogenesis imperfecta: Clinical diagnosis, nomenclature and severity assessment
    • Van Dijk, F. S. & Sillence, D. O. Osteogenesis imperfecta: Clinical diagnosis, nomenclature and severity assessment. Am. J. Med. Genet. A 164, 1470-1481 (2014).
    • (2014) Am. J. Med. Genet. A , vol.164 , pp. 1470-1481
    • Van Dijk, F.S.1    Sillence, D.O.2
  • 97
    • 84899129361 scopus 로고    scopus 로고
    • Next-generation sequencing: A frameshift in skeletal dysplasia gene discovery
    • Lazarus, S., Zankl, A. & Duncan, E. L. Next-generation sequencing: a frameshift in skeletal dysplasia gene discovery. Osteoporos. Int. 25, 407-422 (2014).
    • (2014) Osteoporos. Int , vol.25 , pp. 407-422
    • Lazarus, S.1    Zankl, A.2    Duncan, E.L.3
  • 98
    • 79955042501 scopus 로고    scopus 로고
    • Nosology and classification of genetic skeletal disorders: 2010 revision
    • Warman, M. L., et al. Nosology and classification of genetic skeletal disorders: 2010 revision. Am. J. Med. Genet. A 155A, 943-968 (2011).
    • (2011) Am. J. Med. Genet. A , vol.155 , pp. 943-968
    • Warman, M.L.1
  • 99
    • 83255194118 scopus 로고    scopus 로고
    • EMQN best practice guidelines for the laboratory diagnosis of osteogenesis imperfecta
    • van Dijk, F. S., et al. EMQN best practice guidelines for the laboratory diagnosis of osteogenesis imperfecta. Eur. J. Hum. Genet. 20, 11-19 (2012).
    • (2012) Eur. J. Hum. Genet , vol.20 , pp. 11-19
    • Van Dijk, F.S.1
  • 101
    • 84886095231 scopus 로고    scopus 로고
    • Bone collagen: New clues to its mineralization mechanism from recessive osteogenesis imperfecta
    • Eyre, D. R. & Weis, M. A. Bone collagen: new clues to its mineralization mechanism from recessive osteogenesis imperfecta. Calcif. Tissue Int. 93, 338-347 (2013).
    • (2013) Calcif. Tissue Int , vol.93 , pp. 338-347
    • Eyre, D.R.1    Weis, M.A.2
  • 102
    • 0034488748 scopus 로고    scopus 로고
    • Increased cell surface expression of receptors for transforming growth factor-β on osteoblasts from patients with Osteogenesis imperfecta
    • Gebken, J., et al. Increased cell surface expression of receptors for transforming growth factor-β on osteoblasts from patients with Osteogenesis imperfecta. Pathobiology 68, 106-112 (2000).
    • (2000) Pathobiology , vol.68 , pp. 106-112
    • Gebken, J.1
  • 103
    • 84902207758 scopus 로고    scopus 로고
    • Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta
    • Grafe, I., et al. Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta. Nat. Med. 20, 670-675 (2014).
    • (2014) Nat. Med , vol.20 , pp. 670-675
    • Grafe, I.1
  • 104
    • 77955084141 scopus 로고    scopus 로고
    • Identification of a frameshift mutation in Osterix in a patient with recessive osteogenesis imperfecta
    • Lapunzina, P., et al. Identification of a frameshift mutation in Osterix in a patient with recessive osteogenesis imperfecta. Am. J. Hum. Genet. 87, 110-114 (2010).
    • (2010) Am. J. Hum. Genet , vol.87 , pp. 110-114
    • Lapunzina, P.1
  • 105
    • 84875924767 scopus 로고    scopus 로고
    • Mutations in WNT1 cause different forms of bone fragility
    • Keupp, K., et al. Mutations in WNT1 cause different forms of bone fragility. Am. J. Hum. Genet. 92, 565-574 (2013).
    • (2013) Am. J. Hum. Genet , vol.92 , pp. 565-574
    • Keupp, K.1
  • 106
    • 84877595835 scopus 로고    scopus 로고
    • WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta
    • Laine, C. M., et al. WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta. N. Engl. J. Med. 368, 1809-1816 (2013).
    • (2013) N. Engl. J. Med , vol.368 , pp. 1809-1816
    • Laine, C.M.1
  • 107
    • 84882769760 scopus 로고    scopus 로고
    • Whole-exome sequencing reveals a heterozygous LRP5 mutation in a 6-year-old boy with vertebral compression fractures and low trabecular bone density
    • Fahiminiya, S., et al. Whole-exome sequencing reveals a heterozygous LRP5 mutation in a 6-year-old boy with vertebral compression fractures and low trabecular bone density. Bone 57, 41-46 (2013).
    • (2013) Bone , vol.57 , pp. 41-46
    • Fahiminiya, S.1
  • 108
    • 84859512183 scopus 로고    scopus 로고
    • Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity
    • Korvala, J., et al. Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity. BMC Med. Genet. 13, 26 (2012).
    • (2012) BMC Med. Genet , vol.13 , pp. 26
    • Korvala, J.1
  • 109
    • 27544495586 scopus 로고    scopus 로고
    • Missense mutations in LRP5 are not a common cause of idiopathic osteoporosis in adult men
    • Crabbe, P., et al. Missense mutations in LRP5 are not a common cause of idiopathic osteoporosis in adult men. J. Bone Miner. Res. 20, 1951-1959 (2005).
    • (2005) J. Bone Miner. Res , vol.20 , pp. 1951-1959
    • Crabbe, P.1
  • 110
    • 84885755136 scopus 로고    scopus 로고
    • PLS3 mutations in X-linked osteoporosis with fractures
    • van Dijk, F. S., et al. PLS3 mutations in X-linked osteoporosis with fractures. N. Engl. J. Med. 369, 1529-1536 (2013).
    • (2013) N. Engl. J. Med , vol.369 , pp. 1529-1536
    • Van Dijk, F.S.1
  • 111
    • 84904599955 scopus 로고    scopus 로고
    • Osteoporosis caused by mutations in PLS3: Clinical and bone tissue characteristics
    • Fahiminiya, S., et al. Osteoporosis caused by mutations in PLS3: clinical and bone tissue characteristics. J. Bone Miner. Res. 29, 1805-1814 (2014).
    • (2014) J. Bone Miner. Res , vol.29 , pp. 1805-1814
    • Fahiminiya, S.1
  • 112
    • 84861225711 scopus 로고    scopus 로고
    • Primary osteoporosis without features of OI in children and adolescents: Clinical and genetic characteristics
    • Laine, C. M., et al. Primary osteoporosis without features of OI in children and adolescents: clinical and genetic characteristics. Am. J. Med. Genet. A 158A, 1252-1261 (2012).
    • (2012) Am. J. Med. Genet. A , vol.158 , pp. 1252-1261
    • Laine, C.M.1
  • 113
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong, Y., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107, 513-523 (2001).
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1
  • 114
    • 75149112678 scopus 로고    scopus 로고
    • Various types of LRP5 mutations in four patients with osteoporosis-pseudoglioma syndrome: Identification of a 7.2-kb microdeletion using oligonucleotide tiling microarray
    • Narumi, S., et al. Various types of LRP5 mutations in four patients with osteoporosis-pseudoglioma syndrome: identification of a 7.2-kb microdeletion using oligonucleotide tiling microarray. Am. J. Med. Genet. A 152A, 133-140 (2010).
    • (2010) Am. J. Med. Genet. A , vol.152 , pp. 133-140
    • Narumi, S.1
  • 115
    • 34250840514 scopus 로고    scopus 로고
    • The genetics of low-density lipoprotein receptor-related protein 5 in bone: A story of extremes
    • Balemans, W. & Van Hul, W. The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes. Endocrinology 148, 2622-2629 (2007).
    • (2007) Endocrinology , vol.148 , pp. 2622-2629
    • Balemans, W.1    Van Hul, W.2
  • 116
    • 84866270705 scopus 로고    scopus 로고
    • Mutations in PLOD2 cause autosomal-recessive connective tissue disorders within the Bruck syndrome-osteogenesis imperfecta phenotypic spectrum
    • Puig-Hervas, M. T., et al. Mutations in PLOD2 cause autosomal-recessive connective tissue disorders within the Bruck syndrome-osteogenesis imperfecta phenotypic spectrum. Hum. Mutat. 33, 1444-1449 (2012).
    • (2012) Hum. Mutat , vol.33 , pp. 1444-1449
    • Puig-Hervas, M.T.1
  • 117
    • 79956198322 scopus 로고    scopus 로고
    • Mutations in FKBP10 cause both Bruck syndrome and isolated osteogenesis imperfecta in humans
    • Shaheen, R., et al. Mutations in FKBP10 cause both Bruck syndrome and isolated osteogenesis imperfecta in humans. Am. J. Med. Genet. A 155A, 1448-1452 (2011).
    • (2011) Am. J. Med. Genet. A , vol.155 , pp. 1448-1452
    • Shaheen, R.1
  • 118
    • 84871243967 scopus 로고    scopus 로고
    • Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen
    • Schwarze, U., et al. Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen. Hum. Mol. Genet. 22, 1-17 (2013).
    • (2013) Hum. Mol. Genet , vol.22 , pp. 1-17
    • Schwarze, U.1
  • 120
    • 0035852034 scopus 로고    scopus 로고
    • Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: Results from the National Osteoporosis Risk Assessment
    • Siris, E. S., et al. Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA 286, 2815-2822 (2001).
    • (2001) JAMA , vol.286 , pp. 2815-2822
    • Siris, E.S.1
  • 121
    • 77954526395 scopus 로고    scopus 로고
    • Clinical review 2: Genetic determinants of bone density and fracture risk-state of the art and future directions
    • Duncan, E. L. & Brown, M. A. Clinical review 2: Genetic determinants of bone density and fracture risk-state of the art and future directions. J. Clin. Endocrinol. Metab. 95, 2576-2587 (2010).
    • (2010) J. Clin. Endocrinol. Metab , vol.95 , pp. 2576-2587
    • Duncan, E.L.1    Brown, M.A.2
  • 123
    • 79955578829 scopus 로고    scopus 로고
    • Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk
    • Duncan, E. L., et al. Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet. 7, e1001372 (2011).
    • (2011) PLoS Genet , vol.7 , pp. e1001372
    • Duncan, E.L.1
  • 124
    • 84860331458 scopus 로고    scopus 로고
    • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
    • Estrada, K., et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat. Genet. 44, 491-501 (2012).
    • (2012) Nat. Genet , vol.44 , pp. 491-501
    • Estrada, K.1
  • 125
    • 84863897868 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus
    • Medina-Gomez, C., et al. Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genet. 8, e1002718 (2012).
    • (2012) PLoS Genet , vol.8 , pp. e1002718
    • Medina-Gomez, C.1
  • 126
    • 43049181624 scopus 로고    scopus 로고
    • Bone mineral density, osteoporosis, and osteoporotic fractures: A genome-wide association study
    • Richards, J. B., et al. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 371, 1505-1512 (2008).
    • (2008) Lancet , vol.371 , pp. 1505-1512
    • Richards, J.B.1
  • 127
    • 70350646912 scopus 로고    scopus 로고
    • Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
    • Rivadeneira, F., et al. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat. Genet. 41, 1199-1206 (2009).
    • (2009) Nat. Genet , vol.41 , pp. 1199-1206
    • Rivadeneira, F.1
  • 128
    • 44349167229 scopus 로고    scopus 로고
    • Multiple genetic loci for bone mineral density and fractures
    • Styrkarsdottir, U., et al. Multiple genetic loci for bone mineral density and fractures. N. Engl. J. Med. 358, 2355-2365 (2008).
    • (2008) N. Engl. J. Med , vol.358 , pp. 2355-2365
    • Styrkarsdottir, U.1
  • 129
    • 78049233765 scopus 로고    scopus 로고
    • European bone mineral density loci are also associated with BMD in East-Asian populations
    • Styrkarsdottir, U., et al. European bone mineral density loci are also associated with BMD in East-Asian populations. PLoS ONE 5, e13217 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e13217
    • Styrkarsdottir, U.1
  • 130
    • 84897861546 scopus 로고    scopus 로고
    • Multistage genome-wide association meta-analyses identified two new loci for bone mineral density
    • Zhang, L., et al. Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum. Mol. Genet. 23, 1923-1933 (2014).
    • (2014) Hum. Mol. Genet , vol.23 , pp. 1923-1933
    • Zhang, L.1
  • 131
    • 84893613998 scopus 로고    scopus 로고
    • Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
    • Moayyeri, A., et al. Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Hum. Mol. Genet. 23, 3054-3068 (2014).
    • (2014) Hum. Mol. Genet , vol.23 , pp. 3054-3068
    • Moayyeri, A.1
  • 132
    • 84887568962 scopus 로고    scopus 로고
    • Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus
    • Oei, L., et al. Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus. Bone 59, 20-27 (2014).
    • (2014) Bone , vol.59 , pp. 20-27
    • Oei, L.1
  • 133
    • 84894028523 scopus 로고    scopus 로고
    • A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus
    • Oei, L., et al. A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus. J. Med. Genet. 51, 122-131 (2014).
    • (2014) J. Med. Genet , vol.51 , pp. 122-131
    • Oei, L.1
  • 134
    • 85027951876 scopus 로고    scopus 로고
    • Homozygous deletion of the UGT2B17 gene is not associated with osteoporosis risk in elderly Caucasian women
    • Chew, S., et al. Homozygous deletion of the UGT2B17 gene is not associated with osteoporosis risk in elderly Caucasian women. Osteoporos. Int. 22, 1981-1986 (2011).
    • (2011) Osteoporos. Int , vol.22 , pp. 1981-1986
    • Chew, S.1
  • 135
    • 77950961444 scopus 로고    scopus 로고
    • Genome-wide copy number variation association study suggested VPS13B gene for osteoporosis in Caucasians
    • Deng, F. Y., et al. Genome-wide copy number variation association study suggested VPS13B gene for osteoporosis in Caucasians. Osteoporos. Int. 21, 579-587 (2010).
    • (2010) Osteoporos. Int , vol.21 , pp. 579-587
    • Deng, F.Y.1
  • 136
    • 57149123783 scopus 로고    scopus 로고
    • Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis
    • Yang, T. L., et al. Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis. Am. J. Hum. Genet. 83, 663-674 (2008).
    • (2008) Am. J. Hum. Genet , vol.83 , pp. 663-674
    • Yang, T.L.1
  • 137
    • 84857363082 scopus 로고    scopus 로고
    • Epigenetic influences in the developmental origins of osteoporosis
    • Holroyd, C., Harvey, N., Dennison, E. & Cooper, C. Epigenetic influences in the developmental origins of osteoporosis. Osteoporos. Int. 23, 401-410 (2012).
    • (2012) Osteoporos. Int , vol.23 , pp. 401-410
    • Holroyd, C.1    Harvey, N.2    Dennison, E.3    Cooper, C.4
  • 139
    • 84860537308 scopus 로고    scopus 로고
    • Do epigenetic marks govern bone mass and homeostasis?
    • Delgado-Calle, J., Garmilla, P. & Riancho, J. A. Do epigenetic marks govern bone mass and homeostasis? Curr. Genomics 13, 252-263 (2012).
    • (2012) Curr. Genomics , vol.13 , pp. 252-263
    • Delgado-Calle, J.1    Garmilla, P.2    Riancho, J.A.3
  • 140
    • 82355190885 scopus 로고    scopus 로고
    • Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor
    • Cohen-Kfir, E., et al. Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor. Endocrinology 152, 4514-4524 (2011).
    • (2011) Endocrinology , vol.152 , pp. 4514-4524
    • Cohen-Kfir, E.1
  • 141
    • 84876244055 scopus 로고    scopus 로고
    • RNA-induced silencing complex (RISC) proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators
    • Redfern, A. D., et al. RNA-induced silencing complex (RISC) proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators. Proc. Natl Acad. Sci. USA 110, 6536-6541 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 6536-6541
    • Redfern, A.D.1
  • 142
    • 84879088194 scopus 로고    scopus 로고
    • MicroRNA functions in osteogenesis and dysfunctions in osteoporosis
    • van Wijnen, A. J., et al. MicroRNA functions in osteogenesis and dysfunctions in osteoporosis. Curr. Osteoporos. Rep. 11, 72-82 (2013).
    • (2013) Curr. Osteoporos. Rep , vol.11 , pp. 72-82
    • Van Wijnen, A.J.1
  • 143
    • 84899760651 scopus 로고    scopus 로고
    • MicroRNAs and post-transcriptional regulation of skeletal development
    • Gamez, B., Rodriguez-Carballo, E. & Ventura, F. MicroRNAs and post-transcriptional regulation of skeletal development. J. Mol. Endocrinol. 52, R179-197 (2014).
    • (2014) J. Mol. Endocrinol , vol.52 , pp. R179-197
    • Gamez, B.1    Rodriguez-Carballo, E.2    Ventura, F.3
  • 144
    • 84858713611 scopus 로고    scopus 로고
    • DNA methylation contributes to the regulation of sclerostin expression in human osteocytes
    • Delgado-Calle, J., et al. DNA methylation contributes to the regulation of sclerostin expression in human osteocytes. J. Bone Miner. Res. 27, 926-937 (2012).
    • (2012) J. Bone Miner. Res , vol.27 , pp. 926-937
    • Delgado-Calle, J.1
  • 145
    • 84870279539 scopus 로고    scopus 로고
    • Role of DNA methylation in the regulation of the RANKL-OPG system in human bone
    • Delgado-Calle, J., et al. Role of DNA methylation in the regulation of the RANKL-OPG system in human bone. Epigenetics 7, 83-91 (2012).
    • (2012) Epigenetics , vol.7 , pp. 83-91
    • Delgado-Calle, J.1
  • 146
    • 0029809357 scopus 로고    scopus 로고
    • Pycnodysostosis a lysosomal disease caused by cathepsin K deficiency
    • Gelb, B. D., Shi, G. P., Chapman, H. A., & Desnick, R. J. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 273, 1236-1238 (1996).
    • (1996) Science , vol.273 , pp. 1236-1238
    • Gelb, B.D.1    Shi, G.P.2    Chapman, H.A.3    Desnick, R.J.4
  • 147
    • 84906316938 scopus 로고    scopus 로고
    • Sclerosing bone dysplasias: Leads toward novel osteoporosis treatments
    • Fijalkowski, I., Boudin, E., Mortier, G. & van Hul, W. Sclerosing bone dysplasias: leads toward novel osteoporosis treatments. Curr. Osteoporos. Rep. 12, 243-251 (2014).
    • (2014) Curr. Osteoporos. Rep , vol.12 , pp. 243-251
    • Fijalkowski, I.1    Boudin, E.2    Mortier, G.3    Van Hul, W.4
  • 149
    • 84893044528 scopus 로고    scopus 로고
    • Romosozumab in postmenopausal women with low bone mineral density
    • McClung, M. R., et al. Romosozumab in postmenopausal women with low bone mineral density. N. Engl. J. Med. 370, 412-420 (2014).
    • (2014) N. Engl. J. Med , vol.370 , pp. 412-420
    • McClung, M.R.1
  • 150
    • 84921809759 scopus 로고    scopus 로고
    • A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density
    • Recker, R., et al. A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density. J. Bone Miner. Res. 30, 216-224 (2015).
    • (2015) J. Bone Miner. Res , vol.30 , pp. 216-224
    • Recker, R.1


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