Fruits and dietary phytochemicals in bone protection

Nutrition Research

Volumn 32, Issue 12, 2012, Pages 897-910

  Shen, Chwan Li ^a,b   von Bergen, Vera ^a,b   Chyu, Ming Chien ^a,c   Jenkins, Marjorie R ^b   Mo, Huanbiao ^d   Chen, Chung Hwan ^e   Kwun, In Sook ^f  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c Department of Electrical and Computer Engineering   (United States)

^d TEXAS WOMAN'S UNIVERSITY   (United States)

^e KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f Andong National University   (South Korea)

Author keywords

Antioxidant; Bone mineral density; Fruits; Molecular mechanism; Osteoporosis; Phytochemicals

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; CATALASE; CHLOROGENIC ACID; FLAVONOID; GLUTATHIONE PEROXIDASE; LYCOPENE; PECTIN; PHENOL DERIVATIVE; PHLORIZIN; PICEATANNOL; RESVERATROL; SOMATOMEDIN C; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APPLE; BERRY; BONE DENSITY; BONE MASS; BONE METABOLISM; BONE REMODELING; BONE STRENGTH; CITRUS FRUIT; DIETARY INTAKE; DUAL ENERGY X RAY ABSORPTIOMETRY; FRUIT; GRAPE; HUMAN; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; OXIDATIVE STRESS; PHYTOCHEMISTRY; PLUM; POROSITY; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION; STEM CELL; TOMATO; TRABECULAR BONE;

ANGIOSPERMS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BONE AND BONES; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; DIET; FRUIT; HUMANS; OSTEOPOROSIS; PHYTOTHERAPY;

ANIMALIA; CITRUS; LYCOPERSICON ESCULENTUM; PRUNUS DOMESTICA; VITACEAE;

EID: 84870926998     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2012.09.018     Document Type: Review

References (101)

1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. JAMA 2001, 285:785-795.
2. U.S.Department of Health and Human Service Bone health and osteoporosis: a report of the surgeon general 2004, U.S. Department of Health and Human Services, Office of the Surgeon General, Rockville, MD.
3. Clarke B.L., Khosla S. Physiology of bone loss. Radiol Clin North Am 2010, 48:483-495.
4. Yalin S., Bagis S., Polat G., Dogruer N., CenkAksit S., Hatungil R., et al. Is there a role of free oxygen radicals in primary male osteoporosis?. Clin Exp Rheumatol 2005, 23:689-692.
5. Basu S., Michaëlsson K., Olofsson H., Johansson S., Melhus H. Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun 2001, 288:275-279.
6. Banfi G., Iorio E.L., Corsi M.M. Oxidative stress, free radicals and bone remodeling. Clin Chem Lab Med 2008, 46:1550-1555.
7. Yang S., Madyastha P., Bingel S., Ries W., Key L. A new superoxide-generating oxidase in murine osteoclasts. J Biol Chem 2001, 276:5452-5458.
8. Sontakke A.N., Tare R.S. A duality in the roles of reactive oxygen species with respect to bone metabolism. Clin Chim Acta 2002, 318:145-148.
9. Garrett I.R., Boyce B.F., Oreffo R.O., Bonewald L., Poser J., Mundy G.R. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 1990, 85:632-639.
10. Mody N., Parhami F., Sarafian T.A., Demer L.L. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 2001, 31:509-519.
11. Bai X.C., Lu D., Bai J., Zheng H., Ke Z.Y., Li X.M., et al. Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-κB. Biochem Biophys Res Commun 2004, 314:197-207.
12. Dreher I., Schütze N., Baur A., Hesse K., Schneider D., Köhrle J., et al. Selenoproteins are expressed in fetal human osteoblast-like cells. Biochem Biophys Res Commun 1998, 245:101-107.
13. Maggio D., Barabani M., Pierandrei M., Polidori M.C., Catani M., Mecocci P., et al. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab 2003, 88:1523-1527.
14. Balsano C., Alisi A. Antioxidant effects of natural bioactive compounds. Curr Pharm Des 2009, 15:3063-3073. [Review].
15. Li J.J., Huang Z.W., Wang R.Q., Ma X.M., Zhang Z.Q., Liu Z., et al. Fruit and vegetable intake and bone mass in Chinese adolescents, young and postmenopausal women. Public Health Nutr 2012, 17:1-9.
16. Zalloua P.A., Hsu Y.H., Terwedow H., Zang T., Wu D., Tang G., et al. Impact of seafood and fruit consumption on bone mineral density. Maturitas 2007, 56(1):1-11.
17. New S.A., Robins S.P., Campbell M.K., Martin J.C., Garton M.J., Bolton-Smith C., et al. Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?. Am J Clin Nutr 2000, 71(1):142-151.
18. Prynne C.J., Mishra G.D., O'Connell M.A., Muniz G., Laskey M.A., Yan L., et al. Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts. Am J Clin Nutr 2006, 83(6):1420-1428.
19. Di Mascio P., Kaiser S., Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989, 274:532-538.
20. Rao A.V., Rao L.G. Carotenoids and human health. Pharmacol Res 2007, 55:207-216.
21. Boileau T.W., Boileau A.C., Erdman J.W. Bioavailability of all-trans and cis-isomers of lycopene. Exp Biol Med (Maywood) 2002, 227:914-919. [Review].
22. Rao L.G., Mackinnon E.S., Josse R.G., Murray T.M., Strauss A., Rao A.V. Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women. Osteoporos Int 2007, 18:109-115.
23. Mackinnon E.S., Rao A.V., Josse R.G., Rao L.G. Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women. Osteoporos Int 2011, 22:1091-1101.
24. Mackinnon E.S., Rao A.V., Rao L.G. Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women. J Nutr Health Aging 2011, 15:133-138.
25. Gerster H. The potential role of lycopene for human health. J Am Coll Nutr 1997, 16:109-126.
26. Cheong S.H., Chang K.J. The preventive effect of fermented milk supplement containing tomato (lycopersionesculentum) and taurine on bone loss in ovariectomized rats. Adv Exp Med Biol 2009, 643:333-340.
27. Kim L., Rao A.V., Rao L.G. Lycopene II-effect on osteoblasts: the carotenoid lycopene stimulates cell proliferation and alkaline phosphatase activity of SaOS-2 cells. J Med Food 2003, 6:79-86.
28. Rao L.G., Krishnadev N., Banasikowska K., Rao A.V. Lycopene I-effect on osteoclasts: lycopene inhibits basal and parathyroid hormone-stimulated osteoclast formation and mineral resorption mediated by reactive oxygen species in rat bone marrow cultures. J Med Food 2003, 6:69-78.
29. Piga A., Del Caro A., Corda G. From plums to prunes: influence of drying parameters on polyphenols and antioxidant activity. J Agric Food Chem 2003, 51:3675-3681.
30. McBride J. Can foods forestall aging?. Agric Res 1999, 47:14-17.
31. Stacewicz-Sapuntzakis M., Bowen P.E., Hussain E.A., Damayanti-Wood B.I., Farnsworth N.R. Chemical composition and potential health effects of prunes: a functional food. Crit Rev Food Sci Nutr 2001, 41:251-286.
32. Arjmandi B.H., Khalil D.A., Lucas E.A., Georgis A., Stoecker B.J., Hardin C., et al. Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med 2002, 11:61-68.
33. Hooshmand S., Chai S.C., Saadat R.L., Payton M.E., Brummel-Smith K., Arjmandi B.H. Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr 2011, 31:1-8.
34. Deyhim F., Stoecker B.J., Brusewitz G.H., Devareddy L., Arjmandi B.H. Dried plum reverses bone loss in an osteopenic rat model of osteoporosis. Menopause 2005, 12:755-762.
35. Franklin M., Bu S.Y., Lerner M.R., Lancaster E.A., Bellmer D., Marlow D., et al. Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway. Bone 2006, 39:1331-1342.
36. Halloran B.P., Wronski T.J., VonHerzen D.C., Chu V., Xia X., Pingel J.E., et al. Dietary dried plum increases bone mass in adult and aged male mice. J Nutr 2010, 140:1781-1787.
37. Rendina E., Lim Y.F., Marlow D., Wang Y., Clarke S.L., Kuvibidila S., et al. Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL/6J mice. J Nutr Biochem 2012, 23(1):60-68.
38. Arjmandi B.H., Johnson C.D., Campbell S.C., Hooshmand S., Chai S.C., Akhter M.P. Combining fructooligosaccharide and dried plum has the greatest effect on restoring bone mineral density among select functional foods and bioactive compounds. J Med Food 2010, 13:312-319.
39. Johnson C.D., Lucas E.A., Hooshmand S., Campbell S., Akhter M.P., Arjmandi B.H. Addition of fructooligosaccharides and dried plum to soy-based diets reverses bone loss in the ovariectomized rat. Evid Based Complement Altern Med 2011, 2011:836267.
40. Bu S.Y., Lucas E.A., Franklin M., Marlow D., Brackett D.J., Boldrin E.A., et al. Comparison of dried plum supplementation and intermittent PTH in restoring bone in osteopenic orchidectomized rats. Osteoporos Int 2007, 18:931-932.
41. Bu S.Y., Hunt T.S., Smith B.J. Dried plum polyphenols attenuate the detrimental effects of TNF-alpha on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I. J Nutr Biochem 2009, 20:35-44.
42. Bu S.Y., Lerner M., Stoecker B.J., Boldrin E., Brackett D.J., Lucas E.A., et al. Dried plum polyphenols inhibit osteoclastogenesis by downregulating NFATc1 and inflammatory mediators. Calcif Tissue Int 2008, 82:475-488.
43. Mühlbauer R.C., Lozano A., Reinli A., Wetli H. Various selected vegetables, fruits, mushrooms and red wine residue inhibit bone resorption in rats. J Nutr 2003, 133:3592-3597.
44. Densupsoontorn N., Jirapinyo P., Thamonsiri N., Wongarn R., Phosuya P., Tritiprat A., et al. Comparison of the nutrient content of fresh fruit juices vs commercial fruit juices. J Med Assoc Thai 2002, 85(Suppl. 2):S732-S738.
45. Silaste M.L., Rantala M., Alfthan G., Aro A., Kesäniemi Y.A. Plasma homocysteine concentration is decreased by dietary intervention. Br J Nutr 2003, 89:295-301.
46. Riso P., Visioli F., Gardana C., Grande S., Brusamolino A., Galvano F., et al. Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stress. J Agric Food Chem 2005, 53:941-947.
47. Tian Q., Miller E.G., Ahmad H., Tang L., Patil B.S. Differential inhibition of human cancer cell proliferation by citrus limonoids. Nutr Cancer 2001, 40:180-184.
48. Yu J., Wang L., Walzem R.L., Miller E.G., Pike L.M., Patil B.S. Antioxidant activity of citrus limonoids, flavonoids, and coumarins. J Agric Food Chem 2005, 53:2009-2014.
49. Deyhim F., Garica K., Lopez E., Gonzalez J., Ino S., Garcia M., et al. Citrus juice modulates bone strength in male senescent rat model of osteoporosis. Nutrition 2006, 22:559-563.
50. Morrow R., Deyhim F., Patil B.S., Stoecker B.J. Feeding orange pulp improved bone quality in a rat model of male osteoporosis. J Med Food 2009, 12:298-303.
51. Deyhim F., Villarreal A., Garcia K., Rios R., Garcia C., Gonzales C., et al. Orange pulp improves antioxidant status and suppresses lipid peroxidation in orchidectomized male rats. Nutrition 2007, 23:617-621.
52. Chiba H., Uehara M., Wu J., Wang X., Masuyama R., Suzuki K., et al. Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. J Nutr 2003, 133:1892-1897.
53. Habauzit V., Nielsen I.L., Gil-Izquierdo A., Trzeciakiewicz A., Morand C., Chee W., et al. Increased bioavailability of hesperetin-7-glucoside compared with hesperidin results in more efficient prevention of bone loss in adult ovariectomised rats. Br J Nutr 2009, 102:976-984.
54. Pang W.Y., Wang X.L., Mok S.K., Lai W.P., Chow H.K., Leung P.C., et al. Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells. Br J Pharmacol 2010, 159:1693-1703.
55. Deyhim F., Mandadi K., Faraji B., Patil B.S. Grapefruit juice modulates bone quality in rats. J Med Food 2008, 11:99-104.
56. Deyhim F., Mandadi K., Patil B.S., Faraji B. Grapefruit pulp increases antioxidant status and improves bone quality in orchidectomized rats. Nutrition 2008, 24:1039-1044.
57. Mandadi K., Ramirez M., Jayaprakasha G.K., Faraji B., Lihono M., Deyhim F., et al. Citrus bioactive compounds improve bone quality and plasma antioxidant activity in orchidectomized rats. Phytomedicine 2009, 16:513-520.
58. Trzeciakiewicz A., Habauzit V., Mercier S., Lebecque P., Davicco M.J., Coxam V., et al. Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway. J Nutr Biochem 2010, 21:424-431.
59. Trzeciakiewicz A., Habauzit V., Mercier S., Barron D., Urpi-Sarda M., Manach C., et al. Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation. J Agric Food Chem 2010, 58:668-675.
60. Wong R.W., Rabie A.B. Effect of naringin on bone cells. J Orthop Res 2006, 24:2045-2050.
61. Galati E.M., Monforte M.T., Kirjavainen S., Forestieri A.M., Trovato A., Tripodo M.M. Biological effects of hesperidin, a citrus flavonoid. (Note I): antiinflammatory and analgesic activity. Farmaco 1994, 40:709-712.
62. Miyake Y., Yamamoto K., Tsujihara N., Osawa T. Protective effects of lemon flavonoids on oxidative stress in diabetic rats. Lipids 1998, 33:689-695.
63. Garg A., Garg S., Zaneveld L.J., Singla A.K. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res 2001, 15:655-659.
64. Taruscio T.G., Barney D.L., Exon J. Content and profile of flavanoid and phenolic acid compounds in conjunction with the antioxidant capacity for a variety of northwest Vaccinium berries. J Agric Food Chem 2004, 52:3169-3176.
65. Sellappan S., Akoh C.C., Krewer G. Phenolic compounds and antioxidant capacity of Georgia-grown blueberries and blackberries. J Agric Food Chem 2002, 50:2432-2438.
66. Kalt W., Ryan D.A., Duy J.C., Prior R.L., Ehlenfeldt M.K., Vander Kloet S.P. Interspecific variation in anthocyanins, phenolics, and antioxidant capacity among genotypes of highbush and lowbush blueberries (Vaccinium section cyanococcus spp.). J Agric Food Chem 2001, 49:4761-4767.
67. Devareddy L., Hooshmand S., Collins J.K., Lucas E.A., Chai S.C., Arjmandi B.H. Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis. J Nutr Biochem 2008, 19:694-699.
68. Villarreal A., Stoecker B.J., Garcia C., Garcia K., Rios R., Gonzales C., et al. Cranberry juice improved antioxidant status without affecting bone quality in orchidectomized male rats. Phytomedicine 2007, 14:815-820.
69. Bickford P.C., Tan J., Shytle R.D., Sanberg C.D., El-Badri N., Sanberg P.R. Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev 2006, 15:118-123.
70. Tanabe S., Santos J., La V.D., Howell A.B., Grenier D. A-type cranberry proanthocyanidins inhibit the RANKL-dependent differentiation and function of human osteoclasts. Molecules 2011, 16(30):2365-2374.
71. Ariga T. The antioxidative function, preventive action on disease and utilization of proanthocyanidins. Biofactors 2004, 21:197-201.
72. Gu X., Creasy L., Kester A., Zeece M. Capillary electrophoretic determination of resveratrol in wines. J Agric Food Chem 1999, 47:3223-3227.
73. Mizutani K., Ikeda K., Kawai Y., Yamori Y. Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 2000, 46:78-83.
74. Habold C., Momken I., Ouadi A., Bekaert V., Brasse D. Effect of prior treatment with resveratrol on density and structure of rat long bones under tail-suspension. J Bone Miner Metab 2011, 29:15-22.
75. Li Y., Dånmark S., Edlund U., Finne-Wistrand A., He X., Norgård M., et al. Resveratrol-conjugated poly-ε-caprolactone facilitates in vitro mineralization and in vivo bone regeneration. Acta Biomater 2011, 7:751-758.
76. Boissy P., Andersen T.L., Abdallah B.M., Kassem M., Plesner T., Delaissé J.M. Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation. Cancer Res 2005, 65:9943-9952.
77. Lee Y.S., Kim Y.S., Lee S.Y., Kim G.H., Kim B.J., Lee S.H., et al. AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts. Bone 2010, 47:926-937.
78. He X., Andersson G., Lindgren U., Li Y. Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production. Biochem Biophys Res Commun 2010, 401:356-362.
79. Bowers J.L., Tyulmenkov V.V., Jernigan S.C., Klinge C.M. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinology 2000, 141:3657-3667.
80. Dai Z., Li Y., Quarles L.D., Song T., Pan W., Zhou H., et al. Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation. Phytomedicine 2007, 14:806-814.
81. Zhou H., Shang L., Li X., Zhang X., Gao G., Guo C., et al. Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotentmesenchymal cells. Exp Cell Res 2009, 315:2953-2962.
82. Basly J.P., Marre-Fournier F., Le Bail J.C., Habrioux G., Chulia A.J. Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol. Life Sci 2000, 66:769-777.
83. Gehm B.D., McAndrews J.M., Chien P.Y., Jameson J.L. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci U S A 1997, 94:14138-14143.
84. Chang J.K., Hsu Y.L., Teng I.C., Kuo P.L. Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production. Eur J Pharmacol 2006, 551:1-9.
85. Puel C., Quintin A., Mathey J., Obled C., Davicco M.J., Lebecque P., et al. Prevention of bone loss by phloridzin, an apple polyphenol, in ovariectomized rats under inflammation conditions. Calcif Tissue Int 2005, 77:311-318.
86. Kokkonen H., Cassinelli C., Verhoef R., Morra M., Schols H.A., Tuukkanen J. Differentiation of osteoblasts on pectin-coated titanium. Biomacromolecules 2008, 9:2369-2376.
87. Kokkonen H.E., Ilvesaro J.M., Morra M., Schols H.A., Tuukkanen J. Effect of modified pectin molecules on the growth of bone cells. Biomacromolecules 2007, 8:509-515.
88. Ducy P., Schinke T., Karsenty G. The osteoblast: a sophisticated fibroblast under central surveillance. Science 2000, 289(5484):1501-1504.
89. Glass D.A., Bialek P., Ahn J.D., Starbuck M., Patel M.S., Clevers H., et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 2005, 8(5):751-764.
90. Mbalaviele G., Sheikh S., Stains J.P., Salazar V.S., Cheng S.L., Chen D., et al. β-Catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation. J Cell Biochem 2005, 94(2):403-418.
91. Yakar S., Rosen C.J. From mouse to man: redefining the role of insulin-like growth factor-I in the acquisition of bone mass. Exp Biol Med (Maywood) 2003, 228(3):245-252.
92. Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1988, 93(2):165-176.
93. Yasuda H., Shima N., Nakagawa N., Yamaguchi K., Kinosaki M., Mochizuki S., et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A 1988, 95(7):3597-3602.
94. Udagawa N., Takahashi N., Akatsu T., Tanaka H., Sasaki T., Nishihara T., et al. Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A 1990, 87(18):7260-7264.
95. Takayanagi H., Kim S., Koga T., Nishina H., Isshiki M., Yoshida H., et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 2002, 3(6):889-901.
96. Chambers T.J., Darby J.A., Fuller K. Mammalian collagenase predisposes bone surfaces to osteoclastic resorption. Cell Tissue Res 1985, 241(3):671-675.
97. Delaisse J.M., Engsig M.T., Everts V., del Carmen Ovejero M., Ferreras M., Lund L., et al. Proteinases in bone resorption: obvious and less obvious roles. Clin Chim Acta 2000, 291(2):223-234.
98. Kusano K., Miyaura C., Inada M., Tamura T., Ito A., Nagase H., et al. Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption. Endocrinology 1998, 139(3):1338-1345.
99. Barzel U.S. The skeleton as an ion exchange system: implications for the role of acid-base imbalance in the genesis of osteoporosis. J Bone Miner Res 1995, 10:1431-1436.
100. Ströhle A., Waldmann A., Koschizke J., Leitzmann C., Hahn A. Diet-dependent net endogenous acid load of vegan diets in relation to food groups and bone health-related nutrients: results from the German Vegan Study. Ann Nutr Metab 2011, 59(2-4):117-126.
101. Frassetto L., Morris R.C., Sellmeyer D.E., Todd K., Sebastian A. Diet, evolution and ageing: the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Eur J Nutr 2001, 40:200-213.