Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study

The Lancet

Volumn 371, Issue 9623, 2008, Pages 1505-1512

  Richards, JB ^a   Rivadeneira, F ^b   Inouye, M ^c   Pastinen, TM ^d   Soranzo, N ^c   Wilson, SG ^e,f   Andrew, T ^a   Falchi, M ^a   Gwilliam, R ^c   Ahmadi, KR ^a   Valdes, AM ^a   Arp, P ^b   Whittaker, P ^c   Verlaan, DJ ^d,g   Jhamai, M ^b   Kumanduri, V ^c   Moorhouse, M ^b   van Meurs, JB ^b   Hofman, A ^b   Pols, HAP ^b   Hart, D ^a   Zhai, G ^a   Kato, BS ^a   Mullin, BH ^f   Zhang, F ^a   Deloukas, P ^c   Uitterlinden, AG ^b   Spector, TD ^a   more..

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^f SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^g UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; OSTEOPROTEGERIN;

ADULT; ALLELE; ARTICLE; BONE DENSITY; CELL LINE; CHROMOSOME 11; CHROMOSOME 8; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FEMUR NECK; FRAGILITY FRACTURE; GENE EXPRESSION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; GENOME; HETEROZYGOSITY; HUMAN; LUMBAR SPINE; LYMPHOBLAST; MAJOR CLINICAL STUDY; OSTEOPOROSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM; WESTERN EUROPE;

EID: 43049181624     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(08)60599-1     Document Type: Article

References (59)

1. SR Cummings LJ Melton Epidemiology and outcomes of osteoporotic fractures Lancet 359 2002 1761 1767
2. NF Ray JK Chan M Thamer LJ Melton III Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation J Bone Miner Res 12 1997 24 35
3. JA Kanis F Borgstrom C De Laet Assessment of fracture risk Osteoporos Int 16 2005 581 589
4. NK Arden J Baker C Hogg K Baan TD Spector The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins J Bone Miner Res 11 1996 530 534
5. FM Williams TD Spector The genetics of osteoporosis Aeta Rheum Port 32 2007 103 110
6. JP Ioannidis SH Ralston ST Bennett Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes JAMA 292 2004 2105 2114
7. SH Ralston AG Uitterlinden ML Brandi Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study PLoS Med 3 2006 e90
8. AG Uitterlinden SH Ralston ML Brandi The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis Ann Intern Med 145 2006 255 264
9. KA Frazer DG Ballinger DR Cox A second generation human haplotype map of over 3·1 million SNPs Nature 449 2007 851 861
10. A Hofman Risk of Creutzfeldt-Jakob disease in relation to animal spongiform encephalopathies: a collaborative study in Europe Eur J Epidemiol 7 1991 466 468
11. A Hofman MM Breteler CM van Duijn The Rotterdam Study: objectives and design update Eur J Epidemiol 22 2007 819 829
12. A Hofman DE Grobbee PT de Jong FA van den Ouweland Determinants of disease and disability in the elderly: the Rotterdam Elderly Study Eur J Epidemiol 7 1991 403 422
13. NK Arden GO Griffiths DJ Hart DV Doyle TD Spector The association between osteoarthritis and osteoporotic fracture: the Chingford Study Br J Rheumatol 35 1996 1299 1304
14. AC Looker HW Wahner WL Dunn Updated data on proximal femur bone mineral levels of US adults Osteoporos Int 8 1998 468 489
15. SCE Schuit M van der Klift AEAM Weel Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study Bone 34 2004 195 202
16. Y Fang JB van Meurs A d'Alesio Promoter and 3′-untranslated-region haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: the Rotterdam study Am J Hum Genet 77 2005 807 823
17. L Stolk JB van Meurs M Jhamai The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men J Clin Endocrinol Metab 92 2007 3206 3212
18. JK Pritchard M Stephens P Donnelly Inference of population structure using multilocus genotype data Genetics 155 2000 945 959
19. S Purcell B Neale K Todd-Brown PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses Am J Hum Genet 81 2007 559 575
20. S Wacholder S Chanock M Garcia-Closas L El Ghormli N Rothman Assessing the probability that a positive report is false: an approach for molecular epidemiology studies J Natl Cancer Inst 96 2004 434 442
21. NJ Samani J Erdmann AS Hall Genomewide association analysis of coronary artery disease N Engl J Med 357 5 2007 Aug 2 443 453
22. R Sladek G Rocheleau J Rung A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 445 2007 881 885
23. WTCC Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 2007 661 678
24. F Dudbridge A Gusnanto Estimation of significance thresholds for genomewide association scans Genet Epidemiol 32 2008 227 234
25. J Cuzick A Wilcoxon-type test for trend Stat Med 4 1985 87 90
26. T Pastinen TJ Hudson Cis-acting regulatory variation in the human genome Science 306 2004 647 650
27. IH Consortium A second generation human haplotype map of over 3·1 million SNPs Nature 449 2007 10
28. T Pastinen B Ge S Gurd Mapping common regulatory variants to human haplotypes Hum Mol Genet 14 2005 3963 3971
29. JC Barrett B Fry J Maller MJ Daly Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 21 2005 263 265
30. BE Stranger AC Nica MS Forrest Population genomics of human gene expression Nat Genet 39 2007 1217 1224
31. T Kwan D Benovoy C Dias Genome-wide analysis of transcript isoform variation in humans Nat Genet 40 2008 225 231
32. JA Kanis O Johnell A Oden H Johansson E McCloskey FRAX and the assessment of fracture probability in men and women from the UK Osteoporos Int 19 2008 385 397
33. TP van Staa HGM Leufkens L Abenhaim B Zhang C Cooper Use of oral corticosteroids and risk of fractures J Bone Miner Res 15 2000 993 1000
34. C de Laet J Kanis A Oden Body mass index as a predictor of fracture risk: a meta-analysis Osteoporos Int 16 2005 1330 1338
35. JA Kanis H Johansson A Oden A family history of fracture and fracture risk: a meta-analysis Bone 35 2004 1029 1037
36. JA Kanis O Johnell A Oden Smoking and fracture risk: a meta-analysis Osteoporos Int 16 2005 155 162
37. JA Kanis H Johansson O Johnell Alcohol intake as a risk factor for fracture Osteoporos Int 16 2005 737 742
38. JA Kanis H Johansson A Oden A meta-analysis of prior corticosteroid use and fracture risk J Bone Miner Res 19 2004 893 899
39. T Coleman Special groups of smokers BMJ 328 2004 575 577
40. TP van Staa HG Leufkens L Abenhaim B Begaud B Zhang C Cooper Use of oral corticosteroids in the United Kingdom QJM 93 2000 105 111
41. JB Richards WD Leslie L Joseph Changes to osteoporosis prevalence according to method of risk assessment J Bone Miner Res 22 2007 228 234
42. BL Langdahl M Carstens L Stenkjaer EF Eriksen Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures J Bone Miner Res 17 2002 1245 1255
43. YH Hsu T Niu HA Terwedow Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men Hum Genet 118 2006 568 577
44. T Ueland J Bollerslev SG Wilson No associations between OPG gene polymorphisms or serum levels and measures of osteoporosis in elderly Australian women Bone 40 2007 175 181
45. LC Hofbauer AE Heufelder Clinical review 114: hot topic. The role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in the pathogenesis and treatment of metabolic bone diseases J Clin Endocrinol Metab 85 2000 2355 2363
46. MR McClung EM Lewiecki SB Cohen Denosumab in postmenopausal women with low bone mineral density N Engl J Med 354 2006 821 831
47. V Krishnan HU Bryant OA Macdougald Regulation of bone mass by Wnt signaling J Clin Invest 116 2006 1202 1209
48. Y Gong RB Slee N Fukai LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development Cell 107 2001 513 523
49. Y Gong M Vikkula L Boon Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13 Am J Hum Genet 59 1996 146 151
50. JB van Meurs F Rivadeneira M Jhamai Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men J Bone Miner Res 21 2006 141 150
51. AM Sims N Shephard K Carter Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes J Bone Miner Res 23 2008 499 506
52. JB van Meurs TA Trikalinos SH Ralston Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis JAMA 299 2008 1277 1290
53. DP Kiel S Demissie J Dupuis KL Lunetta JM Murabito D Karasik Genome-wide association with bone mass and geometry in the Framingham Heart Study BMC Med Genet 8 2007 14
54. Y Li G Toraldo A Li B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo Blood 109 2007 3839 3848
55. DW Russell MS Brown JL Goldstein Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins J Biol Chem 264 1989 21682 21688
56. MS Sandhu DM Waterworth SL Debenham LDL-cholesterol concentrations: a genome-wide association study Lancet 371 2008 483 491
57. MN Weedon G Lettre RM Freathy A common variant of HMGA2 is associated with adult and childhood height in the general population Nature Genetics 39 2007 1245 1250
58. TM Frayling NJ Timpson MN Weedon A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 316 2007 889 894
59. J Maller S George S Purcell Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration Nat Genet 38 2006 1055 1059