Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-κB ligand signaling cascade

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 1, 2008, Pages 50-59

  Chen, Jin Ran ^a,b   Shankar, Kartik ^a,b   Nagarajan, Shanmugam ^a,b   Badger, Thomas M ^a,b   Ronis, Martin J J ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALCOHOL; DIPHENYLIODONIUM SALT; ESTRADIOL; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CALVARIA; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; ESTROGEN ACTIVITY; FEMALE; GENE EXPRESSION REGULATION; INHIBITION KINETICS; INTRACELLULAR TRANSPORT; MALE; MOLECULAR MECHANICS; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; BONE RESORPTION; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; ESTRADIOL; ETHANOL; FEMALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NADPH OXIDASE; OSTEOBLASTS; OXIDATIVE STRESS; RANK LIGAND; RATS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKULL; STAT3 TRANSCRIPTION FACTOR;

EID: 37349060697     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.130351     Document Type: Article

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