Dietary protein content and the diet's net acid load: Opposing effects on bone health

American Journal of Clinical Nutrition

Volumn 82, Issue 5, 2005, Pages 921-922

  Sebastian, Anthony ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; PHOSPHORUS; POTASSIUM; SOMATOMEDIN C;

BIOSYNTHESIS; BONE DENSITY; BONE MASS; BONE MATRIX; BONE MINERAL; CATABOLISM; COMPUTER ASSISTED TOMOGRAPHY; DIETARY INTAKE; EDITORIAL; HIP FRACTURE; HUMAN; OSTEOPOROSIS; POSTMENOPAUSE; PROTEIN CONTENT; PROTEIN DIET; PROTEIN INTAKE; ACID BASE BALANCE; BONE; BONE DEVELOPMENT; DRUG EFFECT; METABOLISM; NOTE; PHYSIOLOGY;

ACID-BASE EQUILIBRIUM; BONE AND BONES; BONE DENSITY; BONE DEVELOPMENT; DIETARY PROTEINS; HUMANS; INSULIN-LIKE GROWTH FACTOR I;

EID: 32944459496     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/82.5.921     Document Type: Editorial

References (15)

1. Alexy U, Remer T, Manz F, Neu CM, Schoenau E. Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children. Am J Clin Nutr 2005;82:1107-14.
2. Tucker KL, Hannan MT, Kiel DP. The acid-base hypothesis: diet and bone in the Framingham Osteoporosis Study. Eur J Nutr 2001;40:231-7.
3. Clemmons DR, Seek MM, Underwood LE. Supplemental essential amino acids augment the somatomedin-C/insulin-like growth factor I response to refeeding after fasting. Metabolism 1985;34:391-5.
4. Schurch MA, Rizzoli R, Slosman D, Vadas L, Vergnaud P, Bonjour JP. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1998;128:801-9.
5. Kurtz I, Maher T, Hulter HN, Schambelan M, Sebastian A. Effect of diet on plasma acid-base composition in normal humans. Kidney Int 1983;24:670-80.
6. Sebastian A, Harris ST, Ottaway JH, Todd KM, Morris RC Jr. Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 1994;330:1776-81.
7. Marangella M, DiStefano M, Casalis S, Berutti S, D'Amelio P, Isaia GC. Effects of potassium citrate supplementation on bone metabolism. Calcif Tissue Int 2004;74:330-5.
8. Promislow JH, Goodman-Gruen D, Slymen DJ, Barrett-Connor E. Protein consumption and bone mineral density in the elderly: the Rancho Bernardo Study. Am J Epidemiol 2002;155:636-44.
9. Wengreen HJ, Munger RG, West NA, et al. Dietary protein intake and risk of osteoporotic hip fracture in elderly residents of Utah. J Bone Miner Res 2004;19:537-45.
10. Frassetto LA, Todd KM, Morris RC Jr, Sebastian A. Worldwide incidence of hip fracture in elderly women: relation to consumption of animal and vegetable foods. J Gerontol A Biol Sci Med Sci 2000;55:M585-92.
11. Sellmeyer DE, Stone KL, Sebastian A, Cummings SR. A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group. Am J Clin Nutr 2001;73:118-22.
12. Bushinsky DA. Metabolic alkalosis decreases bone calcium efflux by suppressing osteoclasts and stimulating osteoblasts. Am J Physiol 1996;271:F216-22.
13. Brungger M, Hulter HN, Krapf R. Effect of chronic metabolic acidosis on the growth hormone/IGF-1 endocrine axis: new cause of growth hormone insensitivity in humans. Kidney Int 1997;51:216-21.
14. Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC Jr. Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors. Am J Clin Nutr 2002;76:1308-16.
15. O'Keefe JH Jr, Cordain L. Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer. Mayo Clin Proc 2004;79:101-8.