Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking

Journal of Bone and Mineral Research

Volumn 26, Issue 11, 2011, Pages 2682-2694

  Nojiri, Hidetoshi ^a,b   Saita, Yoshitomo ^a,b   Morikawa, Daichi ^a,b   Kobayashi, Keiji ^a,b   Tsuda, Chizuru ^a   Miyazaki, Tsuyoshi ^a   Saito, Mitsuru ^c   Marumo, Keishi ^c   Yonezawa, Ikuho ^b   Kaneko, Kazuo ^b   Shirasawa, Takuji ^b   Shimizu, Takahiko ^a,d  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

^c JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Bone fragility; Copper zinc superoxide dismutase (CuZn SOD OR SOD1); Low turnover osteoporosis; Reactive oxygen species (ROS); Senescent collagen cross links

Indexed keywords

ASCORBIC ACID; COLLAGEN; COPPER ZINC SUPEROXIDE DISMUTASE; OSTEOCLAST DIFFERENTIATION FACTOR; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE AGE; BONE DENSITY; BONE DEVELOPMENT; BONE FRAGILITY; BONE MASS; BONE TISSUE; BONE TURNOVER; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CROSS LINKING; FEMALE; IN VITRO STUDY; LUMBAR VERTEBRA; MALE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPENIA; OSTEOPOROSIS; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

AGING; ANIMALS; ASCORBIC ACID; BONE AND BONES; BONE RESORPTION; CELL COUNT; CELL SURVIVAL; COLLAGEN; CROSS-LINKING REAGENTS; CYTOPLASM; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; ORGAN SIZE; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; OSTEOPOROSIS; OXIDATION-REDUCTION; PHENOTYPE; RANK LIGAND; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 80055002537     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.489     Document Type: Article

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