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10.1016/j.molmed.2010.03.004 20434954 10.1016/j.molmed.2010.03.004 Epub 2010 Apr 29. Review. PubMed PMID: 20434954; PubMed Central PMCID: PMC3408219
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Huang X, Le QT, Giaccia AJ. MiR-210 - micromanager of the hypoxia pathway. Trends Mol Med. 2010;16:230-7. doi: 10.1016/j.molmed.2010.03.004. Epub 2010 Apr 29. Review. PubMed PMID: 20434954; PubMed Central PMCID: PMC3408219.
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MiR-148a regulates osteoclastogenesis via targeting MAFB
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[Epub ahead of print]. doi: 10.1002/jbmr.1845. PubMed PMID: 23225151. Compelling paper providing evidence for a 'double negative' circuit that promotes osteoclast differentiation
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•• Cheng P, Chen C, He HB, Hu R, Zhou HD, Xie H, et al. MiR-148a regulates osteoclastogenesis via targeting MAFB. J Bone Miner Res. 2012. [Epub ahead of print]. doi: 10.1002/jbmr.1845. PubMed PMID: 23225151. Compelling paper providing evidence for a 'double negative' circuit that promotes osteoclast differentiation.
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A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2
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doi: 10.1073/pnas.1018493108.Epub2011 May 31. PubMed PMID: 21628588; PubMed Central PMCID: PMC3116419. Comprehensive study showing that osteogenic activity of transcription factor Runx2 is controlled by a multiplicity of miRNAs
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Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2
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doi: 10.1074/jbc.M112.340398. Epub 2012 Apr 27. PubMed PMID: 22544738; PubMed Central PMCID: PMC3381153. Key paper revealing a miRNA-transcription factor network that regulates mesenchymal lineage allocation
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•• Zhang Y, Xie RL, Gordon J, LeBlanc K, Stein JL, Lian JB, et al. Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2. J Biol Chem. 2012;287:21926-35. doi: 10.1074/jbc.M112.340398. Epub 2012 Apr 27. PubMed PMID: 22544738; PubMed Central PMCID: PMC3381153. Key paper revealing a miRNA-transcription factor network that regulates mesenchymal lineage allocation.
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MiR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2
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doi: 10.1083/jcb.201201057. Epub 2012 May 7. PubMed PMID: 22564414; PubMed Central PMCID: PMC3352956. First paper to demonstrate a skeletal phenotype linked to a specific microRNA expressed in osteogenic cells
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MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation
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Huang J, Zhao L, Xing L, Chen D. MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells. 2010;28:357-64. doi: 10.1002/stem.288. PubMed PMID: 20039258; PubMed Central PMCID: PMC2837600.
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Zhang JF, Fu WM, He ML, Xie WD, Lv Q, Wan G, et al. MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling. RNA Biol. 2011;8:829-38. doi: 10.4161/rna.8.5.16043.Epub2011Jul28.
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MiR-93/Sp7 function loop mediates osteoblast mineralization
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MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix
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10.1091/mbc.E11-04-0356 21880893 10.1091/mbc.E11-04-0356 Epub2011 Aug 31. PubMed PMID: 21880893; PubMed Central PMCID: PMC3204058
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Zhang JF, Fu WM, He ML, Wang H, Wang WM, Yu SC, et al. MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix. Mol Biol Cell. 2011;22:3955-61. doi: 10.1091/mbc.E11-04-0356.Epub2011 Aug 31. PubMed PMID: 21880893; PubMed Central PMCID: PMC3204058.
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MiR-214 targets ATF4 to inhibit bone formation
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10.1038/nm.3026 23223004 10.1038/nm.3026 Epub 2012 Dec 9. PubMed PMID: 23223004
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Wang X, Guo B, Li Q, Peng J, Yang Z, Wang A, et al. miR-214 targets ATF4 to inhibit bone formation. Nat Med. 2013;19:93-100. doi: 10.1038/nm.3026. Epub 2012 Dec 9. PubMed PMID: 23223004.
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A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans
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Polymorphisms in predicted miRNA binding sites and osteoporosis
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doi: 10.1002/jbmr.186. PubMed PMID: 20641033; PubMed Central PMCID: PMC3179316. Solid study that characterizes a miRNA dependent polymorphisms linked to bone mineral density in human patients
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Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2
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MiRNA-34c regulates Notch signaling during bone development
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doi: 10.1093/hmg/dds129. Epub 2012 Apr 12. PubMed PMID: 22498974; PubMed Central PMCID: PMC3373245.Compelling paper that examines the miRNA dependent interplay between osteoclasts and osteoblasts
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