메뉴 건너뛰기




Volumn 11, Issue 2, 2013, Pages 72-82

MicroRNA functions in osteogenesis and dysfunctions in osteoporosis

Author keywords

Bone mineral density; Mesenchymal stem cell; miRNA; Osteoblast; Osteoclast; Osteogenesis; Osteoporosis; Skeletal development

Indexed keywords

MICRORNA;

EID: 84879088194     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-013-0143-6     Document Type: Article
Times cited : (205)

References (53)
  • 1
    • 0035966319 scopus 로고    scopus 로고
    • MicroRNAs: Tiny regulators with great potential
    • 11779458 10.1016/S0092-8674(01)00616-X Review. PubMed PMID: 11779458
    • Ambros V. MicroRNAs: tiny regulators with great potential. Cell. 2001;107:823-6. Review. PubMed PMID: 11779458.
    • (2001) Cell , vol.107 , pp. 823-826
    • Ambros, V.1
  • 2
    • 84862777464 scopus 로고    scopus 로고
    • MicroRNA control of bone formation and homeostasis
    • doi: 10.1038/nrendo.2011.234. Review. PubMed PMID: 22290358. Comprehensive review of the microRNA literature on skeletal development and disease
    • •• Lian JB, Stein GS, van Wijnen AJ, Stein JL, Hassan MQ, Gaur T, Zhang Y. MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol. 2012;8:212-27. doi: 10.1038/nrendo.2011.234. Review. PubMed PMID: 22290358. Comprehensive review of the microRNA literature on skeletal development and disease.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 212-227
    • Lian, J.B.1    Stein, G.S.2    Van Wijnen, A.J.3    Stein, J.L.4    Hassan, M.Q.5    Gaur, T.6    Zhang, Y.7
  • 3
    • 84866100301 scopus 로고    scopus 로고
    • Macro view of microRNA function in osteoarthritis
    • 10.1038/nrrheum.2012.128 22890245 10.1038/nrrheum.2012.128 Epub 2012 Aug 14. Review. PubMed PMID: 22890245; PubMed Central PMCID: PMC3572197
    • Miyaki S, Asahara H. Macro view of microRNA function in osteoarthritis. Nat Rev Rheumatol. 2012;8:543-52. doi: 10.1038/nrrheum.2012.128. Epub 2012 Aug 14. Review. PubMed PMID: 22890245; PubMed Central PMCID: PMC3572197.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 543-552
    • Miyaki, S.1    Asahara, H.2
  • 4
    • 84255194192 scopus 로고    scopus 로고
    • MicroRNAs and their roles in osteoclast differentiation
    • 10.1007/s11684-011-0168-0 22198753 10.1007/s11684-011-0168-0 Epub2011 Dec 27. Review. PubMed PMID: 22198753
    • Xia Z, Chen C, Chen P, Xie H, Luo X. MicroRNAs and their roles in osteoclast differentiation. Front Med. 2011;5:414-9. doi: 10.1007/s11684-011- 0168-0.Epub2011 Dec 27. Review. PubMed PMID: 22198753.
    • (2011) Front Med , vol.5 , pp. 414-419
    • Xia, Z.1    Chen, C.2    Chen, P.3    Xie, H.4    Luo, X.5
  • 5
    • 84856667040 scopus 로고    scopus 로고
    • Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis
    • 10.1016/j.molmed.2011.11.005 22178468 10.1016/j.molmed.2011.11.005 Epub2011 Dec 17. Review. PubMed PMID: 22178468; PubMed Central PMCID: PMC3282171
    • Goldring MB, Marcu KB. Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis. Trends Mol Med. 2012;18:109-18. doi: 10.1016/j.molmed.2011.11.005.Epub2011 Dec 17. Review. PubMed PMID: 22178468; PubMed Central PMCID: PMC3282171.
    • (2012) Trends Mol Med , vol.18 , pp. 109-118
    • Goldring, M.B.1    Marcu, K.B.2
  • 6
    • 84857978205 scopus 로고    scopus 로고
    • Mechanisms in endocrinology: Micro-RNAs: Targets for enhancing osteoblast differentiation and bone formation
    • 10.1530/EJE-11-0646 22084154 10.1530/EJE-11-0646 Epub2011 Nov 14. Review. PubMed PMID: 22084154
    • Taipaleenmäki H, Bjerre Hokland L, Chen L, Kauppinen S, Kassem M. Mechanisms in endocrinology: micro-RNAs: targets for enhancing osteoblast differentiation and bone formation. Eur J Endocrinol. 2012;166:359-71. doi: 10.1530/EJE-11-0646.Epub2011 Nov 14. Review. PubMed PMID: 22084154.
    • (2012) Eur J Endocrinol , vol.166 , pp. 359-371
    • Taipaleenmäki, H.1    Bjerre Hokland, L.2    Chen, L.3    Kauppinen, S.4    Kassem, M.5
  • 7
    • 84857801296 scopus 로고    scopus 로고
    • Do microRNAs regulate bone marrow stem cell niche physiology?
    • doi: 10.1016/j.gene.2012.01.045. Epub 2012 Jan 28. Review. PubMed PMID: 22306262. Important review that addresses miRNA dependent cell/cell communication in the bone marrow micro-environment
    • • Laine SK, Hentunen T, Laitala-Leinonen T. Do microRNAs regulate bone marrow stem cell niche physiology? Gene. 2012;497:1-9. doi: 10.1016/j.gene.2012.01.045. Epub 2012 Jan 28. Review. PubMed PMID: 22306262. Important review that addresses miRNA dependent cell/cell communication in the bone marrow micro-environment.
    • (2012) Gene , vol.497 , pp. 1-9
    • Laine, S.K.1    Hentunen, T.2    Laitala-Leinonen, T.3
  • 8
    • 0242266620 scopus 로고    scopus 로고
    • Dicer is essential for mouse development
    • 14528307 10.1038/ng1253 Epub 2003 Oct 5. Erratum in: Nat Genet. 2003;35:287. PubMed PMID: 14528307
    • Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, et al. Dicer is essential for mouse development. Nat Genet. 2003;35:215-7. Epub 2003 Oct 5. Erratum in: Nat Genet. 2003;35:287. PubMed PMID: 14528307.
    • (2003) Nat Genet , vol.35 , pp. 215-217
    • Bernstein, E.1    Kim, S.Y.2    Carmell, M.A.3    Murchison, E.P.4    Alcorn, H.5    Li, M.Z.6
  • 9
    • 23344439006 scopus 로고    scopus 로고
    • The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
    • 16040801 10.1073/pnas.0504834102 Epub 2005 Jul 22. PubMed PMID: 16040801; PubMed Central PMCID: PMC1182454
    • Harfe BD, McManus MT, Mansfield JH, Hornstein E, Tabin CJ. The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A. 2005;102:10898-903. Epub 2005 Jul 22. PubMed PMID: 16040801; PubMed Central PMCID: PMC1182454.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10898-10903
    • Harfe, B.D.1    McManus, M.T.2    Mansfield, J.H.3    Hornstein, E.4    Tabin, C.J.5
  • 10
    • 46249107572 scopus 로고    scopus 로고
    • Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells
    • 10.1083/jcb.200802105 18591425 10.1083/jcb.200802105 PubMed PMID: 18591425; PubMed Central PMCID: PMC2442212
    • Mudhasani R, Zhu Z, Hutvagner G, Eischen CM, Lyle S, Hall LL, et al. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol. 2008;181:1055-63. doi: 10.1083/jcb.200802105. PubMed PMID: 18591425; PubMed Central PMCID: PMC2442212.
    • (2008) J Cell Biol , vol.181 , pp. 1055-1063
    • Mudhasani, R.1    Zhu, Z.2    Hutvagner, G.3    Eischen, C.M.4    Lyle, S.5    Hall, L.L.6
  • 11
    • 77649187445 scopus 로고    scopus 로고
    • Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse
    • doi: 10.1016/j.ydbio.2010.01.008. Epub 2010 Jan 15. PubMed PMID: 20079730; PubMed Central PMCID: PMC2840721. Key study showing a post-natal bone phenotype in microRNA deficient mice
    • •• Gaur T, Hussain S, Mudhasani R, Parulkar I, Colby JL, Frederick D, et al. Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse. Dev Biol. 2010;340:10-21. doi: 10.1016/j.ydbio.2010.01.008. Epub 2010 Jan 15. PubMed PMID: 20079730; PubMed Central PMCID: PMC2840721. Key study showing a post-natal bone phenotype in microRNA deficient mice.
    • (2010) Dev Biol. , vol.340 , pp. 10-21
    • Gaur, T.1    Hussain, S.2    Mudhasani, R.3    Parulkar, I.4    Colby, J.L.5    Frederick, D.6
  • 12
    • 77950862042 scopus 로고    scopus 로고
    • Bone progenitor dysfunction induces myelodysplasia and secondary leukemia
    • 10.1038/nature08851 20305640 10.1038/nature08851 Epub 2010 Mar 21. PubMed PMID: 20305640; PubMed Central PMCID: PMC3422863
    • Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukemia. Nature. 2010;464:852-7. doi: 10.1038/nature08851. Epub 2010 Mar 21. PubMed PMID: 20305640; PubMed Central PMCID: PMC3422863.
    • (2010) Nature , vol.464 , pp. 852-857
    • Raaijmakers, M.H.1    Mukherjee, S.2    Guo, S.3    Zhang, S.4    Kobayashi, T.5    Schoonmaker, J.A.6
  • 13
    • 63249113375 scopus 로고    scopus 로고
    • Impaired micro-RNA pathways diminish osteoclast differentiation and function
    • doi: 10.1074/jbc.M805777200. Epub 2008 Dec 5. PubMed PMID: 19059913; PubMed Central PMCID: PMC2640963. First in vivo demonstration of a requirement for Dicer in osteoclast-related bone remodeling
    • •• Sugatani T, Hruska KA. Impaired micro-RNA pathways diminish osteoclast differentiation and function. J Biol Chem. 2009;284:4667-78. doi: 10.1074/jbc.M805777200. Epub 2008 Dec 5. PubMed PMID: 19059913; PubMed Central PMCID: PMC2640963. First in vivo demonstration of a requirement for Dicer in osteoclast-related bone remodeling.
    • (2009) J Biol Chem. , vol.284 , pp. 4667-4678
    • Sugatani, T.1    Hruska, K.A.2
  • 14
    • 77950429619 scopus 로고    scopus 로고
    • Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption
    • doi: 10.1002/jcb.22228. PubMed PMID: 20039311. Important study revealing the biological contribution of Dicer to mature osteoclasts
    • • Mizoguchi F, Izu Y, Hayata T, Hemmi H, Nakashima K, Nakamura T, et al. Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption. J Cell Biochem. 2010;109:866-75. doi: 10.1002/jcb.22228. PubMed PMID: 20039311. Important study revealing the biological contribution of Dicer to mature osteoclasts.
    • (2010) J Cell Biochem , vol.109 , pp. 866-875
    • Mizoguchi, F.1    Izu, Y.2    Hayata, T.3    Hemmi, H.4    Nakashima, K.5    Nakamura, T.6
  • 15
    • 77953436610 scopus 로고    scopus 로고
    • MicroRNAs regulate osteogenesis and chondrogenesis of mouse bone marrow stromal cells
    • 19787082 PubMed PMID: 19787082; PubMed Central PMCID: PMC2733092
    • Suomi S, Taipaleenmäki H, Seppänen A, Ripatti T, Väänänen K, Hentunen T, et al. MicroRNAs regulate osteogenesis and chondrogenesis of mouse bone marrow stromal cells. Gene Regul Syst Bio. 2008;2:177-91. PubMed PMID: 19787082; PubMed Central PMCID: PMC2733092.
    • (2008) Gene Regul Syst Bio , vol.2 , pp. 177-191
    • Suomi, S.1    Taipaleenmäki, H.2    Seppänen, A.3    Ripatti, T.4    Väänänen, K.5    Hentunen, T.6
  • 16
    • 84862562593 scopus 로고    scopus 로고
    • MicroRNAs miR-96, miR-124, and miR-199a regulate gene expression in human bone marrow-derived mesenchymal stem cells
    • 10.1002/jcb.24144 22441842 10.1002/jcb.24144
    • Laine SK, Alm JJ, Virtanen SP, Aro HT, Laitala-Leinonen TK. MicroRNAs miR-96, miR-124, and miR-199a regulate gene expression in human bone marrow-derived mesenchymal stem cells. J Cell Biochem. 2012;113:2687-95. doi: 10.1002/jcb.24144.
    • (2012) J Cell Biochem , vol.113 , pp. 2687-2695
    • Laine, S.K.1    Alm, J.J.2    Virtanen, S.P.3    Aro, H.T.4    Laitala-Leinonen, T.K.5
  • 17
    • 79955016827 scopus 로고    scopus 로고
    • MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
    • doi: 10.1073/pnas.1016758108.Epub2011 Mar 28. PubMed PMID: 21444814; PubMed Central PMCID: PMC3076836. Major study providing proof for miRNA effects on mesenchymal lineage-differentiation in mice using a subcutaneous growth model
    • •• Eskildsen T, Taipaleenmäki H, Stenvang J, Abdallah BM, Ditzel N, Nossent AY, et al. MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo. Proc Natl Acad Sci U S A. 2011;108:6139-44. doi: 10.1073/pnas.1016758108.Epub2011 Mar 28. PubMed PMID: 21444814; PubMed Central PMCID: PMC3076836. Major study providing proof for miRNA effects on mesenchymal lineage-differentiation in mice using a subcutaneous growth model.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 6139-6144
    • Eskildsen T, T.1
  • 18
    • 52949114558 scopus 로고    scopus 로고
    • A microRNA signature for a BMP2-induced osteoblast lineage commitment program
    • 10.1073/pnas.0804438105 18784367 10.1073/pnas.0804438105 Epub 2008 Sep 10. PubMed PMID: 18784367; PubMed Central PMCID: PMC2544552
    • Li Z, Hassan MQ, Volinia S, van Wijnen AJ, Stein JL, Croce CM, et al. A microRNA signature for a BMP2-induced osteoblast lineage commitment program. Proc Natl Acad Sci U S A. 2008;105:13906-11. doi: 10.1073/pnas.0804438105. Epub 2008 Sep 10. PubMed PMID: 18784367; PubMed Central PMCID: PMC2544552.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13906-13911
    • Li, Z.1    Hassan, M.Q.2    Volinia, S.3    Van Wijnen, A.J.4    Stein, J.L.5    Croce, C.M.6
  • 19
    • 67650169908 scopus 로고    scopus 로고
    • Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation
    • 10.1074/jbc.M809787200 19342382 10.1074/jbc.M809787200 Epub 2009 Apr 2. PubMed PMID: 19342382; PubMed Central PMCID: PMC2708864
    • Li Z, Hassan MQ, Jafferji M, Aqeilan RI, Garzon R, Croce CM, et al. Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation. J Biol Chem. 2009;284:15676-84. doi: 10.1074/jbc.M809787200. Epub 2009 Apr 2. PubMed PMID: 19342382; PubMed Central PMCID: PMC2708864.
    • (2009) J Biol Chem , vol.284 , pp. 15676-15684
    • Li, Z.1    Hassan, M.Q.2    Jafferji, M.3    Aqeilan, R.I.4    Garzon, R.5    Croce, C.M.6    Van Wijnen, A.J.7    Stein, J.L.8    Stein, G.S.9    Lian, J.B.10
  • 20
    • 78650548873 scopus 로고    scopus 로고
    • A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program
    • 10.1073/pnas.1007698107 20980664 10.1073/pnas.1007698107 Epub 2010 Oct 27. PubMed PMID: 20980664; PubMed Central PMCID: PMC2993380
    • Hassan MQ, Gordon JA, Beloti MM, Croce CM, van Wijnen AJ, Stein JL, et al. A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program. Proc Natl Acad Sci U S A. 2010;107:19879-84. doi: 10.1073/pnas.1007698107. Epub 2010 Oct 27. PubMed PMID: 20980664; PubMed Central PMCID: PMC2993380.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 19879-19884
    • Hassan, M.Q.1    Gordon, J.A.2    Beloti, M.M.3    Croce, C.M.4    Van Wijnen, A.J.5    Stein, J.L.6
  • 21
    • 84871345038 scopus 로고    scopus 로고
    • MiR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells
    • doi: 10.1074/jbc.M112.377515. Epub 2012 Oct 11. PubMed PMID: 23060446; PubMed Central PMCID: PMC3516754. First identification of a miRNA with osteogenic or osteomimetic properties in, respectively, osseous and non-osseous cells
    • •• Hassan MQ, Maeda Y, Taipaleenmaki H, Zhang W, Jafferji M, Gordon JA, et al. miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem. 2012;287:42084-92. doi: 10.1074/jbc.M112.377515. Epub 2012 Oct 11. PubMed PMID: 23060446; PubMed Central PMCID: PMC3516754. First identification of a miRNA with osteogenic or osteomimetic properties in, respectively, osseous and non-osseous cells.
    • (2012) J Biol Chem. , vol.287 , pp. 42084-42092
    • Hassan, M.Q.1    Maeda, Y.2    Taipaleenmaki, H.3    Zhang, W.4    Jafferji, M.5    Gordon, J.A.6
  • 22
    • 34447262870 scopus 로고    scopus 로고
    • MicroRNA-223 is a key factor in osteoclast differentiation
    • 17471500 10.1002/jcb.21335
    • Sugatani T, Hruska KA. MicroRNA-223 is a key factor in osteoclast differentiation. J Cell Biochem. 2007;101:996-9.
    • (2007) J Cell Biochem , vol.101 , pp. 996-999
    • Sugatani, T.1    Hruska, K.A.2
  • 23
    • 79953686494 scopus 로고    scopus 로고
    • A microRNA expression signature of osteoclastogenesis
    • 10.1182/blood-2010-10-311415 21273303 10.1182/blood-2010-10-311415 Epub2011 Jan 27. PubMed PMID: 21273303; PubMed Central PMCID: PMC3072882
    • Sugatani T, Vacher J, Hruska KA. A microRNA expression signature of osteoclastogenesis. Blood. 2011;117:3648-57. doi: 10.1182/blood-2010-10-311415. Epub2011 Jan 27. PubMed PMID: 21273303; PubMed Central PMCID: PMC3072882.
    • (2011) Blood , vol.117 , pp. 3648-3657
    • Sugatani, T.1    Vacher, J.2    Hruska, K.A.3
  • 24
    • 84876261835 scopus 로고    scopus 로고
    • Down-regulation of miR-21 biogenesis by estrogen action contributes to osteoclastic apoptosis
    • [Epub ahead of print]. doi: 10.1002/jcb.24471. PubMed PMID: 23238785. Exciting study that clarifies the interplay between miRNAs and estrogen levels
    • •• Sugatani T, Hruska KA. Down-regulation of miR-21 biogenesis by estrogen action contributes to osteoclastic apoptosis. J Cell Biochem. 2012. [Epub ahead of print]. doi: 10.1002/jcb.24471. PubMed PMID: 23238785. Exciting study that clarifies the interplay between miRNAs and estrogen levels.
    • (2012) J Cell Biochem
    • Sugatani, T.1    Hruska, K.A.2
  • 25
    • 84876812525 scopus 로고    scopus 로고
    • Expression profiling of microRNAs in RAW264.7 cells treated with a combination of tumor necrosis factor alpha and RANKL during osteoclast differentiation
    • [Epub ahead of print]. doi: 10.1111/jre.12017
    • Kagiya T, Nakamura S. Expression profiling of microRNAs in RAW264.7 cells treated with a combination of tumor necrosis factor alpha and RANKL during osteoclast differentiation. J Periodontal Res. 2012. [Epub ahead of print]. doi: 10.1111/jre.12017.
    • (2012) J Periodontal Res.
    • Kagiya, T.1    Nakamura, S.2
  • 26
    • 84866596352 scopus 로고    scopus 로고
    • Interferon-β-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF
    • 10.1016/j.febslet.2012.06.047 22771905 10.1016/j.febslet.2012.06.047 Epub 2012 Jul 4
    • Zhang J, Zhao H, Chen J, Xia B, Jin Y, Wei W, et al. Interferon-β- induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF. FEBS Lett. 2012;586:3255-62. doi: 10.1016/j.febslet.2012.06.047. Epub 2012 Jul 4.
    • (2012) FEBS Lett , vol.586 , pp. 3255-3262
    • Zhang, J.1    Zhao, H.2    Chen, J.3    Xia, B.4    Jin, Y.5    Wei, W.6
  • 27
    • 84875538389 scopus 로고    scopus 로고
    • MiR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease
    • [Epub ahead of print]. doi: 10.1002/jcp.24306. PubMed PMID: 23254643
    • Rossi M, Pitari MR, Amodio N, Di Martino MT, Conforti F, Leone E, et al. miR-29b negatively regulates human osteoclastic cell differentiation and function: implications for the treatment of multiple myeloma-related bone disease. J Cell Physiol. 2012. [Epub ahead of print]. doi: 10.1002/jcp.24306. PubMed PMID: 23254643.
    • (2012) J Cell Physiol
    • Rossi, M.1    Pitari, M.R.2    Amodio, N.3    Di Martino, M.T.4    Conforti, F.5    Leone, E.6
  • 28
    • 23244460363 scopus 로고    scopus 로고
    • Organization of transcriptional regulatory machinery in osteoclast nuclei: Compartmentalization of Runx1
    • 15828028 10.1002/jcp.20329
    • Saltman LH, Javed A, Ribadeneyra J, Hussain S, Young DW, Osdoby P, et al. Organization of transcriptional regulatory machinery in osteoclast nuclei: compartmentalization of Runx1. J Cell Physiol. 2005;204:871-80.
    • (2005) J Cell Physiol , vol.204 , pp. 871-880
    • Saltman, L.H.1    Javed, A.2    Ribadeneyra, J.3    Hussain, S.4    Young, D.W.5    Osdoby, P.6
  • 29
    • 77955643809 scopus 로고    scopus 로고
    • Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
    • doi: 10.1371/journal.pone.0011803. PubMed PMID: 20668554; PubMed Central PMCID: PMC2910725. Early study that provides evidence for cell/cell contact through miRNA containing microvesicles
    • • Collino F, Deregibus MC, Bruno S, Sterpone L, Aghemo G, Viltono L, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One. 2010;5:e11803. doi: 10.1371/journal.pone.0011803. PubMed PMID: 20668554; PubMed Central PMCID: PMC2910725. Early study that provides evidence for cell/cell contact through miRNA containing microvesicles.
    • (2010) PLoS One. , vol.5
    • Collino, F.1    Deregibus, M.C.2    Bruno, S.3    Sterpone, L.4    Aghemo, G.5    Viltono, L.6
  • 30
    • 75649119273 scopus 로고    scopus 로고
    • Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs
    • doi: 10.1093/nar/gkp857. Epub 2009 Oct 22. PubMed PMID: 19850715; PubMed Central PMCID: PMC2800221. Concurrent early study also showing microvesicle-related secretuib of miRNAs
    • • Chen TS, Lai RC, Lee MM, Choo AB, Lee CN, Lim SK. Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs. Nucleic Acids Res. 2010;38:215-24. doi: 10.1093/nar/gkp857. Epub 2009 Oct 22. PubMed PMID: 19850715; PubMed Central PMCID: PMC2800221. Concurrent early study also showing microvesicle-related secretuib of miRNAs.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 215-224
    • Chen, T.S.1    Lai, R.C.2    Lee, M.M.3    Choo, A.B.4    Lee, C.N.5    Lim, S.K.6
  • 31
    • 79955890241 scopus 로고    scopus 로고
    • MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis
    • 10.1016/j.gene.2011.03.003 21397669 10.1016/j.gene.2011.03.003 Epub2011 Mar 21. PubMed PMID: 21397669; PubMed Central PMCID: PMC3095758
    • Li X, Gibson G, Kim JS, Kroin J, Xu S, van Wijnen AJ, et al. MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene. 2011;480:34-41. doi: 10.1016/j.gene.2011.03.003.Epub2011 Mar 21. PubMed PMID: 21397669; PubMed Central PMCID: PMC3095758.
    • (2011) Gene , vol.480 , pp. 34-41
    • Li, X.1    Gibson, G.2    Kim, J.S.3    Kroin, J.4    Xu, S.5    Van Wijnen, A.J.6
  • 32
    • 77952111459 scopus 로고    scopus 로고
    • MiR-210 - Micromanager of the hypoxia pathway
    • 10.1016/j.molmed.2010.03.004 20434954 10.1016/j.molmed.2010.03.004 Epub 2010 Apr 29. Review. PubMed PMID: 20434954; PubMed Central PMCID: PMC3408219
    • Huang X, Le QT, Giaccia AJ. MiR-210 - micromanager of the hypoxia pathway. Trends Mol Med. 2010;16:230-7. doi: 10.1016/j.molmed.2010.03.004. Epub 2010 Apr 29. Review. PubMed PMID: 20434954; PubMed Central PMCID: PMC3408219.
    • (2010) Trends Mol Med , vol.16 , pp. 230-237
    • Huang, X.1    Le, Q.T.2    Giaccia, A.J.3
  • 33
    • 84879106419 scopus 로고    scopus 로고
    • MiR-148a regulates osteoclastogenesis via targeting MAFB
    • [Epub ahead of print]. doi: 10.1002/jbmr.1845. PubMed PMID: 23225151. Compelling paper providing evidence for a 'double negative' circuit that promotes osteoclast differentiation
    • •• Cheng P, Chen C, He HB, Hu R, Zhou HD, Xie H, et al. MiR-148a regulates osteoclastogenesis via targeting MAFB. J Bone Miner Res. 2012. [Epub ahead of print]. doi: 10.1002/jbmr.1845. PubMed PMID: 23225151. Compelling paper providing evidence for a 'double negative' circuit that promotes osteoclast differentiation.
    • (2012) J Bone Miner Res
    • Cheng, P.1    Chen, C.2    He, H.B.3    Hu, R.4    Zhou, H.D.5    Xie, H.6
  • 34
    • 79960015376 scopus 로고    scopus 로고
    • A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2
    • doi: 10.1073/pnas.1018493108.Epub2011 May 31. PubMed PMID: 21628588; PubMed Central PMCID: PMC3116419. Comprehensive study showing that osteogenic activity of transcription factor Runx2 is controlled by a multiplicity of miRNAs
    • • Zhang Y, Xie RL, Croce CM, Stein JL, Lian JB, van Wijnen AJ, et al. A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. Proc Natl Acad Sci U S A. 2011;108:9863-8. doi: 10.1073/pnas.1018493108.Epub2011 May 31. PubMed PMID: 21628588; PubMed Central PMCID: PMC3116419. Comprehensive study showing that osteogenic activity of transcription factor Runx2 is controlled by a multiplicity of miRNAs.
    • (2011) Proc Natl Acad Sci U S A. , vol.108 , pp. 9863-9868
    • Zhang, Y.1    Xie, R.L.2    Croce, C.M.3    Stein, J.L.4    Lian, J.B.5    Van Wijnen, A.J.6
  • 35
    • 84862699407 scopus 로고    scopus 로고
    • Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2
    • doi: 10.1074/jbc.M112.340398. Epub 2012 Apr 27. PubMed PMID: 22544738; PubMed Central PMCID: PMC3381153. Key paper revealing a miRNA-transcription factor network that regulates mesenchymal lineage allocation
    • •• Zhang Y, Xie RL, Gordon J, LeBlanc K, Stein JL, Lian JB, et al. Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2. J Biol Chem. 2012;287:21926-35. doi: 10.1074/jbc.M112.340398. Epub 2012 Apr 27. PubMed PMID: 22544738; PubMed Central PMCID: PMC3381153. Key paper revealing a miRNA-transcription factor network that regulates mesenchymal lineage allocation.
    • (2012) J Biol Chem. , vol.287 , pp. 21926-21935
    • Zhang, Y.1    Xie, R.L.2    Gordon, J.3    Leblanc, K.4    Stein, J.L.5    Lian, J.B.6
  • 36
    • 84862624955 scopus 로고    scopus 로고
    • MiR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2
    • doi: 10.1083/jcb.201201057. Epub 2012 May 7. PubMed PMID: 22564414; PubMed Central PMCID: PMC3352956. First paper to demonstrate a skeletal phenotype linked to a specific microRNA expressed in osteogenic cells
    • •• Wei J, Shi Y, Zheng L, Zhou B, Inose H, Wang J, et al. miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol. 2012;197:509-21. doi: 10.1083/jcb.201201057. Epub 2012 May 7. PubMed PMID: 22564414; PubMed Central PMCID: PMC3352956. First paper to demonstrate a skeletal phenotype linked to a specific microRNA expressed in osteogenic cells.
    • (2012) J Cell Biol. , vol.197 , pp. 509-521
    • Wei, J.1    Shi, Y.2    Zheng, L.3    Zhou, B.4    Inose, H.5    Wang, J.6
  • 37
    • 77149136767 scopus 로고    scopus 로고
    • MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation
    • 10.1002/stem.288 20039258 PubMed PMID: 20039258; PubMed Central PMCID: PMC2837600
    • Huang J, Zhao L, Xing L, Chen D. MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells. 2010;28:357-64. doi: 10.1002/stem.288. PubMed PMID: 20039258; PubMed Central PMCID: PMC2837600.
    • (2010) Stem Cells. , vol.28 , pp. 357-364
    • Huang, J.1    Zhao, L.2    Xing, L.3    Chen, D.4
  • 38
    • 79953327693 scopus 로고    scopus 로고
    • A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation
    • 10.1074/jbc.M110.176099 21324897 10.1074/jbc.M110.176099 Epub2011 Feb 15. PubMed PMID: 21324897; PubMed Central PMCID: PMC3069436
    • Hu R, Liu W, Li H, Yang L, Chen C, Xia ZY, et al. A Runx2/miR-3960/miR- 2861 regulatory feedback loop during mouse osteoblast differentiation. J Biol Chem. 2011;286:12328-39. doi: 10.1074/jbc.M110.176099.Epub2011 Feb 15. PubMed PMID: 21324897; PubMed Central PMCID: PMC3069436.
    • (2011) J Biol Chem , vol.286 , pp. 12328-12339
    • Hu, R.1    Liu, W.2    Li, H.3    Yang, L.4    Chen, C.5    Xia, Z.Y.6
  • 39
    • 84872687459 scopus 로고    scopus 로고
    • MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling
    • 10.4161/rna.8.5.16043.Epub2011Jul28 21743293 10.4161/rna.8.5.16043
    • Zhang JF, Fu WM, He ML, Xie WD, Lv Q, Wan G, et al. MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling. RNA Biol. 2011;8:829-38. doi: 10.4161/rna.8.5.16043.Epub2011Jul28.
    • (2011) RNA Biol , vol.8 , pp. 829-838
    • Zhang, J.F.1    Fu, W.M.2    He, M.L.3    Xie, W.D.4    Lv, Q.5    Wan, G.6
  • 40
    • 84862487811 scopus 로고    scopus 로고
    • MiR-93/Sp7 function loop mediates osteoblast mineralization
    • 10.1002/jbmr.1621 22467200 10.1002/jbmr.1621 PubMed PMID: 22467200
    • Yang L, Cheng P, Chen C, He HB, Xie GQ, Zhou HD, et al. miR-93/Sp7 function loop mediates osteoblast mineralization. J Bone Miner Res. 2012;27:1598-606. doi: 10.1002/jbmr.1621. PubMed PMID: 22467200.
    • (2012) J Bone Miner Res , vol.27 , pp. 1598-1606
    • Yang, L.1    Cheng, P.2    Chen, C.3    He, H.B.4    Xie, G.Q.5    Zhou, H.D.6    Xie, H.7    Wu, X.P.8    Luo, X.H.9
  • 41
    • 80655125005 scopus 로고    scopus 로고
    • MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix
    • 10.1091/mbc.E11-04-0356 21880893 10.1091/mbc.E11-04-0356 Epub2011 Aug 31. PubMed PMID: 21880893; PubMed Central PMCID: PMC3204058
    • Zhang JF, Fu WM, He ML, Wang H, Wang WM, Yu SC, et al. MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix. Mol Biol Cell. 2011;22:3955-61. doi: 10.1091/mbc.E11-04-0356.Epub2011 Aug 31. PubMed PMID: 21880893; PubMed Central PMCID: PMC3204058.
    • (2011) Mol Biol Cell. , vol.22 , pp. 3955-3961
    • Zhang, J.F.1    Fu, W.M.2    He, M.L.3    Wang, H.4    Wang, W.M.5    Yu, S.C.6
  • 42
    • 84872094361 scopus 로고    scopus 로고
    • MiR-214 targets ATF4 to inhibit bone formation
    • 10.1038/nm.3026 23223004 10.1038/nm.3026 Epub 2012 Dec 9. PubMed PMID: 23223004
    • Wang X, Guo B, Li Q, Peng J, Yang Z, Wang A, et al. miR-214 targets ATF4 to inhibit bone formation. Nat Med. 2013;19:93-100. doi: 10.1038/nm.3026. Epub 2012 Dec 9. PubMed PMID: 23223004.
    • (2013) Nat Med , vol.19 , pp. 93-100
    • Wang, X.1    Guo, B.2    Li, Q.3    Peng, J.4    Yang, Z.5    Wang, A.6
  • 43
    • 72849121740 scopus 로고    scopus 로고
    • A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans
    • 10.1172/JCI39832 19920351 10.1172/JCI39832 Epub 2009 Nov 16. Erratum in: J Clin Invest. 2010;120:395. Liao, Er-Yuan [removed]. PubMed PMID: 19920351; PubMed Central PMCID: PMC2786801
    • Li H, Xie H, Liu W, Hu R, Huang B, Tan YF, et al. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Invest. 2009;119:3666-77. doi: 10.1172/JCI39832. Epub 2009 Nov 16. Erratum in: J Clin Invest. 2010;120:395. Liao, Er-Yuan [removed]. PubMed PMID: 19920351; PubMed Central PMCID: PMC2786801.
    • (2009) J Clin Invest , vol.119 , pp. 3666-3677
    • Li, H.1    Xie, H.2    Liu, W.3    Hu, R.4    Huang, B.5    Tan, Y.F.6
  • 44
    • 78650946447 scopus 로고    scopus 로고
    • Polymorphisms in predicted miRNA binding sites and osteoporosis
    • doi: 10.1002/jbmr.186. PubMed PMID: 20641033; PubMed Central PMCID: PMC3179316. Solid study that characterizes a miRNA dependent polymorphisms linked to bone mineral density in human patients
    • • Lei SF, Papasian CJ, Deng HW. Polymorphisms in predicted miRNA binding sites and osteoporosis. J Bone Miner Res. 2011;26:72-8. doi: 10.1002/jbmr.186. PubMed PMID: 20641033; PubMed Central PMCID: PMC3179316. Solid study that characterizes a miRNA dependent polymorphisms linked to bone mineral density in human patients.
    • (2011) J Bone Miner Res. , vol.26 , pp. 72-78
    • Lei, S.F.1    Papasian, C.J.2    Deng, H.W.3
  • 45
    • 0037184027 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2
    • 12110689 10.1074/jbc.M206057200 Epub 2002 Aug 28. PubMed PMID: 12110689
    • Xiao G, Jiang D, Gopalakrishnan R, Franceschi RT. Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem. 2002;277:36181-7. Epub 2002 Aug 28. PubMed PMID: 12110689.
    • (2002) J Biol Chem , vol.277 , pp. 36181-36187
    • Xiao, G.1    Jiang, D.2    Gopalakrishnan, R.3    Franceschi, R.T.4
  • 46
    • 66149160499 scopus 로고    scopus 로고
    • The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts
    • 10.1002/jcb.22108 19259985 10.1002/jcb.22108 PubMed PMID: 19259985; PubMed Central PMCID: PMC2918404
    • Teplyuk NM, Haupt LM, Ling L, Dombrowski C, Mun FK, Nathan SS, et al. The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts. J Cell Biochem. 2009;107:144-54. doi: 10.1002/jcb.22108. PubMed PMID: 19259985; PubMed Central PMCID: PMC2918404.
    • (2009) J Cell Biochem , vol.107 , pp. 144-154
    • Teplyuk, N.M.1    Haupt, L.M.2    Ling, L.3    Dombrowski, C.4    Mun, F.K.5    Nathan, S.S.6
  • 47
    • 84863531464 scopus 로고    scopus 로고
    • MiRNA-34c regulates Notch signaling during bone development
    • doi: 10.1093/hmg/dds129. Epub 2012 Apr 12. PubMed PMID: 22498974; PubMed Central PMCID: PMC3373245.Compelling paper that examines the miRNA dependent interplay between osteoclasts and osteoblasts
    • • Bae Y, Yang T, Zeng HC, Campeau PM, Chen Y, Bertin T, et al. miRNA-34c regulates Notch signaling during bone development. Hum Mol Genet. 2012;21:2991-3000. doi: 10.1093/hmg/dds129. Epub 2012 Apr 12. PubMed PMID: 22498974; PubMed Central PMCID: PMC3373245.Compelling paper that examines the miRNA dependent interplay between osteoclasts and osteoblasts.
    • (2012) Hum Mol Genet. , vol.21 , pp. 2991-3000
    • Bae, Y.1    Yang, T.2    Zeng, H.C.3    Campeau, P.M.4    Chen, Y.5    Bertin, T.6
  • 48
    • 0141705433 scopus 로고    scopus 로고
    • Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts
    • 14500368
    • Pratap J, Galindo M, Zaidi SK, Vradii D, Bhat BM, Robinson JA, et al. Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts. Cancer Res. 2003;63:5357-62.
    • (2003) Cancer Res , vol.63 , pp. 5357-5362
    • Pratap, J.1    Galindo, M.2    Zaidi, S.K.3    Vradii, D.4    Bhat, B.M.5    Robinson, J.A.6
  • 49
    • 55549120557 scopus 로고    scopus 로고
    • Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors
    • 10.1074/jbc.M802453200 18625716 10.1074/jbc.M802453200 Epub 2008 Jul 14. PubMed PMID: 18625716; PubMed Central PMCID: PMC2562077
    • Teplyuk NM, Galindo M, Teplyuk VI, Pratap J, Young DW, Lapointe D, et al. Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 2008;283:27585-97. doi: 10.1074/jbc.M802453200. Epub 2008 Jul 14. PubMed PMID: 18625716; PubMed Central PMCID: PMC2562077.
    • (2008) J Biol Chem , vol.283 , pp. 27585-27597
    • Teplyuk, N.M.1    Galindo, M.2    Teplyuk, V.I.3    Pratap, J.4    Young, D.W.5    Lapointe, D.6
  • 50
    • 35548957247 scopus 로고    scopus 로고
    • MicroRNAs join the p53 network-another piece in the tumor-suppression puzzle
    • 17914404 10.1038/nrc2232 Review. PubMed PMID: 17914404
    • He L, He X, Lowe SW, Hannon GJ. microRNAs join the p53 network-another piece in the tumor-suppression puzzle. Nat Rev Cancer. 2007;7:819-22. Review. PubMed PMID: 17914404.
    • (2007) Nat Rev Cancer , vol.7 , pp. 819-822
    • He, L.1    He, X.2    Lowe, S.W.3    Hannon, G.J.4
  • 51
    • 52349083651 scopus 로고    scopus 로고
    • Serum microRNAs are promising novel biomarkers
    • 10.1371/journal.pone.0003148 18773077 10.1371/journal.pone.0003148 PubMed PMID: 18773077; PubMed Central PMCID: PMC2519789
    • Gilad S, Meiri E, Yogev Y, Benjamin S, Lebanony D, Yerushalmi N, et al. Serum microRNAs are promising novel biomarkers. PLoS One. 2008;3:e3148. doi: 10.1371/journal.pone.0003148. PubMed PMID: 18773077; PubMed Central PMCID: PMC2519789.
    • (2008) PLoS One , vol.3 , pp. 3148
    • Gilad, S.1    Meiri, E.2    Yogev, Y.3    Benjamin, S.4    Lebanony, D.5    Yerushalmi, N.6
  • 52
    • 48749122914 scopus 로고    scopus 로고
    • Circulating microRNAs as stable blood-based markers for cancer detection
    • 10.1073/pnas.0804549105 18663219 10.1073/pnas.0804549105 Epub2008Jul28. PubMed PMID: 18663219; PubMed Central PMCID: PMC2492472
    • Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2008;105:10513-8. doi: 10.1073/pnas. 0804549105. Epub2008Jul28. PubMed PMID: 18663219; PubMed Central PMCID: PMC2492472.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10513-10518
    • Mitchell, P.S.1    Parkin, R.K.2    Kroh, E.M.3    Fritz, B.R.4    Wyman, S.K.5    Pogosova-Agadjanyan, E.L.6
  • 53
    • 84859595006 scopus 로고    scopus 로고
    • MiR-133a in human circulating monocytes: A potential biomarker associated with postmenopausal osteoporosis
    • doi: 10.1371/journal.pone.0034641. Epub 2012 Apr 10. PubMed PMID: 22506038; PubMed Central PMCID: PMC3323546. First clinically relevant paper indicating the potential utility of circulating microRNAs in predicting differences in bone mineral density in human patients
    • •• Wang Y, Li L, Moore BT, Peng XH, Fang X, Lappe JM, et al. MiR-133a in human circulating monocytes: a potential biomarker associated with postmenopausal osteoporosis. PLoS One. 2012;7:e34641. doi: 10.1371/journal.pone. 0034641. Epub 2012 Apr 10. PubMed PMID: 22506038; PubMed Central PMCID: PMC3323546. First clinically relevant paper indicating the potential utility of circulating microRNAs in predicting differences in bone mineral density in human patients.
    • (2012) PLoS One. , vol.7
    • Wang, Y.1    Li, L.2    Moore, B.T.3    Peng, X.H.4    Fang, X.5    Lappe, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.