AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences

Proteins: Structure, Function and Bioinformatics

Volumn 83, Issue 8, 2015, Pages 1385-1406

  Lapidoth, Gideon D ^a   Baran, Dror ^a   Pszolla, Gabriele M ^a   Norn, Christoffer ^a   Alon, Assaf ^a   Tyka, Michael D ^b   Fleishman, Sarel J ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b GOOGLE INC   (United States)

Author keywords

Canonical conformations; CDRs; Computational protein design; Conformation sequence optimization; Fuzzy logic design; Modular segments; Rosetta; V(D)J recombination

Indexed keywords

ANTIBODY; EPITOPE; COMPLEMENTARITY DETERMINING REGION;

ANTIBODY AFFINITY; ANTIBODY ENGINEERING; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CONFORMATION; FUZZY LOGIC; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DOCKING; NATURAL SELECTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN STABILITY; SURFACE AREA; VDJ RECOMBINATION; ALGORITHM; AMINO ACID SEQUENCE; BIOLOGY; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; HUMAN; MOLECULAR GENETICS; PROCEDURES; SEQUENCE ANALYSIS;

RUMEX;

ALGORITHMS; AMINO ACID SEQUENCE; COMPLEMENTARITY DETERMINING REGIONS; COMPUTATIONAL BIOLOGY; FUZZY LOGIC; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SEQUENCE ANALYSIS, PROTEIN;

EID: 84937736814     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24779     Document Type: Article

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