Structure-based design of supercharged, highly thermoresistant antibodies

Chemistry and Biology

Volumn 19, Issue 4, 2012, Pages 449-455

  Miklos, Aleksandr E ^a   Kluwe, Christien ^a   Der, Bryan S ^b   Pai, Supriya ^a   Sircar, Aroop ^c   Hughes, Randall A ^a   Berrondo, Monica ^c   Xu, Jianqing ^c   Codrea, Vlad ^a   Buckley, Patricia E ^d   Calm, Alena M ^d   Welsh, Heather S ^d   Warner, Candice R ^e   Zacharko, Melody A ^e   Carney, James P ^d   Gray, Jeffrey J ^c   Georgiou, George ^a   Kuhlman, Brian ^b   Ellington, Andrew D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c Johns Hopkins University   (United States)

^d Biosciences Division   (United States)

^e EXCET INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI MS2 ANTIBODY; ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; CYTOPLASM; CYTOSOL; DISULFIDE BOND; ENERGY BALANCE; HEAT TOLERANCE; HYDROGEN BOND; LIGAND BINDING; MOLECULAR BIOLOGY; MUTATION; OXIDATION REDUCTION POTENTIAL; PH; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN STRUCTURE; ROSETTA COMPUTATIONAL DESIGN; SIMULATION; STATIC ELECTRICITY;

HYDROGEN BONDING; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SINGLE-CHAIN ANTIBODIES; SOFTWARE; TEMPERATURE;

EID: 84860145921     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.01.018     Document Type: Article

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