Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses

Science

Volumn 337, Issue 6091, 2012, Pages 183-186

  Burton, Dennis R ^a,b   Poignard, Pascal ^a,c   Stanfield, Robyn L ^a   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b HARVARD UNIVERSITY   (United States)

^c INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENVELOPE PROTEIN; GLYCOPROTEIN E1; GLYCOPROTEIN E2; HEMAGGLUTININ; NEUTRALIZING ANTIBODY;

ANTIBODY; ANTIGEN; IMMUNE SYSTEM; MOLECULAR ANALYSIS; VACCINE; VIRUS;

ANTIBODY RESPONSE; ANTIGENICITY; CROSS REACTION; CRYSTAL STRUCTURE; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; INFLUENZA VIRUS A H2N2; NONHUMAN; PRIORITY JOURNAL; REVIEW; VIRUS; VIRUS ENTRY; VIRUS ENVELOPE;

HEPACIVIRUS;

EID: 84863774072     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1225416     Document Type: Review

References (79)

1. S. Duffy, L. A. Shackelton, E. C. Holmes, Nat. Rev. Genet. 9, 267 (2008).
2. United Nations Program on HIV/AIDS (UNAIDS), "How to get to zero: Faster. Smarter. Better." UNAIDS World Aids Day Report (UNAIDS, Geneva, 2011).
3. D. Graham-Rowe, Nature 480, S2 (2011).
4. C. F. Basler, P. V. Aguilar, Antiviral Res. 79, 166 (2008).
5. C. W. Shepard, L. Finelli, M. J. Alter, Lancet Infect. Dis. 5, 558 (2005).
6. "Combating the silent epidemic of viral hepatitis: Action plan for the prevention, care and treatment of viral hepatitis" (United States Department of Health and Human Services, Washington, DC, 2011); www.hhs.gov/ash/initiatives/hepatitis/actionplan- viralhepatitis2011.pdf.
7. P. N. Graves, J. L. Schulman, J. F. Young, P. Palese, Virology 126, 106 (1983).
8. L. K. Vujcic, G. V. Quinnan Jr., AIDS Res. Hum. Retroviruses 11, 783 (1995).
9. D. R. Burton, Nat. Rev. Immunol. 2, 706 (2002).
10. A. Buchacher et al., in Vaccines '92: Modern Approaches to New Vaccines Including Prevention of AIDS, F. Brown, R. Chanock, H. S. Ginsberg, R. Lerner, Eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1992), pp. 191-194.
11. C. F. Barbas 3rd et al., Proc. Natl. Acad. Sci. U.S.A. 89, 9339 (1992).
12. A. J. Conley et al., Proc. Natl. Acad. Sci. U.S.A. 91, 3348 (1994).
13. D. R. Burton et al., Science 266, 1024 (1994).
14. Y. Okuno, Y. Isegawa, F. Sasao, S. Ueda, J. Virol. 67, 2552 (1993).
15. A. Owsianka, R. F. Clayton, L. D. Loomis-Price, J. A. McKeating, A. H. Patel, J. Gen. Virol. 82, 1877 (2001).
16. A. Owsianka et al., J. Virol. 79, 11095 (2005).
17. D. R. Burton et al., Nat. Immunol. 5, 233 (2004).
18. J. R. Mascola, D. C. Montefiori, Annu. Rev. Immunol. 28, 413 (2010).
19. J. R. Mascola, Curr. Mol. Med. 3, 209 (2003).
20. A. J. Hessell et al., Nat. Med. 15, 951 (2009).
21. A. J. Hessell et al., PLoS Pathog. 5, e1000433 (2009).
22. A. J. Hessell et al., J. Virol. 84, 1302 (2010).
23. D. R. Burton, R. L. Stanfield, I. A. Wilson, Proc. Natl. Acad. Sci. U.S.A. 102, 14943 (2005).
24. D. C. Douek, P. D. Kwong, G. J. Nabel, Cell 124, 677 (2006).
25. L. Stamatatos, L. Morris, D. R. Burton, J. R. Mascola, Nat. Med. 15, 866 (2009).
26. L. M. Walker et al., Science 326, 285 (2009); 10.1126/ science1178746.
27. X. Wu et al., Science 329, 856 (2010); 10.1126/ science.1187659.
28. L. M. Walker et al., Nature 477, 466 (2011).
29. J. F. Scheid et al., Science 333, 1633 (2011); 10.1126/ science.1207227.
30. X. Wu et al., Science 333, 1593 (2011); 10.1126/ science.1207532.
31. R. Diskin et al., Science 334, 1289 (2011); 10.1126/ science.1213782.
32. T. Zhou et al., Science 329, 811 (2010); 10.1126/ science.1192819.
33. R. Pejchal et al., Science 334, 1097 (2011); 10.1126/ science.1213256.
34. J. S. McLellan et al., Nature 480, 336 (2011).
35. D. Corti et al., PLoS ONE 5, e8805 (2010).
36. M. Huber et al., J. Virol. 84, 10700 (2010).
37. X. Xiao et al., Biochem. Biophys. Res. Commun. 390, 404 (2009).
38. M. Bonsignori et al., J. Virol. 85, 4998 (2011).
39. A. K. Kashyap et al., Proc. Natl. Acad. Sci. U.S.A. 105, 5986 (2008).
40. M. Throsby et al., PLoS ONE 3, e3942 (2008).
41. D. C. Ekiert et al., Science 324, 246 (2009); 10.1126/ science.1171491.
42. J. Sui et al., Nat. Struct. Mol. Biol. 16, 265 (2009).
43. D. C. Ekiert et al., Science 333, 843 (2011); 10.1126/ science.1204839.
44. D. Corti et al., Science 333, 850 (2011); 10.1126/ science.1205669.
45. N. Ohshima et al., J. Virol. 85, 11048 (2011).
46. J. C. Krause et al., J. Immunol. 187, 3704 (2011).
47. J. C. Krause et al., J. Virol. 85, 10905 (2011).
48. J. R. Whittle et al., Proc. Natl. Acad. Sci. U.S.A. 108, 14216 (2011).
49. R. Yoshida et al., PLoS Pathog. 5, e1000350 (2009).
50. M. T. Osterholm, N. S. Kelley, A. Sommer, E. A. Belongia, Lancet Infect. Dis. 12, 36 (2012).
51. G. Bommakanti et al., Proc. Natl. Acad. Sci. U.S.A. 107, 13701 (2010).
52. J. Steel et al, mBiol. 1, e000018-10 (2010).
53. C. J. Wei et al., Science 329, 1060 (2010); 10.1126/ science1192517.
54. J. Wrammert et al., J. Exp. Med. 208, 181 (2011).
55. G. M. Li et al., Proc. Natl. Acad. Sci. U.S.A. 109, 9047 (2012).
56. S. J. Fleishman et al., Science 332, 816 (2011).
57. T. J. Broering et al., J. Virol. 83, 12473 (2009).
58. D. J. Schofield et al., Hepatology 42, 1055 (2005).
59. D. X. Johansson et al., Proc. Natl. Acad. Sci. U.S.A. 104, 16269 (2007).
60. M. Law et al., Nat. Med. 14, 25 (2008).
61. Z. Y. Keck et al., J. Virol. 82, 6061 (2008).
62. M. C. Sabo et al., J. Virol. 85, 7005 (2011).
63. E. Giang et al., Proc. Natl. Acad. Sci. U.S.A. 109, 6205 (2012).
64. J. C. Meunier et al., J. Virol. 82, 966 (2008).
65. L. Kong et al., Proc. Natl. Acad. Sci. U.S.A. 109, 9499 (2012).
66. S. B. Halstead, Adv. Virus Res. 60, 421 (2003).
67. P. R. Johnson et al., Nat. Med. 15, 901 (2009).
68. A. B. Balazs et al., Nature 481, 81 (2012).
69. W. Gerhard, Curr. Top. Microbiol. Immunol. 260, 171 (2001).
70. R. Eren et al., J. Virol. 80, 2654 (2006).
71. M. L. Azoitei et al., Science 334, 373 (2011).
72. J. S. McLellan et al., J. Mol. Biol. 409, 853 (2011).
73. J. Liu, A. Bartesaghi, M. J. Borgnia, G. Sapiro, S. Subramaniam, Nature 455, 109 (2008).
74. R. M. Cardoso et al., J. Mol. Biol. 365, 1533 (2007).
75. S. Bryson, J. P. Julien, R. C. Hynes, E. F. Pai, J. Virol. 83, 11862 (2009).
76. Y. D. Kwon et al., Proc. Natl. Acad. Sci. U.S.A. 109, 5663 (2012).
77. A. Bohne-Lang, C. W. von der Lieth, Nucleic Acids Res. 33, W214 (2005).
78. The PyMOL Molecular Graphics System, Version 1.5.0.1. Schrödinger, LLC.
79. R. Xu et al., Science 328, 357 (2010).