Improving the species cross-reactivity of an antibody using computational design

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 14, 2009, Pages 3744-3747

  Farady, Christopher J ^a   Sellers, Benjamin D ^a   Jacobson, Matthew P ^a   Craik, Charles S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antibody maturation; Computational design; Protein engineering; Species cross reactivity

Indexed keywords

ANTIBODY; ARGININE; E2 ANTIBODY; EPITHIN; MATRIPTASE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ARTICLE; COMPUTER MODEL; CROSS REACTION; ENZYME INHIBITION; MOUSE; NONHUMAN; ORTHOLOGY; PREDICTION; PROTEIN ENGINEERING; SPECIES DIFFERENCE; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES; COMPUTATIONAL BIOLOGY; CROSS REACTIONS; DRUG DESIGN; HUMANS; MICE; MUTATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SPECIES SPECIFICITY; THERMODYNAMICS;

ANIMALIA;

EID: 67649647815     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.005     Document Type: Article

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