Computational design of ligand-binding proteins with high affinity and selectivity

Nature

Volumn 501, Issue 7466, 2013, Pages 212-216

  Tinberg, Christine E ^a   Khare, Sagar D ^a,f   Dou, Jiayi ^b,c   Doyle, Lindsey ^d   Nelson, Jorgen W ^c   Schena, Alberto ^e   Jankowski, Wojciech ^f   Kalodimos, Charalampos G ^f   Johnsson, Kai ^e   Stoddard, Barry L ^d   Baker, David ^a,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b University of Washington   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

^e EPFL   (Switzerland)

^f RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DIGOXIGENIN; ESTRADIOL; PROGESTERONE;

ANTIGEN; EVOLUTION; LIGAND; PROTEIN; STEROID; X-RAY;

ARTICLE; BINDING AFFINITY; BIOSENSOR; CRYSTAL STRUCTURE; ENTROPY; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; STEROID BINDING;

BINDING SITES; BIOTECHNOLOGY; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DIGOXIGENIN; DRUG DESIGN; ESTRADIOL; LIGANDS; MODELS, MOLECULAR; PROGESTERONE; PROTEIN BINDING; PROTEINS; REPRODUCIBILITY OF RESULTS; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 84884166196     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12443     Document Type: Article

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