Computational design of a protein-based enzyme inhibitor

Journal of Molecular Biology

Volumn 425, Issue 18, 2013, Pages 3563-3575

  Procko, Erik ^a   Hedman, Rickard ^b   Hamilton, Keith ^c   Seetharaman, Jayaraman ^d   Fleishman, Sarel J ^e   Su, Min ^d   Aramini, James ^c   Kornhaber, Gregory ^c   Hunt, John F ^d   Tong, Liang ^d   Montelione, Gaetano T ^c,f   Baker, David ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c RUTGERS UNIVERSITY   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^f RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Hot spot; Protein engineering and design; Protein protein interactions; Rosetta molecular modeling program

Indexed keywords

ENZYME INHIBITOR; LYSOZYME;

ARTICLE; COMPUTER AIDED DESIGN; CONTROLLED STUDY; CRYSTALLOGRAPHY; EGG; ENERGY; ENZYME ACTIVE SITE; ENZYME INHIBITION; FEMALE; MOLECULAR EVOLUTION; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; ORIENTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

EID: 84883277095     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.06.035     Document Type: Article

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