Single-chain antibodies for the conformation-specific blockade of activated platelet integrin αIIbβ3 designed by subtractive selection from naive human phage libraries

FASEB Journal

Volumn 18, Issue 14, 2004, Pages 1704-1706

  Schwarz, Meike ^a,b   Röttgen, Peter ^c   Takada, Yoshiazuku ^b   Le Gall, Fabrice ^c   Knackmuss, Stefan ^c   Bassler, Nicole ^a   Büttner, Claudia ^c   Little, Melvyn ^c   Bode, Christoph ^a   Peter, Karlheinz ^d  

^a UNIVERSITY OF FREIBURG   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Affimed GmbH   (Germany)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABCIXIMAB; EPITOPE; FIBRINOGEN; FIBRINOGEN RECEPTOR ANTAGONIST; INTEGRIN RECEPTOR; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG DESIGN; EPITOPE MAPPING; HUMAN; HUMAN CELL; LIGAND BINDING; PHAGE DISPLAY; PRIORITY JOURNAL; RECEPTOR BINDING; THROMBOCYTE ACTIVATION;

ANIMALS; ANTIBODY AFFINITY; BINDING SITES, ANTIBODY; CHO CELLS; CRICETINAE; CRICETULUS; FIBRINOGEN; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; PEPTIDE LIBRARY; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN CONFORMATION;

EID: 9444277172     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.04-1513fje     Document Type: Article

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