Computational design of proteins targeting the conserved stem region of influenza hemagglutinin

Science

Volumn 332, Issue 6031, 2011, Pages 816-821

  Fleishman, Sarel J ^a   Whitehead, Timothy A ^a   Ekiert, Damian C ^b   Dreyfus, Cyrille ^b   Corn, Jacob E ^a,d   Strauch, Eva Maria ^a   Wilson, Ian A ^b   Baker, David ^a,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; INFLUENZA VIRUS HEMAGGLUTININ; ISOLEUCINE; LEUCINE; METHIONINE; PHENYLALANINE; SCAFFOLD PROTEIN; VALINE;

AMINO ACID; ANTIBODY; COMPUTER AIDED DESIGN; IDENTIFICATION METHOD; INFLUENZA; INHIBITION; MOLECULAR ANALYSIS; PH; PROTEIN; VIRUS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; COMPUTER ANALYSIS; CONFORMATIONAL TRANSITION; CROSS REACTION; CRYSTAL STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; INFLUENZA VIRUS A H1N1; MOLECULAR DOCKING; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; SOLVATION; SPANISH INFLUENZA; STATIC ELECTRICITY; STRUCTURAL GENOMICS; VIRUS INHIBITION;

ALGORITHMS; AMINO ACID SEQUENCE; BINDING SITES; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; PROTEINS; SOFTWARE;

EID: 79956017135     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1202617     Document Type: Article

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29. Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.