A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells

Cell

Volumn 157, Issue 7, 2014, Pages 1644-1656

  Procko, Erik ^a   Berguig, Geoffrey Y ^b   Shen, Betty W ^c   Song, Yifan ^a   Frayo, Shani ^c   Convertine, Anthony J ^b   Margineantu, Daciana ^c   Booth, Garrett ^c   Correia, Bruno E ^d   Cheng, Yuanhua ^b   Schief, William R ^d   Hockenbery, David M ^c   Press, Oliver W ^c   Stoddard, Barry L ^c   Stayton, Patrick S ^b   Baker, David ^a,e  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b University of Washington   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; BIM PROTEIN; BORTEZOMIB; COPOLYMER; CYCLOPHOSPHAMIDE; CYTOCHROME C; EPITOPE; PROLINE; PROTEIN BCL 2; BHRF1 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; BHRF1 GENE; BINDI GENE; BINDING AFFINITY; CANCER INHIBITION; CANCER SURVIVAL; CODON; CONTROLLED STUDY; CRYSTAL STRUCTURE; EPSTEIN BARR VIRUS; ESCHERICHIA COLI; FLUORESCENCE ACTIVATED CELL SORTING; GEL PERMEATION CHROMATOGRAPHY; HYDROPHOBICITY; LIGAND BINDING; MICELLE; MOUSE; MUTAGENESIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SIDE CHAIN GRAFTING; SITE DIRECTED MUTAGENESIS; TARGET CELL; TUMOR VOLUME; VIRUS GENE; YEAST; CELL SURVIVAL; COMPUTER AIDED DESIGN; EPSTEIN BARR VIRUS INFECTION; HUMAN; HUMAN CELL; LABORATORY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; TUMOR GROWTH; XENOGRAFT;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; EPSTEIN-BARR VIRUS INFECTIONS; HERPESVIRUS 4, HUMAN; HETEROGRAFTS; HUMANS; LYMPHOMA, B-CELL; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASM TRANSPLANTATION; PROTEIN ENGINEERING; PROTEINS; SEQUENCE ALIGNMENT; VIRAL PROTEINS;

EID: 84903142850     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2014.04.034     Document Type: Article

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