Computational design of a pH-sensitive IgG binding protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 2, 2014, Pages 675-680

  Strauch, Eva Maria ^a   Fleishman, Sarel J ^a   Baker, David ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Antibody purification; Computational interface design; PH sensitivity

Indexed keywords

IMMUNOGLOBULIN BINDING FACTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; HUMAN; INTERFEROMETRY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STABILITY;

ANTIBODY PURIFICATION; COMPUTATIONAL INTERFACE DESIGN; PH-SENSITIVITY;

CIRCULAR DICHROISM; CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; FLOW CYTOMETRY; GENE LIBRARY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; INTERFEROMETRY; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN INTERACTION DOMAINS AND MOTIFS;

EID: 84892615437     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1313605111     Document Type: Article

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