A comparison of successful and failed protein interface designs highlights the challenges of designing buried hydrogen bonds

Protein Science

Volumn 22, Issue 1, 2013, Pages 74-82

  Benjamin Stranges, P ^a   Kuhlman, Brian ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Computational protein design; Hydrogen bond modeling; Protein interface design; Rosetta

Indexed keywords

HETERODIMER; HOMODIMER;

ARTICLE; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; HYDROGEN BOND; MOLECULAR MODEL; POLARIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION;

COMPUTATIONAL BIOLOGY; HYDROGEN BONDING; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS; STATIC ELECTRICITY;

EID: 84873024403     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2187     Document Type: Article

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