Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

Protein Science

Volumn 15, Issue 5, 2006, Pages 949-960

  Clark, Louis A ^a   Boriack Sjodin, P Ann ^a   Eldredge, John ^a   Fitch, Christopher ^a   Friedman, Bethany ^a   Hanf, Karl J M ^a   Jarpe, Matthew ^a   Liparoto, Stefano F ^a   Li, You ^a   Lugovskoy, Alexey ^a   Miller, Stephan ^a   Rushe, Mia ^a   Sherman, Woody ^a   Simon, Kenneth ^a   Van Vlijmen, Herman ^a  

^a BIOGEN   (United States)

Author keywords

Affinity maturation; Antibody; Binding energy prediction; Computational protein design; Protein protein interactions

Indexed keywords

ANTIBODY; HYDROGEN; INTEGRIN; VERY LATE ACTIVATION ANTIGEN 1;

ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIBODY STRUCTURE; ARTICLE; BINDING AFFINITY; CHEMICAL MUTAGENESIS; CRYSTAL STRUCTURE; DISSOCIATION; HYDROGEN BOND; MATHEMATICAL ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; ANTIBODIES; ANTIBODY AFFINITY; ANTIGEN-ANTIBODY COMPLEX; BINDING SITES, ANTIBODY; COMPUTER-AIDED DESIGN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; IMMUNOGLOBULINS; INTEGRIN ALPHA1BETA1; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646146483     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.052030506     Document Type: Article

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