메뉴 건너뛰기




Volumn 10, Issue , 2015, Pages 4321-4340

Central nervous system toxicity of metallic nanoparticles

Author keywords

Autophagy; Blood brain barrier; Nanomaterials; Neurotoxicity; ROS

Indexed keywords

CARBON NANOTUBE; DRUG CARRIER; MULTI WALLED NANOTUBE; NANOPARTICLE; METAL NANOPARTICLE;

EID: 84936887301     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S78308     Document Type: Review
Times cited : (167)

References (174)
  • 1
    • 85123316636 scopus 로고    scopus 로고
    • Nanomaterials and nanoparticles: Sources and toxicity
    • Buzea C, Pacheco Blandino II, Robbie K. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases. 2007;2(4):17–71.
    • (2007) Biointerphases , vol.2 , Issue.4 , pp. 17-71
    • Buzea, C.1    Pacheco Blandino, I.I.2    Robbie, K.3
  • 2
    • 84871445326 scopus 로고    scopus 로고
    • Considerations on the EU definition of a nanomaterial: Science to support policy making
    • Bleeker EAJ, de Jong WH, Geertsma RE, et al. Considerations on the EU definition of a nanomaterial: science to support policy making. Regul Toxicol Pharmacol. 2013;65(1):119–125.
    • (2013) Regul Toxicol Pharmacol , vol.65 , Issue.1 , pp. 119-125
    • Bleeker, E.1    De Jong, W.H.2    Geertsma, R.E.3
  • 3
    • 84883173205 scopus 로고    scopus 로고
    • Engineered nanomaterial uptake and tissue distribution: From cell to organism
    • Kettiger H, Schipanski A, Wick P, Huwyler J. Engineered nanomaterial uptake and tissue distribution: from cell to organism. Int J Nanomedicine. 2013;8:3255–3269.
    • (2013) Int J Nanomedicine , vol.8 , pp. 3255-3269
    • Kettiger, H.1    Schipanski, A.2    Wick, P.3    Huwyler, J.4
  • 4
    • 84868210145 scopus 로고    scopus 로고
    • Demonstration of an olfactory bulb-brain translocation pathway for ZnO nanoparticles in rodent cells in vitro and in vivo
    • Kao YY, Cheng TJ, Yang DM, Wang CT, Chiung YM, Liu PS. Demonstration of an olfactory bulb-brain translocation pathway for ZnO nanoparticles in rodent cells in vitro and in vivo. J Mol Neurosci. 2012;48(2):464–471.
    • (2012) J Mol Neurosci , vol.48 , Issue.2 , pp. 464-471
    • Kao, Y.Y.1    Cheng, T.J.2    Yang, D.M.3    Wang, C.T.4    Chiung, Y.M.5    Liu, P.S.6
  • 5
    • 84878145752 scopus 로고    scopus 로고
    • Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor
    • Wiley DT, Webster P, Gale A, Davis ME. Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor. Proc Natl Acad Sci U S A. 2013;110(21):8662–8667.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.21 , pp. 8662-8667
    • Wiley, D.T.1    Webster, P.2    Gale, A.3    Davis, M.E.4
  • 6
    • 84893215365 scopus 로고    scopus 로고
    • Paracrine signalling of inflammatory cytokines from an in vitro blood brain barrier model upon exposure to polymeric nanoparticles
    • Raghnaill MN, Bramini M, Ye D, et al. Paracrine signalling of inflammatory cytokines from an in vitro blood brain barrier model upon exposure to polymeric nanoparticles. Analyst. 2014;139(5):923–930.
    • (2014) Analyst , vol.139 , Issue.5 , pp. 923-930
    • Raghnaill, M.N.1    Bramini, M.2    Ye, D.3
  • 7
    • 84872675495 scopus 로고    scopus 로고
    • Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus
    • Wu J, Ding TT, Sun J. Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus. Neurotoxicology. 2013;34: 243–253.
    • (2013) Neurotoxicology , vol.34 , pp. 243-253
    • Wu, J.1    Ding, T.T.2    Sun, J.3
  • 8
    • 84862833607 scopus 로고    scopus 로고
    • Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats
    • Han DD, Tian YT, Zhang T, Ren GG, Yang Z. Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats. Int J Nanomedicine. 2011;6:1453–1461.
    • (2011) Int J Nanomedicine , vol.6 , pp. 1453-1461
    • Han, D.D.1    Tian, Y.T.2    Zhang, T.3    Ren, G.G.4    Yang, Z.5
  • 9
    • 78650987932 scopus 로고    scopus 로고
    • Effects of titanium dioxide nano-particles on growth and some histological parameters of zebrafish (Danio rerio) after a long-term exposure
    • Chen JY, Dong X, Xin YY, Zhao MR. Effects of titanium dioxide nano-particles on growth and some histological parameters of zebrafish (Danio rerio) after a long-term exposure. Aquat Toxicol. 2011;101(3–4):493–499.
    • (2011) Aquat Toxicol , vol.101 , Issue.3-4 , pp. 493-499
    • Chen, J.Y.1    Dong, X.2    Xin, Y.Y.3    Zhao, M.R.4
  • 10
    • 33847678943 scopus 로고    scopus 로고
    • RadomskiMW. Nanoparticles: Pharmacological and toxicological significance
    • Medina C, Santos-Martinez MJ, Radomski A, Corrigan OI, RadomskiMW. Nanoparticles: pharmacological and toxicological significance. Br J Pharmacol. 2007;150(5):552–558.
    • (2007) Br J Pharmacol , vol.150 , Issue.5 , pp. 552-558
    • Medina, C.1    Santos-Martinez, M.J.2    Radomski, A.3    Corrigan, O.I.4
  • 11
    • 79957680045 scopus 로고    scopus 로고
    • Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles
    • Hu RP, Zheng L, Zhang T, et al. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. J Hazard Mater. 2011;191(1–3):32–40.
    • (2011) J Hazard Mater , vol.191 , Issue.1-3 , pp. 32-40
    • Hu, R.P.1    Zheng, L.2    Zhang, T.3
  • 12
    • 0030612262 scopus 로고    scopus 로고
    • Polyhydroxylated C60, fullerenol, a novel free-radical trapper, prevented hydrogen peroxide- and cumene hydroperoxide-elicited changes in rat hippocampus in-vitro
    • Tsai MC, Chen YH, Chiang LY. Polyhydroxylated C60, fullerenol, a novel free-radical trapper, prevented hydrogen peroxide- and cumene hydroperoxide-elicited changes in rat hippocampus in-vitro. J Pharm Pharmacol. 1997;49(4):438–445.
    • (1997) J Pharm Pharmacol , vol.49 , Issue.4 , pp. 438-445
    • Tsai, M.C.1    Chen, Y.H.2    Chiang, L.Y.3
  • 14
    • 84856638259 scopus 로고    scopus 로고
    • Clinical development of liposome-based drugs: Formulation, characterization, and therapeutic efficacy
    • Chang HI, Yeh MK. Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy. Int J Nanomedicine. 2012;7:49–60.
    • (2012) Int J Nanomedicine , vol.7 , pp. 49-60
    • Chang, H.I.1    Yeh, M.K.2
  • 15
    • 84857250783 scopus 로고    scopus 로고
    • Gold nanoparticles as novel agents for cancer therapy
    • Jain S, Hirst DG, O’Sullivan JM. Gold nanoparticles as novel agents for cancer therapy. Br J Radiol. 2012;85(1010):101–113.
    • (2012) Br J Radiol , vol.85 , Issue.1010 , pp. 101-113
    • Jain, S.1    Hirst, D.G.2    O’Sullivan, J.M.3
  • 16
    • 84902113412 scopus 로고    scopus 로고
    • Neurotrophic factors in spinal cord injury
    • Boyce VS, Mendell LM. Neurotrophic factors in spinal cord injury. Handb Exp Pharmacol. 2014;220:443–460.
    • (2014) Handb Exp Pharmacol , vol.220 , pp. 443-460
    • Boyce, V.S.1    Mendell, L.M.2
  • 17
    • 84882247304 scopus 로고    scopus 로고
    • The future of the patient-specific Body-on-a-chip
    • Williamson A, Singh S, Fernekorn U, Schober A. The future of the patient-specific Body-on-a-chip. Lab Chip. 2013;13(18):3471–3480.
    • (2013) Lab Chip , vol.13 , Issue.18 , pp. 3471-3480
    • Williamson, A.1    Singh, S.2    Fernekorn, U.3    Schober, A.4
  • 18
    • 84890819985 scopus 로고    scopus 로고
    • Biocompatability of carbon nanotubes with stem cells to treat CNS injuries
    • Bokara KK, Kim JY, Lee YI, Yun K, Webster TJ, Lee JE. Biocompatability of carbon nanotubes with stem cells to treat CNS injuries. Anat Cell Biol. 2013;46(2):85–92.
    • (2013) Anat Cell Biol , vol.46 , Issue.2 , pp. 85-92
    • Bokara, K.K.1    Kim, J.Y.2    Lee, Y.I.3    Yun, K.4    Webster, T.J.5    Lee, J.E.6
  • 19
    • 80051885786 scopus 로고    scopus 로고
    • Interfacing neurons with carbon nanotubes: (re)engineering neuronal signaling
    • Fabbro A, Cellot G, Prato M, Ballerini L. Interfacing neurons with carbon nanotubes: (re)engineering neuronal signaling. Prog Brain Res. 2011;194:241–252.
    • (2011) Prog Brain Res , vol.194 , pp. 241-252
    • Fabbro, A.1    Cellot, G.2    Prato, M.3    Ballerini, L.4
  • 20
    • 33645504776 scopus 로고    scopus 로고
    • Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision
    • Ellis-Behnke RG, Liang YX, You SW, et al. Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc Natl Acad Sci U S A. 2006;103(13): 5054–5059.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.13 , pp. 5054-5059
    • Ellis-Behnke, R.G.1    Liang, Y.X.2    You, S.W.3
  • 21
    • 84925641948 scopus 로고    scopus 로고
    • Multi-porous electroactive poly(L-lactic acid)/polypyrrole composite micro/nano fibrous scaffolds promote neurite outgrowth in PC12 cells
    • Yu QZ, Xu SL, Zhang KH, Shan YM. Multi-porous electroactive poly(L-lactic acid)/polypyrrole composite micro/nano fibrous scaffolds promote neurite outgrowth in PC12 cells. Neural Regen Res. 2013; 8(1):31–38.
    • (2013) Neural Regen Res , vol.8 , Issue.1 , pp. 31-38
    • Yu, Q.Z.1    Xu, S.L.2    Zhang, K.H.3    Shan, Y.M.4
  • 22
    • 78049288200 scopus 로고    scopus 로고
    • High-frequency nanofluidics: A universal formulation of the fluid dynamics of MEMS and NEMS
    • Ekinci KL, Yakhot V, Rajauria S, Colosqui C, Karabacak DM. High-frequency nanofluidics: a universal formulation of the fluid dynamics of MEMS and NEMS. Lab Chip. 2010;10(22):3013–3025.
    • (2010) Lab Chip , vol.10 , Issue.22 , pp. 3013-3025
    • Ekinci, K.L.1    Yakhot, V.2    Rajauria, S.3    Colosqui, C.4    Karabacak, D.M.5
  • 24
    • 84907833300 scopus 로고    scopus 로고
    • Multifunctional 1D magnetic and fluorescent nanoparticle chains for enhanced MRI, fluorescent cell imaging, and combined photothermal/chemotherapy
    • Wang H, Mararenko A, Cao GX, et al. Multifunctional 1D magnetic and fluorescent nanoparticle chains for enhanced MRI, fluorescent cell imaging, and combined photothermal/chemotherapy. ACS Appl Mater Interfaces. 2014;6(17):15309–15317.
    • (2014) ACS Appl Mater Interfaces , vol.6 , Issue.17 , pp. 15309-15317
    • Wang, H.1    Mararenko, A.2    Cao, G.X.3
  • 25
    • 84907321155 scopus 로고    scopus 로고
    • Enhanced contrast efficiency in MRI by PEGylated magnetoliposomes loaded with PEGylated SPION: Effect of SPION coating and micro-environment
    • Carvalho A, Martins MB, Corvo ML, Feio G. Enhanced contrast efficiency in MRI by PEGylated magnetoliposomes loaded with PEGylated SPION: effect of SPION coating and micro-environment. Mater Sci Eng C Mater Biol Appl. 2014;43:521–526.
    • (2014) Mater Sci Eng C Mater Biol Appl , vol.43 , pp. 521-526
    • Carvalho, A.1    Martins, M.B.2    Corvo, M.L.3    Feio, G.4
  • 26
    • 77953942346 scopus 로고    scopus 로고
    • Nanoparticles from lipid-based liquid crystals: Emulsifier influence on morphology and cytotoxicity
    • Murgia S, Falchi AM, Mano M, et al. Nanoparticles from lipid-based liquid crystals: emulsifier influence on morphology and cytotoxicity. J Phys Chem B. 2010;114(10):3518–3525.
    • (2010) J Phys Chem B , vol.114 , Issue.10 , pp. 3518-3525
    • Murgia, S.1    Falchi, A.M.2    Mano, M.3
  • 27
    • 70449523002 scopus 로고    scopus 로고
    • Association of F18-fluoro-ethyl-tyrosin uptake and 5-aminolevulinic acid-induced fluorescence in gliomas
    • Stockhammer F, Misch M, Horn P, Koch A, Fonyuy N, Plotkin M. Association of F18-fluoro-ethyl-tyrosin uptake and 5-aminolevulinic acid-induced fluorescence in gliomas. Acta Neurochir (Wien). 2009;151(11):1377–1383.
    • (2009) Acta Neurochir (Wien) , vol.151 , Issue.11 , pp. 1377-1383
    • Stockhammer, F.1    Misch, M.2    Horn, P.3    Koch, A.4    Fonyuy, N.5    Plotkin, M.6
  • 28
    • 84861463132 scopus 로고    scopus 로고
    • Tissue distribution of inhaled micro- and nano-sized cerium oxide particles in rats: Results from a 28-day exposure study
    • Geraets L, Oomen AG, Schroeter JD, Coleman VA, Cassee FR. Tissue distribution of inhaled micro- and nano-sized cerium oxide particles in rats: results from a 28-day exposure study. Toxicol Sci. 2012;127(2): 463–473.
    • (2012) Toxicol Sci , vol.127 , Issue.2 , pp. 463-473
    • Geraets, L.1    Oomen, A.G.2    Schroeter, J.D.3    Coleman, V.A.4    Cassee, F.R.5
  • 29
    • 84904310183 scopus 로고    scopus 로고
    • Quantitative analysis of drug delivery to the brain via nasal route
    • Kozlovskaya L, Abou-Kaoud M, Stepensky D. Quantitative analysis of drug delivery to the brain via nasal route. J Control Release. 2014;189(10):133–140.
    • (2014) J Control Release , vol.189 , Issue.10 , pp. 133-140
    • Kozlovskaya, L.1    Abou-Kaoud, M.2    Stepensky, D.3
  • 30
    • 84879509747 scopus 로고    scopus 로고
    • Nanotechnology for CNS delivery of bio-therapeutic agents
    • Shah L, Yadav S, Amiji M. Nanotechnology for CNS delivery of bio-therapeutic agents. Drug Deliv Transl Res. 2013;3(4):336–351.
    • (2013) Drug Deliv Transl Res , vol.3 , Issue.4 , pp. 336-351
    • Shah, L.1    Yadav, S.2    Amiji, M.3
  • 31
    • 84877292573 scopus 로고    scopus 로고
    • Diffusion of macromolecules in the brain: Implications for drug delivery
    • Wolak DJ, Thorne RG. Diffusion of macromolecules in the brain: implications for drug delivery. Mol Pharm. 2013;10(5):1492–1504.
    • (2013) Mol Pharm , vol.10 , Issue.5 , pp. 1492-1504
    • Wolak, D.J.1    Thorne, R.G.2
  • 32
    • 34547802614 scopus 로고    scopus 로고
    • Immunohistological markers for staging neurogenesis in adult hippocampus
    • von Bohlen und Halbach O. Immunohistological markers for staging neurogenesis in adult hippocampus. Cell Tissue Res. 2007;329(3):409–420.
    • (2007) Cell Tissue Res , vol.329 , Issue.3 , pp. 409-420
    • Bohlen, V.1    Halbach, O.2
  • 33
    • 84872422862 scopus 로고    scopus 로고
    • Bio-distribution and in vivo antioxidant effects of cerium oxide nanoparticles in mice
    • Hirst SM, Karakoti A, Singh S, et al. Bio-distribution and in vivo antioxidant effects of cerium oxide nanoparticles in mice. Environ Toxicol. 2013;28(2):107–118.
    • (2013) Environ Toxicol , vol.28 , Issue.2 , pp. 107-118
    • Hirst, S.M.1    Karakoti, A.2    Singh, S.3
  • 34
    • 70350418852 scopus 로고    scopus 로고
    • Distribution, translocation and accumulation of silver nanoparticles in rats
    • Tang JL, Xiong L, Wang S, et al. Distribution, translocation and accumulation of silver nanoparticles in rats. J Nanosci Nanotechnol. 2009;9(8):4924–4932.
    • (2009) J Nanosci Nanotechnol , vol.9 , Issue.8 , pp. 4924-4932
    • Tang, J.L.1    Xiong, L.2    Wang, S.3
  • 35
    • 70350624697 scopus 로고    scopus 로고
    • Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity
    • Ma LL, Liu J, Li N, et al. Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity. Biomaterials. 2010;31(1):99–105.
    • (2010) Biomaterials , vol.31 , Issue.1 , pp. 99-105
    • Ma, L.L.1    Liu, J.2    Li, N.3
  • 36
    • 33846131928 scopus 로고    scopus 로고
    • Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
    • Wang JX, Zhou GQ, Chen CY, et al. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett. 2007;168(2):176–185.
    • (2007) Toxicol Lett , vol.168 , Issue.2 , pp. 176-185
    • Wang, J.X.1    Zhou, G.Q.2    Chen, C.Y.3
  • 37
    • 84864501817 scopus 로고    scopus 로고
    • The neurotoxic potential of engineered nanomaterials
    • Boyes WK, Chen R, Chen CY, Yokel RA. The neurotoxic potential of engineered nanomaterials. Neurotoxicology. 2012;33(4):902–910.
    • (2012) Neurotoxicology , vol.33 , Issue.4 , pp. 902-910
    • Boyes, W.K.1    Chen, R.2    Chen, C.Y.3    Yokel, R.A.4
  • 38
    • 80053215779 scopus 로고    scopus 로고
    • Nanoparticles and neurotoxicity
    • Win-Shwe TT, Fujimaki H. Nanoparticles and neurotoxicity. Int J Mol Sci. 2011;12(9):6267–6280.
    • (2011) Int J Mol Sci , vol.12 , Issue.9 , pp. 6267-6280
    • Win-Shwe, T.T.1    Fujimaki, H.2
  • 39
    • 1942505913 scopus 로고    scopus 로고
    • Myoclonic status epilepticus following repeated oral ingestion of colloidal silver
    • Mirsattari SM, Hammond RR, Sharpe MD, Leung FY, Young GB. Myoclonic status epilepticus following repeated oral ingestion of colloidal silver. Neurology. 2004;62(8):1408–1410.
    • (2004) Neurology , vol.62 , Issue.8 , pp. 1408-1410
    • Mirsattari, S.M.1    Hammond, R.R.2    Sharpe, M.D.3    Leung, F.Y.4    Young, G.B.5
  • 40
    • 77956012861 scopus 로고    scopus 로고
    • Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles
    • Hu RP, Gong XL, Duan YM, et al. Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles. Biomaterials. 2010;31(31):8043–8050.
    • (2010) Biomaterials , vol.31 , Issue.31 , pp. 8043-8050
    • Hu, R.P.1    Gong, X.L.2    Duan, Y.M.3
  • 41
    • 84881105475 scopus 로고    scopus 로고
    • Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells
    • Siddiqui MA, Alhadlaq HA, Ahmad J, Al-Khedhairy AA, Musarrat J, Ahamed M. Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells. PLoS One. 2013;8(8):e69534.
    • (2013) Plos One , vol.8 , Issue.8
    • Siddiqui, M.A.1    Alhadlaq, H.A.2    Ahmad, J.3    Al-Khedhairy, A.A.4    Musarrat, J.5    Ahamed, M.6
  • 42
    • 77955139818 scopus 로고    scopus 로고
    • Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice
    • Hougaard KS, Jackson P, Jensen KA, et al. Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice. Part Fibre Toxicol. 2010;7:16.
    • (2010) Part Fibre Toxicol , vol.7
    • Hougaard, K.S.1    Jackson, P.2    Jensen, K.A.3
  • 43
    • 60549103734 scopus 로고    scopus 로고
    • Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems
    • Takeda K, Suzuki KI, Ishihara A, et al. Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems. J Health Sci. 2009;55(1):95–102.
    • (2009) J Health Sci , vol.55 , Issue.1 , pp. 95-102
    • Takeda, K.1    Suzuki, K.I.2    Ishihara, A.3
  • 44
    • 77958034786 scopus 로고    scopus 로고
    • Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice
    • Takahashi Y, Mizuo K, Shinkai Y, Oshio S, Takeda K. Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice. J Toxicol Sci. 2010; 35(5):749–756.
    • (2010) J Toxicol Sci , vol.35 , Issue.5 , pp. 749-756
    • Takahashi, Y.1    Mizuo, K.2    Shinkai, Y.3    Oshio, S.4    Takeda, K.5
  • 45
    • 68949212357 scopus 로고    scopus 로고
    • Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse
    • Shimizu M, Tainaka H, Oba T, Mizuo K, Umezawa M, Takeda K. Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse. Part Fibre Toxicol. 2009;6:20.
    • (2009) Part Fibre Toxicol , vol.6
    • Shimizu, M.1    Tainaka, H.2    Oba, T.3    Mizuo, K.4    Umezawa, M.5    Takeda, K.6
  • 46
    • 82455212152 scopus 로고    scopus 로고
    • Effects of developmental exposure to TiO2 nanoparticles on synaptic plasticity in hippocampal dentate gyrus area: An in vivo study in anesthetized rats
    • Gao X, Yin S, Tang M, et al. Effects of developmental exposure to TiO2 nanoparticles on synaptic plasticity in hippocampal dentate gyrus area: an in vivo study in anesthetized rats. Biol Trace Elem Res. 2011; 143(3):1616–1628.
    • (2011) Biol Trace Elem Res , vol.143 , Issue.3 , pp. 1616-1628
    • Gao, X.1    Yin, S.2    Tang, M.3
  • 47
    • 84896724707 scopus 로고    scopus 로고
    • Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring
    • Mohammadipour A, Fazel A, Haghir H, et al. Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring. Environ Toxicol Pharmacol. 2014;37(2):617–625.
    • (2014) Environ Toxicol Pharmacol , vol.37 , Issue.2 , pp. 617-625
    • Mohammadipour, A.1    Fazel, A.2    Haghir, H.3
  • 49
    • 65549103248 scopus 로고    scopus 로고
    • Potential health impact of nanoparticles
    • Xia T, Li N, Nel AE. Potential health impact of nanoparticles. Annu Rev Publ Health. 2009;30:137–150.
    • (2009) Annu Rev Publ Health , vol.30 , pp. 137-150
    • Xia, T.1    Li, N.2    Nel, A.E.3
  • 50
    • 84902955442 scopus 로고    scopus 로고
    • Causes and consequences of age-related changes in DNA methylation: A role for ROS?
    • Rang FJ, Boonstra J. Causes and consequences of age-related changes in DNA methylation: a role for ROS? Biology. 2014;3(2):403–425.
    • (2014) Biology , vol.3 , Issue.2 , pp. 403-425
    • Rang, F.J.1    Boonstra, J.2
  • 51
    • 84890535338 scopus 로고    scopus 로고
    • Oxidative stress and neurodegenerative disorders
    • O W
    • Li J, O W, Li W, Jiang ZG, Ghanbari HA. Oxidative stress and neurodegenerative disorders. Int J Mol Sci. 2013;14(12):24438–24475.
    • (2013) Int J Mol Sci , vol.14 , Issue.12 , pp. 24438-24475
    • Li, J.1    Li, W.2    Jiang, Z.G.3    Ghanbari, H.A.4
  • 52
    • 84875725411 scopus 로고    scopus 로고
    • Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration
    • Smith JA, Park S, Krause JS, Banik NL. Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration. Neurochem Int. 2013;62(5):764–775.
    • (2013) Neurochem Int , vol.62 , Issue.5 , pp. 764-775
    • Smith, J.A.1    Park, S.2    Krause, J.S.3    Banik, N.L.4
  • 53
    • 67651184281 scopus 로고    scopus 로고
    • NOX enzymes in the central nervous system: From signaling to disease
    • Sorce S, Krause KH. NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal. 2009;11(10):2481–2504.
    • (2009) Antioxid Redox Signal , vol.11 , Issue.10 , pp. 2481-2504
    • Sorce, S.1    Krause, K.H.2
  • 54
    • 33845746706 scopus 로고    scopus 로고
    • GendelmanHE. Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: Relevance for the pathogenesis of Parkinson’s disease
    • Thomas MP, Chartrand K, Reynolds A, Vitvitsky V, Banerjee R, GendelmanHE. Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson’s disease. J Neurochem. 2007;100(2):503–519.
    • (2007) J Neurochem , vol.100 , Issue.2 , pp. 503-519
    • Thomas, M.P.1    Chartrand, K.2    Reynolds, A.3    Vitvitsky, V.4    Banerjee, R.5
  • 55
    • 47149088045 scopus 로고    scopus 로고
    • Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase
    • Schappi MG, Jaquet V, Belli DC, Krause KH. Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase. Semin Immunopathol. 2008;30(3):255–271.
    • (2008) Semin Immunopathol , vol.30 , Issue.3 , pp. 255-271
    • Schappi, M.G.1    Jaquet, V.2    Belli, D.C.3    Krause, K.H.4
  • 56
    • 79954596666 scopus 로고    scopus 로고
    • Reactive oxygen species in the regulation of synaptic plasticity and memory
    • Massaad CA, Klann E. Reactive oxygen species in the regulation of synaptic plasticity and memory. Antioxid Redox Signal. 2011;14(10):2013–2054.
    • (2011) Antioxid Redox Signal , vol.14 , Issue.10 , pp. 2013-2054
    • Massaad, C.A.1    Klann, E.2
  • 58
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science. 2006;311(5761):622–627.
    • (2006) Science , vol.311 , Issue.5761 , pp. 622-627
    • Nel, A.1    Xia, T.2    Madler, L.3    Li, N.4
  • 59
    • 74649084231 scopus 로고    scopus 로고
    • The influences of cell type and ZnO nanoparticle size on immune cell cytotoxicity and cytokine induction
    • Hanley C, Thurber A, Hanna C, Punnoose A, Zhang JH, Wingett DG. The influences of cell type and ZnO nanoparticle size on immune cell cytotoxicity and cytokine induction. Nanoscale Res Lett. 2009;4(12): 1409–1420.
    • (2009) Nanoscale Res Lett , vol.4 , Issue.12 , pp. 1409-1420
    • Hanley, C.1    Thurber, A.2    Hanna, C.3    Punnoose, A.4    Zhang, J.H.5    Wingett, D.G.6
  • 60
    • 84877938404 scopus 로고    scopus 로고
    • Cadmium-based quantum dot induced autophagy formation for cell survival via oxidative stress
    • Luo YH, Wu SB, Wei YH, et al. Cadmium-based quantum dot induced autophagy formation for cell survival via oxidative stress. Chem Res Toxicol. 2013;26(5):662–673.
    • (2013) Chem Res Toxicol , vol.26 , Issue.5 , pp. 662-673
    • Luo, Y.H.1    Wu, S.B.2    Wei, Y.H.3
  • 61
    • 84875489407 scopus 로고    scopus 로고
    • Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation
    • Yu KN, Yoon TJ, Minai-Tehrani A, et al. Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation. Toxicol In Vitro. 2013;27(4):1187–1195.
    • (2013) Toxicol in Vitro , vol.27 , Issue.4 , pp. 1187-1195
    • Yu, K.N.1    Yoon, T.J.2    Minai-Tehrani, A.3
  • 62
    • 84555195856 scopus 로고    scopus 로고
    • Autophagy, mitochondria and oxidative stress: Cross-talk and redox signalling
    • Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J. 2012;441(2): 523–540.
    • (2012) Biochem J , vol.441 , Issue.2 , pp. 523-540
    • Lee, J.1    Giordano, S.2    Zhang, J.3
  • 63
    • 84876952909 scopus 로고    scopus 로고
    • Mitochondrial dysfunction, oxidative stress, and major depressive disorder
    • Tobe EH. Mitochondrial dysfunction, oxidative stress, and major depressive disorder. Neuropsychiatr Dis Treat. 2013;9:567–573.
    • (2013) Neuropsychiatr Dis Treat , vol.9 , pp. 567-573
    • Tobe, E.H.1
  • 64
    • 84859482117 scopus 로고    scopus 로고
    • Psychiatric disorders and mitochondrial dysfunctions
    • Marazziti D, Baroni S, Picchetti M, et al. Psychiatric disorders and mitochondrial dysfunctions. Eur Rev Med Pharmacol. 2012;16(2):270–275.
    • (2012) Eur Rev Med Pharmacol , vol.16 , Issue.2 , pp. 270-275
    • Marazziti, D.1    Baroni, S.2    Picchetti, M.3
  • 65
    • 33746255334 scopus 로고    scopus 로고
    • Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): Implications for nanoparticle neurotoxicity
    • Long TC, Saleh N, Tilton RD, Lowry GV, Veronesi B. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity. Environ Sci Technol. 2006;40(14):4346–4352.
    • (2006) Environ Sci Technol , vol.40 , Issue.14 , pp. 4346-4352
    • Long, T.C.1    Saleh, N.2    Tilton, R.D.3    Lowry, G.V.4    Veronesi, B.5
  • 67
    • 84902000387 scopus 로고    scopus 로고
    • Titanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cells
    • Huerta-Garcia E, Perez-Arizti JA, Marquez-Ramirez SG, et al. Titanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cells. Free Radical Biol Med. 2014;73:84–94.
    • (2014) Free Radical Biol Med , vol.73 , pp. 84-94
    • Huerta-Garcia, E.1    Perez-Arizti, J.A.2    Marquez-Ramirez, S.G.3
  • 68
    • 84875539389 scopus 로고    scopus 로고
    • Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFκB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling
    • Zanotto A, Braganhol E, Battastini AM, Moreira JC. Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFκB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling. Invest New Drugs. 2012;30(6):2252–2262.
    • (2012) Invest New Drugs , vol.30 , Issue.6 , pp. 2252-2262
    • Zanotto, A.1    Braganhol, E.2    Battastini, A.M.3    Moreira, J.C.4
  • 69
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120(4):483–495.
    • (2005) Cell , vol.120 , Issue.4 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 70
    • 77955060907 scopus 로고    scopus 로고
    • Brain distribution and toxicological evaluation of a systemically delivered engineered nanoscale ceria
    • Hardas SS, Butterfield DA, Sultana R, et al. Brain distribution and toxicological evaluation of a systemically delivered engineered nanoscale ceria. Toxicol Sci. 2010;116(2):562–576.
    • (2010) Toxicol Sci , vol.116 , Issue.2 , pp. 562-576
    • Hardas, S.S.1    Butterfield, D.A.2    Sultana, R.3
  • 71
    • 84905992451 scopus 로고    scopus 로고
    • Rat hippocampal responses up to 90 days after a single nanoceria dose extends a hierarchical oxidative stress model for nanoparticle toxicity
    • Hardas SS, Sultana R, Warrier G, et al. Rat hippocampal responses up to 90 days after a single nanoceria dose extends a hierarchical oxidative stress model for nanoparticle toxicity. Nanotoxicology. 2014;8: 155–166.
    • (2014) Nanotoxicology , vol.8 , pp. 155-166
    • Hardas, S.S.1    Sultana, R.2    Warrier, G.3
  • 72
    • 84870679766 scopus 로고    scopus 로고
    • Multi walled carbon nano tubes induced hepatotoxicity in Swiss albino mice
    • Awasthi KK, John PJ, Awasthi A, Awasthi K. Multi walled carbon nano tubes induced hepatotoxicity in Swiss albino mice. Micron. 2013;44:359–364.
    • (2013) Micron , vol.44 , pp. 359-364
    • Awasthi, K.K.1    John, P.J.2    Awasthi, A.3    Awasthi, K.4
  • 73
    • 84860535497 scopus 로고    scopus 로고
    • Accumulation and toxicity of copper oxide nanoparticles in the digestive gland of Mytilus galloprovincialis
    • Gomes T, Pereira CG, Cardoso C, Pinheiro JP, Cancio I, Bebianno MJ. Accumulation and toxicity of copper oxide nanoparticles in the digestive gland of Mytilus galloprovincialis. Aquat Toxicol. 2012;118:72–79.
    • (2012) Aquat Toxicol , vol.118 , pp. 72-79
    • Gomes, T.1    Pereira, C.G.2    Cardoso, C.3    Pinheiro, J.P.4    Cancio, I.5    Bebianno, M.J.6
  • 74
    • 59149098596 scopus 로고    scopus 로고
    • Effects of waterborne nano-iron on medaka (Oryzias latipes): Antioxidant enzymatic activity, lipid peroxidation and histopathology
    • Li HC, Zhou QF, Wu Y, Fu JJ, Wang T, Jiang GB. Effects of waterborne nano-iron on medaka (Oryzias latipes): antioxidant enzymatic activity, lipid peroxidation and histopathology. Ecotoxicol Environ Safe. 2009;72(3):684–692.
    • (2009) Ecotoxicol Environ Safe , vol.72 , Issue.3 , pp. 684-692
    • Li, H.C.1    Zhou, Q.F.2    Wu, Y.3    Fu, J.J.4    Wang, T.5    Jiang, G.B.6
  • 75
    • 33847620225 scopus 로고    scopus 로고
    • Aging: A revisited theory based on free radicals generated by NOX family NADPH oxidases
    • Krause KH. Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases. Exp Gerontol. 2007;42(4):256–262.
    • (2007) Exp Gerontol , vol.42 , Issue.4 , pp. 256-262
    • Krause, K.H.1
  • 76
    • 84878648124 scopus 로고    scopus 로고
    • Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox-and Nrf2-independent manner
    • Wilhelmi V, Fischer U, Weighardt H, et al. Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox-and Nrf2-independent manner. PLoS One. 2013;8(6):e65704.
    • (2013) Plos One , vol.8 , Issue.6
    • Wilhelmi, V.1    Fischer, U.2    Weighardt, H.3
  • 77
    • 84866009247 scopus 로고    scopus 로고
    • EPR spin trapping evaluation of ROS production in human fibroblasts exposed to cerium oxide nanoparticles: Evidence for NADPH oxidase and mitochondrial stimulation
    • Culcasi M, Benameur L, Mercier A, et al. EPR spin trapping evaluation of ROS production in human fibroblasts exposed to cerium oxide nanoparticles: evidence for NADPH oxidase and mitochondrial stimulation. Chem Biol Interact. 2012;199(3):161–176.
    • (2012) Chem Biol Interact , vol.199 , Issue.3 , pp. 161-176
    • Culcasi, M.1    Benameur, L.2    Mercier, A.3
  • 78
    • 80053922007 scopus 로고    scopus 로고
    • Cellular toxicity of inorganic nanoparticles: Common aspects and guidelines for improved nanotoxicity evaluation
    • Soenen SJ, Rivera-Gil P, Montenegro JM, Parak WJ, De Smedt SC, Braeckmans K. Cellular toxicity of inorganic nanoparticles: common aspects and guidelines for improved nanotoxicity evaluation. Nano Today. 2011;6(5):446–465.
    • (2011) Nano Today , vol.6 , Issue.5 , pp. 446-465
    • Soenen, S.J.1    Rivera-Gil, P.2    Montenegro, J.M.3    Parak, W.J.4    De Smedt, S.C.5    Braeckmans, K.6
  • 79
    • 84887196378 scopus 로고    scopus 로고
    • ZnO nanoparticles induce TNF-α expression via ROS-ERK-Egr-1 pathway in human keratinocytes
    • Jeong SH, Kim HJ, Ryu HJ, et al. ZnO nanoparticles induce TNF-α expression via ROS-ERK-Egr-1 pathway in human keratinocytes. J Dermatol Sci. 2013;72(3):263–273.
    • (2013) J Dermatol Sci , vol.72 , Issue.3 , pp. 263-273
    • Jeong, S.H.1    Kim, H.J.2    Ryu, H.J.3
  • 80
    • 84928386430 scopus 로고    scopus 로고
    • ZnO nanoparticle-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes
    • Wang J, Deng X, Zhang F, Chen D, Ding W. ZnO nanoparticle-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes. Nanoscale Res Lett. 2014;9(1):117.
    • (2014) Nanoscale Res Lett , vol.9 , Issue.1
    • Wang, J.1    Deng, X.2    Zhang, F.3    Chen, D.4    Ding, W.5
  • 82
    • 67649491055 scopus 로고    scopus 로고
    • Understanding biophysicochemical interactions at the nano-bio interface
    • Nel AE, Madler L, Velegol D, et al. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater. 2009;8(7):543–557.
    • (2009) Nat Mater , vol.8 , Issue.7 , pp. 543-557
    • Nel, A.E.1    Madler, L.2    Velegol, D.3
  • 83
    • 84904976129 scopus 로고    scopus 로고
    • Histidine adsorption on TiO2 nanoparticles: An integrated spectroscopic, thermodynamic, and molecular-based approach toward understanding nano-bio interactions
    • Mudunkotuwa IA, Grassian VH. Histidine adsorption on TiO2 nanoparticles: an integrated spectroscopic, thermodynamic, and molecular-based approach toward understanding nano-bio interactions. Langmuir. 2014;30(29):8751–8760.
    • (2014) Langmuir , vol.30 , Issue.29 , pp. 8751-8760
    • Mudunkotuwa, I.A.1    Grassian, V.H.2
  • 84
    • 84887006898 scopus 로고    scopus 로고
    • Biological and environmental transformations of copper-based nanomaterials
    • Wang ZY, von dem Bussche A, Kabadi PK, Kane AB, Hurt RH. Biological and environmental transformations of copper-based nanomaterials. ACS Nano. 2013;7(10):8715–8727.
    • (2013) ACS Nano , vol.7 , Issue.10 , pp. 8715-8727
    • Wang, Z.Y.1    Von Dem Bussche, A.2    Kabadi, P.K.3    Kane, A.B.4    Hurt, R.H.5
  • 85
    • 84879661776 scopus 로고    scopus 로고
    • Lysosomal membrane permeabilization by targeted magnetic nanoparticles in alternating magnetic fields
    • Domenech M, Marrero-Berrios I, Torres-Lugo M, Rinaldi C. Lysosomal membrane permeabilization by targeted magnetic nanoparticles in alternating magnetic fields. ACS Nano. 2013;7(6):5091–5101.
    • (2013) ACS Nano , vol.7 , Issue.6 , pp. 5091-5101
    • Domenech, M.1    Marrero-Berrios, I.2    Torres-Lugo, M.3    Rinaldi, C.4
  • 86
    • 84906490693 scopus 로고    scopus 로고
    • Lysosomal membrane permeabilization: Carbon nanohorn-induced reactive oxygen species generation and toxicity by this neglected mechanism
    • Yang M, Zhang M, Tahara Y, et al. Lysosomal membrane permeabilization: carbon nanohorn-induced reactive oxygen species generation and toxicity by this neglected mechanism. Toxicol Appl Pharmacol. 2014;280(1):117–126.
    • (2014) Toxicol Appl Pharmacol , vol.280 , Issue.1 , pp. 117-126
    • Yang, M.1    Zhang, M.2    Tahara, Y.3
  • 87
    • 79953024009 scopus 로고    scopus 로고
    • The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles
    • Li W, Zhao LN, Wei TT, Zhao YL, Chen CY. The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles. Biomaterials. 2011;32(16):4030–4041.
    • (2011) Biomaterials , vol.32 , Issue.16 , pp. 4030-4041
    • Li, W.1    Zhao, L.N.2    Wei, T.T.3    Zhao, Y.L.4    Chen, C.Y.5
  • 88
    • 77956603465 scopus 로고    scopus 로고
    • Lidocaine oxidation by electrogenerated reactive oxygen species in the light of oxidative drug metabolism
    • Nouri-Nigjeh E, Permentier HP, Bischoff R, Bruins AP. Lidocaine oxidation by electrogenerated reactive oxygen species in the light of oxidative drug metabolism. Anal Chem. 2010;82(18):7625–7633.
    • (2010) Anal Chem , vol.82 , Issue.18 , pp. 7625-7633
    • Nouri-Nigjeh, E.1    Permentier, H.P.2    Bischoff, R.3    Bruins, A.P.4
  • 89
    • 79954466823 scopus 로고    scopus 로고
    • Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress
    • Naqvi S, Samim M, Abdin MZ, et al. Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress. Int J Nanomedicine. 2010;5:983–989.
    • (2010) Int J Nanomedicine , vol.5 , pp. 983-989
    • Naqvi, S.1    Samim, M.2    Abdin, M.Z.3
  • 90
    • 39249084071 scopus 로고    scopus 로고
    • Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells
    • Park EJ, Choi J, Park YK, Park K. Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells. Toxicology. 2008; 245(1–2):90–100.
    • (2008) Toxicology , vol.245 , Issue.1-2 , pp. 90-100
    • Park, E.J.1    Choi, J.2    Park, Y.K.3    Park, K.4
  • 91
    • 77952536074 scopus 로고    scopus 로고
    • Comparative cytotoxicity of Al2O3, CeO2, TiO2 and ZnO nanoparticles to human lung cells
    • Kim IS, Baek M, Choi SJ. Comparative cytotoxicity of Al2O3, CeO2, TiO2 and ZnO nanoparticles to human lung cells. J Nanosci Nanotechnol. 2010;10(5):3453–3458.
    • (2010) J Nanosci Nanotechnol , vol.10 , Issue.5 , pp. 3453-3458
    • Kim, I.S.1    Baek, M.2    Choi, S.J.3
  • 92
    • 84884274380 scopus 로고    scopus 로고
    • Mechanisms of nanoparticle-induced oxidative stress and toxicity
    • Manke A, Wang LY, Rojanasakul Y. Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int. 2013;2013:942916.
    • (2013) Biomed Res Int , vol.2013
    • Manke, A.1    Wang, L.Y.2    Rojanasakul, Y.3
  • 93
    • 79960708216 scopus 로고    scopus 로고
    • Cancer-cell-specific cytotoxicity of non-oxidized iron elements in iron core-gold shell NPs
    • Wu YN, Chen DH, Shi XY, et al. Cancer-cell-specific cytotoxicity of non-oxidized iron elements in iron core-gold shell NPs. Nanomed Nanotechnol. 2011;7(4):420–427.
    • (2011) Nanomed Nanotechnol , vol.7 , Issue.4 , pp. 420-427
    • Wu, Y.N.1    Chen, D.H.2    Shi, X.Y.3
  • 94
    • 84867230254 scopus 로고    scopus 로고
    • The outdoor air pollution and brain health workshop
    • Block ML, Elder A, Auten RL, et al. The outdoor air pollution and brain health workshop. Neurotoxicology. 2012;33(5):972–984.
    • (2012) Neurotoxicology , vol.33 , Issue.5 , pp. 972-984
    • Block, M.L.1    Elder, A.2    Auten, R.L.3
  • 95
    • 77951710094 scopus 로고    scopus 로고
    • Silica-based nanoparticle uptake and cellular response by primary microglia
    • Choi J, Zheng QD, Katz HE, Guilarte TR. Silica-based nanoparticle uptake and cellular response by primary microglia. Environ Health Perspect. 2010;118(5):589–595.
    • (2010) Environ Health Perspect , vol.118 , Issue.5 , pp. 589-595
    • Choi, J.1    Zheng, Q.D.2    Katz, H.E.3    Guilarte, T.R.4
  • 96
    • 84907854626 scopus 로고    scopus 로고
    • Organic nanoparticles from different fuel blends: In vitro toxicity and inflammatory potential
    • Gualtieri M, Capasso L, D’Anna A, Camatini M. Organic nanoparticles from different fuel blends: in vitro toxicity and inflammatory potential. J Appl Toxicol. 2014;34(11):1247–1255.
    • (2014) J Appl Toxicol , vol.34 , Issue.11 , pp. 1247-1255
    • Gualtieri, M.1    Capasso, L.2    D’Anna, A.3    Camatini, M.4
  • 97
    • 84866292862 scopus 로고    scopus 로고
    • Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro
    • Xue Y, Wu J, Sun J. Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro. Toxicol Lett. 2012;214(2):91–98.
    • (2012) Toxicol Lett , vol.214 , Issue.2 , pp. 91-98
    • Xue, Y.1    Wu, J.2    Sun, J.3
  • 98
    • 84882254367 scopus 로고    scopus 로고
    • The role of autophagy in neurodegenerative disease
    • Nixon RA. The role of autophagy in neurodegenerative disease. Nat Med. 2013;19(8):983–997.
    • (2013) Nat Med , vol.19 , Issue.8 , pp. 983-997
    • Nixon, R.A.1
  • 99
    • 79960308079 scopus 로고    scopus 로고
    • Autophagy deregulation in neurodegenerative diseases – recent advances and future perspectives
    • Cheung ZH, Ip NY. Autophagy deregulation in neurodegenerative diseases – recent advances and future perspectives. J Neurochem. 2011;118(3):317–325.
    • (2011) J Neurochem , vol.118 , Issue.3 , pp. 317-325
    • Cheung, Z.H.1    Ip, N.Y.2
  • 100
    • 84872523960 scopus 로고    scopus 로고
    • Toxicity of engineered nanomaterials: A physicochemical perspective
    • Podila R, Brown JM. Toxicity of engineered nanomaterials: a physicochemical perspective. J Biochem Mol Toxicol. 2013;27(1):50–55.
    • (2013) J Biochem Mol Toxicol , vol.27 , Issue.1 , pp. 50-55
    • Podila, R.1    Brown, J.M.2
  • 101
    • 79952115823 scopus 로고    scopus 로고
    • Nano rare-earth oxides induced size-dependent vacuolization: An independent pathway from autophagy
    • Zhang Y, Yu CG, Huang GY, Wang CL, Wen LP. Nano rare-earth oxides induced size-dependent vacuolization: an independent pathway from autophagy. Int J Nanomedicine. 2010;5:601–609.
    • (2010) Int J Nanomedicine , vol.5 , pp. 601-609
    • Zhang, Y.1    Yu, C.G.2    Huang, G.Y.3    Wang, C.L.4    Wen, L.P.5
  • 102
    • 84855945488 scopus 로고    scopus 로고
    • Induction of oxidative stress, lysosome activation and autophagy by nanoparticles in human brain-derived endothelial cells
    • Kenzaoui BH, Bernasconi CC, Guney-Ayra S, Juillerat-Jeanneret L. Induction of oxidative stress, lysosome activation and autophagy by nanoparticles in human brain-derived endothelial cells. Biochem J. 2012;441:813–821.
    • (2012) Biochem J , vol.441 , pp. 813-821
    • Kenzaoui, B.H.1    Bernasconi, C.C.2    Guney-Ayra, S.3    Juillerat-Jeanneret, L.4
  • 103
    • 84896911789 scopus 로고    scopus 로고
    • Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition
    • Roy R, Singh SK, Chauhan KS, Das M, Tripathi A, Dwivedi PD. Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition. Toxicol Lett. 2014;227(1):29–40.
    • (2014) Toxicol Lett , vol.227 , Issue.1 , pp. 29-40
    • Roy, R.1    Singh, S.K.2    Chauhan, K.S.3    Das, M.4    Tripathi, A.5    Dwivedi, P.D.6
  • 104
    • 78650890352 scopus 로고    scopus 로고
    • Regulation of autophagy by ROS: Physiology and pathology
    • Scherz-Shouval R, Elazar Z. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci. 2011;36(1):30–38.
    • (2011) Trends Biochem Sci , vol.36 , Issue.1 , pp. 30-38
    • Scherz-Shouval, R.1    Elazar, Z.2
  • 105
    • 84857195479 scopus 로고    scopus 로고
    • Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction
    • Shi CS, Shenderov K, Huang NN, et al. Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol. 2012;13(3): 255–263.
    • (2012) Nat Immunol , vol.13 , Issue.3 , pp. 255-263
    • Shi, C.S.1    Shenderov, K.2    Huang, N.N.3
  • 106
    • 84886682963 scopus 로고    scopus 로고
    • Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles
    • Wang F, Bexiga MG, Anguissola S, et al. Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles. Nanoscale. 2013;5(22):10868–10876.
    • (2013) Nanoscale , vol.5 , Issue.22 , pp. 10868-10876
    • Wang, F.1    Bexiga, M.G.2    Anguissola, S.3
  • 107
    • 84862197399 scopus 로고    scopus 로고
    • Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity
    • Stern ST, Adiseshaiah PP, Crist RM. Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity. Part Fibre Toxicol. 2012;9:20.
    • (2012) Part Fibre Toxicol , vol.9
    • Stern, S.T.1    Adiseshaiah, P.P.2    Crist, R.M.3
  • 108
    • 80053334646 scopus 로고    scopus 로고
    • Mechanisms of cellular adaptation to quantum dots – the role of glutathione and transcription factor EB
    • Neibert KD, Maysinger D. Mechanisms of cellular adaptation to quantum dots – the role of glutathione and transcription factor EB. Nanotoxicology. 2012;6(3):249–262.
    • (2012) Nanotoxicology , vol.6 , Issue.3 , pp. 249-262
    • Neibert, K.D.1    Maysinger, D.2
  • 109
    • 84916928995 scopus 로고    scopus 로고
    • Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
    • Polito VA, Li HM, Martini-Stoica H, et al. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med. 2014;6(9):1142–1160.
    • (2014) EMBO Mol Med , vol.6 , Issue.9 , pp. 1142-1160
    • Polito, V.A.1    Li, H.M.2    Martini-Stoica, H.3
  • 110
    • 84884332903 scopus 로고    scopus 로고
    • The variability of autophagy and cell death susceptibility unanswered questions
    • Loos B, Engelbrecht AM, Lockshin RA, Klionsky DJ, Zakeri Z. The variability of autophagy and cell death susceptibility unanswered questions. Autophagy. 2013;9(9):1270–1285.
    • (2013) Autophagy , vol.9 , Issue.9 , pp. 1270-1285
    • Loos, B.1    Engelbrecht, A.M.2    Lockshin, R.A.3    Klionsky, D.J.4    Zakeri, Z.5
  • 111
    • 67650261911 scopus 로고    scopus 로고
    • Cell death: A dynamic response concept
    • Loos B, Engelbrecht AM. Cell death: a dynamic response concept. Autophagy. 2009;5(5):590–603.
    • (2009) Autophagy , vol.5 , Issue.5 , pp. 590-603
    • Loos, B.1    Engelbrecht, A.M.2
  • 112
    • 84868499831 scopus 로고    scopus 로고
    • IglesiasGG, Lopez-Marure R. Titanium dioxide nanoparticles inhibit proliferation and induce morphological changes and apoptosis in glial cells
    • Marquez-Ramirez SG, Delgado-Buenrostro NL, Chirino YI, IglesiasGG, Lopez-Marure R. Titanium dioxide nanoparticles inhibit proliferation and induce morphological changes and apoptosis in glial cells. Toxicology. 2012;302(2–3):146–156.
    • (2012) Toxicology , vol.302 , Issue.2-3 , pp. 146-156
    • Marquez-Ramirez, S.G.1    Delgado-Buenrostro, N.L.2    Chirino, Y.I.3
  • 113
    • 69249190460 scopus 로고    scopus 로고
    • Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts
    • Lai JC, Lai MB, Jandhyam S, et al. Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts. Int J Nanomedicine. 2008;3(4):533–545.
    • (2008) Int J Nanomedicine , vol.3 , Issue.4 , pp. 533-545
    • Lai, J.C.1    Lai, M.B.2    Jandhyam, S.3
  • 114
    • 71849101617 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells
    • Liu SC, Xu LJ, Zhang T, Ren GG, Yang Z. Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells. Toxicology. 2010;267(1–3):172–177.
    • (2010) Toxicology , vol.267 , Issue.1-3 , pp. 172-177
    • Liu, S.C.1    Xu, L.J.2    Zhang, T.3    Ren, G.G.4    Yang, Z.5
  • 115
    • 38449092828 scopus 로고    scopus 로고
    • Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro
    • Long TC, Tajuba J, Sama P, et al. Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro. Environ Health Perspect. 2007;115(11):1631–1637.
    • (2007) Environ Health Perspect , vol.115 , Issue.11 , pp. 1631-1637
    • Long, T.C.1    Tajuba, J.2    Sama, P.3
  • 116
    • 73949087550 scopus 로고    scopus 로고
    • Effect of surface properties on nanoparticle-cell interactions
    • Verma A, Stellacci F. Effect of surface properties on nanoparticle-cell interactions. Small. 2010;6(1):12–21.
    • (2010) Small , vol.6 , Issue.1 , pp. 12-21
    • Verma, A.1    Stellacci, F.2
  • 117
    • 84880287247 scopus 로고    scopus 로고
    • Molecular mechanism of titanium dioxide nanoparticles-induced oxidative injury in the brain of mice
    • Ze Y, Zheng L, Zhao X, et al. Molecular mechanism of titanium dioxide nanoparticles-induced oxidative injury in the brain of mice. Chemosphere. 2013;92(9):1183–1189.
    • (2013) Chemosphere , vol.92 , Issue.9 , pp. 1183-1189
    • Ze, Y.1    Zheng, L.2    Zhao, X.3
  • 118
    • 79953078284 scopus 로고    scopus 로고
    • Engineered nanomaterials: Exposures, hazards, and risk prevention
    • Yokel RA, MacPhail RC. Engineered nanomaterials: exposures, hazards, and risk prevention. J Occup Med Toxicol. 2011;6:7.
    • (2011) J Occup Med Toxicol , vol.6
    • Yokel, R.A.1    Macphail, R.C.2
  • 121
    • 84885233952 scopus 로고    scopus 로고
    • Size- and age-dependent neurotoxicity of engineered metal nanoparticles in rats
    • Sharma A, Muresanu DF, Patnaik R, Sharma HS. Size- and age-dependent neurotoxicity of engineered metal nanoparticles in rats. Mol Neurobiol. 2013;48(2):386–396.
    • (2013) Mol Neurobiol , vol.48 , Issue.2 , pp. 386-396
    • Sharma, A.1    Muresanu, D.F.2    Patnaik, R.3    Sharma, H.S.4
  • 122
    • 50149110878 scopus 로고    scopus 로고
    • The effect of particle design on cellular internalization pathways
    • Gratton SE, Ropp PA, Pohlhaus PD, et al. The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci U S A. 2008;105(33):11613–11618.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.33 , pp. 11613-11618
    • Gratton, S.E.1    Ropp, P.A.2    Pohlhaus, P.D.3
  • 123
    • 79959811662 scopus 로고    scopus 로고
    • Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism
    • Meng H, Yang S, Li ZX, et al. Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism. ACS Nano. 2011;5(6):4434–4447.
    • (2011) ACS Nano , vol.5 , Issue.6 , pp. 4434-4447
    • Meng, H.1    Yang, S.2    Li, Z.X.3
  • 124
    • 84860228570 scopus 로고    scopus 로고
    • Effects of four types of hydroxyapatite nanoparticles with different nanocrystal morphologies and sizes on apoptosis in rat osteoblasts
    • Xu ZL, Liu CS, Wei J, Sun J. Effects of four types of hydroxyapatite nanoparticles with different nanocrystal morphologies and sizes on apoptosis in rat osteoblasts. J Appl Toxicol. 2012;32(6):429–435.
    • (2012) J Appl Toxicol , vol.32 , Issue.6 , pp. 429-435
    • Xu, Z.L.1    Liu, C.S.2    Wei, J.3    Sun, J.4
  • 125
    • 42549152143 scopus 로고    scopus 로고
    • Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats
    • Jain TK, Reddy MK, Morales MA, Leslie-Pelecky DL, Labhasetwar V. Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. Mol Pharm. 2008;5(2):316–327.
    • (2008) Mol Pharm , vol.5 , Issue.2 , pp. 316-327
    • Jain, T.K.1    Reddy, M.K.2    Morales, M.A.3    Leslie-Pelecky, D.L.4    Labhasetwar, V.5
  • 126
    • 70449088926 scopus 로고    scopus 로고
    • The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function
    • Huang XL, Teng X, Chen D, Tang FQ, He JQ. The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function. Biomaterials. 2010;31(3):438–448.
    • (2010) Biomaterials , vol.31 , Issue.3 , pp. 438-448
    • Huang, X.L.1    Teng, X.2    Chen, D.3    Tang, F.Q.4    He, J.Q.5
  • 127
    • 84869443946 scopus 로고    scopus 로고
    • Biocompatibility of mesoporous silica nanoparticles
    • Asefa T, Tao ZM. Biocompatibility of mesoporous silica nanoparticles. Chem Res Toxicol. 2012;25(11):2265–2284.
    • (2012) Chem Res Toxicol , vol.25 , Issue.11 , pp. 2265-2284
    • Asefa, T.1    Tao, Z.M.2
  • 128
    • 46149100704 scopus 로고    scopus 로고
    • Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells
    • Thorek DL, Tsourkas A. Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells. Biomaterials. 2008;29(26):3583–3590.
    • (2008) Biomaterials , vol.29 , Issue.26 , pp. 3583-3590
    • Thorek, D.L.1    Tsourkas, A.2
  • 129
    • 77955329314 scopus 로고    scopus 로고
    • Effect of nanoparticle surface charge at the plasma membrane and beyond
    • Arvizo RR, Miranda OR, Thompson MA, et al. Effect of nanoparticle surface charge at the plasma membrane and beyond. Nano Lett. 2010;10(7):2543–2548.
    • (2010) Nano Lett , vol.10 , Issue.7 , pp. 2543-2548
    • Arvizo, R.R.1    Miranda, O.R.2    Thompson, M.A.3
  • 130
    • 84875359495 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticle nanocarriers: Biofunctionality and biocompatibility
    • Tarn D, Ashley CE, Xue M, Carnes EC, Zink JI, Brinker CJ. Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility. Acc Chem Res. 2013;46(3):792–801.
    • (2013) Acc Chem Res , vol.46 , Issue.3 , pp. 792-801
    • Tarn, D.1    Ashley, C.E.2    Xue, M.3    Carnes, E.C.4    Zink, J.I.5    Brinker, C.J.6
  • 131
    • 77957324488 scopus 로고    scopus 로고
    • Penetration of lipid membranes by gold nanoparticles: Insights into cellular uptake, cytotoxicity, and their relationship
    • Lin JQ, Zhang HW, Chen Z, Zheng YG. Penetration of lipid membranes by gold nanoparticles: insights into cellular uptake, cytotoxicity, and their relationship. ACS Nano. 2010;4(9):5421–5429.
    • (2010) ACS Nano , vol.4 , Issue.9 , pp. 5421-5429
    • Lin, J.Q.1    Zhang, H.W.2    Chen, Z.3    Zheng, Y.G.4
  • 133
    • 73249145214 scopus 로고    scopus 로고
    • Fullerene nanoparticles selectively enter oxidation-damaged cerebral microvessel endothelial cells and inhibit JNK-related apoptosis
    • Lao F, Chen L, Li W, et al. Fullerene nanoparticles selectively enter oxidation-damaged cerebral microvessel endothelial cells and inhibit JNK-related apoptosis. ACS Nano. 2009;3(11):3358–3368.
    • (2009) ACS Nano , vol.3 , Issue.11 , pp. 3358-3368
    • Lao, F.1    Chen, L.2    Li, W.3
  • 134
    • 79956337963 scopus 로고    scopus 로고
    • Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials
    • Zhao F, Zhao Y, Liu Y, Chang XL, Chen CY, Zhao YL. Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. Small. 2011; 7(10):1322–1337.
    • (2011) Small , vol.7 , Issue.10 , pp. 1322-1337
    • Zhao, F.1    Zhao, Y.2    Liu, Y.3    Chang, X.L.4    Chen, C.Y.5    Zhao, Y.L.6
  • 135
    • 56049102066 scopus 로고    scopus 로고
    • Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles
    • Wang JX, Liu Y, Jiao F, et al. Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles. Toxicology. 2008;254(1–2):82–90.
    • (2008) Toxicology , vol.254 , Issue.1-2 , pp. 82-90
    • Wang, J.X.1    Liu, Y.2    Jiao, F.3
  • 136
    • 56549115351 scopus 로고    scopus 로고
    • Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases
    • Wang JX, Chen CY, Liu Y, et al. Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases. Toxicol Lett. 2008;183(1–3):72–80.
    • (2008) Toxicol Lett , vol.183 , Issue.1-3 , pp. 72-80
    • Wang, J.X.1    Chen, C.Y.2    Liu, Y.3
  • 137
    • 80053384428 scopus 로고    scopus 로고
    • Rutile TiO2 particles exert size and surface coating dependent retention and lesions on the murine brain
    • Zhang LL, Bai R, Li B, et al. Rutile TiO2 particles exert size and surface coating dependent retention and lesions on the murine brain. Toxicol Lett. 2011;207(1):73–81.
    • (2011) Toxicol Lett , vol.207 , Issue.1 , pp. 73-81
    • Zhang, L.L.1    Bai, R.2    Li, B.3
  • 138
    • 78649851994 scopus 로고    scopus 로고
    • Functionalized gold nanoparticles: A detailed in vivo multimodal microscopic brain distribution study
    • Sousa F, Mandal S, Garrovo C, et al. Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study. Nanoscale. 2010;2(12):2826–2834.
    • (2010) Nanoscale , vol.2 , Issue.12 , pp. 2826-2834
    • Sousa, F.1    Mandal, S.2    Garrovo, C.3
  • 139
    • 84903486219 scopus 로고    scopus 로고
    • Secreted biomolecules alter the biological identity and cellular interactions of nanoparticles
    • Albanese A, Walkey CD, Olsen JB, Guo HB, Emili A, Chan WC. Secreted biomolecules alter the biological identity and cellular interactions of nanoparticles. ACS Nano. 2014;8(6):5515–5526.
    • (2014) ACS Nano , vol.8 , Issue.6 , pp. 5515-5526
    • Albanese, A.1    Walkey, C.D.2    Olsen, J.B.3    Guo, H.B.4    Emili, A.5    Chan, W.C.6
  • 140
    • 84903488238 scopus 로고    scopus 로고
    • Enhancing therapeutic efficacy through designed aggregation of nanoparticles
    • Sadhukha T, Wiedmann TS, Panyam J. Enhancing therapeutic efficacy through designed aggregation of nanoparticles. Biomaterials. 2014; 35(27):7860–7869.
    • (2014) Biomaterials , vol.35 , Issue.27 , pp. 7860-7869
    • Sadhukha, T.1    Wiedmann, T.S.2    Panyam, J.3
  • 141
    • 84865423058 scopus 로고    scopus 로고
    • The influence of the surface chemistry of silver nanoparticles on cell death
    • Sur I, Altunbek M, Kahraman M, Culha M. The influence of the surface chemistry of silver nanoparticles on cell death. Nanotechnology. 2012;23(37):375102.
    • (2012) Nanotechnology , vol.23 , Issue.37
    • Sur, I.1    Altunbek, M.2    Kahraman, M.3    Culha, M.4
  • 142
    • 79955618820 scopus 로고    scopus 로고
    • The devil is in the details (Or the surface): Impact of surface structure and surface energetics on understanding the behavior of nanomaterials in the environment
    • Mudunkotuwa IA, Grassian VH. The devil is in the details (or the surface): impact of surface structure and surface energetics on understanding the behavior of nanomaterials in the environment. J Environ Monit. 2011;13(5):1135–1144.
    • (2011) J Environ Monit , vol.13 , Issue.5 , pp. 1135-1144
    • Mudunkotuwa, I.A.1    Grassian, V.H.2
  • 143
    • 84902374023 scopus 로고    scopus 로고
    • Nonlinear effects of nanoparticles: Biological variability from hormetic doses, small particle sizes, and dynamic adaptive interactions
    • Bell IR, Ives JA, Jonas WB. Nonlinear effects of nanoparticles: biological variability from hormetic doses, small particle sizes, and dynamic adaptive interactions. Dose Response. 2014;12(2):202–232.
    • (2014) Dose Response , vol.12 , Issue.2 , pp. 202-232
    • Bell, I.R.1    Ives, J.A.2    Jonas, W.B.3
  • 144
    • 79951858161 scopus 로고    scopus 로고
    • Cytotoxicity screening of 23 engineered nanomaterials using a test matrix of ten cell lines and three different assays
    • Kroll A, Dierker C, Rommel C, et al. Cytotoxicity screening of 23 engineered nanomaterials using a test matrix of ten cell lines and three different assays. Part Fibre Toxicol. 2011;8:9.
    • (2011) Part Fibre Toxicol , vol.8
    • Kroll, A.1    Dierker, C.2    Rommel, C.3
  • 145
    • 84869478358 scopus 로고    scopus 로고
    • Validation of an in vitro exposure system for toxicity assessment of air-delivered nanomaterials
    • Kim JS, Peters TM, O’Shaughnessy PT, Adamcakova-Dodd A, Thorne PS. Validation of an in vitro exposure system for toxicity assessment of air-delivered nanomaterials. Toxicol In Vitro. 2013;27(1):164–173.
    • (2013) Toxicol in Vitro , vol.27 , Issue.1 , pp. 164-173
    • Kim, J.S.1    Peters, T.M.2    O’Shaughnessy, P.T.3    Adamcakova-Dodd, A.4    Thorne, P.S.5
  • 146
    • 84899046918 scopus 로고    scopus 로고
    • Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models
    • Adamcakova-Dodd A, Stebounova LV, Kim JS, et al. Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models. Part Fibre Toxicol. 2014;11:15.
    • (2014) Part Fibre Toxicol , vol.11
    • Adamcakova-Dodd, A.1    Stebounova, L.V.2    Kim, J.S.3
  • 147
    • 84879196737 scopus 로고    scopus 로고
    • Metal-based nanoparticle interactions with the nervous system: The challenge of brain entry and the risk of retention in the organism
    • Yokel R, Grulke E, MacPhail R. Metal-based nanoparticle interactions with the nervous system: the challenge of brain entry and the risk of retention in the organism. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013;5(4):346–373.
    • (2013) Wiley Interdiscip Rev Nanomed Nanobiotechnol , vol.5 , Issue.4 , pp. 346-373
    • Yokel, R.1    Grulke, E.2    Macphail, R.3
  • 148
    • 84864425359 scopus 로고    scopus 로고
    • Flake-shell capsules: Adjustable inorganic structures
    • Ji QM, Guo CY, Yu XY, et al. Flake-shell capsules: adjustable inorganic structures. Small. 2012;8(15):2345–2349.
    • (2012) Small , vol.8 , Issue.15 , pp. 2345-2349
    • Ji, Q.M.1    Guo, C.Y.2    Yu, X.Y.3
  • 149
    • 84879780600 scopus 로고    scopus 로고
    • Autophagy: Shaping the tumor microenvironment and therapeutic response
    • Maes H, Rubio N, Garg AD, Agostinis P. Autophagy: shaping the tumor microenvironment and therapeutic response. Trends Mol Med. 2013;19(7):428–446.
    • (2013) Trends Mol Med , vol.19 , Issue.7 , pp. 428-446
    • Maes, H.1    Rubio, N.2    Garg, A.D.3    Agostinis, P.4
  • 150
    • 33746381483 scopus 로고    scopus 로고
    • Antibacterial activity of fullerene water suspensions: Effects of preparation method and particle size
    • Lyon DY, Adams LK, Falkner JC, Alvarezt PJ. Antibacterial activity of fullerene water suspensions: effects of preparation method and particle size. Environ Sci Technol. 2006;40(14):4360–4366.
    • (2006) Environ Sci Technol , vol.40 , Issue.14 , pp. 4360-4366
    • Lyon, D.Y.1    Adams, L.K.2    Falkner, J.C.3    Alvarezt, P.J.4
  • 152
    • 78649371189 scopus 로고    scopus 로고
    • Fullerenes as unique nanopharmaceuticals for disease treatment
    • Ma HL, Liang XJ. Fullerenes as unique nanopharmaceuticals for disease treatment. Sci China Chem. 2010;53(11):2233–2340.
    • (2010) Sci China Chem , vol.53 , Issue.11 , pp. 2233-2340
    • Ma, H.L.1    Liang, X.J.2
  • 153
    • 84855836038 scopus 로고    scopus 로고
    • Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: Imprisoning instead of poisoning cancer cells
    • Meng H, Xing GM, Blanco E, et al. Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells. Nanomedicine. 2012;8(2):136–146.
    • (2012) Nanomedicine , vol.8 , Issue.2 , pp. 136-146
    • Meng, H.1    Xing, G.M.2    Blanco, E.3
  • 154
    • 0034668386 scopus 로고    scopus 로고
    • Polyhydroxylated C(60), fullerenols, as glutamate receptor antagonists and neuroprotective agents
    • Jin H, Chen WQ, Tang XW, et al. Polyhydroxylated C(60), fullerenols, as glutamate receptor antagonists and neuroprotective agents. J Neurosci Res. 2000;62(4):600–607.
    • (2000) J Neurosci Res , vol.62 , Issue.4 , pp. 600-607
    • Jin, H.1    Chen, W.Q.2    Tang, X.W.3
  • 155
    • 0035868478 scopus 로고    scopus 로고
    • Neuroprotective effect of hexasulfobutylated C60 on rats subjected to focal cerebral ischemia
    • Huang SS, Tsai SK, Chih CL, et al. Neuroprotective effect of hexasulfobutylated C60 on rats subjected to focal cerebral ischemia. Free Radic Biol Med. 2001;30(6):643–649.
    • (2001) Free Radic Biol Med , vol.30 , Issue.6 , pp. 643-649
    • Huang, S.S.1    Tsai, S.K.2    Chih, C.L.3
  • 156
    • 84901473966 scopus 로고    scopus 로고
    • Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?
    • Kreuter J. Drug delivery to the central nervous system by polymeric nanoparticles: what do we know? Adv Drug Deliv Rev. 2014;71:2–14.
    • (2014) Adv Drug Deliv Rev , vol.71 , pp. 2-14
    • Kreuter, J.1
  • 157
    • 84877953644 scopus 로고    scopus 로고
    • Potential use of polymeric nanoparticles for drug delivery across the blood–brain barrier
    • Tosi G, Bortot B, Ruozi B, et al. Potential use of polymeric nanoparticles for drug delivery across the blood–brain barrier. Curr Med Chem. 2013;20(17):2212–2225.
    • (2013) Curr Med Chem , vol.20 , Issue.17 , pp. 2212-2225
    • Tosi, G.1    Bortot, B.2    Ruozi, B.3
  • 158
    • 84883887168 scopus 로고    scopus 로고
    • Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery
    • Kulkarni SA, Feng SS. Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery. Pharm Res. 2013;30(10):2512–2522.
    • (2013) Pharm Res , vol.30 , Issue.10 , pp. 2512-2522
    • Kulkarni, S.A.1    Feng, S.S.2
  • 159
    • 0343191443 scopus 로고    scopus 로고
    • Stealth corona-core nanoparticles surface modified by polyethylene glycol (PEG): Influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption
    • Gref R, Luck M, Quellec P, et al. ‘Stealth’ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf B Biointerfaces. 2000;18(3–4):301–313.
    • (2000) Colloids Surf B Biointerfaces , vol.18 , Issue.3-4 , pp. 301-313
    • Gref, R.1    Luck, M.2    Quellec, P.3
  • 160
    • 0003312375 scopus 로고    scopus 로고
    • Marked enhancement in gene expression by targeting the human insulin receptor
    • Zhang Y, Boado RJ, Pardridge WM. Marked enhancement in gene expression by targeting the human insulin receptor. J Gene Med. 2003;5(2):157–163.
    • (2003) J Gene Med , vol.5 , Issue.2 , pp. 157-163
    • Zhang, Y.1    Boado, R.J.2    Pardridge, W.M.3
  • 161
    • 69249209818 scopus 로고    scopus 로고
    • Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood–brain barrier
    • Chang J, Jallouli Y, Kroubi M, et al. Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood–brain barrier. Int J Pharma. 2009;379(2):285–292.
    • (2009) Int J Pharma , vol.379 , Issue.2 , pp. 285-292
    • Chang, J.1    Jallouli, Y.2    Kroubi, M.3
  • 162
    • 0032712180 scopus 로고    scopus 로고
    • Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles
    • Gulyaev AE, Gelperina SE, Skidan IN, Antropov AS, Kivman GY, Kreuter J. Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharm Res. 1999;16(10):1564–1569.
    • (1999) Pharm Res , vol.16 , Issue.10 , pp. 1564-1569
    • Gulyaev, A.E.1    Gelperina, S.E.2    Skidan, I.N.3    Antropov, A.S.4    Kivman, G.Y.5    Kreuter, J.6
  • 163
    • 0033427851 scopus 로고    scopus 로고
    • Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity
    • Olivier JC, Fenart L, Chauvet R, Pariat C, Cecchelli R, Couet W. Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity. Pharm Res. 1999;16(12):1836–1842.
    • (1999) Pharm Res , vol.16 , Issue.12 , pp. 1836-1842
    • Olivier, J.C.1    Fenart, L.2    Chauvet, R.3    Pariat, C.4    Cecchelli, R.5    Couet, W.6
  • 164
    • 0030993566 scopus 로고    scopus 로고
    • Delivery of loperamide across the blood–brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • Alyautdin RN, Petrov VE, Langer K, Berthold A, Kharkevich DA, Kreuter J. Delivery of loperamide across the blood–brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Pharm Res. 1997;14(3):325–328.
    • (1997) Pharm Res , vol.14 , Issue.3 , pp. 325-328
    • Alyautdin, R.N.1    Petrov, V.E.2    Langer, K.3    Berthold, A.4    Kharkevich, D.A.5    Kreuter, J.6
  • 166
    • 35748963227 scopus 로고    scopus 로고
    • Bioadhesive capacity and immunoadjuvant properties of thiamine-coated nanoparticles
    • Salman HH, Gamazo C, Agueros M, Irache JM. Bioadhesive capacity and immunoadjuvant properties of thiamine-coated nanoparticles. Vaccine. 2007;25(48):8123–8132.
    • (2007) Vaccine , vol.25 , Issue.48 , pp. 8123-8132
    • Salman, H.H.1    Gamazo, C.2    Agueros, M.3    Irache, J.M.4
  • 167
    • 0037344134 scopus 로고    scopus 로고
    • Specific association of thiamine-coated gadolinium nanoparticles with human breast cancer cells expressing thiamine transporters
    • Oyewumi MO, Liu SQ, Moscow JA, Mumper RJ. Specific association of thiamine-coated gadolinium nanoparticles with human breast cancer cells expressing thiamine transporters. Bioconjugate Chem. 2003;14(2):404–411.
    • (2003) Bioconjugate Chem , vol.14 , Issue.2 , pp. 404-411
    • Oyewumi, M.O.1    Liu, S.Q.2    Moscow, J.A.3    Mumper, R.J.4
  • 168
    • 84912079069 scopus 로고    scopus 로고
    • Brain-targeted delivery of docetaxel by glutathione-coated nanoparticles for brain cancer
    • Grover A, Hirani A, Pathak Y, Sutariya V. Brain-targeted delivery of docetaxel by glutathione-coated nanoparticles for brain cancer. AAPS Pharm Sci Tech. 2014;15(6):1562–1568.
    • (2014) AAPS Pharm Sci Tech , vol.15 , Issue.6 , pp. 1562-1568
    • Grover, A.1    Hirani, A.2    Pathak, Y.3    Sutariya, V.4
  • 169
    • 84907990121 scopus 로고    scopus 로고
    • Retro-inverso isomer of angiopep-2: A stable d-peptide ligand inspires brain-targeted drug delivery
    • Wei X, Zhan C, Chen X, Hou J, Xie C, Lu W. Retro-inverso isomer of angiopep-2: a stable d-peptide ligand inspires brain-targeted drug delivery. Mol Pharm. 2014;11(10):3261–3268.
    • (2014) Mol Pharm , vol.11 , Issue.10 , pp. 3261-3268
    • Wei, X.1    Zhan, C.2    Chen, X.3    Hou, J.4    Xie, C.5    Lu, W.6
  • 170
    • 84918811527 scopus 로고    scopus 로고
    • Angiopep-conjugated electro-responsive hydrogel nanoparticles: Therapeutic potential for epilepsy
    • Ying X, Wang Y, Liang J, et al. Angiopep-conjugated electro-responsive hydrogel nanoparticles: therapeutic potential for epilepsy. Angew Chem Int Ed Engl. 2014;53(46):12436–12440.
    • (2014) Angew Chem Int Ed Engl , vol.53 , Issue.46 , pp. 12436-12440
    • Ying, X.1    Wang, Y.2    Liang, J.3
  • 171
    • 34447623755 scopus 로고    scopus 로고
    • Preparation, characterisation and maintenance of drug efficacy of doxorubicin-loaded human serum albumin (HSA) nanoparticles
    • Dreis S, Rothweller F, Michaelis A, Cinatl J, Kreuter J, Langer K. Preparation, characterisation and maintenance of drug efficacy of doxorubicin-loaded human serum albumin (HSA) nanoparticles. Int J Pharm. 2007;341(1–2):207–214.
    • (2007) Int J Pharm , vol.341 , Issue.1-2 , pp. 207-214
    • Dreis, S.1    Rothweller, F.2    Michaelis, A.3    Cinatl, J.4    Kreuter, J.5    Langer, K.6
  • 172
    • 0035889882 scopus 로고    scopus 로고
    • Intraarterial chemotherapy with polyoxyethylated castor oil free paclitaxel, incorporated in albumin nanoparticles (ABI-007) – phase I study of patients with squamous cell carcinoma of the head and neck and anal canal: Preliminary evidence of clinical activity
    • Damascelli B, Cantu G, Mattavelli F, et al. Intraarterial chemotherapy with polyoxyethylated castor oil free paclitaxel, incorporated in albumin nanoparticles (ABI-007) – phase I study of patients with squamous cell carcinoma of the head and neck and anal canal: preliminary evidence of clinical activity. Cancer. 2001;92(10):2592–2602.
    • (2001) Cancer , vol.92 , Issue.10 , pp. 2592-2602
    • Damascelli, B.1    Cantu, G.2    Mattavelli, F.3
  • 173
    • 80051824807 scopus 로고    scopus 로고
    • HI 6 human serum albumin nanoparticles – development and transport over an in vitro blood–brain barrier model
    • Dadparvar M, Wagner S, Wien S, et al. HI 6 human serum albumin nanoparticles – development and transport over an in vitro blood–brain barrier model. Toxicol Lett. 2011;206(1):60–66.
    • (2011) Toxicol Lett , vol.206 , Issue.1 , pp. 60-66
    • Dadparvar, M.1    Wagner, S.2    Wien, S.3
  • 174
    • 84887001690 scopus 로고    scopus 로고
    • Human serum albumin and other proteins as templating agents for the synthesis of nanosized dopamine-eumelanin
    • Chassepot A, Ball V. Human serum albumin and other proteins as templating agents for the synthesis of nanosized dopamine-eumelanin. J Colloid Interf Sci. 2014;414:97–102.
    • (2014) J Colloid Interf Sci , vol.414 , pp. 97-102
    • Chassepot, A.1    Ball, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.