Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: Relevance for the pathogenesis of Parkinson's disease

Journal of Neurochemistry

Volumn 100, Issue 2, 2007, Pages 503-519

  Thomas, Mark P ^a,b,c,d   Chartrand, Kathryn ^a,b   Reynolds, Ashley ^a,b   Vitvitsky, Victor ^c   Banerjee, Ruma ^c   Gendelman, Howard E ^a,b,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^d UNIVERSITY OF NORTHERN COLORADO   (United States)

Author keywords

synuclein; Chloride; Macrophage; Mice; Potassium; Proton

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; ION CHANNEL; OXYGEN RADICAL; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BONE MARROW; CELL ACTIVATION; CELL MEMBRANE; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CHLORIDE CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE COURSE; DOPAMINERGIC NERVE CELL; ION CURRENT; ION TRANSPORT; LEWY BODY; MACROPHAGE; MALE; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; PARKINSON DISEASE; PATCH CLAMP; PATHOGENESIS; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN SECRETION;

ALPHA-SYNUCLEIN; ANIMALS; ANIMALS, NEWBORN; BONE MARROW CELLS; CELLS, CULTURED; CHARYBDOTOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG INTERACTIONS; ELECTRIC STIMULATION; GENE EXPRESSION REGULATION; ION CHANNELS; MACROPHAGES; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICROGLIA; NEUROTOXINS; PATCH-CLAMP TECHNIQUES; PIPERIDINES; REACTIVE OXYGEN SPECIES; ZINC;

MURINAE;

EID: 33845746706     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04315.x     Document Type: Article

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