Fullerenes as unique nanopharmaceuticals for disease treatment

Science China Chemistry

Volumn 53, Issue 11, 2010, Pages 2233-2240

  Ma, Huili ^a   Liang, Xing Jie ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

Author keywords

biological effect; clinical application; fullerene; nanomedicine; nanoparticle

Indexed keywords

BIODISTRIBUTIONS; BIOLOGICAL ACTIVITIES; BIOLOGICAL EFFECTS; BIOLOGICAL MECHANISMS; BIOLOGICAL PROPERTIES; CANCER THERAPY; CLINICAL APPLICATION; DISEASE TREATMENT; FUNCTIONALIZED; HIGH EFFICIENCY; HUMAN IMMUNODEFICIENCY VIRUS; IN-VIVO; LIPID PEROXIDATION; LOW CONCENTRATIONS; LOW TOXICITY; NANO-MATERIALS; NANOMEDICINES; NANOPHARMACEUTICALS; REACTIVE OXYGEN SPECIES;

DISEASE CONTROL; DISEASES; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; OXYGEN; TOXICITY; VIRUSES;

FULLERENES;

EID: 78649371189     PISSN: 16747291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11426-010-4118-5     Document Type: Review

References (64)

1. 60: Buckminsterfullerene Nature 318 162 163 1:CAS:528: DyaL28XotVOktQ%3D%3D 10.1038/318162a0
2. M. Okumura M. Mikawa T. Yokawa Y. Kanazawa H. Kato H. Shinohara 2002 Evaluation of water-soluble metallofullerenes as MRI contrast agents Acad Radiol 9 Suppl2 S495 497 10.1016/S1076-6332(03)80274-X
3. Y.Y. Ding Z.Y. Zhang P.J. Zhou J.C. Liu Z.M. Wang Y.L. Zhao 2007 Research and development of gadolinium loaded liquid scintillator for Daya Bay neutrino experiment J Rare Earths 25 310 313
4. 10 as a MRI contrast agent J Am Chem Soc 125 5471 5478 1:CAS:528:DC%2BD3sXivVClsbs%3D 10.1021/ja0340984
5. L. Qu W.B. Cao G.M. Xing J. Zhang H. Yuan J. Tang Y. Cheng B. Zhang Y.L. Zhao H. Lei 2006 Study of rare earth encapsulated carbon nanomolecules for biomedical uses J Alloy Compd 408/412 400 404 10.1016/j.jallcom.2004.12.101
6. G.M. Xing H. Yuan R. He X.Y. Gao L. Jing F. Zhao Z.F. Chai Y.L. Zhao 2008 The strong MRI relaxivity of paramagnetic nanoparticles J Phys Chem B 112 6288 6291 1:CAS:528:DC%2BD1cXkvF2lsbs%3D 10.1021/jp8012706
7. H. Meng G. Xing B. Sun F. Zhao H. Lei W. Li Y. Song Z. Chen H. Yuan X. Wang J. Long C. Chen X. Liang N. Zhang Z. Chai Y. Zhao 2010 Potent angiogenesis inhibition by the particulate form of fullerene derivatives Acs Nano 4 2773 2783 1:CAS:528:DC%2BC3cXltlygs7k%3D 10.1021/nn100448z
8. J.-J. Yin F. Lao P.P. Fu W.G. Wamer Y.L. Zhao G.M. Xing X.Y. Gao B.Y. Sun X.Y. Li P.C. Wang C.Y. Chen X.-J. Liang 2008 Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavenger Molecular Pharmacol 74 1132 1140 1:CAS:528:DC%2BD1cXht1SgtbzM 10.1124/mol.108.048348
9. X.-J. Liang H. Meng Y.Z. Wang H.Y. He J. Meng J. Lu P.C. Wang Y.L. Zhao X.Y. Gao B.Y. Sun C.Y. Chen G.M. Xing D.W. Shen M.M. Gottesman Y. Wu J.-J. Yin L. Jia 2010 Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis Proc Natl Acad Sci 107 7449 7454 1:CAS:528:DC%2BC3cXlsFWhsb0%3D 10.1073/pnas.0909707107
10. 60), a novel carbon allotrope, and its derivatives J Pharmacol Sci 100 513 518 1:CAS:528:DC%2BD28XmvVajsrk%3D 10.1254/jphs.CPJ06002X
11. (n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity Nano Lett 5 2050 2057 1:CAS:528:DC%2BD2MXhtVegt7fJ 10.1021/nl051624b
12. (n) nanoparticles in tumor-bearing mice Biochem Pharmacol 71 872 881 1:CAS:528:DC%2BD28XhtlKmtb4%3D 10.1016/j.bcp.2005.12.001
13. (22) nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity Biomaterials 30 3934 3945 1:CAS:528:DC%2BD1MXmvVyktro%3D 10.1016/j.biomaterials.2009.04.001
14. Y. Wang L.V. Juan X. Ma D. Wang Y. Chang G. Nie L. Jia X. Duan X.J. Liang 2010 Specific hemosiderin deposition in spleen induced by a low dose of cisplatin: Altered iron metabolism and its implication as an acute hemosiderin formation model Curr Drug Metab 11 207 515
15. Y. Liu F. Jiao Y. Qiu W. Li Y. Qu C. Tian Y. Li R. Bai F. Lao Y. Zhao Z.F. Chai C. Chen 2009 Immunostimulatory properties and enhanced TNF- alpha mediated cellular immunity for tumor therapy by C60(OH)20 nanoparticles Nanotechnology 20 415102 10.1088/0957-4484/20/41/415102
16. T.Y. Zakharian A. Seryshev B. Sitharaman B.E. Gilbert V. Knight L.J. Wilson 2005 A fullerene-paclitaxel chemotherapeutic: Synthesis, characterization, and study of biological activity in tissue culture J Am Chem Soc 127 12508 12509 1:CAS:528:DC%2BD2MXpt1Wisbw%3D 10.1021/ja0546525
17. R. Partha L.R. Mitchell J.L. Lyon P.P. Joshi J.L. Conyers 2008 Buckysomes: Fullerene-based nanocarriers for hydrophobic molecule delivery Acs Nano 2 1950 1958 1:CAS:528:DC%2BD1cXhtVWlsr7L 10.1021/nn800422k
18. P. Chaudhuri A. Paraskar S. Soni R.A. Mashelkar S. Sengupta 2009 Fullerenol-cytotoxic conjugates for cancer chemotherapy Acs Nano 3 2505 2514 1:CAS:528:DC%2BD1MXpvFKjurs%3D 10.1021/nn900318y
19. Y. Tabata Y. Murakami Y. Ikada 1997 Photodynamic effect of polyethylene glycol-modified fullerene on tumor Jpn J Cancer Res 88 1108 1116 1:CAS:528:DyaK2sXnvFWlsL8%3D
20. P. Chaudhuri R. Harfouche S. Soni D.M. Hentschel S. Sengupta 2010 Shape effect of carbon nanovectors on angiogenesis Acs Nano 4 574 582 1:CAS:528:DC%2BC3cXjtFKm 10.1021/nn901465h
21. 60) Biomaterials 29 3561 3573 1:CAS:528:DC%2BD1cXotFCitLY%3D 10.1016/j.biomaterials.2008.05.005
22. J.J. Yin F. Lao P.P. Fu W.G. Wamer Y.L. Zhao P.C. Wang Y. Qiu B.Y. Sun G.M. Xing J.Q. Dong X.J. Liang C.Y. Chen 2009 The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials Biomaterials 30 611 621 1:CAS:528:DC%2BD1cXhsVensr7F 10.1016/j.biomaterials.2008.09.061
23. Lao F, Li W, Han D, Qu Y, Liu Y, Zhao YL, Chen CY. Fullerene derivatives protect endothelial cells against NO-induced damage. Nanotechnology, 2009, 20: 225103(9pp)
24. A.A. Corona-Morales A. Castell A. Escobar R. Drucker-Colin L. Zhang 2003 Fullerene C60 and ascorbic acid protect cultured chromaffin cells against levodopa toxicity J Neurosci Res 71 121 126 1:CAS:528:DC%2BD3sXht1Ogtg%3D%3D 10.1002/jnr.10456
25. J.J. Ryan H.R. Bateman A. Stover G. Gomez S.K. Norton W. Zhao L.B. Schwartz R. Lenk C.L. Kepley 2007 Fullerene nanomaterials inhibit the allergic response J Immunol 179 665 672 1:CAS:528:DC%2BD2sXmsF2gurg%3D
26. 24 Nitric Oxide 11 201 207 1:CAS:528:DC%2BD2cXos1Kktrg%3D 10.1016/j.niox.2004.08.003
27. 24 through inhibition of oxidative stress Pharmacol Rep 61 335 342 1:CAS:528: DC%2BD1MXhtl2ktrbE
28. 24 effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line J Radiat Res (Tokyo) 49 321 327 1:CAS:528:DC%2BD1cXhtVWnur7K 10.1269/jrr.07092
29. 24 and amifostine in irradiated rats Colloids Surf B Biointerfaces 58 39 43 1:CAS:528:DC%2BD2sXlvVOksrs%3D 10.1016/j.colsurfb.2007.01.005
30. N. Gharbi M. Pressac M. Hadchouel H. Szwarc S. Wilson F. Moussa 2005 [60] Fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity Nano Lett 5 2578 2585 1:CAS:528:DC%2BD2MXht1eisbjP 10.1021/nl051866b
31. (60) fulleropyrrolidine-thalidomide dyad as a new anti-inflammation agent Bioorg Med Chem 16 8619 8626 1:CAS:528: DC%2BD1cXhtFantLvJ 10.1016/j.bmc.2008.08.004
32. B. Daroczi G. Kari M.F. McAleer J.C. Wolf U. Rodeck A.P. Dicker 2006 In vivo radioprotection by the fullerene nanoparticle DF-1 as assessed in a zebrafish model Clin Cancer Res 12 7086 7091 1:CAS:528:DC%2BD28Xht1Kns7nK 10.1158/1078-0432.CCR-06-0514
33. Z. Markovic B. Todorovic-Markovic D. Kleut N. Nikolic S. Vranjes-Djuric M. Misirkic L. Vucicevic K. Janjetovic A. Isakovic L. Harhaji B. Babic-Stojic M. Dramicanin V. Trajkovic 2007 The mechanism of cell-damaging reactive oxygen generation by colloidal fullerenes Biomaterials 28 5437 5448 1:CAS:528:DC%2BD2sXht1WqtbnF 10.1016/j.biomaterials.2007.09.002
34. P. Mroz A. Pawlak M. Satti H. Lee T. Wharton H. Gali T. Sarna M.R. Hamblin 2007 Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism Free Radic Biol Med 43 711 719 1:CAS:528:DC%2BD2sXotlSmsL4%3D 10.1016/j.freeradbiomed.2007.05.005
35. R.F. Schinazi R. Sijbesma G. Srdanov C.L. Hill F. Wudl 1993 Synthesis and virucidal activity of a water-soluble, configurationally stable, derivatized C60 fullerene Antimicrob Agents Chemother 37 1707 1710 1:CAS:528: DyaK2cXksFagug%3D%3D
36. S.H. Friedman P.S. Ganapathi Y. Rubin G.L. Kenyon 1998 Optimizing the binding of fullerene inhibitors of the HIV-1 protease through predicted increases in hydrophobic desolvation J Med Chem 41 2424 2429 1:CAS:528:DyaK1cXjtlynu70%3D 10.1021/jm970689r
37. S.H. Friedman D.L. DeCamp R.P. Sijbesma G. Srdanov F. Wudl G.L. Kenyon 1993 Inhibition of the HIV-1 protease by fullerene derivatives: model building studies and experimental verification J Am Chem Soc 115 6506 6509 1:CAS:528:DyaK3sXltlCisrw%3D 10.1021/ja00068a005
38. T. Mashino K. Shimotohno N. Ikegami D. Nishikawa K. Okuda K. Takahashi S. Nakamura M. Mochizuki 2005 Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives Bioorg Med Chem Lett 15 1107 1109 1:CAS:528:DC%2BD2MXos1ClsA%3D%3D 10.1016/j.bmcl.2004.12.030
39. S. Bosi T. Da Ros G. Spalluto J. Balzarini M. Prato 2003 Synthesis and anti-HIV properties of new water-soluble bis-functionalized[60] fullerene derivatives Bioorg Med Chem Lett 13 4437 40 1:CAS:528:DC%2BD3sXpt1yrurg%3D 10.1016/j.bmcl.2003.09.016
40. S. Marchesan T. Da Ros G. Spalluto J. Balzarini M. Prato 2005 Anti-HIV properties of cationic fullerene derivatives Bioorg Med Chem Lett 15 3615 3618 1:CAS:528:DC%2BD2MXlvV2gu7Y%3D 10.1016/j.bmcl.2005.05.069
41. Z. Zhu D.I. Schuster M.E. Tuckerman 2003 Molecular dynamics study of the connection between flap closing and binding of fullerene-based inhibitors of the HIV-1 protease Biochemistry 42 1326 1333 1:CAS:528:DC%2BD3sXjt1ykug%3D%3D 10.1021/bi020496s
42. V.S. Lee P. Nimmanpipug O. Aruksakunwong S. Promsri P. Sompornpisut S. Hannongbua 2007 Structural analysis of lead fullerene-based inhibitor bound to human immunodeficiency virus type 1 protease in solution from molecular dynamics simulations J Mol Graph Model 26 558 570 1:CAS:528:DC%2BD2sXpvFKhu7g%3D 10.1016/j.jmgm.2007.03.013
43. G. Pastorin S. Marchesan J. Hoebeke T. Da Ros L. Ehret-Sabatier J.P. Briand M. Prato A. Bianco 2006 Design and activity of cationic fullerene derivatives as inhibitors of acetylcholinesterase Org Biomol Chem 4 2556 2562 1:CAS:528:DC%2BD28Xmt1Gmuro%3D 10.1039/b604361e
44. V. Zarubaev I. Belousova O. Kiselev L. Piotrovsky P. Anfimov T. Krisko T. Muraviova V. Rylkov A. Starodubzev A. Sirotkin 2007 Photodynamic inactivation of influenza virus with fullerene C60 suspension in allantoic fluid Photodiagn Photodyn Ther 4 31 35 10.1016/j.pdpdt.2006.08.003
45. A. Kumar S.K. Menon 2009 Fullerene derivatized s-triazine analogues as antimicrobial agents Eur J Med Chem 44 2178 2183 1:CAS:528:DC%2BD1MXjsl2gs7g%3D 10.1016/j.ejmech.2008.10.036
46. A. Kumar G. Patel S.K. Menon 2009 Fullerene isoniazid conjugate-a tuberculostat with increased lipophilicity: Synthesis and evaluation of antimycobacterial activity Chem Biol Drug Des 73 553 557 1:CAS:528: DC%2BD1MXltlagt74%3D 10.1111/j.1747-0285.2009.00804.x
47. N. Tsao T.Y. Luh C.K. Chou T.Y. Chang J.J. Wu C.C. Liu H.Y. Lei 2002 In vitro action of carboxyfullerene J Antimicrob Chemother 49 641 649 1:CAS:528:DC%2BD38XivFynurs%3D 10.1093/jac/49.4.641
48. N. Tsao P.P. Kanakamma T.Y. Luh C.K. Chou H.Y. Lei 1999 Inhibition of Escherichia coli-induced meningitis by carboxyfullerence Antimicrob Agents Chemother 43 2273 2277 1:CAS:528:DyaK1MXlvVGrurg%3D
49. N. Tsao T.Y. Luh C.K. Chou J.J. Wu Y.S. Lin H.Y. Lei 2001 Inhibition of group A streptococcus infection by carboxyfullerene Antimicrob Agents Chemother 45 1788 1793 1:CAS:528:DC%2BD3MXjslyqsLk%3D 10.1128/AAC.45.6.1788-1793.2001
50. F. Pellarini D. Pantarotto T. Da Ros A. Giangaspero A. Tossi M. Prato 2001 A novel [60]fullerene amino acid for use in solid-phase peptide synthesis Org Lett 3 1845 1848 1:CAS:528:DC%2BD3MXjs1SnsL0%3D 10.1021/ol015934m
51. D. Pantarotto A. Bianco F. Pellarini A. Tossi A. Giangaspero I. Zelezetsky J.P. Briand M. Prato 2002 Solid-phase synthesis of fullerene-peptides J Am Chem Soc 124 12543 12549 1:CAS:528:DC%2BD38XntlOrt78%3D 10.1021/ja027603q
52. 60 derivative: Kinetics and mechanisms Environ Sci Technol 43 7410 7415 1:CAS:528:DC%2BD1MXhtVyhs73P 10.1021/es901262z
53. T. Mashino N. Usui K. Okuda T. Hirota M. Mochizuki 2003 Respiratory chain inhibition by fullerene derivatives: Hydrogen peroxide production caused by fullerene derivatives and a respiratory chain system Bioorg Med Chem 11 1433 1438 1:CAS:528:DC%2BD3sXhvFGrs74%3D 10.1016/S0968-0896(02)00610-7
54. D.Y. Lyon L. Brunet G.W. Hinkal M.R. Wiesner P.J. Alvarez 2008 Antibacterial activity of fullerene water suspensions (nC60) is not due to ROS-mediated damage Nano Lett 8 1539 1543 1:CAS:528:DC%2BD1cXks1Wntrw%3D 10.1021/nl0726398
55. S. Bosi T. Da Ros S. Castellano E. Banfi M. Prato 2000 Antimycobacterial activity of ionic fullerene derivatives Bioorg Med Chem Lett 10 1043 1045 1:CAS:528:DC%2BD3cXjsl2ltL8%3D 10.1016/S0960-894X(00)00159-1
56. D. Bedrov G.D. Smith H. Davande L. Li 2008 Passive transport of C60 fullerenes through a lipid membrane: A molecular dynamics simulation study J Phys Chem B 112 2078 2084 1:CAS:528:DC%2BD1cXhtFCiu70%3D 10.1021/jp075149c
57. 60 and its derivatives across a lipid bilayer Nano Lett 7 614 619 1:CAS:528:DC%2BD2sXhvF2qsbo%3D 10.1021/nl062515f
58. 60 cytotoxicity is due to lipid peroxidation Biomaterials 26 7587 7595 1:CAS:528:DC%2BD2MXot1Wktbs%3D 10.1016/j.biomaterials.2005.05.027
59. Li W, Chen CY, Ye C, Wei TT, Zhao YL, Lao F, Chen Z, Meng H, Gao YX, Yuan H, Xing GM, Zhao F, Chai ZF, Zhang XJ, Yang FY, Han D, Tang XH, Zhang YG. The translocation of Fullerenic nanoparticles into Iysosome via the pathway of clathrin-mediated endocytosis. Nanotechnology, 2008, 19: 145102(12pp)
60. 22 in different tissues of tumor-bearing mice. J Nanosci Nanotechnol, 2009, accepted
61. M. Geisow 1980 Pathways of endocytosis Nature 288 434 436 1:STN:280:DyaL3M%2FnsV2msg%3D%3D 10.1038/288434a0
62. J.L. Goldstein R.G. Anderson M.S. Brown 1979 Coated pits, coated vesicles, and receptor-mediated endocytosis Nature 279 679 685 1:CAS:528:DyaL3cXhs1Og 10.1038/279679a0
63. J. Yang K. Wang J. Driver A.R. Barron 2007 The use of fullerene substituted phenylalanine amino acid as a passport for peptides through cell membranes Org Biomol Chem 5 260 266 1:CAS:528:DC%2BD2sXhtlSgtg%3D%3D 10.1039/b614298b
64. S. Yamago H. Tokuyama E. Nakamura K. Kikuchi S. Kananishi K. Sueki H. Nakahara S. Enomoto F. Ambe 1995 In vivo biological behavior of a water-miscible fullerene: 14C labeling, absorption, distribution, excretion and acute toxicity Chem Biol 2 385 389 1:CAS:528:DyaK2MXntFWnsrw%3D 10.1016/1074-5521(95)90219-8