Polyhydroxylated C60, fullerenols, as glutamate receptor antagonists and neuroprotective agents

Journal of Neuroscience Research

Volumn 62, Issue 4, 2000, Pages 600-607

  Jin, H ^a   Chen, W Q ^a   Tang, X W ^a   Chiang, L Y ^b   Yang, C Y ^c   Schloss, J V ^a   Wu, J Y ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

C60 compounds; Calcium homeostasis; Ionotropic Glu receptors; Neuroprotection; Neurotoxicity

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CALCIUM ION; FULLERENE DERIVATIVE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; SCAVENGER; 4 AMINOBUTYRIC ACID RECEPTOR; AMINO ACID RECEPTOR BLOCKING AGENT; CALCIUM; CARBON; FERRIC CHLORIDE; FERRIC ION; FULLERENOL; GLUTAMIC ACID; HYDROGEN PEROXIDE; NEUROTRANSMITTER RECEPTOR; TAURINE RECEPTOR;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; FEMALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SYNTHESIS; ANIMAL; BINDING SITE; BRAIN; CELL CULTURE; CELL DEATH; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; FETUS; INTRACELLULAR FLUID; METABOLISM; NERVE CELL; NERVE DEGENERATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT;

ANIMALS; BINDING SITES; BRAIN; CALCIUM; CARBON; CELL DEATH; CELLS, CULTURED; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; FERRIC COMPOUNDS; FETUS; FREE RADICAL SCAVENGERS; FULLERENES; GLUTAMIC ACID; HYDROGEN PEROXIDE; INTRACELLULAR FLUID; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA; RECEPTORS, GLUTAMATE; RECEPTORS, NEUROTRANSMITTER;

EID: 0034668386     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20001115)62:4<600::AID-JNR15>3.0.CO;2-F     Document Type: Article

References (23)

1. Efficient one flask synthesis of water soluble [60] fullerenols
2. 60 fullerene molecules
3. 60 fullerene functionalization
4. Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage
5. Oxidative stress, glutamate, and neurode-generative disorders
6. Studies of NMDA and non-NMDA-mediated neurotoxicity in cultured neurons
7. Buckminster-fullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons
8. Carboxyfullerenes as neuroprotective agents
9. Inhibition of the HIV-1 protease by fullerene derivatives: Model building studies and experimental verification
10. 60 on vascular smooth muscle cells
11. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
12. Purification and characterization of a low-molecular weight endogenous glutamate binding inhibitor (LGBI) in porcine brain
13. 2+ in AMPA-mediated poly phosphoinositides turnover in primary neuronal cultures
14. Physiological and pathophysiological roles of excitatory amino acids during central neuron system development
15. Glutamate and the pathophysiology of hypoxic-ischemic brain damage
16. Oxidative stress and neurodegenerative disorders
17. Isolation of endogenous modulators for the GABA binding site of the GABA(A) receptor
18. Biphasic effect of taurine on excitatory amino acid-induced neurotoxicity
19. 60, fullerenol, a novel free-radical trapper, prevented hydrogen peroxide- and cumene hydroperoxide-elicited changes in rat hippocampus in vitro
20. Photo-induced biochemical activity of fullerene carboxylic acid
21. Interactions between N acetylaspartylglutamate and AMPA, kainate, and NMDA binding sites
22. Taurine receptor: Kinetic analysis and pharmacologic studies
23. Calcium permeability change and neurotransmitter release in cultured brain neurons