Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Adamcakova Dodd, Andrea ^a   Stebounova, Larissa V ^b   Kim, Jong S ^a   Vorrink, Sabine U ^a   Ault, Andrew P ^b   O'Shaughnessy, Patrick T ^a   Grassian, Vicki H ^b   Thorne, Peter S ^a  

^a UNIVERSITY OF IOWA   (United States)

^b E11 SSH   (United States)

Author keywords

Dissolution; Inhalation; Murine model; Pulmonary response; Toxicity; Zinc oxide nanoparticles

Indexed keywords

BLEOMYCIN; CYTOKINE; INTERLEUKIN 12P40; INTERLEUKIN 4; INTERLEUKIN 5; LACTATE DEHYDROGENASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; METHACHOLINE; NANOPARTICLE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ZINC; ZINC OXIDE; ZINC OXIDE NANOPARTICLE;

ACUTE TOXICITY; AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BRAIN; CELL DAMAGE; CHRONIC TOXICITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; ENZYME ACTIVITY; EOSINOPHIL; EXPOSURE; FIBROSIS; GRANULOCYTE; HEART; HISTOPATHOLOGY; INTERSTITIAL FLUID; KIDNEY; LIVER; LUNG ALVEOLUS CELL; LUNG LAVAGE; LUNG TOXICITY; LYSOSOME; MACROPHAGE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; SPLEEN; TISSUE LEVEL; TOXICITY TESTING; WEIGHT GAIN; WEIGHT REDUCTION; ZINC BLOOD LEVEL;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; ATMOSPHERE EXPOSURE CHAMBERS; BODY BURDEN; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTOR AGENTS; CELL SURVIVAL; LIPID PEROXIDATION; LUNG DISEASES; MALE; METHACHOLINE CHLORIDE; MICE; MICE, INBRED C57BL; NANOPARTICLES; OXIDATIVE STRESS; PNEUMONIA; REACTIVE OXYGEN SPECIES; RESPIRATORY MECHANICS; SOLUBILITY; TOXICITY TESTS, ACUTE; TOXICITY TESTS, CHRONIC; WEIGHT GAIN; ZINC OXIDE;

EID: 84899046918     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-11-15     Document Type: Article

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