Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells

Biomaterials

Volumn 29, Issue 26, 2008, Pages 3583-3590

  Thorek, Daniel L J ^a   Tsourkas, Andrew ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Micron sized paramagnetic iron oxide; Molecular imaging; MRI; Nanoparticles; Standard superparamagnetic iron oxide; Ultrasmall superparamagnetic iron oxide

Indexed keywords

(1 1 0) SURFACE; (ALGORITHMIC) COMPLEXITY; (PL) PROPERTIES; BIO-DISTRIBUTION; CELL LABELING; CELLULAR UPTAKE; CHARGE DEPENDENCE; CONCENTRATION (COMPOSITION); CONTRAST ENHANCEMENT; CONTRAST-ENHANCED; CYTOMETRY; DOSE DEPENDENT; FUNCTIONALIZATION; GENERAL (CO); IN-VIVO; IRON OXIDE PARTICLE (IOP); LABELED CELLS; MAGNETIC RESONANCE (MR); PHAGOCYTIC CELLS; RELAXOMETRY; SUPERPARAMAGNETIC IRON OXIDE (SPIO); T CELLS; TRANSFECTION AGENTS;

SUPERPARAMAGNETIC IRON OXIDE;

ARTICLE; CELL HOMING; CELL LABELING; CONTRAST ENHANCEMENT; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IRON TRANSPORT; PARTICLE SIZE; PHENOTYPE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; T LYMPHOCYTE;

BIOCOMPATIBLE MATERIALS; CONTRAST MEDIA; FERRIC COMPOUNDS; HUMANS; IMAGE ENHANCEMENT; JURKAT CELLS; MAGNETIC RESONANCE IMAGING; MAGNETICS; MATERIALS TESTING; PARTICLE SIZE; SURFACE PROPERTIES;

EID: 46149100704     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2008.05.015     Document Type: Article

References (45)

1. Bulte J.W., Douglas T., Witwer B., Zhang S.C., Strable E., Lewis B.K., et al. Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 19 12 (2001) 1141-1147
2. Rogers W.J., Meyer C.H., and Kramer C.M. Technology insight: in vivo cell tracking by use of MRI. Nat Clin Pract Cardiovasc Med 3 10 (2006) 554-562
3. Ahrens E.T., Flores R., Xu H.Y., and Morel P.A. In vivo imaging platform for tracking immunotherapeutic cells. Nat Biotechnol 23 8 (2005) 983-987
4. Pittet M.J., Grimm J., Berger C.R., Tamura T., Wojtkiewicz G., Nahrendorf M., et al. In vivo imaging of T cell delivery to tumors after adoptive transfer therapy. Proc Natl Acad Sci U S A 104 30 (2007) 12457-12461
5. Sauer M.G., Ericson M.E., Weigel B.J., Herron M.J., Panoskaltsis-Mortari A., Kren B.T., et al. A novel system for simultaneous in vivo tracking and biological assessment of leukemia cells and ex vivo generated leukemia-reactive cytotoxic T cells. Cancer Res 64 11 (2004) 3914-3921
6. Sundstrom J.B., Mao H., Santoianni R., Villinger F., Little D.M., Huynh T.T., et al. Magnetic resonance imaging of activated proliferating rhesus macaque T cells labeled with superparamagnetic monocrystalline iron oxide nanoparticles. J Acquir Immune Defic Syndr 35 1 (2004) 9-21
7. Kircher M.F., Grimm J., Swirski F.K., Libby P., Gerszten R.E., Allport J.R., et al. Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions. Circulation 117 3 (2008) 388-395
8. Hadjantonakis A.K., and Papaioannou V.E. Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in mice. BMC Biotechnol 4 (2004)
9. Puri S., and Hebrok M. Dynamics of embryonic pancreas development using real-time imaging. Dev Biol 306 1 (2007) 82-93
10. Voura E.B., Jaiswal J.K., Mattoussi H., and Simon S.M. Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy. Nat Med 10 9 (2004) 993-998
11. Cahill K.S., Gaidosh G., Huard J., Silver X., Byrne B.J., and Walter G.A. Noninvasive monitoring and tracking of muscle stem cell transplants. Transplantation 78 11 (2004) 1626-1633
12. Yoneyama R., Chemaly E.R., and Hajjar R.J. Tracking stem cells in vivo. Ernst Schering Res Found Workshop 60 (2006) 99-109
13. Zhang S.J., and Wu J.C. Comparison of imaging techniques for tracking cardiac stem cell therapy. J Nucl Med 48 12 (2007) 1916-1919
14. Hoshino K., Ly H.Q., Frangioni J.V., and Hajjar R.J. In vivo tracking in cardiac stem cell-based therapy. Prog Cardiovasc Dis 49 6 (2007) 414-420
15. Weissleder R., Hahn P.F., Stark D.D., Elizondo G., Saini S., Todd L.E., et al. Superparamagnetic iron oxide: enhanced detection of focal splenic tumors with MR imaging. Radiology 169 2 (1988) 399-403
16. Weissleder R., Elizondo G., Wittenberg J., Rabito C.A., Bengele H.H., and Josephson L. Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 175 2 (1990) 489-493
17. Shapiro E.M., Skrtic S., and Koretsky A.P. Sizing it up: cellular MRI using micron-sized iron oxide particles. Magn Reson Med 53 2 (2005) 329-338
18. Metz S., Bonaterra G., Rudelius M., Settles M., Rummeny E.J., and Daldrup-Link H.E. Capacity of human monocytes to phagocytose approved iron oxide MR contrast agents in vitro. Eur Radiol 14 10 (2004) 1851-1858
19. Montet-Abou K., Montet X., Weissleder R., and Josephson L. Cell internalization of magnetic nanoparticles using transfection agents. Mol Imaging 6 1 (2007) 1-9
20. Petri-Fink A., and Hofmann H. Superparamagnetic iron oxide nanoparticles (SPIONs): from synthesis to in vivo studies - a summary of the synthesis, characterization, in vitro, and in vivo investigations of SPIONs with particular focus on surface and colloidal properties. IEEE Trans Nanobioscience 6 4 (2007) 289-297
21. Matuszewski L., Persigehl T., Wall A., Schwindt W., Tombach B., Fobker M., et al. Cell tagging with clinically approved iron oxides: feasibility and effect of lipofection, particle size, and surface coating on labeling efficiency. Radiology 235 1 (2005) 155-161
22. Lewin M., Carlesso N., Tung C.H., Tang X.W., Cory D., Scadden D.T., et al. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol 18 4 (2000) 410-414
23. Arbab A.S., Yocum G.T., Kalish H., Jordan E.K., Anderson S.A., Khakoo A.Y., et al. Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI. Blood 104 4 (2004) 1217-1223
24. Tai J.H., Foster P., Rosales A., Feng B., Hasilo C., Martinez V., et al. Imaging islets labeled with magnetic nanoparticles at 1.5 Tesla. Diabetes 55 11 (2006) 2931-2938
25. Walczak P., Kedziorek D.A., Gilad A.A., Lin S., and Bulte J.W.M. Instant MR labeling of stem cells using magnetoelectroporation. Magn Reson Med 54 4 (2005) 769-774
26. Shapiro E.M., Skrtic S., Sharer K., Hill J.M., Dunbar C.E., and Koretsky A.P. MRI detection of single particles for cellular imaging. Proc Natl Acad Sci U S A 101 30 (2004) 10901-10906
27. de Vries I.J., Lesterhuis W.J., Barentsz J.O., Verdijk P., van Krieken J.H., Boerman O.C., et al. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol 23 11 (2005) 1407-1413
28. Shapiro E.M., Medford-Davis L.N., Fahmy T.M., Dunbar C.E., and Koretsky A.P. Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI. Contrast Media Mol Imaging 2 3 (2007) 147-153
29. Oude Engberink R.D., van der Pol S.M., Dopp E.A., de Vries H.E., and Blezer E.L. Comparison of SPIO and USPIO for in vitro labeling of human monocytes: MR detection and cell function. Radiology 243 2 (2007) 467-474
30. Foster-Gareau P., Heyn C., Alejski A., and Rutt B.K. Imaging single mammalian cells with a 1.5 T clinical MRI scanner. Magn Reson Med 49 5 (2003) 968-971
31. Shapiro E.M., Sharer K., Skrtic S., and Koretsky A.P. In vivo detection of single cells by MRI. Magn Reson Med 55 2 (2006) 242-249
32. 2 and tat-CLIO. Korean J Radiol 8 5 (2007) 365-371
33. Shen T., Weissleder R., Papisov M., Bogdanov A., and Brady T.J. Monocrystalline iron-oxide nanocompounds (Mion) - physicochemical properties. Magn Reson Med 29 5 (1993) 599-604
34. Pittet M.J., Swirski F.K., Reynolds F., Josephson L., and Weissleder R. Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles. Nat Protoc 1 1 (2006) 73-79
35. Zhao M., Kircher M.F., Josephson L., and Weissleder R. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem 13 4 (2002) 840-844
36. Ayyub P., Palkar V.R., Chattopadhyay S., and Multani M. Effect of crystal size-reduction on lattice symmetry and cooperative properties. Phys Rev B 51 9 (1995) 6135-6138
37. Solomon I. Relaxation processes in a system of two spins. Phys Rev 99 (1955) 559
38. Bloembergen N. Proton relaxation times in paramagnetic solutions. J Chem Phys 27 2 (1957) 572-573
39. Giljohann D.A., Seferos D.S., Patel P.C., Millstone J.E., Rosi N.L., and Mirkin C.A. Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles. Nano Lett 7 12 (2007) 3818-3821
40. Duncan R., and Izzo L. Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev 57 15 (2005) 2215-2237
41. Foged C., Brodin B., Frokjaer S., and Sundblad A. Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model. Int J Pharm 298 2 (2005) 315-322
42. Chung T.H., Wu S.H., Yao M., Lu C.W., Lin Y.S., Hung Y., et al. The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles 3T3-L1 cells and human mesenchymal stem cells. Biomaterials 28 19 (2007) 2959-2966
43. Luo D., and Saltzman W.M. Synthetic DNA delivery systems. Nat Biotechnol 18 1 (2000) 33-37
44. Shi X.Y., Wang S.H., Sun H.P., and Baker J.R. Improved biocompatibility of surface functionalized dendrimer entrapped gold nanoparticles. Soft Matter 3 1 (2007) 71-74
45. Malik N., Wiwattanapatapee R., Klopsch R., Lorenz K., Frey H., Weener J.W., et al. Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of I-125-labelled polyamidoamine dendrimers in vivo. 2000;65:133. J Control Release 68 2 (2000) 299-302