Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition

Toxicology Letters

Volumn 227, Issue 1, 2014, Pages 29-40

  Roy, Ruchi ^a,b   Singh, Sunil Kumar ^c   Chauhan, L K S ^a   Das, Mukul ^a,b   Tripathi, Anurag ^a   Dwivedi, Premendra D ^a,b  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^c CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Apoptosis; Autophagy; Macrophages; Oxidative stress; Zinc oxide nanoparticles

Indexed keywords

ACETYLCYSTEINE; BECLIN 1; CARBONYL DERIVATIVE; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN DEPENDENT KINASE INHIBITOR 1; HISTONE H2AX; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 ISOFORM II; NANOPARTICLE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ZINC OXIDE; ZINC OXIDE NANOPARTICLE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENOTOXICITY; INTERNALIZATION; LIPID PEROXIDATION; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

APOPTOSIS; AUTOPHAGY; MACROPHAGES; OXIDATIVE STRESS; ZINC OXIDE NANOPARTICLES;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; AUTOPHAGY; CELLS, CULTURED; FEMALE; GENE SILENCING; MACROPHAGES, PERITONEAL; METAL NANOPARTICLES; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; OXIDATIVE STRESS; PARTICLE SIZE; PHOSPHATIDYLINOSITOL 3-KINASES; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SURFACE PROPERTIES; ZINC OXIDE;

EID: 84896911789     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.02.024     Document Type: Article

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